scholarly journals A Bibliometric and Visualized Analysis of Cardiac Regeneration Over a 20-Year Period

2021 ◽  
Vol 8 ◽  
Author(s):  
Siyuan Ma ◽  
Junyu Yan ◽  
Lu Chen ◽  
Yingqi Zhu ◽  
Kaitong Chen ◽  
...  
Keyword(s):  
Web Of Science ◽  
Cardiac Regeneration ◽  
The United States ◽  
Harvard University ◽  
Cardiomyocyte Proliferation ◽  
Comprehensive Understanding ◽  
Microsoft Excel ◽  
Increasing Trend ◽  
Flow Map ◽  
First And Second Generation

Background: Recent research has suggested that cardiac regeneration may have the widely applicable potential of treating heart failure (HF). A comprehensive understanding of the development status of this field is conducive to its development. However, no bibliometric analysis has summarized this field properly. We aimed to analyze cardiac regeneration-related literature over 20 years and provide valuable insights.Methods: Publications were collected from the Web of Science Core Collection (WoSCC). Microsoft Excel, VOSviewer, CiteSpace, and alluvial generator were used to analyze and present the data.Results: The collected 11,700 publications showed an annually increasing trend. The United States and Harvard University were the leading force among all the countries and institutions. The majority of articles were published in Circulation Research, and Circulation was the most co-cited journal. According to co-citation analysis, burst detection and alluvial flow map, cardiomyocyte proliferation, stem cells, such as first-and second-generation, extracellular vesicles especially exosomes, direct cardiac reprogramming, macrophages, microRNAs, and inflammation have become more and more popular recently.Conclusions: Cardiac regeneration remains a research hotspot and develops rapidly. How to modify cardiac regeneration endogenously and exogenously may still be the hotspot in the future and should be discussed more deeply.

Abstract 336: Interleukin 4 and 13 Signaling in Myeloid Cells Regulates Cardiac Regeneration

2020 ◽  
Vol 127 (Suppl_1) ◽  
Author(s):  
Santiago Alvarez ◽  
Samantha Paddock ◽  
Caitlin Omeara
Keyword(s):  
Immune Cell ◽  
Myeloid Cells ◽  
Cardiac Regeneration ◽  
Mannose Receptor ◽  
The United States ◽  
Interleukin 4 ◽  
Current Therapy ◽  
Specific Cell ◽  
Cardiomyocyte Proliferation ◽  
Arginase 1

Introduction: Heart failure is a very important disease in the United States and worldwide, with a projected prevalence of 8 million by 2030. Current therapy partially decreases progression; however, mortality continues to be high, and progression to terminal HF is still significant, requiring heart transplant and other interventions that further increase morbidity and overall disease burden and costs. Therefore, the need to develop new therapies that target HF progression. Our prior work and published studies demonstrate that IL13 promotes cardiac regeneration, however, the mechanism mediating this response is currently unknown. IL13 and IL4 share a common receptor, and both cytokines are known to polarize macrophages into a pro-reparative phenotype. Here, we hypothesize that IL4/13 signaling in myeloid cells promotes heart regeneration after cardiac injury. Methods and Results: We compared cardiac regeneration in IL4Ra null/FLOXed (IL4Rα-/fl) and IL4Rα-/fl lysosome M Cre littermate mice, knocking out IL4Rα in myeloid cells. We performed apical resection on postnatal day 1 (P1) mice and assessed cardiac regeneration by histological analysis. We found that mice lacking IL4Ra in myeloid cells (IL4rafl/-, LysMCre) had significantly impaired cardiac regenerative capacity compared to Cre negative littermate controls. We also performed gene expression analysis by qPCR in whole hearts collected at 2dpi to quantify macrophages markers. Cre positive mice trended higher for expression of arginase 1 and mannose receptor 1 (p=0.055 and 0.057, respectively; student t-test) compared to Cre negative littermates. Conclusions and Discussion: Lack of IL4/13 signaling in myeloid cells impairs cardiac regeneration after injury in neonatal mice and modulated expression of immune markers. To confirm these results, flow cytometry to quantify immune cell infiltration can be performed. Other components that limit damage extension can also be assessed, like angiogenesis and cardiomyocyte proliferation. Our data suggest that IL4/IL13 signaling polarizes myeloid cells to a pro-reparative state in the neonatal heart. Additional studies are required to delineate the specific cell population mediating this response.

scholarly journals Towards a Science Map on Sustainability in Higher Education

2019 ◽  
Vol 11 (13) ◽  
pp. 3521 ◽  
Author(s):  
Jesus S. Alejandro-Cruz ◽  
Rosa M. Rio-Belver ◽  
Yara C. Almanza-Arjona ◽  
Alejandro Rodriguez-Andara
Keyword(s):  
Higher Education ◽  
Regional Planning ◽  
Web Of Science ◽  
The United States ◽  
Sustainable Planning ◽  
Sustainability In Higher Education ◽  
First And Second Generation ◽  
Insight Into ◽  
The Web ◽  
Global Research

This article analyses how the concept of sustainability is being incorporated into global research of higher education. This study utilizes different scientometric reviews of global research between 1991 and 2018 using text mining techniques in order to generate first and second-generation bibliometric indicators, the latter are displayed in science maps. A total of 6724 articles and conference proceedings were collected from the Web of Science and Scopus databases to generate this research. From the results obtained, it was possible to build a canvas of the main institutions that have significantly contributed to the topic of sustainability in higher education, and it was found that 40.58% of the records originated in institutions from the United States, China, United Kingdom, and Australia. This study also provides an insight into emerging trend themes, and patterns of research in the area of sustainability worldwide. Terms such as regional planning and environmental protection inside the top keywords found, suggest a greater interest in issues of sustainable planning and social awareness and that higher education is becoming the cornerstone of environmental awareness, innovation, and guidance to achieve sustainability goals in higher education institutions, as well as in society and government.

scholarly journals Bibliometric analysis about compassion fatigue based on Web of Science database

2019 ◽  
Vol 6 (2) ◽  
pp. 151-156 ◽  
Author(s):  
Xi-Liang Kang ◽  
Xiao Gao
Keyword(s):  
Compassion Fatigue ◽  
Web Of Science ◽  
Research Output ◽  
Research Direction ◽  
The United States ◽  
High Yield ◽  
Oncology Nursing ◽  
Main Research ◽  
Increasing Trend ◽  
Highly Cited

Abstract Objective To analyze the related foreign literature about compassion fatigue (CF) and to provide the basis for further improving the level of research in this field. Methods Based on the Web of Science core database and its own analysis function, HistCite analysis software was used to study the diploma research about CF. Results A total of 652 paper were retrieved, the output of literature showed an increasing trend year by year. The United States ranked first, and China ranked eleventh. The “Oncology Nursing Forum” had the largest number of articles (4.0%). The main research direction was in nursing (29.6%), and the main research output was from articles (73.2%). The key words highly cited were “compassion” and “fatigue”. Figley was the author of the high-yield field, and mainly research institutions were universities. The highly cited article was entitled “Compassion fatigue: Psychotherapists’ chronic lack of self-care”. Conclusions In recent years, the related heat of CF has been high fever. Our research in this field is still in the primary stage, and it needs to be further excavated and promoted.

scholarly journals Characteristics of Publications on Occupational Stress: Contributions and Trends

2021 ◽  
Vol 9 ◽  
Author(s):  
Yang Zhang ◽  
Lei Huang ◽  
Yongwei Wang ◽  
Yajia Lan ◽  
Yonggang Zhang
Keyword(s):  
United States ◽  
Job Satisfaction ◽  
Occupational Stress ◽  
Job Stress ◽  
Web Of Science ◽  
The United States ◽  
Future Research ◽  
Comprehensive Understanding ◽  
Research Topics ◽  
Link Strength

This study aimed to analyze the bibliometric characteristics of the publications on occupational stress and highlight key research topics and future trends. The Web of Science Core Collection database was searched to collect publications on occupational stress, from inception to December 9, 2020. Two authors independently screened eligible literature and extracted the data. Bibliometric analyses were performed using VOSviewer 1.6.6 and R 3.6.3 software. Overall, 6,564 publications on occupational stress were included. “Stress,” with a total link strength of 1,252, appeared as the most co-occurrence keyword, followed by “occupational stress,” “job stress,” and “job satisfaction.” All studies were published between 1956 and 2020. Among them, 6,176 (94.35%) papers were written in English, and 4,706 (70.25%) were original articles. The top three Web of Science categories were “public environmental occupational health” (n = 1,711), “psychology, applied” (n = 846), and “psychology, multidisciplinary” (n = 650). The 100 top-cited articles were mentioned a total of 36,145 times, with a median of 361, ranging from 174 to 5,574. The United States was the most productive country, with 1,780 publications. The main partners of the United States were England and China. Three themes of occupational stress research were identified: job satisfaction, burnout, and occupational stress-related health problems. This bibliometric analysis provides a comprehensive understanding of the trends and most influential contributions to the field of occupational stress, thus promoting ideas for future research.

scholarly journals Hotspots and trends in liver kinase B1 research: A bibliometric analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259240
Author(s):  
Yaowen Song ◽  
Fangkun Zhao ◽  
Wei Ma ◽  
Guang Li
Keyword(s):  
Bibliometric Analysis ◽  
Web Of Science ◽  
The United States ◽  
Harvard University ◽  
Future Trends ◽  
Cellular Processes ◽  
The Past ◽  
Liver Kinase B1 ◽  
Number Of Publications ◽  
Future Direction

Introduction In the past 22 years, a large number of publications have reported that liver kinase B1 (LKB1) can regulate a variety of cellular processes and play an important role in many diseases. However, there is no systematic bibliometric analysis on the publications of LKB1 to reveal the research hotspots and future direction. Methods Publications were retrieved from the Web of Science Core Collection (WoSCC), Scopus, and PubMed databases. CiteSpace and VOSviewer were used to analysis the top countries, institutions, authors, source journals, discipline categories, references, and keywords. Results In the past 22 years, the number of LKB1 publications has increased gradually by year. The country, institution, author, journals that have published the most articles and cited the most frequently were the United States, Harvard University, Prof. Benoit Viollet, Journal of Biochemistry and Plos One. The focused research hotspot was the molecular functions of LKB1. The emerging hotspots and future trends are the clinical studies about LKB1 and co-mutated genes as biomarkers in tumors, especially in lung adenocarcinoma. Conclusions Our research could provide knowledge base, frontiers, emerging hotspots and future trends associated with LKB1 for researchers in this field, and contribute to finding potential cooperation possibilities.

scholarly journals Cardiac regeneration: epicardial mediated repair

2015 ◽  
Vol 282 (1821) ◽  
pp. 20152147 ◽  
Author(s):  
Teresa Kennedy-Lydon ◽  
Nadia Rosenthal
Keyword(s):  
Stem Cells ◽  
Endothelial Cells ◽  
Cardiac Fibroblasts ◽  
Cardiac Regeneration ◽  
Repair Process ◽  
Regenerative Process ◽  
Cardiac Stem Cell ◽  
Cardiomyocyte Proliferation ◽  
Lower Vertebrates

The hearts of lower vertebrates such as fish and salamanders display scarless regeneration following injury, although this feature is lost in adult mammals. The remarkable capacity of the neonatal mammalian heart to regenerate suggests that the underlying machinery required for the regenerative process is evolutionarily retained. Recent studies highlight the epicardial covering of the heart as an important source of the signalling factors required for the repair process. The developing epicardium is also a major source of cardiac fibroblasts, smooth muscle, endothelial cells and stem cells. Here, we examine animal models that are capable of scarless regeneration, the role of the epicardium as a source of cells, signalling mechanisms implicated in the regenerative process and how these mechanisms influence cardiomyocyte proliferation. We also discuss recent advances in cardiac stem cell research and potential therapeutic targets arising from these studies.

scholarly journals Bibliometric Analysis of Microtia-Related Publications From 2006 to 2020

2021 ◽  
pp. 014556132110376
Author(s):  
Wei Wang ◽  
Xinxin Dong ◽  
Jianwen Qu ◽  
Yangyang Lin ◽  
Lei Liu
Keyword(s):  
Core Collection ◽  
Web Of Science ◽  
The United States ◽  
Research Trends ◽  
External Ear ◽  
Future Directions ◽  
Occurrence Matrix ◽  
Author Citations ◽  
Over Time

Objective: Microtia is a congenital auricular malformation with a hypoplastic external ear that ranges in severity from a slightly smaller auricle to complete the absence of the auricle. The present study was conducted to identify and analyze the characteristics of microtia-related articles published from 2006 to 2020 by using bibliometric analyses. Method: Microtia-related studies published from 2006 to 2020 were retrieved from the Web of Science Core Collection database. Keywords, first author, citations, date of publication, and publication journal were extracted and quantitatively analyzed using Bibliographic Item Co-Occurrence Matrix Builder software and the Bibliometric ( https://bibliometric.com/app ). VOSviewer was used to visualize research and form a network map on keywords and citations. Results: A total of 1031 articles from 2006 to 2020 were included. The number of articles showed an overall trend of growth over time. The United States and China are the top 2 countries in terms of the number of microtia-related articles. From the analysis of keyword clustering, keywords could be mainly divided into 4 clusters in the field of microtia research: surgery, tissue engineering, epidemiology, and rehabilitation including hearing-related treatments, evaluation of effects, and quality of life after surgery. The top 10 most frequently cited papers from 2006 to 2020 were also extracted and analyzed. Conclusion: A bibliometric research of microtia-related articles from 2006 to 2020 was conducted. This study may be helpful to understand the current research status of microtia and find the research trends in this field, thus proposing future directions for microtia research.

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