Oxidized Substrates of APEH as a Tool to Study the Endoprotease Activity of the Enzyme

APEH is a ubiquitous and cytosolic serine protease belonging to the prolyl oligopeptidase (POP) family, playing a critical role in the processes of degradation of proteins through both exo- and endopeptidase events. Endopeptidase activity has been associated with protein oxidation; however, the actual mechanisms have yet to be elucidated. We show that a synthetic fragment of GDF11 spanning the region 48–64 acquires sensitivity to the endopeptidase activity of APEH only when the methionines are transformed into the corresponding sulphoxide derivatives. The data suggest that the presence of sulphoxide-modified methionines is an important prerequisite for the substrates to be processed by APEH and that the residue is crucial for switching the enzyme activity from exo- to endoprotease. The cleavage occurs on residues placed on the C-terminal side of Met(O), with an efficiency depending on the methionine adjacent residues, which thereby may play a crucial role in driving and modulating APEH endoprotease activity.

A Study on Rural Consumption in Sichuan Province Under the Influence of COVID-19

Research on rural consumption is an important prerequisite for analyzing rural consumption market. The research on rural consumption in Sichuan province shows that the trend of rural consumption is good, the demand is huge, the will is strong, the structure is optimized and the environment is improved, but it is influenced by Covid-19. It also reflects farmers limited disposable income, lack of social security, lack of financial support and new consumption ecological weakness.

The Impact of Augmented Reality Techniques on Cartographic Visualization

Augmented reality (AR) is playing an increasingly important role in a variety of everyday application scenarios. Users are not completely disconnected from the current sensory influences of reality. They are merely confronted with additional virtual objects that are projected into reality. This allows users to obtain additional spatial information, which makes this technology interesting for cartographic applications (e.g. navigation). The dynamic positioning of the superimposed image in the scene being viewed is crucial for the generation of AR elements displayed correctly in terms of perspective. Understanding these technical basics is an important prerequisite for the cartographic use of augmented reality. The different techniques influence the visualization and the perception of AR elements in 3D space. This article highlights important visualization properties of current augmented reality techniques.

Research on the Construction of the Third-Party Evaluation Index System of Science and Technology Achievements

The evaluation of science and technology achievements is directly related to its transformation, and the construction of a third-party evaluation index system for its achievements is an important prerequisite for its evaluation. The third party refers to a service organization with high business capabilities and evaluation qualifications, which is relatively more objective, independent and fair. The authors explore and analyzes the problems existing in the evaluation of science and technology achievements, and puts forward an effective strategy for the construction of a third-party evaluation index system for science and technology achievements, hoping to help the smooth development of its third-party evaluation.

ANAHIT MANASYAN Constitutional stability as an important prerequisite for stable democracy

The author of the book examines the issues of constitutional stability and its role in ensuring sustainable democracy.

Parental transmission and the importance of the (non-causal) effects of education on political engagement: Missing the forest for the trees

By most accounts, an important prerequisite for a well-functioning democracy is engaged citizens. A very prominentexplanation of variation in political engagement suggests that parental transmission through socialization accountsfor individual-level differences in political engagement. In this paper, we show that classic formulations of parentaltransmission theory can be supplemented by findings from the bio-politics literature, allowing us to disentangle whenheritable factors are important and when socialization factors are important predictors of political engagement. The paperdemonstrates that the effect of education on various measures of political engagement is confounded by both genes andparental socialization; no previous study has documented the importance of both of these confounders. We then go onto show that as the level of family politicization and consistency increases, the influence of genes decreases. We takethis to imply that family socialization can compensate for (genetic) individual differences and foster increased politicalengagement. By only focusing on the “causal” effect of education, we are missing the forest for the trees.

Sustainability at Border Villages of Punjab (India): A Critical Study on Initiatives and Practices

The focus of this review is the sustainability of villages under the ‘Smart Village’ concept with special emphasis on the Border Villages, primarily that of the Punjab state. Based on various case studies, this article summarizes some of the major issues and challenges which these border villages face. What hindrances they have? Which rural development plans are implemented and how sustainable are their environments?The review is based on the implementation of ‘Smart Village’ concept in the villages worldwide, an effort to make them more sustainable.Fast progress and development of rural and urban communities is adversely affecting the environment on account of unsustainable technologies. Sustainability of ecosystem is the most important prerequisite of all development plans, be it the Smart City or Smart Village. The study aims to project different case studies taken up globally as well as locally under thisconcept.It reflects that border villages are in a state of neglect and need attention. It also aims to highlight various constraints and problems of the border villages along with certain trans-boundary environmental issues.Findings indicate that the various government plans/schemes launched at different times,are less effective due to lack of proper follow up.Theneed of the hour is to make a country wide comprehensive development plan to identify the actual issues. It must be in an integrated manner, primarilywithpeople’s participation to make the villages in the vicinity of international border environmentally smart and sustainable.

Unsupervised DNF Blocking for Efficient Linking of Knowledge Graphs and Tables

Entity Resolution (ER) is the problem of identifying co-referent entity pairs across datasets, including knowledge graphs (KGs). ER is an important prerequisite in many applied KG search and analytics pipelines, with a typical workflow comprising two steps. In the first ’blocking’ step, entities are mapped to blocks. Blocking is necessary for preempting comparing all possible pairs of entities, as (in the second ‘similarity’ step) only entities within blocks are paired and compared, allowing for significant computational savings with a minimal loss of performance. Unfortunately, learning a blocking scheme in an unsupervised fashion is a non-trivial problem, and it has not been properly explored for heterogeneous, semi-structured datasets, such as are prevalent in industrial and Web applications. This article presents an unsupervised algorithmic pipeline for learning Disjunctive Normal Form (DNF) blocking schemes on KGs, as well as structurally heterogeneous tables that may not share a common schema. We evaluate the approach on six real-world dataset pairs, and show that it is competitive with supervised and semi-supervised baselines.

On the Reproductive Diapause in the Predatory Ladybird Cheilomenes sexmaculata (Fabricius, 1781) (Coleoptera, Coccinellidae)

The ability to enter reproductive diapause was experimentally studied in females of the laboratory population of the predatory ladybird Cheilomenes sexmaculata originated from individuals collected in Nepal in a region of subtropical monsoon climate. The experiment included 12 regimes, i.e. combinations of 2 temperatures (20 and 24°C), 3 photoperiods (day lengths of 10, 12, and 14 h), and 2 diets (the green peach aphid Myzus persicae and eggs of the grain moth Sitotroga cerealella). Females with undeveloped ovaries and well developed fat body were considered as diapausing. The proportion of diapausing females was significantly dependent only on the temperature being 0.8% at 24°С and 7.4% at 20°С. Although found in only a small fraction of the studied population, the ability to enter reproductive diapause (as suggested by literature data) was probably an important prerequisite for Ch. sexmaculata spread northwards to the temperate zone.

Razzle dazzle

Creating an interactive and engaging school library environment for your school community is an important prerequisite to establishing a creditable identity with teaching staff, which in turn, leads to opportunities to develop collaborative curriculum programs. The library and its personnel must be perceived as a hub for learning and part of the core business of the school by the whole community, including senior administration, teachers, students and parents. Such an environment demonstrates the value adding to the curriculum, literacy, information literacy and student learning outcomes that occur when professional library staff are part of the staffing equation in a school.