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2022 ◽  
Author(s):  
Daniel T Bowers ◽  
Justin L Brown

Abstract Mechanotransduction arises from information encoded in the shape of materials such as curvature. It induces activation of small GTPase signaling affecting cell phenotypes including differentiation. We carried out a set of preliminary experiments to test the hypothesis that curvature (1/radius) would also affect cell motility due to signal pathway crosstalk. High molecular weight poly (methyl methacrylate) straight nanofibers were electrospun with curvature ranging from 41 to 1 μm−1 and collected on a passivated glass substrate. The fiber curvature increased mouse mesenchymal stem cell aspect ratio (P < 0.02) and decreased cell area (P < 0.01). Despite little effect on some motility patterns such as polarity and persistence, we found selected fiber curvatures can increase normalized random fibroblastic mouse embryonic cell (MEF) migration velocity close to 2.5 times compared with a flat surface (P < 0.001). A maximum in the velocity curve occurred near 2.5 μm−1 and may vary with the time since initiation of attachment to the surface (range of 0–20 h). In the middle range of fiber curvatures, the relative relationship to curvature was similar regardless of treatment with Rho-kinase inhibitor (Y27632) or cdc42 inhibitor (ML141), although it was decreased on most curvatures (P < 0.05). However, below a critical curvature threshold MEFs may not be able to distinguish shallow curvature from a flat surface, while still being affected by contact guidance. The preliminary data in this manuscript suggested the large low curvature fibers were interpreted in a manner similar to a non-curved surface. Thus, curvature is a biomaterial construct design parameter that should be considered when specific biological responses are desired. Statement of integration, innovation, and insight  Replacement of damaged or diseased tissues that cannot otherwise regenerate is transforming modern medicine. However, the extent to which we can rationally design materials to affect cellular outcomes remains low. Knowing the effect of material stiffness and diameter on stem cell differentiation, we investigated cell migration and signaling on fibrous scaffolds. By investigating diameters across orders of magnitude (50–2000 nm), we identified a velocity maximum of ~800 nm. Furthermore, the results suggest large fibers may not be interpreted by single cells as a curved surface. This work presents insight into the design of constructs for engineering tissues.


2022 ◽  
Vol 10 (1) ◽  
pp. 81
Author(s):  
Kaoru Uesugi ◽  
Kazuaki Nagayama ◽  
Euichi Hirose

While nanoscale nipple arrays are expected to reduce light reflection and/or dust contamination in some insects, similar structures have been reported in various marine invertebrates. To evaluate the anti-contamination property of the structure in aquatic regimes, we measured the adsorption and adhesion forces on the flat surface and MOSMITE™ (Mitsubishi Chemical Corporation, Tokyo, Japan), a synthetic material mimicking the nipple array, under water. A small force toward the surface occurred when the probe approached the substrate surface. This adsorption force was significantly smaller on MOSMITE™ than on the flat surface. The adhesion force toward the surface occurred when the probe was detached from the surface, and it was also significantly smaller on MOSMITE™ than on the flat surface. The adhesion force in the air was much greater than the force under water, and the force was also significantly smaller on MOSMITE™ than on the flat surface. In the aquatic regime, the nipple array provides less adsorption/adhesion properties for the surface and thus, the organisms would have less contamination of microparticles on their body surface. As the adsorption and adhesion forces are also involved in the attachment of cells, tissue, and larvae, less adhesive body surfaces should be beneficial for survival in aquatic environments, as well as land environments.


2022 ◽  
Vol 2150 (1) ◽  
pp. 012004
Author(s):  
S A Isaev ◽  
A I Leontiev ◽  
D V Nikushchenko ◽  
D Kong ◽  
K M Chung ◽  
...  

Abstract An energy-efficient flat surface is formed when applying single-row cross-flow zigzag grooves (VVVVVV) in a dense arrangement. Convective heat transfer is considered in turbulent flow around a longitudinal fragment of a plate with a length of 40 and a width of 4 with a package of 14 singlerow inclined backslash(\)-shaped grooves with symmetry conditions at the lateral boundaries. The width of the grooves is 1, the depth is 0.25, the edge rounding radius is 0.2, the angles of inclination are 30°, 45°, 50° and 60°, the pitch is 2.4, the Reynolds number is 104, and the thickness of the incoming boundary layer is 0.175. The phenomenon of anomalous enhancement of the separation flow and heat transfer in zigzag grooves and acceleration of the wall flow discovered in inclined oval-trench dimples has been confirmed.


2022 ◽  
Vol 64 (1) ◽  
pp. 125
Author(s):  
В.В. Погосов

Within the framework of the quantum-statistical functional and the Ritz method, the the problem of finding the surface energy per unit area and work function electrons of a metal flat surface with a inhomogeneous dielectric coating, taken into account in the approximation of a continuous medium. For a uniform coating, the calculated values are insensitive to the selection one-parameter functions for an electronic profile, but sensitive to the gradient series of kinetic energy non-interacting electrons. Calculations are performed for Al, Na and the comparison with the calculations by the Kohn-Shem method is made. Analytically the connection between the theory of the Ritz method for inhomogeneous coatings and calculations by the Kohn-Shem method work function of electrons for metal-dielectric nanosandwiches. As it turned out, the influence inhomogeneous coating on the characteristics of the metal surface can be scaled down to a uniform coverage case. The possibility of using the obtained results in various experimental situations are discussed.


2022 ◽  
Vol 355 ◽  
pp. 01020
Author(s):  
Nataliya Karaush-Karmazin ◽  
Glib Baryshnikov ◽  
Boris Minaev

The crystal structure of the new diazatrioxa[9]circulene and tetrahydro-diazatetraoxa[10]circulene which represent the first synthesized representatives of “higher” hetero[n]circulenes with n>8, was analyzed in details. Hirshfeld surface analyses, the dnorm surfaces and two-dimensional fingerprint plots were used to verify the contributions of the different intermolecular interactions within the crystal structure of diazatrioxa[9]circulene and tetrahydro-diazatetraoxa[10]circulene. The Hirshfeld surface analysis of the crystal structure clarifies that the most important contribution for crystal packing is from H∙∙∙H and C∙∙∙H intermolecular interactions for both circulenes. The shape-index surface shows that in the case of diazatrioxa[9]circulene two sides of the molecules are involved with the same contacts in neighbouring molecules and curvedness plots show flat surface patches that are characteristic of planar stacking. Such face-to-face structural organization provides the main charge transfer pathway in [9]circulene. In the case of [10]circulene, the area involved in the same contacts is much less, however, two types of intermolecular packing modes can form such flat surface patches at curvedness plots which is useful for more efficient charge transfer.


Materials ◽  
2021 ◽  
Vol 15 (1) ◽  
pp. 242
Author(s):  
Manuel Domínguez ◽  
Jose G. Fueyo ◽  
Alberto Villarino ◽  
Natividad Anton

Dowel-type fasteners are one of the most used type of connections in timber joints. Its design follows the equations included in the Eurocode 5. The problem with these equations is that they do not adequately contemplate the resistive capacity increase of these joints, when using configurations which provoke the so-called rope effect. This effect appears when using threaded surface dowels instead of flat surface dowels, expansion kits or nut-washer fixings at the end of the dowel. The standards consider this increase through a constant value, which is a poor approximation, because it is clearly variable, depending on the joint displacement and because is much bigger, especially when using nut-washer fixings. It is also very important because of the rope effect trigger interesting mechanisms that avoids fragile failures without warning of the joints. For these reasons, it is essential to know how these configurations work, how they help the joint to resist the external loads and how much is the increase resistance capacity in relationship with the joint displacement. The methods used to address these issues consisted of a campaign of experimental tests using actual size specimens with flat surface dowels, threaded surface dowels and dowels with washer-nut fixings at their ends. The resistance capacity results obtained in all the cases has been compared with the values that will come using the equations in the standards. After the tests the specimens were cut to analyze the timber crushings, their widths, the positions and level of plasticizations suffer in the steel dowels and in the washer-nut fixings and the angle formed in the dowel plastic hinges. With all this information the failure mode suffered by the joints has been identified and compared with the ones that the standards predict. The results for the size materials and types of joints studied shows that the crush width average values go from 20 mm with flat surface dowels, to 24 mm in threaded to 32 mm in threaded with washer-nut fixings. The rope effect force/displacement goes from 100 N/m in threaded surface dowels to 500 N/m in threaded with washer-nut fixings. Finally, the load capacities are on average 290% higher those indicated in the standard. The main conclusion is that the rope effect force should be considered in the standards in more detail as a function of multiple variables, especially the displacement of the joint.


2021 ◽  
Vol 11 (40) ◽  
pp. 208-208
Author(s):  
Indrani Chakraborty ◽  
Arniban Sukul ◽  
Nirmal Sukul

Potentized Nux Vomica has been reported to produce antialcoholic effect in mice, rats and toads. The effect relates to consumption of alcohol and alcohol-induced loss of righting reflex (RR). RR’s maintain normal erect posture of an animal and are centrally controlled in the midbrain. In the present study young toads, Duttaphrynus melanostictus were first treated with Nux vomica 200 CH and then partially immersed in 209 mM ethanol solution in such a way that their head remained above the level of ethanol solution. Toadlets were removed from the ethanol solution every 10 min, tested for the loss of RR and returned to the ethanol solution. Toadlets were placed in a supine position on a dry flat surface. Failure to right within 60 sec was considered as the loss of RR. The experiment was repeated 10 times. Control toadlets were pretreated with 90% ethanol instead of Nux Vomica 200 CH. The percentages of toadlets showing loss of RR, both in the control as well as in the Nux-treated groups, were shown in graphs against the duration of exposure to ethanol solution. Differences in the percentage distribution between the control and the treatment groups losing RR were tested by χ2 test. All the experiments were conducted at room temperature. The percentage of toadlets losing RR increased with time of exposure to ethanol solution. The increase was significantly higher with the control than with the Nux-treated group. Nux Vomica 200 CH might have influenced the mid-brain of toadlets thereby countering the hypnotic effect of ethanol in the toadlets.


2021 ◽  
Vol 6 (2) ◽  
pp. 7-27
Author(s):  
Lea Vidakovic ◽  

Animation is considered a prevalent medium in contemporary moving image culture, which increasingly appears across non-conventional surfaces and spaces. And while storytelling in animation films has been extensively theorized, narrative forms that employ physical space as part of storytelling have been less explored. This paper will examine the narrative aspect of animation works which are screened outside the traditional cinematic venues. It will look at how these animation works tell stories differently - using the full potential of the space, as a narrative device, a tool, and a stage where the narratives unfold. This paper will look at the historical perspective and the state of the art in animation installation today, exploring the relationship between the space and narrative in pre-cinematic, cinematic and post-cinematic conditions. It will examine how narrative structures in animation have changed over time, on their way from the black box of the cinema to the white cube of the gallery and even further, where they became part of any space or architecture. Through case studies of works by Tabaimo, Rose Bond, William Kentridge and other relevant artists, the interdependency of the narrative and the space where it appears will be explored, in order to identify new strategies for storytelling in animation. The aim of this paper is to emphasize the storytelling novelty that animation installations offer, which goes beyond the narrative structures that we are used to see on a single flat surface.


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