Applications of Nanoemulsion for the Wound-Healing Process

Attention to nanoemulsions has significantly grown in recent years as a result of their unique features like better stability, special appearance, higher performance, and sensorial merits. Chronic injuries are the consequence of a disturbance in the extremely coordinated cataract of wound healing actions. Nevertheless, correlated with variations in the timescales of various physical methods embroiled in tissue renewal, the aggression of the tumor microenvironment, rich in decaying enzymes, as well as its increased pH, demands the use of efficient drug delivery applications. This chapter summarizes that the various stages of wound healing include four phases: hemostatic stage, inflammation, proliferation, and remodeling process, respectively. Moreover, the major reported classes of lipid-based elements were either vesicular (liposome, permeation increased vesicle, etc.), emulsion-based behavior (nano-emulsion and micro-emulsion), or comprise a solid-based liquid matrix in the wound-healing process.

Nanopolymers: powerful tools in neuroprotection and neuroregeneration

: Disorders of the central and peripheral nervous systems are still major human health issues. Researchers have been seeking ways to boost neuroregeneration and neuroprotection since ancient times in order to overcome the brain's, spinal cord's, and peripheral nerves' limited ability to regenerate spontaneously.In this scenario, nanopolymers have shown great potential in terms of drug delivery systems and scaffolds, diminishing the scale of tissue damage and promoting functional recovery in both acute and chronic injuries. A diversity of natural and synthetic polymers has been exploited due to the unique characteristics of these polymers regarding their mechanical and biological properties. These properties dictate how the biomaterial interact with biological systems and how they are distinct in each polymer. This makes them suitable for numerous applications that range from the controlled release of an anti-inflammatory drug to axonal guidance. The versatility of nanopolymers makes them a rich source for therapeutic approaches in the neuroscience field, especially in neuroprotection and neuroregeneration.

Role of the Popliteal Fossa in Knee Problems: Theoretical Considerations and Practical Implications

The popliteal fossa is located at the back of the knee joint and it is an area where blood vessels and nerves and also lymph nodes pass. Popliteal fossa injuries includes nearly 2% of acute knee injuries. The treatment of chronic injuries are always more difficult than acute ones, because its diagnosis would depend on careful interpretation of specific clinical exams. In this review, we describe our current understanding of role of popliteal fossa in knee problems, and summarize the anatomy and functional role of popliteal fossa and popliteomeniscal fibers, and mechanism of popliteomeniscal fibers injuries, and discuss strategies for diagnosis of popliteomeniscal fibers lesions, differential diagnosis, and treatment of the posterolateral corner injuries.

Alternatives to Knee Braces

Knee braces continue to be a widely utilized piece of medical equipment, ranging from simple over the counter sleeves to more complex functional braces, with the ability to provide electrical stimulation to muscle groups. Despite their popularity, alternatives to knee braces exist for patients who find braces to be ineffective, uncomfortable, cumbersome, or overly expensive. While high-quality studies are lacking for modalities such as neoprene sleeves, compression stockings, and kinesiotaping, there is promising evidence that these interventions can confer an element of stability and pain relief for a variety of knee pathologies both with regard to acute and chronic injuries as well as in the postoperative rehabilitation period. While no “holy grail” exists for the ideal brace, or bracing alternative, it is important for providers to be aware of the options available to patients as well as the current evidence for these various modalities, so that the provider can best guide musculoskeletal care.

Exploring the key attributes of former racehorses considered to have the potential for a successful second career in horseball

The British horseracing industry is committed to safeguarding the welfare of racehorses throughout their racing careers and beyond. Former racehorses who do not retire to a stud career and are suitable for second careers are often retrained to compete in other equestrian sports. Horseball is a growing discipline, which proactively supports retraining of racehorses (RoR) that could offer a suitable second career for former racehorses. This study explored the key attributes that horseball competitors look for in a potential former racehorse to promote a successful career in the sport. Participants voluntarily completed an online, 18 question survey (SurveyMonkey®), distributed through horseball related communication channels (Facebook™, Instagram™ and the British Horseball Association). Horseball competitors were asked (a) what key physical and behavioural characteristics they considered necessary for a successful horseball horse and (b) whether they would consider competing a former racehorse. A total of 45 horseball competitors completed the survey representing a margin of error of ±13% at the 95% confidence interval for the UK horseball population (n=200). Most respondents celebrated former racehorses’ suitability for horseball competition; 73.72% (n=32) had already owned and competed a former Thoroughbred racehorse in horseball and 97.78% (n=44) would consider purchasing and competing one in the future. Former racehorses were recognised to possess key performance attributes: agility, temperament, and speed suitable for a successful second career in competitive horseball. However, injuries that impeded former racehorse performance; lameness and other chronic injuries, were deemed as detrimental to success in competitive horseball. Further work in collaboration with racehorse rehoming stakeholders is required to produce guidelines to identify specific behavioural and physical characteristics which could predict the suitability of former racehorses for successful second careers across equestrian disciplines.

Use of an Abductor Pollicis Brevis Tendon Slip for Reconstruction of the Radial Collateral Ligament of the Thumb Metacarpophalangeal Joint: An Anatomical Investigation

Background Reconstruction of the radial collateral ligament (RCL) of the thumb metacarpophalangeal (MP) joint is commonly performed for chronic injuries. This study aims to evaluate the anatomical feasibility and reliability of using the abductor pollicis brevis (APB) tendon to reconstruct the RCL. Methods Ten cadaver arms were dissected to evaluate the relationship between insertions of the RCL and APB. A slip of the APB was divided from tendon and reflected proximally. The dissected tendon was deemed sufficient for reconstruction if it could be reflected to the footprint of the RCL origin. The size of the dissected APB slip was then compared with that of the RCL. Results The dissected slip of the APB could be fully reflected proximally to the RCL origin in all specimens. The APB insertion was also found to be closely approximated to the RCL insertion, averaging 2.1 mm distal and 1.8 mm dorsal. Significant differences existed between the lengths ( P < .001) of the APB slip and RCL, with no significant difference in widths ( P = .051). Conclusions A sufficient APB tendon slip can be obtained to reliably reconstruct the RCL of the thumb MP. The location of the APB insertion closely approximates the RCL insertion.