The demographic reasons of new period of fertility decline in the northern regions of Russia.

At the last time the North is a one of important vector of country’s economy strategic development. A rich mineral resource and fuel and energy bases give the reason for development and implementation of the new investment projects. Successful economic developing of territories needs in human resources, however a number of northern regions of the country have persistent problems in demographic sphere: low level of birth-rate and migration outflow. Here are Republic of Karelia, Komi Republic, Arkhangelsk, Murmansk, Magadan, Sakhalin and Kamchatka regions and in 2018–2019 the Chukotka Autonomous Region also can be included. In the last years in these regions, as in the whole in Russia, the deterioration of the birth-rate situation began. Therefore, the purpose of the research is to identify demographic reasons of birth-rate reduction in the Russian northern regions. The index method was used. It helped to find what value at the dynamics of total birth-rate coefficient belongs to changes in the proportion of women aged 15–49 years old in a population, in the age birth-rate coefficient, and also in the age structure of a female reproductive group. According to research it was found a favorable effect in 2014–2016 on the preservation of the positive dynamic of the total birth-rate coefficient in the conditions of negative influence of factors of demographic structure exactly for a reason of increasing of the real fertility. It was detected, that in 2017–2019, a negative effect on the dynamic of the total birth-rate coefficient has implemented significant decrease in birth-rate itself and not only structural factors. The revealed beginning of the reduction of age- specific birth rates confirms the importance of prolongation of family and demographic policy in the field of improving the economic situation of families with children, increasing the status of parenthood in society. The high-priority task in the conditions of factors increasing, that complicate to preserve economic stability in the country, is to provide a decent level and quality of life, an accessibility of the most important living benefits — comfortable housing and jobs with salary, that can qualitatively satisfy a wide range of needs of families with children.

Perosomus Elumbis in Piglets: Pathological, Radiological and Cytogenetic Findings

Perosomus elumbis (PE) is a rare congenital condition characterized by agenesis of the lumbar, sacral and coccygeal vertebrae. Perosomus elumbis has rarely been reported in literature as morphological description of singles or few cases. Here we report the first extensive description of eight cases of PE detected in two consecutive litters from the same parents of Casertana pig breed. In August 2018, eight piglets were investigated for multiple malformations. All malformed animals, but one, died in the first day of life. The survivor piglet died at 23 days of age. Pathological, radiological and cytogenetic examination was performed. Furthermore, a farm epidemiological investigation was carried out to investigate the percentage of piglets born dead or with malformations in 2018. The radiological and pathological exams showed skeletal abnormalities at the spinal cord level and visceral malformations. Cytogenetic investigations showed a normal chromosome arrangement. Finally, epidemiological investigation revealed a low prevalence of malformations in newborn pigs, equal to 0.5% of the total birth rate of the farm. Our findings report the first extensive description of PE cases in pigs and suggest an underestimation of this malformation in veterinary medicine. Our findings also suggest a specific genetic etiological basis as cause of PE in pigs and exclude chromosomal abnormalities. Further studies will be performed to confirm this hypothesis.

3.3. ANALYSIS OF FACTORS OF FERTILITY OF POPULATION IN THE REGIONS OF THE RUSSIAN FEDERATION BY THE MODEL OF MODELING

Рассмотрена динамика суммарного коэффициента рождаемости в Российской Федерации и факторы рождаемости. Выделено пять групп регионов РФ по уровню суммарного коэффициента рождаемости. На примере пяти регионов-лидеров и пяти регионов-антилидеров проанализировано воздействие на по-казатель рождаемости девяти социально-экономических факторов. Рассмотрена динамика ко-эффициента рождаемости и выявлена основная тен-денция изменения данного показателя. С помощью корреляционно-регрессионного анализа выявлены факторы, оказывающие определяющее воздействие на рождаемость в РФ. Выделены группы факторов по степени влияния на рождаемость населения. The dynamics of the total fertility rate in Russia and fertility factors are considered. Five groups of Russian regions were identified by the level of the total birth rate. Using the example of 5 leading regions and 5 anti-leader regions, we analyzed the impact on the birth rate of 9 socio-economic factors. The dynamics of the birth rate is examined and the main tendency for this indicator to change. Using correlation and re-gression analysis, factors were identified that have a decisive effect on fertility in Russia. Groups of factors are identified by the degree of influence on the birth rate of the population.

Sexual Crime Against Schoolchildren With Disabilities: A Nationwide Prospective Birth Cohort Study

Numerous studies have shown that the rate of sexual victimization against children with disabilities is higher than the rate for children without disabilities. The study focuses on examining sexual crime against children with disabilities and explaining differences in victimization to elucidate to what extent types of disability, family disadvantages, gender, high-risk behavior, and location influence adolescents’ risk of sexual victimization. Data are based on a national study of reported sexual crime against children in Denmark aged between 7 and 18 years using total birth cohorts ( N = 679,683). The statistical analysis is a discrete-time Cox model. An extended list of potential risk factors was included in the analysis to adjust for confounding. The potentially confounding risk factors were collected independently from various population-based registers, for example, employment statistics, housing statistics, education statistics, income compensation benefits, and population statistics (e.g., gender, age, location). Hospital records with information on types of disability based on the national inpatient register and national psychiatric register were collected independently of the collection of law enforcement records about reported sexual offenses under the Danish Central Crime Register. Among total birth cohorts, 8,039 persons or 1.18%. were victims of a reported sexual crime once or several times. Children with intellectual disabilities were more likely to be victimized of a reported sexual crime than non-disabled children were: attention-deficit/hyperactivity disorder (ADHD), odds ratio: 3.7 (3.5–3.9); mental retardation, odds ratio: 3.8 (3.6–4.0); and autism, odds ratio: 3.8 (3.6–4.0). This contrasts with children with speech disability, stuttering, and dyslexia who were less likely to be victimized when adjusted for family vulnerability and other confounding risk factors. Intellectual disability and family vulnerability, for example, parental substance abuse, parental violence, family separation, the child in care, and parental unemployment, indicate an increased risk of being a victim of a sexual crime, while speech disability seems to be ensuring protection.

Development of assisted reproductive technology services in Thailand between 2008 and 2014 before the new law: Results generated from the National ART Registry, Royal Thai College of Obstetricians and Gynecologists

BackgroundWhile the assisted reproductive technology (ART) relieves the burden of infertility in many couples, it presents significant public health challenges due to the substantial risk for multiple birth delivery and preterm birth, which are associated with poor maternal and fetal health outcomes. For this reason, it is important to monitor the development and effectiveness of ART services in Thailand.ObjectiveTo analyze the trends of ART services in Thailand between 2008 and 2014.MethodsART clinics in Thailand are required to submit data to the Royal Thai College of Obstetricians and Gynecologists via the National Reporting System. The data from 2008 to 2014 were collected and analyzed.ResultsThe number of ART centers was increased from 35 to 47. The total fresh ART cycles were also increased from 3,723 to 6,516. The percentage values of intracytoplasmic sperm injection (ICSI), in vitro fertilization, gamete intrafallopian transfer, and zygote intrafallopian transfer cycles were changed from 77.87 to 95.59, 21.43 to 4.31, 0.21 to 0.09, and 0.45 to 0.05, respectively. The clinical pregnancy rates were 28.79–33.19, 22.84–51.34, 14.29–42.86, and 0.00–26.67, respectively. The clinical pregnancy rates in fresh vs. frozen-thawed cycles were 31.01–36.33 vs. 31.54–37.34 (P < 0.05). The clinical pregnancy rates in female age <35 vs. 35–39 vs. ≥40 years were 36.97–40.70 vs. 32.74–33.42 vs. 21.08–31.34, respectively (P < 0.001), and the percentage values of multifetal pregnancy rate were 18.75 vs. 13.30 and 13.69, respectively (P < 0.001). There were increasing preimplantation genetic screening (PGS) cycles, with the percentage of the clinical pregnancy rate (25.90–42.63, P < 0.05). The clinical pregnancy rates in medium-sized ART centers (100–300 cycles per year) vs. in small and large centers were 30.79–41.14 vs. 28.01–34.04 and 8.70–40.35, respectively (P < 0.001). Trends of increasing percentage of ART birth rate to total birth rate ratio were 0.24–0.34 (P < 0.05).ConclusionsThere were higher clinical pregnancy rates in frozen-thawed cycles. Higher multifetal pregnancy rate and clinical pregnancy rate were also found in younger females. There were increasing uses of ICSI and PGS. A trend toward increasing ART birth to total birth ratio was observed.

Incidence of Glucose-6-Phosphate Dehydrogenase Deficiency among Swedish Newborn Infants

Sweden has 10.2 million inhabitants and more than 2.4 million have a foreign background. A substantial number of immigrants come from countries where glucose-6-phosphate dehydrogenase deficiency (G6PDD) is frequent. The total birth rate annually in Sweden is approximately 117,000 and newborn screening is centralized to one laboratory. We determined glucose-6-phosphate dehydrogenase (G6PD) activity in 10,098 dried blood spot samples (DBS) from the whole country with a fluorometric assay (LabSystems Diagnostics Oy, Finland). The first 5451 samples were anonymised and run as singletons, whilst the following 4647 samples were coded. Enzyme activity ≤40% of the mean of the day was found in 58 samples (1/170) and among these, 29 had activities ≤10% (1/350). Twenty-nine samples with residual activities between 2–39% in the coded cohort were subjected to Sanger sequencing. Disease-causing variants were identified in 26 out of 29 infants, of which six were girls. In three patients, we did not find any disease-causing variants, although two patients were hemizygous for the known polymorphisms c.1311T>C and c.1365-13C>T. The most common disease-causing variant found in 15 of the 29 samples (12 hemizygotes, two heterozygotes, one homozygote) was the Mediterranean mutation, c.563C>T (p.(Ser188Phe)) in exon 6. G6PDD is thus a surprisingly prevalent disorder in Sweden.

Factors influencing colostrum yield by sows

ABSTRACT An adequate colostrum intake, in order to ensure the survival and weight gain of piglets, depends on the sow's ability to produce enough colostrum for the whole litter. The aim of this study was to evaluate factors involved in colostrum yield (CY) variability related to the sow, the litter and the farrowing process. The experiment was conducted with 96 Camborough 25(r) sows of parities one to seven, whose farrowing was spontaneous. Colostrum production of each sow was estimated by summing up the colostrum intake of each piglet in the litter, estimated by an equation that takes into account the birth weight and weight gain during the first 24h of life. The multiple regression model explained 28% of variation in CY, with 24% and 4% respectively of variation being explained by the litter birth weight and the width of the first mammary glands. Litter birth weight was positively correlated with the number of total born (r= 0.73) and born alive piglets (r= 0.83). When categorised into two groups of colostrum yield (LOWCY; ≤3.4kg; n= 46 vs HIGHCY; >3.4kg; n= 50), LOWCY sows had fewer total born and born alive piglets and lighter litters (P<0.05). The logistic regression analysis showed that sows from parities 1, 2 and >3 had greater odds (P≤0.05) of belonging to the LOWCY group than parity 3 sows. Sows with two or more obstetrical interventions had higher odds (P<0.05) of belonging to the LOWCY group than sows without interventions during farrowing. The higher colostrum yield observed in sows of parity 3 and sows with less than two obstetrical interventions during farrowing was associated with a greater number of nursed piglets. This study showed that total birth weight of born alive piglets is the most important factor involved in colostrum yield variability, indirectly representing the number of piglets nursed by the sow.

Maternal Risk Factors for Perinatal Mortality

Objective: This prospective clinical study was designed on maternal risk factors for perinatal mortality.Material and Methods: This is cross sectional study conducted in the Department of Obstetrics & Gynae and Department of pediatrics Sylhet M A G Osmani Medical College Hospital, Sylhet, during the period from 1st July 2008 – 30th June 2009. Here study population were all fresh & macerated stillborn & early neonatal death cases during the study period. For convenience sampling total 100 cases were studied for this study during the study period.Results: During this period 8398 deliveries were done & there were 715 perinatal deaths. In Sylhet region neonatal mortality rate is higher (53 /1000 total birth) than our national neonatal mortality rate (37/1000 total birth) (BDHS, 2007). From this study it was revealed that most important maternal risk factor for perinatal mortality was pre-eclampsia, eclampsia and obstructed labour.Conclusion: Perinatal mortality rate serves as the most sensitive index of maternal and neonatal care. DOI: http://dx.doi.org/10.3329/bjog.v26i2.13786 Bangladesh J Obstet Gynaecol, 2011; Vol. 26(2) : 86-91