Generally, In Pakistan, people perceived that the quality of distance learning education is poor. Therefore, we decided to study to see if it's only people's opinion or legend. The study aims to analyze the association between instructor performance (IP), student-instructor interaction (SII), course evaluation (CE), and student satisfaction (SS) variables in distance education by taking Virtual COMSATS as a Case study. The target population of this research was the COMSATS (VIRTUAL CAMPUS). Students out of which 251 graduate and undergraduate students were selected as sample for current research. The purpose of this research study was to understand the key factors affecting student satisfaction in distance learning. Researchers also collect information through primary data using a survey questionnaire distributed through email to all the students of VCOMSAT. The literature review found that in distance learning education, student satisfaction is based on instructor performance, student-instructor interaction, course evaluation, Learning management system use, instructor attitude, etc. From the literature review, we found that course evaluation and instructor performance is very important for student satisfaction in distance learning. Researchers need to compare student's satisfaction with the subject wise. A comparison of practical subjects and without practical subjects needs to identify with student satisfaction. There is also required to compare lecturer motivation with student satisfaction and performance. Future research is also needed to compare the satisfaction of rural areas and urban areas students in distance learning education and the need to compare them with traditional education.