Anti–Diabetic Activity of Murraya koenigii – A Comprehensive Review

Diabetes mellitus, one of the noncommunicable illnesses, is a severe problem worldwide as one of the leading causes of death. Because existing synthetic medications have various drawbacks, researchers are still looking for better anti-hyperglycemic treatments. Plants have been used in ancient medicine for thousands of years. India is the biggest producer of medicinal plants and is aptly regarded as the "World's Botanical Garden." Murraya koenigii Linn, also known as Meethi neem, is a Rutaceae plant. Curry trees are unique to India and likely found almost everywhere else on the subcontinent, except in the Himalayan highlands. For centuries, curry leaves were used as an antiemetic, diarrhea remedy, febrifuge, and blood purifier. Curry leaves are useful as an antioxidant, anti-diabetic, antibacterial, antihypertensive, cytotoxic, and in treating bronchial respiratory problems. Traditionally, the leaves were utilized as a spice in curries as well as other dishes. It includes coumarins and derivatives, alkaloids, flavonoids, phenolic compounds, and essential oil. Numerous studies have found that these phytochemicals have a significant effect on type 2 diabetes. This review focuses on this plant's anti-diabetic action and concludes that it has the potential to be evaluated as a candidate for developing a new diabetes mellitus medication.

Seuchengötter, Heilungsgötter

The article discusses the impact of different ideas on epidemic, endemic, and pandemic diseases in antiquity, concentrating on the times of the New Testament and the early church. Different explanations of diseases coexist and to some degree compete: Diseases are sent by God for punishment and admonition, caused by demons or magic, and in ancient medicine caused by strictly natural factors. Contrary to a common cliché, divine punishing is only a minor idea in reflections on disease, and natural causes are generally taken for granted. A demonological interpretation understands disease as something that is fought by Jesus and also by other charismatic healers in ancient Christianity. In this respect, early Christianity can be called a healing movement.

Ginger, a Possible Candidate for the Treatment of Dementias?

As the human life expectancy increases, age-linked diseases have become more and more frequent. The worldwide increment of dementia cases demands medical solutions, but the current available drugs do not meet all the expectations. Recently the attention of the scientific community was attracted by natural compounds, used in ancient medicine, known for their beneficial effects and high tolerability. This review is focused on Ginger (Zingiber officinale) and explore its properties against Alzheimer’s Disease and Vascular Dementia, two of the most common and devastating forms of dementia. This work resumes the beneficial effects of Ginger compounds, tested in computational in vitro and in vivo models of Alzheimer’s Disease and Vascular Dementia, along with some human tests. All these evidences suggest a potential role of the compounds of ginger not only in the treatment of the disease, but also in its prevention.

Animal Models as a Tool to Design Therapeutical Strategies for CMT-like Hereditary Neuropathies

Since ancient times, animal models have provided fundamental information in medical knowledge. This also applies for discoveries in the field of inherited peripheral neuropathies (IPNs), where they have been instrumental for our understanding of nerve development, pathogenesis of neuropathy, molecules and pathways involved and to design potential therapies. In this review, we briefly describe how animal models have been used in ancient medicine until the use of rodents as the prevalent model in present times. We then travel along different examples of how rodents have been used to improve our understanding of IPNs. We do not intend to describe all discoveries and animal models developed for IPNs, but just to touch on a few arbitrary and paradigmatic examples, taken from our direct experience or from literature. The idea is to show how strategies have been developed to finally arrive to possible treatments for IPNs.

Cannabinoids and Cancer

Cannabinoids, active components of the plant Cannabis sativa, had been used for centuries in ancient medicine as therapeutic remedies for a variety of conditions, before becoming stigmatized due to their psychoactive effects [...]

Galen: A Thinking Doctor in Imperial Rome by Vivian Nutton

The popularity that ancient medicine and Galenic studies in particular now enjoy in anglophone scholarship is owing in no small part to the author of the monograph under review. Through his textual critical and analytic work over the past 50 years, Nutton has made the life, writings, and thought of the secondcentury ad Greek doctor Galen of Pergamum (d. ca 216) more accessible to generations of students and scholars. As Nutton admits in the introduction, the present book has the apologetic aim of defending his careerlong interest in Galen against critics who might view Galen’s obsolete medical theories and practices as evidence of a lack of intellectual worth. Reviewed by: Aileen R. Das, Published Online (2021-08-31)Copyright © 2021 by Aileen R. DasThis open access publication is distributed under a Creative Commons Attribution-NonCommercial-NoDerivatives License (CC BY-NC-ND) Article PDF Link: https://jps.library.utoronto.ca/index.php/aestimatio/article/view/37740/28739 Corresponding Author: Aileen R. Das,University of MichiganE-Mail: [email protected]