EP.FRI.300 Equine related trauma: a 20-year district general hospital experience

Introduction Although a popular recreational and competitive sport, horse riding carries risk of injury. We aimed to characterise demographics, injury patterns and outcomes of patients with an equine-related injury over a 20-year period. Methods Patients were identified through local coding. Data relevant to the study aims were extracted. Statistical analysis was used to determine any association between patient demographic with injury pattern or outcome. Results Of the 701 patients included, 71.3% were female and the mean age was 34.9 years. Simple head injury (25.4%) and upper limb fracture (21.3%) were the commonest injuries. Abdominal visceral injury occurred in 1.6% with 2 patients requiring laparotomy and splenectomy. Overall, operations were performed in 32.8%. Open reduction and internal fixation was the commonest procedure (42.4%). 30-day mortality was 0.3% and 3.1% required transfer to a tertiary centre. Older patients were more likely to have a rib (46.3 vs 33.5 years, p = <0.05) or lower limb fracture (37.9 vs 34.5 years, p = 0.04) whilst upper limb fractures were seen in younger patients (30.3 vs 36.1 years, p = <0.05). There was no statistical difference with other injury patterns or gender. Conclusion Although mortality is rare, a significant proportion of patients sustain injury requiring surgical intervention. Given the predisposition towards orthopaedic injury, adequate rehabilitation facilities need to be available. Continued development and promotion of safety equipment are also required to reduced incidence.

Enabling Clustering for Privacy-Aware Data Dissemination Based on Medical Healthcare-IoTs (MH-IoTs) for Wireless Body Area Network

There is a need to develop an effective data preservation scheme with minimal information loss when the patient’s data are shared in public interest for different research activities. Prior studies have devised different approaches for data preservation in healthcare domains; however, there is still room for improvement in the design of an elegant data preservation approach. With that motivation behind, this study has proposed a medical healthcare-IoTs-based infrastructure with restricted access. The infrastructure comprises two algorithms. The first algorithm protects the sensitivity information of a patient with quantifying minimum information loss during the anonymization process. The algorithm has also designed the access polices comprising the public access, doctor access, and the nurse access, to access the sensitivity information of a patient based on the clustering concept. The second suggested algorithm is K-anonymity privacy preservation based on local coding, which is based on cell suppression. This algorithm utilizes a mapping method to classify the data into different regions in such a manner that the data of the same group are placed in the same region. The benefit of using local coding is to restrict third-party users, such as doctors and nurses, when trying to insert incorrect values in order to access real patient data. Efficiency of the proposed algorithm is evaluated against the state-of-the-art algorithm by performing extensive simulations. Simulation results demonstrate benefits of the proposed algorithms in terms of efficient cluster formation in minimum time, minimum information loss, and execution time for data dissemination.

Novel Local Coding Algorithm for Finger Multimodal Feature Description and Recognition

Recently, finger-based biometrics, including fingerprint (FP), finger-vein (FV) and finger-knuckle-print (FKP) with high convenience and user friendliness, have attracted much attention for personal identification. The features expression which is insensitive to illumination and pose variation are beneficial for finger trimodal recognition performance improvement. Therefore, exploring suitable method of reliable feature description is of great significance for developing finger-based biometric recognition system. In this paper, we first propose a correction approach for dealing with the pose inconsistency among the finger trimodal images, and then introduce a novel local coding-based feature expression method to further implement feature fusion of FP, FV, and FKP traits. First, for the coding scheme a bank of oriented Gabor filters is used for direction feature enhancement in finger images. Then, a generalized symmetric local graph structure (GSLGS) is developed to fully express the position and orientation relationships among neighborhood pixels. Experimental results on our own-built finger trimodal database show that the proposed coding-based approach achieves excellent performance in improving the matching accuracy and recognition efficiency.

An Efficient Feature Extraction Technique Based on Local Coding PSSM and Multifeatures Fusion for Predicting Protein-Protein Interactions

Background: Increasing evidence has indicated that protein-protein interactions (PPIs) play important roles in various aspects of the structural and functional organization of a cell. Thus, continuing to uncover potential PPIs is an important topic in the biomedical domain. Although various feature extraction methods with machine learning approaches have enhanced the prediction of PPIs. There remains room for improvement by developing novel and effective feature extraction methods and classifier approaches to identify PPIs. Method: In this study, we proposed a sequence-based feature extraction method called LCPSSMMF, which combined local coding position-specific scoring matrix (PSSM) with multifeatures fusion. First, we used a novel local coding method based on PSSM to build a new PSSM (CPSSM); the advantage of this method is that it incorporated global and local feature extraction, which can account for the interactions between residues in both continuous and discontinuous regions of amino acid sequences. Second, we adopted 2 different feature extraction methods (Local Average Group [LAG] and Bigram Probability [BP]) to capture multiple key feature information by employing the evolutionary information embedded in the CPSSM matrix. Finally, feature vectors were acquired by using multifeatures fusion method. Result: To evaluate the performance of the proposed feature extraction approach, we employed support vector machine (SVM) as a prediction classifier and applied this method to yeast and human PPI datasets. The prediction accuracies of LCPSSMMF were 93.43% and 90.41% on the yeast and human datasets, respectively. Moreover, we also compared the proposed method with the previous sequence-based approaches on the yeast datasets by using the same SVM classifier. The experimental results indicated that the performance of LCPSSMMF significantly exceeded that of several other state-of-the-art methods. It is proven that the LCPSSMMF approach can capture more local and global discriminatory information than almost all previous methods and can function remarkably well in identifying PPIs. To facilitate extensive research in future proteomics studies, we developed a LCPSSMMFSVM server, which is freely available for academic use at http://219.219.62.123:8888/LCPSSMMFSVM .

Locally Linear Factorization Machines

Factorization Machines (FMs) are a widely used method for efficiently using high-order feature interactions in classification and regression tasks. Unfortunately, despite increasing interests in FMs, existing work only considers high order information of the input features which limits their capacities in non-linear problems and fails to capture the underlying structures of more complex data. In this work, we present a novel Locally Linear Factorization Machines (LLFM) which overcomes this limitation by exploring local coding technique. Unlike existing local coding classifiers that involve a phase of unsupervised anchor point learning and predefined local coding scheme which is suboptimal as the class label information is not exploited in discovering the encoding and thus can result in a suboptimal encoding for prediction, we formulate a joint optimization over the anchor points, local coding coordinates and FMs variables to minimize classification or regression risk. Empirically, we demonstrate that our approach achieves much better predictive accuracy than other competitive methods which employ LLFM with unsupervised anchor point learning and predefined local coding scheme.

Nested-Clique Network Model of Neural Associative Memory

Clique-based neural associative memories introduced by Gripon and Berrou (GB), have been shown to have good performance, and in our previous work we improved the learning capacity and retrieval rate by local coding and precoding in the presence of partial erasures. We now take a step forward and consider nested-clique graph structures for the network. The GB model stores patterns as small cliques, and we here replace these by nested cliques. Simulation results show that the nested-clique structure enhances the clique-based model.

Understanding NHS hospital admissions in England, Scotland and Wales: data linkage to the King’s College Military Cohort Study

ABSTRACT ObjectiveSecondary health systems in the United Kingdom (UK) are unique for recording Outpatient, Inpatient and Accident & Emergency (A&E) visits in the form of electronic health (eHealth) records. Linking regional healthcare datasets is a problematic, further challenging when linking externally, such as to the King’s College Military Cohort Study (KCMCS). We introduce our methodology used for eRecord linkage. ApproacheHealth records from England, Scotland and Wales offer a variety of parameters such as admission/discharge date, diagnosis, treatment/procedure undertaken and the cost of treatment. To acquire eHealth records, unique patient identifiers: NHS number, forename, surname, sex and date of birth extracted from KCMCS were provided to each region. The KCMCS contains self-reported questionnaire results for 9,990 serving/ex-serving military personal, 8,602 participants consented to linkage. eHealth records prepared for linkage in two stages. First, admission and discharge date were checked to ensure a valid date. Second, episodes were checked for consistency, ensuring that no records for individual participants were duplicated. Data available varied based on the region, this disparity between regions can result in data type variation. Hence, linkage was performed on mutual variables to ensure a uniform admission history. Creation of the linked dataset was as follows. First, records and episodes relating to an individual were brought together, to create a personal admission history. Secondly, personal admission history were linked to the KCMCS. ResultsLinking to regional health datasets is not without its challenges. England, Scotland and Wales obtain, store and process eHealth records using different methodologies. A total of 6,336 (76.66%) participants were matched by regional health providers, with a total of 61,558 eHealth records. A total of 187 eHealth records were identified and discounted from linkage due to failure to meet criteria listed above. Verifying diagnoses completeness, Inpatient admissions were consistently code, with full completeness. Conversely, Outpatient admissions were poorly coded with 98% lacking any type of diagnosis. In addition, A&E records were sparsely coded; we identified four different regional and local coding systems to identify reason for admission. The eHealth records show promise for identifying health traits of the military. However, further work is required to identify synergy and overcome regional variations. ConclusionLinkage techniques provide new opportunities for exploring the health of serving and veteran population. However, quality of identifier and linkage error are still of major concern. Further, record completeness, diagnoses accuracy and data cleaning impact the data quality.

Representing the World

This chapter explores the neurobiology of representations, and more specifically how nervous systems represent in the occurrent sense. It first provides an overview of the basic anatomy and physiology of the mammalian visual system before discussing how neurons encode information by drawing on the comparison between “grandmother” coding and distributed coding. In particular, it considers vector coding vs. local coding and the conceptual fecundity of “state space,” along with the question of whether nervous systems honor at all the distinction between vectors of activation and matrices for processing. The chapter proceeds by analyzing the shape-from-shading model, computational models of stereo vision, hyperacuity, and vector averaging.