The radioisotope batteries have drawn extensive attention due to the high energy density. Nowadays, the radioisotope thermophotovoltaic systems are one of the most promising radioisotope batteries. In this work, the crystal emitter design and the associated performance of the radioisotope thermophotovoltaic generators are investigated. First, the design of photonic crystal emitter together with the adoptions of both the multi-layer insulation and supporting materials are discussed. In order to optimize the system efficiency, the effects of the area of emitters are mainly investigated. We have analyzed the efficiency of system using GaSb cells and Si cells, respectively. With Si cells, the system efficiency can computationally reach about [Formula: see text] with an output power of 7 W. When GaSb cells are employed, the system performance is estimated to an efficiency of [Formula: see text] with 61.6 W output.