The Asia-Pacific or APAC region covers a vast area of great linguistic, cultural, geographic, and economic diversity and is home to over 65% of the world’s population with disabilities. While many of the accessibility challenges are common and include prioritization, lack of awareness, affordability, availability, infrastructure, language, and training, there are also wide regional differences in areas such as resources, infrastructure, development, policy, and accessibility of technologies and content across APAC countries. This chapter seeks to give a regional overview of digital accessibility by utilizing the DARE Index to analyze gaps in implementing digital accessibility policies in the region, and then reviewing four country case studies (Bangladesh, India, Myanmar, and Sri Lanka).