Asceticism

This chapter examines the idealization of asceticism, itself motivated by an extreme form of ressentiment motivated by the construal of all human suffering as a threat to the agent’s power. I circumscribe the “priestly” (or moral) asceticism that poses problem for Nietzsche and discuss the ways in which it is a paradoxical phenomenon. The ascetic solution to the problem of suffering consists in “interpreting it under the perspective of guilt,” or as punishment. I attempt to determine both the nature of the problem of suffering and how this ascetic strategy is meant to address it. I then describe Nietzsche’s functional critique of this ascetic strategy: it is “ruinous” to the health of the agent. Drawing on his conception of health and sickness, I suggest that, when ascetic morality functions in service to the will to power of the agent, it undermines it. Its functionality is self-undermining.

POS1332 ETANERCEPT-ASSOCIATED NEW ONSET UVEITIS IN PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS UNDER BIOLOGICAL THERAPY: SINGLE CENTER EXPERIENCE

Background:Biological agents (BA), especially TNF inhibitors, are high efficacy options for current therapy for patients (pts) with juvenile idiopathic arthritis (JIA). They are successfully used not only for the arthritis but also for JIA-associated uveitis, however, development of uveitis de novo in pts treated with BA is a well-established paradoxical phenomenon.Objectives:to evaluate the frequency of new onset (no-) uveitis, occurring under BA therapy in JIA pts, to establish clinical features, which may be associated with development of such effects.Methods:retrospective cohort study involved all JIA pts (1136) who were treated with BA in our clinic from 2004 to 2020. All cases of no-uveitis were collected for the describing of their clinical features in disease onset and course, activity level, JIA category, exposure to Methotrexate (MTX) and BA, presence of ANA, HLA B27.Results:among of 1136 pts treated with different BA we identified 36 (3.3%) pts (19 female/17 male) with no-uveitis under BA. Mostly during etanercept (ETA) therapy (34 cases from 488 ETA courses, 7%), 1/166 - in abatacept (ABA) and 1/372 - in adalimumab (ADA). 30 pts (83%) with no-uveitis developed it on the 1st line of BA treatment (29 ETA vs 1 ADA). 4pts (11%) developed no-uveitis on 2 nd line (3 ETA vs 1 ABA). 2 pts (6%) on third line (all ETA, both pts had also psoriasis). There are no cases of no-uveitis under other BA. Frequency of no-uveitis was much higher in ETA group. ETA exposure was 26.8 ± 28.8 months (mo). It means there are no “safe” period of therapy from paradoxical phenomenon of no-uveitis. JIA subtypes were as follows: RF-neg polyarthritis 9 (25%), persistent oligoarthritis 3 (8%), extended oligoarthritis 21 (59%), enthesitis-related arthritis (ERA) - 3 (8%). Average age at JIA onset was 4.6 ± 3.9 yrs. 20/36 patients had high laboratory activity (CRP 54 ± 23 mg/l; ESR 41 ± 19 mm/h) and severe arthritis before BA initiation. However most of pts (25/36) achieved 90-100% ACRpedi-response by the uveitis development. 23/36 pts were ANA-positive, 17/36 pts had HLAB27, including 7 pts who had the both features. Uveitis was occurred earlier in ANA plus HLAB27 positive pts (mean exposure - 15.3 mo) than in only ANA-positive or HLAB27-positive pts (27.7 mo and 27.6 mo accordingly). 29/36 (81%) of pts received methotrexate (MTX) in mean dosage 11.5 mg/m2/week. There are no differences in time of uveitis development depending of MTX. In all cases of no-uveitis BA was switched.Conclusion:Our study suggested that new onset of uveitis is rare adverse event during BA therapy in JIA. Uveitis can develop despite the excellent effect of therapy on joint manifestation. The most typical development of no-uveitis is under ETA therapy, especially in the predisposed cases (certain variants of JIA, ANF positivity, HLAB27 presence) and in patients with very high disease activity at the time of the start of biological therapy.Disclosure of Interests:Irina Nikishina Speakers bureau: Novartis, MSD, Pfizer, Abbvie, Hofman la Roche, Svetlana Arsenyeva: None declared, Maria Kaleda Speakers bureau: Novartis, Roche, MSD, Olga Kostareva: None declared, Anna Shapovalenko: None declared, Ekaterina Denisova: None declared, Anna Panova: None declared

Water Jet Applied to an Object Floating on Water. Part 1: Parallelepiped Shape Object. Investigation of a Braking Phenomenon by the Venturi Effect

The action of a water jet on a rectangular shape object causes its attraction under the effect of the creation of a depression due a priori, to the Venturi effect known in fluid mechanics. The actual observation has been made. We are trying here to find an explanation for this paradoxical phenomenon. Apart from braking, the phenomenon can be applied for recoil, propulsion of an object floating on the water, as well as its rotation in one direction and the other

Water Jet Applied to an Object Floating on Water. Part 2: Cylindrical and Spherical Shape Object. Investigation of an Attraction and Entrainment Phenomenon by the Coanda and Magnus Effects

The action of a jet of water on an object of rectangular, cylindrical and spherical shape causes its attraction under the effect of the creation of a depression due a priori, to the effect Venturi, Coanda, Magnus etc. known in fluid mechanics. The real observation has been made. We are trying here to find an explanation for this paradoxical phenomenon. Apart from braking, the phenomenon can be applied for recoil, propulsion of an object floating on the water, as well as its rotation in one direction and the other.

IDEOLOGICAL FEATURES OF NEOHISTORICAL TRENDS IN THE ARCHITECTURE OF POSTCOMMUNIST CIRCUMFERENCE IN THE CONTEXT OF THEIR STYLISTIC IDENTIFICATION

The aim of the article is to reveal the ideological features that where characteristic of post-communist circumference, which formed the basis of the architectural worldview of the period 1990-2010; to determine the correctness of the term "postmodernism" to the buildings created at this time and the feasibility of its alternative. The specific character of the architecture of post-communist circumference, marked by the tendency to historicism and retrospectivism. The author cites significant differences between such architecture and traditional Western postmodernism. Chief among them is the utopia of feudalism as an ideal past, which was perceived by post-communist circles as an obligatory ideological dogma. This was significantly different from Western postmodernism, which proclaimed the end of any ideology and monopoly of a single correct doctrine. In addition, the article reveals the complicated process of switching the relationship between modern values from architectural modernism to the architecture of historicism. This paradoxical phenomenon of post-communist culture is due to the fact that the socialist system itself built within the Soviet "camp" a feudal and hierarchical content, which was materialized in the architectural forms of modernism, which, in its time, emerged as a style of democratic and socially responsible society. Thus, the protest against modernism in post-communist societies and the shift to historicism was in fact based on a desire for a modern society that was paradoxically associated with feudal one.

THE ORNAMENT CONCEPT IN THE MANIFESTOS OF THE ARCHITECT B. TSCHUMI

The article elevates the problem of studying ornamental forms in architecture. Ornament in the context of deconstructivism seems to be a paradoxical phenomenon, but, nevertheless, its presence is marked by the conceptual texts of deconstructivist architects. The ornament is studied as a formal aspect, the structure of which is able to involve, link and produce a number of essential characteristics that determine architectural shaping. Ornament is interconnected with form, semantic, communicative, and formal aspects that are integrated and localized in the concepts, form, and space of architecture. The research is based on the concepts, manifestations and theoretical research of the deconstructivist architect Bernard Tschumi. The research is aimed at expanding the subject field of ornamental form in the direction of conceptual and structural aspects. The phenomenon of the ornamental form is revealed as a multiplicity of abstract structural equivalents, where the connections between the subject and abstract aspects of the structure of the ornamental form are paradoxically actualized.

Die Hypothese des Ressourcenfluchs

Some studies point to comparatively slow economic growth in resource-rich countries. This seemingly paradoxical phenomenon is referred to as the resource curse. David Röder identifies in this paper relevant literature, shows and evaluates the economic and political causes of this "curse" and discusses different avoidance strategies taking into account critical sources. Theoretical considerations, empirical results and various models are used for a better understanding.

Social Entrepreneurship: The Logic of Paradox

Social entrepreneurship is a paradoxical phenomenon wherein seemingly incompatible elements such as business and social logics coexist. Previous research has been insufficient to systematically describe how social entrepreneurship organizations (SEO) try to balance these logics and why these same paradoxical elements make social entrepreneurship what it is. Using the systematic literature review method, this paper examines six major paradoxes and how they affect both the theory and practice of social entrepreneurship by furthering the nascent discussion about the role of paradoxes in SEOs. Viewed through the lens of organizational logics, this paper argues that the dynamic interplay between these paradoxes initiates and drives the innovations and changes necessary for the very existence of SEOs.

The Hijrah Communities and Religious Superficiality: Ideology and Religiosity of the Islamic Hijrah Communities on Social Media

The Hijrah communities in Indonesia are a complex and paradoxical phenomenon. These communities can be identified by how its members express religious attitudes on social media, especially Facebook. This position on social media affects the members’ religious and ideological merits in the Hijrah communities. This research applied a netnographic approach concerned with understanding how Hijrah community Facebook groups express their religiosity in texts, status, and images. The data sources were the members of Hijrah community Facebook groups in Indonesia. Through a qualitative approach with a netnographic design, this research succeeded in discovering a new hypothesis that ‘Facebook is one of the authoritative sources as well as Instagram, Twitter, WhatsApp, and offline meetings in improving religious knowledge by the Hijrah communities.’ This social media presence encouraged religious superficiality. In terms of ideology, the Hijrah communities showed ideological hybridity. In this case, exposed from various societies and streams received from populist Islamic scholarly authorities, religious attitudes virtually agreed upon by Hijrah communities were mixed.