Direct reaction contribution in the very low-energy 19F(p,α0) reaction

The direct reaction component of the [Formula: see text]F([Formula: see text]) reaction at [Formula: see text][Formula: see text]keV is studied for the data that became very recently available. This component is significant in this work using the direct pickup model in the framework of the DWBA formalism and indicate the strong cluster structure of [Formula: see text]F. The direct component of astrophysical S-factor is calculated for [Formula: see text]F([Formula: see text]).

Density-dependent migration characteristics of cancer cells driven by pseudopod coordination

The ability of cancer cells to invade neighboring tissue from primary tumors is an important determinant of metastatic behavior. Quantification of cell migration characteristics such as migration speed and persistence helps to understand the requirements for such invasiveness. One factor that may influence invasion is how local tumor cell density shapes cell migration characteristics, which we here investigate with a combined experimental and computational modeling approach. First, we generated and analyzed time-lapse imaging data on two aggressive Triple-Negative Breast Cancer (TNBC) cell lines, HCC38 and Hs578T, during 2D migration assays at various cell densities. HCC38 cells exhibited a counter-intuitive increase in speed and persistence with increasing density, whereas Hs578T did not exhibit such an increase. Moreover, HCC38 cells exhibited strong cluster formation with active pseudopod-driven migration, especially at low densities, whereas Hs578T cells maintained a dispersed positioning. In order to obtain a mechanistic understanding of the density-dependent cell migration characteristics and cluster formation, we developed realistic spatial simulations using a Cellular Potts Model (CPM) with an explicit description of pseudopod dynamics. Model analysis demonstrated that strong coordination between pseudopods within single cells could explain the experimentally observed increase in speed and persistence with increasing density in HCC38 cells. Thus, the density-dependent migratory behavior could be an emergent property of single-cell characteristics without the need for additional mechanisms. This implies that coordination amongst pseudopods may play a role in the aggressive nature of cancers through mediating dispersal.

Strong positivity for quantum theta bases of quantum cluster algebras

We construct “quantum theta bases,” extending the set of quantum cluster monomials, for various versions of skew-symmetric quantum cluster algebras. These bases consist precisely of the indecomposable universally positive elements of the algebras they generate, and the structure constants for their multiplication are Laurent polynomials in the quantum parameter with non-negative integer coefficients, proving the quantum strong cluster positivity conjecture for these algebras. The classical limits recover the theta bases considered by Gross–Hacking–Keel–Kontsevich (J Am Math Soc 31(2):497–608, 2018). Our approach combines the scattering diagram techniques used in loc. cit. with the Donaldson–Thomas theory of quivers.

Assessing the Need for Ecotourism Cluster Establishment in Georgia: Ways to Increase the Country’s Competitiveness

Georgia is famous for wine, hospitality, culture, and history at the international level. Before now, tourism in Georgia was only related to wine tourism and sea resorts, but in recent years, the country is positioning itself as an emerging destination for adventurous tourism. Industry potential is not fully utilized and it has more hidden possibilities to attract more visitors. This paper focuses on assessing the need for ecotourism cluster establishment in Georgia. In fulfilling this objective, a survey was conducted. Questionnaires were distributed to ecotourism service providers of the country. 54 managers of national parks and other protected areas (Lagodekhi Protected Areas, Kazbegi National Park, Martvili Canyon Natural Monument, Borjomi-Kharagauli National Park and Machakhela National Park) were chosen for the survey. The selected respondents are the managers of the most popular ecotourism destinations among Georgian and foreign ecoturists. Due to the various locations in different parts of Georgia, it took about two weeks to conduct the survey. The results of the survey showed that ecotourism industry representatives agree on the need of cluster establishment for more development of the field. The paper also demonstrated that building promising ecotourism industry through strong cluster development is directly related to increasing the country’s competitiveness.

Cluster Radioactivity

Cluster radioactivity (spontaneous emission of heavy particles from nuclei) is presented from theoretical point of view in good agreement with experimental results. After a brief hystorical account we give details about the analytical super asymmetric fission (ASAF) model extensively used for predicting the half-lives of heavy and superheavy (Z ≥ 104) elements. For the already measured 26 cluster decays (from 14C to 32,34Si of parent nuclides with Z = 87-96) it is clear that cluster radioactivity is a rare phenomenon in the best case about 9 orders of magnitude weaker than the competing alpha decay. Then we show the theoretical possibility of a strong cluster decay compared to alpha decay for some superheavy nuclei with Z ≥ 122, e.g. 306122; 310-314122; 306-324124, and 311-323124.

Adoption and Performance of Complementary Clinical Information Technologies: Analysis of a Survey of General Practitioners

Background The benefits from the combination of 4 clinical information systems (CISs)—electronic health records (EHRs), health information exchange (HIE), personal health records (PHRs), and telehealth—in primary care depend on the configuration of their functional capabilities available to clinicians. However, our empirical knowledge of these configurations and their associated performance implications is very limited because they have mostly been studied in isolation. Objective This study aims to pursue 3 objectives: (1) characterize general practitioners (GPs) by uncovering the typical profiles of combinations of 4 major CIS capabilities, (2) identify physician and practice characteristics that predict cluster membership, and (3) assess the variation in the levels of performance associated with each configuration. Methods We used data from a survey of GPs conducted throughout the European Union (N=5793). First, 4 factors, that is, EHRs, HIE, PHRs, and Telehealth, were created. Second, a cluster analysis helps uncover clusters of GPs based on the 4 factors. Third, we compared the clusters according to five performance outcomes using an analysis of variance (ANOVA) and a Tamhane T2 post hoc test. Fourth, univariate and multivariate multinomial logistic regressions were used to identify predictors of the clusters. Finally, with a multivariate multinomial logistic regression, among the clusters, we compared performance in terms of the number of patients treated (3 levels) over the last 2 years. Results We unveiled 3 clusters of GPs with different levels of CIS capability profiles: strong (1956/5793, 37.36%), medium (2764/5793, 47.71%), and weak (524/5793, 9.04%). The logistic regression analysis indicates that physicians (younger, female, and less experienced) and practice (solo) characteristics are significantly associated with a weak profile. The ANOVAs revealed a strong cluster associated with significantly high practice performance outcomes in terms of the quality of care, efficiency, productivity, and improvement of working processes, and two noncomprehensive medium and weak profiles associated with medium (equifinal) practice performance outcomes. The logistic regression analysis also revealed that physicians in the weak profile are associated with a decrease in the number of patients treated over the last 2 years. Conclusions Different CIS capability profiles may lead to similar equifinal performance outcomes. This underlines the importance of looking beyond the adoption of 1 CIS capability versus a cluster of capabilities when studying CISs. GPs in the strong cluster exhibit a comprehensive CIS capability profile and outperform the other two clusters with noncomprehensive profiles, leading to significantly high performance in terms of the quality of care provided to patients, efficiency of the practice, productivity of the practice, and improvement of working processes. Our findings indicate that medical practices should develop high capabilities in all 4 CISs if they have to maximize their performance outcomes because efforts to develop high capabilities selectively may only be in vain.

Co-Solvent Exfoliation of Hexagonal Boron Nitride: Effect of Raw Bulk Boron Nitride Size and Co-Solvent Composition

Exfoliation of two-dimensional boron nitride nanosheets (BNNSs) from parent bulk material has been receiving intensive attention because of its fascinating physical properties. Liquid exfoliation is a simple, scalable approach to produce single-layer or few-layer BNNS. In this paper, water/propanol co-solvent exfoliation of bulk boron nitride under the assistance of sonication was investigated in detail. Special attention was paid on the effect of raw bulk boron nitride size and co-solvent composition. The results show that sonication of small-size hexagonal boron nitride tends to generate large nanosheets, due to a predominant solvent wedge effect. In addition, it is found that the composition of water/propanol co-solvent has an important effect on exfoliation efficiency. Interestingly, although two isomers of 1-propanol (NPA) and 2-propanol (IPA) have the same molecular weight and similar surface tension, their aqueous solutions allow the formation of boron nitride nanosheets dispersion with markedly different concentrations. It is proposed that due to their spatial configuration difference, NPA with its longer molecular chain and fewer hydrophobic methyl group tends to form dynamic water-NPA clusters with larger size than water-IPA clusters. The hydrodynamic radius of the co-solvent “clusters” was calculated to be 0.72 nm for water/NPA system and 0.44 nm for water/IPA system at their maximum, respectively. Their size changes, represented by two curves, indicate a strong “cluster size” effect on exfoliation efficiency. Our work provides an insight into co-solvent exfoliation of hexagonal boron nitride and emphasizes the importance of co-solvent cluster size in exfoliation efficiency.

Effective Strategic Positioning of Institutions of Secondary Professional Education in the Knowledge Economy

The purpose of the article is to develop a strategy for the forming a strong cluster of secondary vocational education in Russia. In the era of globalization, toughening competition in the global education market, high economic and political risks, the development and implementation of an educational institution development strategy requires a search for new approaches and the development of new methods and ways to implement it. The paper proposes a model of breakthrough positioning of institutions of secondary vocational education, by which it is possible to identify effective strategies of institutions and to carry out their ranking. The work carried out the positioning of institutions of secondary vocational education on the modified matrix of Cagan and Vogel and proposed strategies for their development in accordance with the position taken. The article developed a tool for identifying the strategic priorities of institutions of secondary vocational education, which allows to identify promising dominants of the strategic development of organizations and their financing. When using the positioning model, it is shown that not all types of positioning can be effectively used by an organization, and an untimely choice of a more promising strategy can be unsuccessful for an institution.

Population relationships based on 170 ancestry SNPs from the combined Kidd and Seldin panels

The benefits of ancestry informative SNP (AISNP) panels can best accrue and be properly evaluated only as sufficient reference population data become readily accessible. Ideally the set of reference populations should approximate the genetic diversity of human populations worldwide. The Kidd and Seldin AISNP sets are two panels that have separately accumulated thus far the largest and most diverse collections of data on human reference populations from the major continental regions. A recent tally in the ALFRED allele frequency database finds 164 reference populations available for all the 55 Kidd AISNPs and 132 reference populations for all the 128 Seldin AISNPs. Although much more of the genetic diversity in human populations around the world still needs to be documented, 81 populations have genotype data available for all 170 AISNPs in the union of the Kidd and Seldin panels. In this report we examine admixture and principal component analyses on these 81 worldwide populations and some regional subsets of these reference populations to determine how well the combined panel illuminates population relationships. Analyses of this dataset that focused on Native American populations revealed very strong cluster patterns associated with many of the individual populations studied.