Еstimation of the complication rate and conformation for the case using orthopedic structures

Aim. Analyze the frequency and structure of complications for the case using various types of orthopedic structures, which were identified by dentists in Tyumen. Materials and methods. According to the developed questionnaire, a survey was conducted of 100 dentists of various profiles with experience from 3 to 35 years, practicing on the basis of public and private clinics in Tyumen. Results. Based on the results of the questionnaire, materials and orthopedic structures were identified, which, according to doctors, cause various complications. It was revealed that the most common complications are complete removable, bridges (31%), partially removable prostheses (24.3%) and stamped-brazed prostheses (21.1%). Among structural materials, the most common complications are caused by structures made of acrylic plastic (35.1%), composite materials (22.2%). Complications revealed most often for the case using orthopedic structures: mechanical trauma (28%), allergic stomatitis (14.5%). Conclusion. Despite the improvement of construction materials and manufacturing processes for orthopedic structures, complications are common.

MANUFACTURING OF FULL REMOVABLE LAMINAR DENTURES USING DIFFERENT GROUPS OF MATERIALS FOR DENTURE BASES AND THEIR COMPARATIVE CHARACTERISTICS

Restoration of complete maxillary or mandibular adentia, despite the advances of dentistry nowadays, has always been and is still remaining one of the most challenging among the clinical issues of orthopedic dentistry. The effectiveness of a high-quality complete removable denture is largely predetermined by the properties of the denture base material. However, long experience in manufacturing the dentures has revealed a number of their disadvantages. The development of new denture base materials and their studies have been being carried out for many years. The aim of this work was to investigate the effectiveness of thermoplastic base material "Vertex ThermoSense" (Netherlands) and fluorine-containing acrylic plastic "Ftoraks" (Ukraine) used in manufacturing the dentures for edentulous patients who previously worn full removable dentures made of acrylic plastic over the past 3- 5 years. We examined and treated 43 patients with complete anodontia who went to the orthodontic clinic to order a new denture. We used fluorine-containing acrylic co-polymers "Ftorax" (Ukraine) and polyamide (nylon) "Vertex ThermoSense" (Netherlands), recommended by manufacturers for making removable dentures. We assessed the level subjective satisfaction with new dentures in different follow-up time intervals, checked the restoration of the chewing function in the patients using electromyographic techniques. Clinical findings obtained supported the superiority of Vertex ThermoSense thermoplastic material over fluorine-containing acrylic resins in terms of high functional quality and strength that facilitate the durability of these complete dentures. In addition, the denture base made of "Vertex ThermoSense" does not contain residual monomer, thereby preventing the occurrence of allergic reactions. The results of our work allow us to strongly recommend the material "Vertex ThermoSense" to implement into prosthodontic practice for manufacturing complete removable dentures.

Validation of Nanoparticle Response to the Sound Pressure Effect during the Drug-Delivery Process

Intravenous delivery is the fastest conventional method of delivering drugs to their targets in seconds, whereas intramuscular and subcutaneous injections provide a slower continuous delivery of drugs. In recent years, nanoparticle-based drug-delivery systems have gained considerable attention. During the progression of nanoparticles into the blood, the sound waves generated by the particles create acoustic pressure that affects the movement of nanoparticles. To overcome this issue, the impact of sound pressure levels on the development of nanoparticles was studied herein. In addition, a composite nanostructure was developed using different types of nanoscale substances to overcome the effect of sound pressure levels in the drug-delivery process. The results demonstrate the efficacy of the proposed nanostructure based on a group of different nanoparticles. This study suggests five materials, namely, polyimide, acrylic plastic, Aluminum 3003-H18, Magnesium AZ31B, and polysilicon for the design of the proposed structure. The best results were obtained in the case of the movement of these molecules at lower frequencies. The performance of acrylic plastic is better than other materials; the sound pressure levels reached minimum values at frequencies of 1, 10, 20, and 60 nHz. Furthermore, an experimental setup was designed to validate the proposed idea using advanced biomedical imaging technologies. The experimental results demonstrate the possibilities of detecting, tracking, and evaluating the movement behaviors of nanoparticles. The experimental results also demonstrate that the lowest sound pressure levels were observed at lower frequency levels, thus proving the validity of the proposed computational model assumptions. The outcome of this study will pave the way to understand the interaction behaviors of nanoparticles with the surrounding biological environments, including the sound pressure effect, which could lead to the useof such an effect in facilitating directional and tactic movements of the micro- and nano-motors.

PECULIARITIES OF PRO- AND ANTI-INFLAMMATION CYTOCINS LEVEL IN PREVENTION OF PROSTHETIC STOMATITIS IN PATIENTS WITH REMOVABLE ACRYLIC PROSTHESES

Due to the using of removable laminar dentures made of acrylic plastic, the complications in the form of chronic inflammation of the oral mucosa are developed in a certain category of patients, as a result of the complex impact of dentures on the tissues of the prosthetic bed in terms of mechanical, chemical, toxic, microbiological and immunological factors. In conditions of mechanical or chemical damage to the mucous membrane epithelium by the action of the microbial factor the activation of epithelial cells occurs and they acquire the properties of immunocompetent cells. As a result, the epithelial cells begin to produce cytokines. A special place in the implementation of acute inflammatory process is held by proinflammatory cytokines: interleukin (IL-1β) and tumor necrosis factor (TNF-α). They regulate all successive stages in the development of inflammation and an adequate response to the etiological factor. Interleukin 10 (IL-10) is the main anti-inflammatory cytokine, which inhibits the synthesis of proinflammatory cytokines. Determination of the level of pro- and anti-inflammatory cytokines is a diagnostic criterion in the development of prosthetic stomatitis and at the same time it is used to test the effectiveness of the proposed method of prevention or treatment of complications on the part of the tissues of the prosthetic bed. The aim of the research is to study the concentration of proinflammatory cytokines (TNFα, IL-1β) and anti-inflammatory cytokines (IL-10) in the oral fluid of patients with complete and partial defects of the dentition after prosthetics with removable laminar dentures made of acrylic plastic and dentures coated with fullerene C60 molecules. Material and methods of research. The study included 39 patients who were between 40 to 80 years old, including 19 male (48.7%) and 20 female (51.3%) subjects. The partial and complete defects of the dentition were diagnosed. The control group consisted of apparently healthy individuals, namely 10 people without defects of the dentition and periodontal tissue diseases. The patients were divided into 3 groups: the first group comprised apparently healthy people with intact dentition; the second group included patients with complete and partial defects of the dentition after prosthetics with removable laminar dentures made of acrylic plastic (20 patients) 7 days after prosthetics; the third group – patients with complete and partial defects of the dentition with removable laminar dentures made of acrylic plastic (20 patients) 30 days after prosthetics; the fourth group – patients with complete and partial defects of the dentition after prosthetics with removable laminar dentures made of acrylic plastic and coated with fullerene C60 molecules. The concentration of cytokines IL-1β and TNFα and IL-10 (pg / ml) was determined in the mouth before treatment at day 7, 2 weeks and 1 month. Statistical processing was conducted using STATISTICA 6.0 (StatSoft, USA). Results of the studies and their discussion. The results of the studies show that the level of cytokines in patients before prosthetics is higher than in apparently healthy people. On the 7th and 30th day after prosthetics in the study groups, there was a sharp increase in the concentration of proinflammatory and anti-inflammatory cytokines in the oral fluid as contrasted with the comparison group. These data confirm that activation of local synthesis of proinflammatory cytokines in the oral fluid is an important pathogenetic factor that determines the formation and maintenance of an active inflammatory response in the mucosa of the prosthetic bed. After fullerene C60 coating of the surface of denture, which is in contact with the tissues of the prosthetic bed, there is a significant decrease in the level of proinflammatory (IL-1β and TNFα) and anti-inflammatory (IL-10) cytokines.

Clinical experience of quartz reinforcing mesh usage in production of full removable laminar upper dentures

The study is devoted to one of relevant topics in orthopaedic dentistry: orthopaedic treatment for fully edentulous patients with application of removable laminar dentures the basis of which is produced from acrylic plastic. The main problem of this approach has been formulated: the possibility of frequent crashing of the basis by the patient within earlier and later periods after the beginning of prosthesis exploitation. Options in prevention of this problem have been considered — reinforcing of the denture basis using standard and individually produced metal meshes — as well as their disadvantages. A study based on longitudinal clinical observation within terms of up to five years of exploitation effectiveness in quartz reinforcing mesh application to removable denture bases as an alternative approach to modern technologies has been carried out. Application features and advantages of this technology have been presented.

Gun Bullet Collision and Penetration Behaviors for Protecting Board

In this research, the bullet-collision test was done in the different velocity. The influence of its velocity on the deformation shape after collision was discussed by comparison with experiment and simulation. The velocity of the bullet was chosen in several kinds of speed ranges at 80m/s-250m/s. The angle of incidence with the collision object is 90 degree (head-on collision). The deformation shape was measured by 3D measurement instrument and reconstructed with 3D-CAD based on the 3D digital data. The deformation mark of the polycarbonate plate and the penetration shape of acrylic plastic plate caused by the bullet's collision with the object were examined. In addition, the collision simulation of the bullet was done by using FE analysis code “LS-DYNA”, and these analytical results were compared with the 3D digital data which is the experimental results.

Efficient and catalyst free synthesis of acrylic plastic precursors: methyl propionate and methyl methacrylate synthesis through reversible CO2 capture

Single solvent based, room temperature and catalyst free synthesis of acrylic plastic precursors namely methyl propionate and methacrylate was performed via reversible CO2 capture.