THE INFLUENCE OF CRYOCORSERVED PLACENTA ON THE DYNAMICS OF CHANGES IN CLINICAL INDICATORS IN THE TREATMENT OF PATIENTS WITH PHLEGMONS OF JAW-FACIAL LOCALITIS

Today, information about circadian rhythms is widespread. Circadian rhythms are generated by clocks that are endogenous in nature and fluctuate even in the absence of environmental signals. Circadian clocks affect a wide range of biological processes, including neuronal, endocrine, metabolic, and behavioral functions. One of the key factors influencing behavioral patterns is the chronotype, which is defined as the human circadian typology and is a behavioral manifestation of the human internal circadian clock system that can be assessed using several methodologies that classify people into morning or evening chronotypes[1]. The aim of our study was to establish how to use a standardized protocol for medical care for odontogenic phlegmons of maxillofacial localization, taking into account the biological rhythm of patients.A total of 30 patients with odontogenic phlegmons of maxillofacial localization (2-3 cell spaces), aged 35 to 60 years, without systemic chronic diseases, regardless of gender, who underwent surgery in the form of opening and drainage of phlegmon with intravenous introduction of cryopreserved placenta.For clinical characterization of the process of purulent wound healing we used the proposed standardization tables of quantitative values of indicators that determine the dynamics of changes in general condition (P-1), the dynamics of local changes in patients with phlegmons of maxillofacial localization (P-2) and the dynamics of changes in a purulent wound (indicator P-3).Analyzing the dynamics of changes in the P-1.1 indicator, it should be emphasized that this indicator reached its maximum values for 1 day after surgery, which is probably due to the body's response to iatrogenic trauma on the background of the inflammatory process. Analyzing the decrease of this indicator during the 3rd and 5th days, it should be noted that its significant value is observed in the period between the 3rd and 5th days closer to the 5th, on average by 1.78 ± 0.24. Analysis of the dynamics of the indicator P-1.2 gives grounds to show its uniform decrease during 1, 3 and 5 days after the operating period with normalization of the indicator for 7 days. The change in the dynamics of the P-1.3 indicator by its significant decrease on the 3rd day in 28% of cases and on the 5th day in 72% of cases with normalization of quantitative data on the 7th day is noteworthy. In the study of masticatory disorders (indicator P-4) should be noted the maximum value of this indicator on the 1st day, which is associated with known complications onthe background of purulent inflammatory process and the presence of additional inflammatory process. A significant decrease in this indicator by 0.31 ± 0.09 points on the 5th day in 62% of cases with partial normalization on the 7th day in 62.3% and full normalization in 37.7% of cases is noteworthy. A similar picture was observed in the study of the dynamics of changes in P-1.5, but in contrast to the previous indicator, normalization on day 7 occurred in 82.9% of cases.In the study of indicators showing the dynamics of local changes deserves special attention indicator P- 2.1, which on the 1st day after the operating period reached maximum values with a gradual decrease throughout the postoperative period, but the largest difference in its reduction by an average of 0.23 ± 00.9 scores were recorded on the 5th day in 56.9% of cases in patients with morning chronotype, operated on in the first half of the day.According to the study, it was found that intravenous cryopreserved placenta have an impact on the course of reparative processes in patients with purulent-inflammatory diseases of the maxillofacial localization, depending on the time of surgery.

Evaluation of tritium retention in plasma facing components during JET tritium operations

An assessment of the tritium (T) inventory in plasma facing components (PFC) during JET T & DT operations is presented based on the most comprehensive ex-situ fuel retention data set on JET PFCs from the 2015-2016 ILW3 operating period is presented. The global fuel retention is 4.19 x 1023 D atoms, 0.19% of injected fuel. The inner divertor remains the region of highest fuel retention (46.5%). The T inventory in PFCs at the end of JET operations is calculated as 7.48 x 1022 atoms and is informative for accountancy, clean-up efficacy and waste liability assessments. The T accumulation rate at the upper inner divertor during JET deuterium-tritium (DT) operations has been used to assess the requirements and frequency of operation of a new laser induced desorption diagnostic to be installed on JET for the final DT experiments in 2023.

The Rheometric Analysis of the Polymer Modifier’s Properties in the Environment of Hydrated Cement

This paper investigates the effect of polymer modifiers (re-dispersible powder, multifunctional additives, methylhydroxyethylcellulose) on the rheological behavior of emulsions, saturated of calcium hydrosilicates to simulate a hydrating cement structure. The subjects of the study were modified emulsions which had varied concentrations of each additive and they were examined comparatively to a base emulsion. Tests were performed with a CR-rheometer (“Himpribor-1”, Tula, Russia) applying the Searle measuring principle at various shear rates to characterize viscosity properties. The performance of modified mixtures within the operating period was analyzed by using two parameters—effective viscosity (η) and the proportion of structural failure (|m|). The test results showed that the most important factor influencing rheological characteristics is the addition of methylhydroxyethylcellulose additive—the higher additive amount in the emulsion, the higher the viscosity. Furthermore it was noted in the work that adding olefin sulfonate sodium salt causes reduced viscosities as well as lower shear moduli. If ethylhydroxyethylcellulose and ethylene vinyl acetate additives are used in the same mixture together, the rate of structural failure |m| can be relatively similar and low regardless of whether the mixture has large or small viscosity values.

Analysis of the payback period of a modernized pump unit with induction electric motors of advanced energy efficiency classes

Aim. The comparative analysis of energy consumption, electricity costs during lifetime cycle and payback period of a pump unit with 90 kW 2-pole induction motors, belonging to various energy efficiency classes, feeding directly from power grid. Methods. The examined operating modes aligned with a typical operating cycle of a pump unit with approximately constant flow rate of 75-110 % of the rated flow. The calculations were based on the pump and induction motors nameplate data, which, in their turn, were based on the manufacturers’ experimental data. Results. The calculations of energy consumption, electricity costs and payback periods of a pump unit with 90 kW 2-pole induction motors, feeding directly from power grid have been performed in the article. The application of induction motors belonging to IE2, IE3 and IE4 energy efficiency classes has been discussed. Practical value. It has been demonstrated, than in case of replacement of an induction motor of energy efficiency class IE2 due to planned retrofit, payback period for an IE4 induction motor is 2.18 years, energy savings within a calculated 20-year operating period are 268MW·h, which makes €41110 in money terms. Under the same conditions, the replacement of an induction motor of energy efficiency class IE2 with an induction motor of energy efficiency class IE3 will allow to save 88 MW·h within a calculated operating period, which, expressed in monetary terms, is €13500 and the payback period is 5.11 years. Thus, the article proves that despite a higher initial price, the choice of an induction motor of energy efficiency class IE4 tends to be more economically advantageous.

Wireline Retrievable ESP Deployment: Observation, Challenges and Intervention

The Offshore Field X Project comprises of greenfield scope to expand the Waterflood scheme towards delivering the peak production levels similar to those achieved in the 1990s. Although various artificial lift systems have been successfully deployed in Brunei Shell Petroleum, offshore ESP installation, especially on this scale, is a first and a new journey for the company and its Offshore Assets in which gas lift was predominantly the artificial lift method. The first offshore ESP well was only installed and kicked off in 2017 as part of the Field X Project. As wells are located offshore, cost, resources and logistics remain a challenge for well interventions. With a high workover cost associated with conventional ESP change out, a technology trial was embarked upon to install wireline retrievable ESP systems. A total of 4 out of the 22 ESP wells were approved to be installed and completed with wireline retrievable ESP system on a pilot basis. The business goal was to prove the production deferment reduction and cost advantage for a failed ESP replacement. A critical selection process was followed as well as FAT/industry benchmarking in order to land on WRESP decision for the pilot. System installation and commissioning of the wells was completed by June 2019, however a series of start-up problems were encountered, leading to an intervention requirement to rectify 1 well. Job planning for this intervention was not straight forward and was classified as a high-risk job requiring regulator's approval. Rigorous logistics planning, integration of various vendors, detailed workflow analysis, intervention equipment stack up and modifications were among the planning scope conducted. This paper captures details of the deployment value proposition, case success definition and challenges faced in ensuring all the installed WRESPs are up and running to enable the pilot performance proper evaluation. As no full workover has been executed yet due to the limited operating period, a lifecycle comparison between WL retrievable and conventional ESPs has not been done yet. Once sufficient performance data is available, a detailed study will be conducted to assess the performance of the WRESP system. This analysis will then conclude the technology trial and may change the future of ESP wells in BSP and Shell global.

Numerical modeling of clogging of landfill leachate collection systems with co-disposal of municipal solid waste (MSW) and incinerator ash

The influence of co-disposal of municipal solid waste (MSW) and incinerator ash used as daily cover on the clogging of leachate collection systems (LCSs) from landfills is examined. The “BioClog” model is used to simulate the fate and transport of the nine leachate constituents most responsible for clogging the LCSs as they move through the porous media. It then calculates the thicknesses of five films that attach to the porous media and the effect of this clog mass–volume on the porosity and hydraulic conductivity of the granular material. Then it models the consequent growth in the leachate mound with increasing clog mass over time until the service life of the LCS is reached. The modeling shows that the concentrated source of leachable minerals in the incinerator ash accelerates the clogging rate and reduces the service life of the LCSs compared to inert daily cover. If an LCS is not designed to accommodate these higher concentrations of cations in the influent leachate during the landfill operating period, the ash can significantly reduce the LCS service life. Means of extending LCS service life are discussed. A practical technique is also utilized to estimate the service life of LCSs with conservative and reasonable agreement with BioClog.

Gas hydrates technologies in the joint concept of geoenergy usage

The paper represents the analysis, which has helped to establish the usage of gas hydrate technologies in the methane conversion. This gas could be obtained in different ways. Possibilities and sources for the gas obtaining have been demonstrated. Use of other environmentally friendly sources to support operation in such systems in terms of joint energy complex has been considered. The necessary kinetic connections to provide operational sustainability of all the constituents have been given. The approach helps evaluate quantitatively the priority of its physicochemical transformations to obtain gas hydrates artificially. It is possible to transport methane at considerable distances when it is solidified. Actually, in this case there is no necessity to build costly compressor stations and pipelines for its transportation to consumers. The approach is extremely important for mining regions as it helps prolong the operating period and working out of the abandoned and off-balance coal reserves. In this case, it is proposed to apply special gasification technologies tending to maximum methane recovery. The proposed solutions give the possibility to define the trends of our further research. They will be highlighted in the following authors’ studies.

Microarray Breast Cancer Data Clustering Using Map Reduce Based K-Means Algorithm

Breast cancer is one of the world's most advanced and most common cancers occurring in women. An early diagnosis of breast cancer offers treatment for it; therefore, several experiments are in development establishing approaches for the early detection of breast cancer. The great increase in research in the last decade in microarray data processing is a potent tool of diagnosing diseases. Based on genomic knowledge, micro-arrays have changed the way clinical pathology recognizes, identifies, and classifies the diseases of humans, particularly those of cancer. In this article, we examined microarray data for breast cancer with the k-means clustering algorithm, but it was hard to scale and process a large number of micro-array data alone. To this end, we use a chart to minimize the paradigm for evaluating microarray data on breast cancer. Moreover, the efficiency of the parallel k-means model is measured with the operating period, the scaling, and all runtime of the model.

Mechanical Parameter Identification of Hydraulic Engineering with the Improved Deep Q-Network Algorithm

During the long-term operating period, the mechanical parameters of hydraulic structures and foundation deteriorated gradually because of the environmental factors. In order to evaluate the overall safety and durability, these parameters should be calculated by some accurate analysis methods, which are hindered by slow computational efficiency and optimization performance. The improved deep Q-network (DQN) algorithm combined with the deep neural network (DNN) surrogate model was proposed in this paper to ameliorate the above problems. Through the study cases of different zoning in the dam body and the actual engineering foundation, it is shown that the improved DQN algorithm has a good application effect on inversion analysis of material mechanical parameters in this paper.