Evolution of the Verbal-Derivational Field of the Political Media Concept of «Maidan» in the Russian Media

The proposed article demonstrates that the formation and development of a new political concept is accompanied by an increase in the number of units representing it, which also occurs due to active word-formation processes that lead to the emergence of a significant number of non-derivatives formed from the main representative of the concept. The hypothesis is verified by the example of the description of the verbal-derivational field of the “maidan” media concept.In the course of the research, the method of constructing a word-formation nest was used; to assess the frequency of use of new derivatives, the method of content analysis was used. The material for the study was texts related to media discourse for the period from 2004 to 2019. The article highlights two periods in the development of the concept of “Maidan” in the media discourse, associated with two major protests in Ukraine and their consequences, for each period new derivatives formed from the root of the Maidan are identified and described, the ways of forming new words are determined, their frequency is analyzed. which ultimately allows us to trace the evolution of the concept’s verbal-derivational field. It has been established that each of the periods under consideration is characterized by a significant increase in the number of derivatives of the “maidan” media concept, in particular, at the first stage, 17 new derivative words appeared, at the second stage, their number increases to 41 units, which is accompanied by an increase in the frequency of all non-derivatives. The bulk of the new words allows us to characterize 1) the typology of protests (avtomaydan, eromaydan, mikhomaidan, anti-maidan), 2) its participants (maidan, maidan, maidan, maidan, etc.) and 3) the process of protest and its phases (zamaydan, maidan, re-maidan , domaydanit, etc.). Thus, the results obtained confirm the thesis about the important role of derivational processes in the formation and development of concepts and indicate the increasing importance of the “Maidan” media concept for the national political concept sphere.

Lexicon of pandemics: a semantic analysis of the Spanish flu and the Covid-19 timeframe terminology

PurposeThe aim of this study is a semantic comparative analysis between the current pandemic and the Spanish flu. It is based on a bilingual terminological perspective oriented to evaluate and compare the terms used to describe and communicate the pandemic's issues both to biomedical experts and to a non-specialist public.Design/methodology/approachThe analysis carried out is a terminological comparative investigation performed on two corpora, the first containing scientific English articles, the second Italian national newspapers' issues on two pandemics, the Spanish flu and the current Covid-19 disease, towards the detection of semantic similarities and differences among them through the implementation of computational tasks and corpus linguistics methodologies.FindingsGiven the cross-fielding representativeness of terms, and their relevance within specific historical eras, our study is conducted both on a synchronic and on a diachronic level to discover the common lexical usages in the dissemination of the pandemic issues.Originality/valueThe study presents the extraction of the main representative terms about two pandemics and their usages to share news about their trends among the population and the integration of a topic modeling detection procedure to discover some of the main categories representing the lexicon of the pandemics with reference to a list of classes created by external thesauri and ontologies on pandemics. As a result, a detailed overview of the discrepancies, as well as similarities, retrieved in two historical corpora dealing with a common subject, i.e. the pandemics' terminology, is provided.

OSSETIAN TEACHERS: SELF-AWARENESS AND EVERYDAY LIFE (LATE XIX – EARLY XX CENTURY)

Статья посвящена одному из аспектов истории образования в Осетии конца XIX – начала XX в. – самосознанию социопрофессиональной группы – осетинского учительства. Формирование профессиональных групп было выражением модернизации социальной структуры пореформенного осетинского общества. Ввиду особенностей истории образования в Осетии главным представителем этой группы являлись учителя церковно-приходских школ – основного типа начальной школы в крае. Осознание профессиональных интересов, общественного статуса и материального положения народного учителя было проявлением оформления этого социального сообщества. В центре внимания педагогической публицистики – учительская повседневность, размеры жалования, проблема пенсий, жилье, питание, взаимоотношения учителя с школьной и сельской администрацией, представителями сельского общества, статус и перспективы педагогического труда. Обсуждение многих проблем носило полемический характер; участники дискуссии высказывали противоположные суждения о материальной обеспеченности народного учителя, качестве жилья, возможности подсобного хозяйства, будущего образования детей учителя. Освещалась запутанность ситуации с учительскими пенсиями, которые в реальности не выплачивались. В актуальной публицистике освещены не все проблемы учительской повседневности, а только социально значимые, волновавшие демократическую интеллигенцию. Изучение субкультуры и самосознания осетинского учительства актуально в русле методологических поисков отечественной «новой социальной истории», а также «историко-антропологического» подхода, дающих возможность реконструкции поведенческих стратегий этой группы интеллигенции. «Интеллектуальная история» Осетии дореволюционного периода формировалась во многом представителями этой образовательной общности, развивавшей общественную мысль на протяжении десятилетий. Публицистическая подборка, составившая основу статьи, информативна и свидетельствует о перспективности изучения такой социопрофессиональной и культурной группы, как осетинское учительство. The article considers one of the aspects of the history of education in Ossetia in the end of XIX – early XX century – the self-awareness of the Ossetian teachers as socio-professional group. The formation of professional groups was an expression of the modernization of the social structure of the post-reform Ossetian society. In view of the peculiarities of the history of education in Ossetia, the main representative of this group was the teachers of parish schools, the main type of elementary school in the region. Awareness of the professional interests, social status and material situation of the people's teacher was a manifestation of the formation of this social community. The focus of pedagogical journalism is on teachers' everyday life, salaries, the problem of pensions, housing, food, the teacher's relationship with the school and rural administration, representatives of rural society, the status and prospects of pedagogical work. Discussion of many problems was polemical in nature; the participants in the discussion expressed opposite opinions about the material security of a people's teacher, the quality of housing, the possibility of subsidiary farming, and the future education of the teacher's children. The confusion of the situation with teachers' pensions, which in reality were not paid, was highlighted. In actual journalism, not all problems of teachers' everyday life are highlighted, but only socially significant ones that worried the democratic intelligentsia. The study of the subculture and self-consciousness of the Ossetian teachers is relevant in line with the methodological searches of the national “new social history”, as well as the “historical-anthropological” approach, which makes it possible to reconstruct the behavioral strategies of this group of intelligentsia. The "intellectual history" of Ossetia in the pre-revolutionary period was formed in many respects by representatives of this educational community, which had been developing public thought for decades. This journalistic selection is informative and testifies to the prospects of studying such a socio-professional and cultural group as the Ossetian teachers.

Imidazole Analogs of Vascular-Disrupting Combretastatin A-4 with Pleiotropic Efficacy against Resistant Colorectal Cancer Models

Specific targeting of the tumoral vasculature by vascular-disrupting agents (VDA), of which combretastatin A-4 (CA-4) is a main representative, has been considered a new therapeutic strategy against multidrug-resistant tumors. In addition, CA-4 and analogs are tubulin-targeting agents and can exert direct antitumor effects by different mechanisms. Herein, we analyzed a series of synthetic CA-4 analogs featuring N-methylimidazole-bridged Z-alkenes with different halo- or amino-substituted aryl rings in vitro and in vivo, focusing on models of colorectal cancer. Combined in vitro/in vivo structure–activity relationship studies using cell lines and xenograft tumors susceptible to VDA-induced vascular damage demonstrated a clear association of cytotoxic and vascular-disrupting activity with the ability to inhibit tubulin polymerization, which was determined by specific substitution constellations. The most active compounds were tested in an extended panel of colorectal cancer (CRC) cell lines and showed activity in CA-4-resistant and chemotherapy-resistant cell lines. The bromo derivative brimamin was then compared with the known fosbretabulin (CA-4P) by activity tests on DLD-1- (multidrug-resistant) and HT29- (CA-4-resistant) derived xenograft tumors. Treatment did not induce pronounced vascular-disrupting effects in these tumors. Histological analyses revealed distinct tumor substructures and vessel compositions of DLD-1/HT29 tumors, which clearly differed from the tumor models susceptible to VDA treatment. Even so, brimamin effectively retarded the growth of DLD-1 tumors, overcoming their resistance to standard treatment, and it inhibited the outgrowth of disseminated HT29 tumor cells in an experimental metastasis model. In conclusion, combretastatin analogous N-methylimidazoles proved capable of inducing vascular-disrupting effects, comparable to those of CA-4P. In addition, they showed antitumor activities in models of drug-resistant colorectal cancer, independent of vascular-disrupting effects.

OP316 Patients’ Testimonials In The National Committee For Health Technology Incorporation In Brazilian Public Health System (Conitec) Meetings

IntroductionThe Department of Management and Incorporation of Technologies and Innovation in Health (DGITIS) acts as Conitec's Executive Secretariat. Among its attributions, it promotes the public/patient involvement in the health technology assessment (HTA) process. Recently, Conitec has been working on the inclusion of patient's testimonials about their illness experience in the plenary sessions, that is, the monthly meeting where technologies are assessed.MethodsTo support the action of including patient reporting in Conitec's HTA process, DGITIS developed research on HTA agencies websites worldwide. The main criteria was the inclusion of patients’ reports in their Committee meetings. DGITIS contacted some of these agencies and requested a listserv question to the International Network of Agencies for Health Technology Assessment (INAHTA) members. These findings supported the DGITIS for the inclusion of patient participation in Conitec's meetings, from the selection process to the actual participation.ResultsFor the Conitec's HTA process, the patients’ participation should occur in the prior session to the public consultation, guaranteeing the inclusion of their perspective since the recommendation process beginning. Hence, every demand for incorporation to be discussed at Conitec's meeting should be preceded by a public call for patients with the clinical condition. The DGITIS will also hold preparatory meetings, which will serve as moments for shared construction of knowledge and literacy.ConclusionsThe nomination process, so far, has been grounded as a consensus among the patients. Thus, Conitec acts as a mediator, connecting the involved stakeholders, in a way that they can autonomously organize themselves and indicate the main representative and an alternate one. With the inclusion of the patient's perspective in the Conitec's meeting, another form of patient participation was opened in the HTA process. Therefore, the consolidation of this participation space is feasible and contributes to enrich the Brazilian HTA process.

Cysteinolic Acid Is a Widely Distributed Compatible Solute of Marine Microalgae

Phytoplankton rely on bioactive zwitterionic and highly polar small metabolites with osmoregulatory properties to compensate changes in the salinity of the surrounding seawater. Dimethylsulfoniopropionate (DMSP) is a main representative of this class of metabolites. Salinity-dependent DMSP biosynthesis and turnover contribute significantly to the global sulfur cycle. Using advanced chromatographic and mass spectrometric techniques that enable the detection of highly polar metabolites, we identified cysteinolic acid as an additional widely distributed polar metabolite in phytoplankton. Cysteinolic acid belongs to the class of marine sulfonates, metabolites that are commonly produced by algae and consumed by bacteria. It was detected in all dinoflagellates, haptophytes, diatoms and prymnesiophytes that were surveyed. We quantified the metabolite in different phytoplankton taxa and revealed that the cellular content can reach even higher concentrations than the ubiquitous DMSP. The cysteinolic acid concentration in the cells of the diatom Thalassiosira weissflogii increases significantly when grown in a medium with elevated salinity. In contrast to the compatible solute ectoine, cysteinolic acid is also found in high concentrations in axenic algae, indicating biosynthesis by the algae and not the associated bacteria. Therefore, we add this metabolite to the family of highly polar metabolites with osmoregulatory characteristics produced by phytoplankton.

Cronobiological and Sleep Related Aspects Associated to Neurodevelopment and Academic Performance in Pediatric Age

Biological rhythms and sleep as their main representative are relevant biofunctional factors to the neuro-cognitive and behavioral development with particular interest in pediatric domain. Some aspects associated to central nervous system and higher function homeostasis, like social-afective equilibrium, critical judgement and memories consolidations and learning, have, in this phase of life, a relationship with the circadian timing system stability and with cronotype. On the other hand, inadequate or insufficient sleep has a negative impact in several biopsychosocial parameters interacting with these domains and conditioning the normal development causing changes in neuro-cognitive and behavioral performance. This review looked for the fundamental aspects of chronobiology and sleep physiology applied to neurodevelopment and its impact in the educational context regarding academic performance.

Preliminary Characterisation of Wastes Generated from the Rapeseed and Sunflower Protein Isolation Process and Their Valorisation in Delaying Oil Oxidation

Since rapeseed and sunflower meals are two of the most representative oilseed crops in the world, this study was focused on ethanol-wash solutes (EWS) obtained as wastes from the protein isolation process of rapeseed and sunflower meals. These meals have been previously valorised; however, the use of the EWS is unexplored. The present study is aimed at the characterisation of their phenolic profile, and antioxidant capacity for preventing lipid oxidation in rapeseed, sunflower, and soybean oil, which has been used as a reference oil. The sunflower EWS exhibited more total phenolic compounds (TPC) and antioxidant activity (119.39 ± 1.13 mg GA/g and 193.97 ± 9.77 mg TE/g, respectively) than the rapeseed one (103.44 ± 5.94 mg GA/g and 89.51 ± 3.17 mg TE/g). The phenolic identification showed hydroxybenzoic and protocatechuic acid in the rapeseed EWS, and pyrogallol and caffeic acid in the sunflower EWS, as the main representative phenols. Both EWS at 15% increased significantly (p < 0.05) the oxidative stability of the oils in the Rancimat equipment with values of antioxidant activity index (AAI) from 1.01 to 1.20, depending on the type of oil employed. In conclusion, the rapeseed and sunflower EWS showed great potential, and they could be used as a source of natural antioxidants within the food industry, replacing the synthetic ones, and promoting the circular economy since they are agro-food wastes.

Prenatal tobacco exposure and risk of asthma and allergy outcomes in childhood

BackgroundHarmful effects of prenatal tobacco exposure and possible interaction with 17q12-21 genetic variants have been shown for some asthma outcomes in childhood, whereas findings related to allergy outcomes are more inconsistent. This study aimed to examine the effect of prenatal tobacco exposure and relation to 17q12-21 genotype on a wide array of asthma and allergy-related outcomes in early childhood.MethodsPrenatal tobacco exposure was determined by maternal smoking during 3rd trimester (yes/no) in 411 children from the COPSAC2000 birth cohort with clinical follow-up till age 7 years. The rs7216389 SNP was used as main representative of the 17q12-21 locus. Asthma endpoints included asthma diagnosis, exacerbations, episodes with troublesome lung symptoms and lower respiratory tract infections (LRTI), spirometry, plethysmography, bronchial responsiveness to methacholine, exercise and cold dry air. Allergy-related endpoints included aeroallergen sensitisation, allergic rhinitis, fractional exhaled nitric oxide, blood eosinophil count and urine eosinophil protein X levels. Statistical analyses were done using Cox regression, linear regression, logistic regression and Quasi-Poisson regression.ResultsPrenatal tobacco exposure increased the risk of asthma (adjusted hazard ratio (aHR)=2.05, (95% CI 1.13; 3.73), p=0.02)), exacerbations (aHR=3.76, (2.05; 6.91), p<0.001), number of LRTIs (aIRR=1.87, (1.34; 2.55), p<0.001), and associated with decreased spirometry indices (FEV1: aMD=−0.07 L (−0.13; −0.005), p=0.03, MMEF: aMD=−0.19 L·s−1 (−0.34; −0.04), p=0.01) and increased bronchial responsiveness to methacholine (PD20: aGMR=0.55 (0.31; 0.96), p=0.04). In contrast, there was no association with any allergy-related endpoints. The effect on asthma depended on 17q12-21 genotype with an increased risk only among children without risk alleles.ConclusionPrenatal tobacco exposure was associated with asthma dependent on 17q12-21 genotype and with exacerbations, lung function and bronchial responsiveness, but not with any allergy-related outcomes. This suggests that tobacco exposure in utero leads to adverse lung developmental/structural effects rather than susceptibility to develop allergy and Type 2 inflammation.

A novel comparative chromatographic research of secoiridoid glycosides in two species of centaury herb

The aim: A novel comparative analysis of the secoiridoid glycosides composition in Centaurium erythraea Rafn. and Cеntaurium pulchellum (Sw.) Druce has being described. Swertiamarin has been chosen as an active marker and its comparative quantitative estimation in two species of the raw material has been carried out by HPLC method. Materials and methods: The quantitative HPLC analysis of swertiamarin was conducted using a chromatographic column ACE 5 C18. Methanol and 0,5 % acetic acid aqueous solution were used as mobile phases; the chromatographic procedure was carried out in a gradient mode. Results: The content of swertiamarin in the C. pulchellum herb ranges from 2.51 to 3.07 mg/100 mg. In that time swertiamarin content in C. erythraea herb varies and depends from 3.83 to 8.94 mg/100 mg. The content of swertiamarin in C. pulchellum herb is much lower than in C. erythraea herb. Taking into account this fact the possibility of using of C. pulchellum herb for medicine instead of C. erythraea herb must be proven additionally by biological experiments. Also it could be preliminary concluded that the most appropriate climate for swertiamarin accumulation in C. erythraea herb is located in Central and Eastern parts of Ukraine. Conclusions: It was discovered that the main representative of secoiridoid glycosides in C. erythraea is swertiamarin when in C. pulchellum Druce that are represented by both sweroside and swertiamarin. A more perspective raw material – C. erythraea herb, according to the content of swertiamarin, was chosen