Non-anticoagulant and other properties of low molecular weight heparins

Низкомолекулярные гепарины (НМГ) являются уникальными препаратами: образуя одну группу, объединенную антитромботическим действием, каждое МНН (международное непатентованное наименование) дополнительно предоставляет свой спектр плейотропного (неантитромботического) действия со своим профилем клинической эффективности. Из-за различий в структуре этих препаратов не следует переносить результаты, полученные с одним НМГ, на другой. Однако различия между ними не делают какой-то один НМГ лучше или хуже другого. Напротив, они позволяют выбрать если не оптимальный, то наиболее подходящий препарат для конкретного пациента. При выборе НМГ для конкретного пациента необходимо строго руководствоваться инструкцией по медицинскому применению и тщательным подбором индивидуальной дозы препарата, исходя из массы тела пациента, степени тяжести заболевания, сопутствующей патологии, а также принимая во внимание ряд других факторов. Low molecular weight heparins (LMWHs) make one pharmacological group due to their antithrombotic action, but each of their international nonproprietary names provides additionally its own spectrum of pleiotropic (non-antithrombotic) actions with a specific profile for clinical efficacy. Due to the differences in the structure of these medications the results obtained with one LMWH should not be transferred to another. However, differences between LMWHs do not make one better or worse than the other. On the contrary, it allows you to choose if not optimal then the most suitable LMWH for the patient taking into account a number of influencing factors as well.

Identification of Volatile Compounds in Blackcurrant Berries: Differences Among Cultivars

Berries of blackcurrant are known to produce a strong flavor. Some previous studies have reported that a given cultivar of blackcurrant can produce berries with a specific profile of volatile compounds. For the Burgundy region in France, the Noir de Bourgogne cultivar is especially important because it is the main ingredient of a liquor with a designation of origin. The aim of the present study was to characterize the volatile fractions of berries from 15 cultivars in order to explore the possibility of using different cultivars for liquor production. The plants were cultivated under the same conditions and harvested in the same year. The volatile fractions of the harvested berries were analyzed using HS-SPME-GC-MS. Thorough univariate statistical analysis and multivariate analysis were applied to the dataset, which made it possible to identify groups within cultivars. The Rosenthal cultivar exhibited a quite flat profile; the Lositkia, Ben Tiran, and Barchatnaia cultivars shared common features; the Noir de Bourgogne cultivar showed the highest amounts of molecules such as 3-carene, limonene, β-phellandrene, ocimene, α-terpinolene, and bicyclogermacrene. None of the studied varieties were close to the Noir de Bourgogne on the basis of VOC analysis.

Controlling turning contouring of shaped parts

The machining of contoured shaped surfaces of parts with a circular cross-section is executed on CNC lathes using control programs. All known CAM systems offer canned cycles for such surfaces. In most cases, it is recommended to use G71, G72 and G73 canned cycles for roughing contouring. The aim of the study is to analyze the cutting processes in roughing and finishing and to assess their influence on the surface quality of the part. A modeling technique is proposed, which is based on the use of an original application soft that allows simulating all machining cycles with fixing the results in the form of oscillograms of changes in the depth of cut. Comparative analysis of the results allows you to choose the most acceptable machining cycle for a specific profile of the contour of the part. The developed program also makes it possible to obtain the predicted accuracy of machining along the entire contour, which may arise as a result of technological heredity. In addition, the array of data on cutting depth obtained during the simulation, which is the main disturbance of the process, allows one to design the law of control of the cutting mode, for example, on the feed, which will lead to the stabilization of the cutting process. Анотація. Обробка контурних фасонних поверхонь деталей, що мають круглий поперечний переріз, виконується на токарних верстатах з ЧПУ по керуючим програмами. Всі відомі САМ-системи пропонують стандартні цикли для обробки таких поверхонь. У більшості випадків рекомендується застосовувати стандартні цикли чорнової контурної обробки G71, G72 і G73. Метою дослідження є аналіз процесів різання в чорновий і фінішної обробки і оцінка їх впливу на якість поверхні деталі. Порівняльний аналіз результатів дозволяє вибрати найбільш прийнятний цикл обробки для конкретного профілю контуру деталі. Розроблена програма також дозволяє отримати прогнозовану точність обробки по всьому контуру, яка може виникнути в результаті технологічної спадковості. Крім того, отриманий під час моделювання масив даних по глибині різання, який є головним обуренням процесу, дозволяє спроектувати закон управління режимом, наприклад, з подачі, які призведе до стабілізації процесу різання.

Contribution of Segments to Overall Result in Elite Triathletes: Sprint Distance

As an alternative to analysing the contribution of performance in specific segments of a triathlon to the overall result as measured in terms of time or position, which has several limitations, previous studies have instead analysed the performance indicator in triathlon. Therefore, the purpose of the study was to analyse the relationship between performance in specific segments and overall performance in terms of sprint distance in elite triathletes through the triathlon performance indicator, instead of using time or position. The official sprint distance results from World Triathlon Series elite events from 2012 to 2019 were examined. In total, 2144 entries were considered, 1143 of which were men and 1001 were women. Performance in the cycling segment presents the best concordance with the overall performance for both elite men (ICCa = 0.871, IC95% = (0.711–0.927)) and elite women (ICCa = 0.907, IC95% = (0.875–0.929)). Although the performance in the running segment does not show the best concordance with the overall performance, the position in this segment does better explain the overall position, especially in elite men and in draft-legal races. These results can support coaches and athletes to identify a specific profile of the strengths and weaknesses of triathletes in competitions, in comparison to their rivals, over a specific distance.

High-Throughput Transcription-mediated amplification (TMA), a real and consolidated alternative for the diagnosis of SARS-COV2. Review.

The exceptional situation in which we have found ourselves since the first case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified, which rapidly evolved into a global pandemic, translated into the need to incorporate the largest number of diagnostic tests to detect possible cases and contain the spread of the virus. The FDA authorized different trials using emergency procedures. One of the molecular assays adapted to the diagnosis of COVID19 is the transcription-mediated amplification (TMA) assay. We intend to answer the questions that are asked from a laboratory when a new technique is introduced. How does it work? Are your results comparable to gold standard techniques in terms of agreement and limit of detection? After the systematic review of the literature, an almost perfect concordance between the TMA and the RT-PCR was observed, taking into account the values of Cohen's kappa coefficient, positive percentage agreement, negative percentage agreement and global percentage agreement close to 100%. Regarding the concordance between the results obtained by TMA and the antigenic test, it presents a lower concordance, although it is true that the latter test is only optimal for the detection of SARS-CoV2 in a specific profile of patients. The literature shows that the TMA test has been used to study possible cases of reinfection. After analyzing the results, we concluded in the proven consolidation of TMA for the diagnosis and follow-up of SARS-COV2.

Sections of the Early 18th Century Ditch at Fort Umrevinsky

This article describes identified sections of an early 18th century ditch at Fort Umrevinsky in the Upper Ob Basin. Such protective structures mark a certain stage in the evolution of military engineering in the era of Peter the Great (1694–1725) in southwestern Siberia. The design of the earliest parts of the preserved ditches allows us to address the influence of European fortification on Early Modern Russian defensive architecture. Several factors affecting the depth and profile of early 18th century ditches at Umrevinsky are discussed. They include seasonality of specialized trenching tools and the adoption and transformation of European fortification principles by 17th and early 18th Russian military engineers. At Umrevinsky, apart from the specific profile of the ditch, specialized tools were revealed, similar to those mentioned in documents on 18th century fortification. Also, specific features of the preserved parts of the ditch mirror the utmost irregularity in adoption of de Vauban’s fortification principles of the Tsardom of Muscovy, including Siberia. Our finds at Fort Umrevinsky supplement the scarce descriptions of Siberian forts in Russian documents.

Deployable Convex Generalized Cylindrical Surfaces Using Torsional Joints

The ability to deploy a planar surface to a desired convex profile with a simple actuation can enhance foldable or morphing airfoils, deployable antennae and reflectors, and other applications where a specific profile geometry is desired from a planar sheet. A model using a system of rigid links joined by torsional springs of tailorable stiffness is employed to create an approximate curved surface when two opposing tip loads are applied. A system of equations describing the shape of the surface during deployment is developed. The physical implementation of the model uses compliant torsion bars as the torsion springs. A multidimensional optimization algorithm is presented to place joints to minimize the error from the rigid-link approximation and account for additional manufacturing and stress considerations in the torsion bars. A proof is presented to show that equal torsion spring spacing along the horizontal axis of deployed parabolic profiles will result in minimizing the area between the model's rigid-link approximation and smooth curve. The model is demonstrated through the physical construction of a deployable airfoil surface and a metallic deployable parabolic reflector.

Attitudes towards Social Robots in Education: Enthusiast, Practical, Troubled, Sceptic, and Mindfully Positive

While social robots bring new opportunities for education, they also come with moral challenges. Therefore, there is a need for moral guidelines for the responsible implementation of these robots. When developing such guidelines, it is important to include different stakeholder perspectives. Existing (qualitative) studies regarding these perspectives however mainly focus on single stakeholders. In this exploratory study, we examine and compare the attitudes of multiple stakeholders on the use of social robots in primary education, using a novel questionnaire that covers various aspects of moral issues mentioned in earlier studies. Furthermore, we also group the stakeholders based on similarities in attitudes and examine which socio-demographic characteristics influence these attitude types. Based on the results, we identify five distinct attitude profiles and show that the probability of belonging to a specific profile is affected by such characteristics as stakeholder type, age, education and income. Our results also indicate that social robots have the potential to be implemented in education in a morally responsible way that takes into account the attitudes of various stakeholders, although there are multiple moral issues that need to be addressed first. Finally, we present seven (practical) implications for a responsible application of social robots in education following from our results. These implications provide valuable insights into how social robots should be implemented.