The rare earth mine containing high concentrations of natural radionuclides (238U, 232Th, and 40K) in Muong Hum commune, Nam Pung, Bat Xat district, Lao Cai province, a mine with large reserves of rare earth resources in Vietnam, will be exploited and processed in the near future. The activity of natural radionuclides in the environment of air, soil, water, and effective annual dose are important parameters in assessing the impact of radiation on the environment when the mine goes into operating and processing rare earth ore. Investigating and determining radioactivity in soil, water, and plants at Muong Hum rare earth mine by means of radioactive gas measurement (RAD-7), gamma radiation dose rate (DKS-96), sample analysis using an ICP-MS mass spectrometer, will be performed in this study. The results showed that some soil samples had radionuclides activity 238U, 232Th higher than the allowed standard. The annual effective dose value in the region is 6.1 times higher than the world average (2.4 mSv/year). The obtained results are the basis for monitoring the impact of the radioactive environment and providing solutions to minimize the effects of radioactive substances on the ecological environment when the mine goes into mining and processing of rare earth ores.