Clinical applications of concentrated growth factors combined with bone substitutes for alveolar ridge preservation in maxillary molar area: a randomized controlled trial

Purpose To evaluate the clinical effects of concentrated growth factors (CGFs) combined with bone substitutes for alveolar ridge preservation (ARP) in the maxillary molar area. Methods Thirty-six patients who underwent extraction of the upper molars were recruited and randomly divided into three groups: 1. Grafted with CGFs combined with deproteinized bovine bone mineral (DBBM) and covered with CGFs membrane (CGFs/DBBM group), 2. Grafted with DBBM alone and covered with collagen membrane (DBBM group), 3. Control group spontaneous healing. The area of the alveolar bone in center (C-), mesial (M-) and distal (D-) section was compared with preoperative in radiography. Bone cores were obtained for histopathology observation and comparison. Results In C-, M- and D-section, the alveolar ridge area in all three groups was significantly reduced at 8 months postoperatively compared to the baseline (P < 0.05). The alveolar ridge area declines in the CGFs/DBBM group (C-12.75 ± 2.22 mm2, M-14.69 ± 2.82 mm2, D-16.95 ± 4.17 mm2) and DBBM group (C-14.08 ± 2.51 mm2, M-15.42 ± 3.47 mm2, D-16.09 ± 3.97 mm2) were non-significant differences. They were significantly less than the decline in the control group (C-45.04 ± 8.38 mm2 M-31.98 ± 8.34 mm2, D-31.85 ± 8.52 mm2) (P < 0.05). The percentage of newly formed bone in the CGFs/DBBM group (41.99 ± 12.99%) was significantly greater than that in DBBM group (30.68 ± 10.95%) (P < 0.05). The percentage of residual materials in the CGFs/DBBM group (16.19 ± 6.63%) was significantly less than that in the DBBM group (28.35 ± 11.70%) (P < 0.05). Conclusion Combined application of CGFs and DBBM effectively reduced the resorption of alveolar ridge and resulted in more newly formed bone than the use of DBBM with collagen membranes.

Mesozoic Tectonic Setting of SE Sundaland After Magmatism and Suture Evidences in JS-1 Ridge Area

Mesozoic plate convergence in SE Sundaland has been a source of debate for decades. A determination of plate convergence boundaries and timing have been explained in many publications, but not all boundaries were associated with magmatism. Through integration of both plate configurations and magmatic deposits, the basement can be accurately characterized over time and areal extents. This paper will discuss Cretaceous subductions and magmatic arc trends in SE Sundaland area with additional evidence found in JS-1 Ridge. At least three subduction trends are captured during the Mesozoic in the study area: 1) Early Jurassic – Early Cretaceous trend of Meratus, 2) Early Cretaceous trend of Bantimala and 3) Late Cretaceous trend in the southernmost study area. The Early Jurassic – Early Cretaceous subduction occurred along the South and East boundary of Sundaland (SW Borneo terrane) and passes through the Meratus area. The Early Cretaceous subduction occurred along South and East boundary of Sundaland (SW Borneo and Paternoster terranes) and pass through the Bantimala area. The Late Cretaceous subduction occurred along South and East boundary of Sundaland (SW Borneo, Paternoster and SE Java – South Sulawesi terranes), but is slightly shifted to the South approaching the Oligocene – Recent subduction zone. Magmatic arc trends can also be generally grouped into three periods, with each period corresponds to the subduction processes at the time. The first magmatic arc (Early Jurassic – Early Cretaceous) is present in core of SW Borneo terrane and partly produces the Schwaner Magmatism. The second Cretaceous magmatic arc (Early Cretaceous) trend is present in the SW Borneo terrane but is slightly shifted southeastward It is responsible for magmatism in North Java offshore, northern JS-1 Ridge and Meratus areas. The third magmatic arc trend is formed by Late Cretaceous volcanic rocks in Luk Ulo, the southern JS-1 Ridge and the eastern Makassar Strait areas. These all occur during the same time within the Cretaceous magmatic arc. Though a mélange rock sample has not been found in JS-1 Ridge area, there is evidence of an accretionary prism in the area as evidenced by the geometry observed on a new 3D seismic dataset. Based on the structural trend of Meratus (NNE-SSW) coupled with the regional plate boundary understanding, this suggests that both Meratus & JS-1 Ridge are part of the same suture zone between SW Borneo and Paternoster terranes. The gradual age transition observed in the JS-1 Ridge area suggests a southward shift of the magmatic arc during Early Cretaceous to Late Cretaceous times.

Pendekatan Hidrogeomorfologi Dan Pendugaan Geolistrik Untuk Identifikasi Potensi Airtanah Di Jedong Malang

This study aims to identify the potential groundwater in Jedong, Malang, East Java. The hydrogeomorphological approach is a suitable approach to describe the relationship between hydrological and geomorphological processes on and below the earth's surface. The survey of geoelectricity complements the hydrogeomorphological approach. It will give a better description of the groundwater conditions below the earth's surface. Based on the research, there are 2 hydrogeomorphological units in the study area, which are: Volcanic Foot Valley Unit and Volcanic Foot Ridge Unit. The best groundwater potential is in Volcanic Foot Valley Hydrogeomorphological unit, namely Awar-awar Valley and Cokro Valley. The valleys are dominated by gully erosion and landslides. They have surface deposits up to a depth of 7 meters, and lots of outcrops of breccia, pumice, and andesite boulders. The valley’s springs discharge between 56 - 198 m3/day. The average infiltration rate in the valley is 1776 mm / hour, with sandy soil material. The best aquifer consisting of sandy material is more than 10 meters in depth, based on the geoelectrical survey. Water in the aquiclude layer, cannot be exploited because it is breccia and tuff material. The Sawah valley cannot be exploited further because the groundwater potential is very low. This can be identified by the thick water outflow seepage. In the Volcanic Foot Ridge Hydrogeomorphological unit, the groundwater potential is also very small. Hydrogeomorphically, water will flow down the slope to the valley. It will reduce the infiltration rate. In general, the ridge area is only used for settlement, while the slopes are used for dryland agriculture. The geoelectric analysis results show that the groundwater potential is at a depth of more than 45 meters. This research’s results show that the combination of the hydrogeomorphological approach and the geoelectric use will provide a better description of the potential groundwater.

Plasma skimming efficiency of human blood in the spiral groove bearing of a centrifugal blood pump

This work investigates the plasma skimming effect in a spiral groove bearing within a hydrodynamically levitated centrifugal blood pump when working with human blood having a hematocrit value from 0 to 40%. The present study assessed the evaluation based on a method that clarified the limitations associated with such assessments. Human blood was circulated in a closed-loop circuit via a pump operating at 4000 rpm at a flow rate of 5 L/min. Red blood cells flowing through a ridge area of the bearing were directly observed using a high-speed microscope. The hematocrit value in the ridge area was calculated using the mean corpuscular volume, the bearing gap, the cross-sectional area of a red blood cell, and the occupancy of red blood cells. The latter value was obtained from photographic images by dividing the number of pixels showing red blood cells in the evaluation area by the total number of pixels in this area. The plasma skimming efficiency was calculated as the extent to which the hematocrit of the working blood was reduced in the ridge area. For the hematocrit in the circuit from 0 to 40%, the plasma skimming efficiency was approximately 90%, meaning that the hematocrit in the ridge area became 10% as compared to that in the circuit. For a hematocrit of 20% and over, red blood cells almost completely occupied the ridge. Thus, a valid assessment of plasma skimming was only possible when the hematocrit was less than 20%.

Alternative impression technique for edentulous anterior maxillary flabby tissue

This present study describes an impression technique to rehabilitate patients with flabby ridge in pre-maxilla through complete dentures. The proposed technique consists on the association of nondisplacive impression of the flabby area in the primary and functional impression. Therefore, a primary impression was performed with irreversible hydrocolloid with a dual impression. The impression material was removed at the region corresponding to the flabby area, characterizing a window, where a re-impression was conducted with the same material in a more fluid consistency. The functional impression was executed with a custom tray with perforations at the flabby area fabricated over a primary anatomic cast previously relieved. As a result, an anatomic impression with reduced compression over the flabby ridge was obtained. Moreover, an accentuated decrease of the mucosa compression was obtained through the material overflow from the custom tray perforations at the functional impression. After the acrylization of the prosthetic piece, a delimited box corresponding to the flabby mucosa in the prosthesis base was verified. Thus, it is concluded that the association of techniques proposed in this study reduced the compression over the flabby ridge area resulting in a complete denture copying anatomically the flabby area at rest. Thereby, in this case through a precise negative reproduction, a more favorable retention of the maxillary complete denture was obtained in patients with flabby ridge at the pre-maxillary area.

Investigating the potential for a commercial fishery in the Northeast Atlantic utilizing mesopelagic species

During three cruises in the Mid Atlantic Ridge area in 2016 and 2017, we studied the biomass of mesopelagic fish and its potential as a source of protein and oil for animal feed and human consumption. We collected samples of mesopelagic species down to a depth of 600 m, studied fish behaviour, identified and quantified the species composition of the catches, analysed the chemical composition of the catch samples, and evaluated the presence of unwanted substances. Results showed that Maurolicus muelleri (Mueller’s pearlside) and Benthosema glaciale (Glacier lantern fish) were the most abundant fish species in our samples and catches containing 80% fish can be a good source of protein and marine lipids including eicosapentaenoic acid (C20:5n3) and docosahexaenoic acid (C22:6n3). Unwanted substances, except for Cd and As, were present at levels far lower than the limits set by European Union regulations. However, our experiments identified challenges that may limit the efficiency of commercial operations in the Northeast Atlantic. Combined real-time optical and/or multifrequency acoustic systems will be needed to improve species identification and ensure cost-effective fishing operations. Also, selective trawls that target only fish and release unwanted species are needed to secure high-quality oils and proteins.