LACTATE CAN BE A MARKER OF METABOLIC SYNDROME IN SEVERE OBESITY?

ABSTRACT Background: In the last decades, numerous studies have confirmed the importance of lactate - by-product to the nutrient signal of the intracellular redox state - to regulatory functions in energy metabolism. Aim: To evaluate changes in blood lactate in patients with severe obesity and its correlation with body composition and metabolic profile. Methods: Twenty-four people with severe obesity (BMI=40 kg/m2) were evaluated in a prospective case-control study before and six months after Roux-in-Y gastric bypass. The blood lactate, total cholesterol, and fractions, C-reactive protein and HOMA-IR were analyzed after 12 h fasting. Body mass composition was evaluated by bioelectrical impedance and respiratory quotient was measured by indirect calorimetry. Results: The initial lactate level was 2.5±1.1 mmol/l and returned to normal level (1.9±3.6 mmol/l, p=0.0018) after surgery. This reduction was positively correlated with a decrease in BMI (p=0.0001), % free fat mass (p=0,001), % fat mass (p=0.001) and HOMA-IR (p=0.01). There was normalization of lactatemia in 70% of patients. There was no correlation between lactatemia and C-reactive protein. Conclusions: There was a significant improvement of metabolic parameters, normalization of blood lactate, fat mass loss, although these individuals remained with a high BMI.

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Perbandingan Penghitungan Massa Tubuh Dengan Menggunakan Metode Indeks Massa Tubuh (IMT) dan Bioelectrical Impedance Analysis (BIA)

Jurnal Manajemen Kesehatan Yayasan RS Dr Soetomo ◽

10.29241/jmk.v6i1.280 ◽

2020 ◽

Vol 6 (1) ◽

pp. 43

Author(s):

Yonathan Wiranata ◽

Inayatul Inayah

Keyword(s):

Body Mass ◽

Body Fat ◽

Fat Mass ◽

Bioelectrical Impedance Analysis ◽

Pearson Correlation ◽

Bioelectrical Impedance ◽

Impedance Analysis ◽

Mass Composition ◽

Body Fat Mass ◽

Body Mass Composition

Anthropometric is a method of body mass composition calculation resulting either roughly or directly (detail). BMI is an anthropometric method performed by measuring body weight and height to classify one’s body mass index. BIA is an anthropometric methods used to asses body mass composition, including water mass, musculoskeletal, and mainly body fat mass. The purpose of this study isto find the relationship between the two methods of anthropometry and see the comparasion of body mass composition resulted by the two methods. Study design with descriptive analytics with cross sectional approach, the sampling technique use quota sampling, 41 respondents. Data analysis with analysis of Pearson correlation test (significance level α = 0.05, p – value < α). Results of a normal BMI of 25 respondents (61%), the results of normal BIA 29 respondents (71%) and fat mass between (from 11.00 to 37.30, the average 24.05). obtained a result of a positive relationship between BMI with the composition of body fat (r = 0.708, p <0.000). With it was found that BMI and body fat composition has a significant relationship (p <0.000). It can be cloncuded BMI has strong correlation with body fat mass that were measured by using the BIA method resulted from PSIK student at the University of Muhammadiyah Malang. BIA method is no better than BMI method as a parameter to determine body mass composition.Kata Kunci: Indeks Massa Tubuh, Bioelectrical Impedance Analysis, Komposisi Tubuh.

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Correlation between endocrine function, inflammation, body composition, cardiorespiratory and muscular function in coronary patients

European Journal of Public Health ◽

10.1093/eurpub/ckab120.072 ◽

2021 ◽

Vol 31 (Supplement_2) ◽

Author(s):

Catarina Gonçalves ◽

Jorge Bravo ◽

Ana Abreu ◽

Armando Raimundo

Keyword(s):

Body Composition ◽

Blood Glucose ◽

Muscle Strength ◽

Body Mass ◽

Thyroid Function ◽

Mass Composition ◽

C Reactive Protein ◽

Reactive Protein ◽

Muscular Function ◽

Body Mass Composition

Abstract Background Cardiovascular diseases (CVD) are among the most prevalent illnesses worldwide, causing substantial mortality, morbidity and hospitalization. Understanding the correlation of thyroid function and glycemic metabolism and inflammation to body composition and cardiorespiratory and muscular function is imperative. This manuscript's main goal is to evaluate the association of thyroid function and glycemic metabolism to body mass composition and cardiovascular fitness (CRF) and muscular function in a group of coronary artery disease (CAD) patients. Methods To examine cross-sectional associations of thyroid function, glycemia, hemoglobin A1c (HgA1c) and C-reactive protein (CRP) with CRF, muscular function and body mass composition. Forty-five stable CAD patients were enrolled (aged 54.9 ± 10.0 years). Participants were assessed for body composition (DXA®), muscle strength (Biodex®), cardiorespiratory fitness (6-minute walking test) and blood biomarkers, including [CRP, Tyrode Hormones higher free thyroxine (FT4), lower total triiodothyronine (FT3) and metabolic parameters]. The Pearson correlation and t-test statistical measures were used for associations between thyroid function, glycemia, insulin, HgA1c and CRF/muscle strength, body composition. Results We found significant inter-correlations between body fat and FT4 (P < 0.01), HgA1c (P = 0.01), insulin (P = 0.01) and blood glucose (P = 0.05); lean mass and FT3 (P = 0.001); and a negative inter-correlation between C-reactive protein and knee extensor and flexor isokinetic peak torques (P < 0.01), and cardiorespiratory fitness (P < 0.05). Conclusions Our findings showed that THs function and body mass fat, HgA1c, blood glucose, insulin and CRP were associated with the CRF, muscle strength or body composition. These results highlight the importance of endocrine and metabolic mechanisms concerning CRF and muscle strength in a group of patients with CAD.

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A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and C-reactive protein levels in patients with severe obesity

The American Journal of Medicine ◽

10.1016/j.amjmed.2004.04.009 ◽

2004 ◽

Vol 117 (6) ◽

pp. 398-405 ◽

Cited By ~ 96

Author(s):

Prakash Seshadri ◽

Nayyar Iqbal ◽

Linda Stern ◽

Monica Williams ◽

Kathryn L. Chicano ◽

...

Keyword(s):

Severe Obesity ◽

Randomized Study ◽

C Reactive Protein ◽

Carbohydrate Diet ◽

Lipoprotein Subfractions ◽

Protein Levels ◽

Reactive Protein ◽

Low Carbohydrate Diet ◽

Low Carbohydrate ◽

Conventional Diet

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Abstract P137: Aerobic, Resistance or Combination Exercise Training does not Reduce C-Reactive Protein Levels in Individuals with Type 2 Diabetes

Circulation ◽

10.1161/circ.125.suppl_10.ap137 ◽

2012 ◽

Vol 125 (suppl_10) ◽

Author(s):

Damon L Swift ◽

Neil M Johannsen ◽

Conrad P Earnest ◽

Steven N Blair ◽

Timothy S Church

Keyword(s):

Type 2 Diabetes ◽

Exercise Training ◽

Aerobic Exercise ◽

Fat Mass ◽

Fasting Glucose ◽

Aerobic Exercise Training ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein

Introduction: Type 2 diabetes is associated with elevated C-reactive protein levels (CRP), which is an independent risk factor for cardiovascular disease. Aerobic exercise training especially with weight/adiposity reduction has been shown to improve CRP, however few studies have evaluated the effect of other exercise training modalities (aerobic, resistance or combination training) on CRP in individuals with type 2 diabetes. Hypothesis: We hypothesize that combination training will improve CRP to a greater extent than other modalities of exercise training, and change in CRP levels will be associated with changes in weight and adiposity. Methods: The present study is a secondary analysis of the Health Benefits of Aerobic and Resistance Training in Individuals with Type 2 Diabetes (HART-D) study. Participants (n=204) were randomized to aerobic exercise (aerobic), resistance exercise (resistance) or a combination of both (combination) for nine months. Results: Baseline CRP was correlated with fat mass, waist circumference, BMI, and inversely correlated with VO2 peak (p<0.05). CRP was not reduced in the aerobic (0.16 mg•L-1, 95% CI: -1.0, 1.3), resistance (-0.03 mg•L-1, 95% CI: -1.1, 1.0) or combination (-0.49 mg•L-1, 95% CI: -1.5 to 0.6) groups compared to control (0.35 mg•L-1, 95% CI: -1.0, 1.7). Change in CRP was associated with change in fasting glucose (r=0.20, p= 0.009), glycated hemoglobin (HbA1C) (r=0.21 p=0.005), and fat mass (r=0.19, p=0.016), but not change in fitness or weight (p > 0.05). Conclusions: In conclusion, aerobic, resistance or a combination of both did not reduce CRP levels in individuals with type 2 diabetes. However, exercise related improvements in HbA1C, fasting glucose, and fat mass were associated with reductions in CRP.

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C-reactive protein is inversely and independently associated with maximal oxygen uptake in adolescents with obesity

Revista Brasileira de Educação Física e Esporte ◽

10.11606/1807-5509202000030463 ◽

2020 ◽

Vol 34 (3) ◽

pp. 463-469

Author(s):

João Elias Dias Nunes ◽

Heitor Santos Cunha ◽

Renata Roland Teixeira ◽

Foued S. Espindola ◽

Nádia Carla Cheik

Keyword(s):

Body Composition ◽

Cardiorespiratory Fitness ◽

Fat Body ◽

High Sensitivity ◽

Bioelectrical Impedance ◽

Tnf Alpha ◽

Maximum Oxygen Consumption ◽

C Reactive Protein ◽

Reactive Protein ◽

Control Plasma

The purposes of this study were: 1) investigate whether different markers of infl ammation (CRP and TNF-alpha) are correlated to cardiorespiratory fi tness in adolescents with obesity; 2) examine the association of these variables when adjusted by parameters of body composition. Were selected 57 individuals, 34 girls and 23 boys, with 16.4±1.56 years and body mass index 36.0±4.3 kg/m2. Anthropometric measurements (weight, height and abdominal circunference) and body composition (BMI, visceral fat, body fat) were assessment. Body composition was estimated by analyzer of tetrapolar bioelectrical impedance. Obesity was defi ned as BMI>95th percentile of the curve proposed by the Center for Diseases Control. Plasma TNF-alpha was measured by a quantitative two-site high-sensitivity enzyme immunoassay and CRP was measured by high-sensitivityimmunoturbidimetric assay. Graded maximal exercise testing was performed to obtain the maximum oxygen consumption (VO2max) and velocity associated with the VO2max (vVO2max). Signifi cant correlations of CRP with VO2max and vVO2max were found (r=-0.40 and r=-0,36, respectively). No correlations were observed between TNF-alpha and VO2max e vVO2max. CRP was associated to the VO2max and vVO2max independently of measurements of body composition. The CRP was independently and inversely associated with direct measurement of VO2max and the indirect variable of cardiorespiratory fitness vVO2max, in obese adolescents, even after adjustments in body composition, a potential confounding factor. No association was found between TNF-alpha and the parameters of cardiorespiratory fitness.

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An integrative approach to investigate the association among high-sensitive C-reactive protein, body fat mass distribution, and other cardiometabolic risk factors in young healthy women

Methods ◽

10.1016/j.ymeth.2018.04.016 ◽

2018 ◽

Vol 145 ◽

pp. 60-66

Author(s):

Bin Wu ◽

Jingshan Huang ◽

Lihua Zhang ◽

Mohan Vamsi Kasukurthi ◽

Fangwan Huang ◽

...

Keyword(s):

Risk Factors ◽

Mass Distribution ◽

Body Fat ◽

Fat Mass ◽

Cardiometabolic Risk ◽

Protein Body ◽

Integrative Approach ◽

Body Fat Mass ◽

C Reactive Protein ◽

Reactive Protein

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A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and C-reactive protein levels in patients with severe obesity

ACC Current Journal Review ◽

10.1016/j.accreview.2004.12.027 ◽

2005 ◽

Vol 14 (1) ◽

pp. 19

Author(s):

P. Seshadri ◽

N. Iqbal ◽

L. Stern

Keyword(s):

Severe Obesity ◽

Randomized Study ◽

C Reactive Protein ◽

Carbohydrate Diet ◽

Lipoprotein Subfractions ◽

Protein Levels ◽

Reactive Protein ◽

Low Carbohydrate Diet ◽

Low Carbohydrate ◽

Conventional Diet

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The mediating role of C-reactive protein (CRP) and insulin resistance in the association of mid-childhood fat mass and airflow limitation at 15 years

10.1183/13993003.congress-2020.2063 ◽

2020 ◽

Author(s):

Gabriela P. Peralta ◽

Raquel Granell ◽

Annabelle Bédard ◽

Laura Howe ◽

Anne-Elie Carsin ◽

...

Keyword(s):

Insulin Resistance ◽

Fat Mass ◽

Airflow Limitation ◽

C Reactive Protein ◽

Mediating Role ◽

Reactive Protein

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HUBUNGAN STATUS GIZI DAN TEKANAN DARAH DENGAN KADAR C-REACTIVE PROTEIN DARAH PADA SUBJEK DISLIPIDEMIA

Jurnal Gizi dan Pangan ◽

10.25182/jgp.2013.8.1.17-24 ◽

2013 ◽

Vol 8 (1) ◽

pp. 17

Author(s):

Mira Dewi ◽

Rimbawan Rimbawan ◽

Agustino Agustino

Keyword(s):

Blood Pressure ◽

Nutritional Status ◽

Diastolic Blood Pressure ◽

Body Fat ◽

Fat Mass ◽

Body Fat Mass ◽

C Reactive Protein ◽

Cross Sectional Survey ◽

Reactive Protein ◽

Waist Hip Ratio

The objective of this study was to analyze the association of nutritional status (Body Mass Index, waist circumference, waist-hip ratio, and body fat mass) and blood pressure with inflammation status which was assessed by blood C-reactive protein level in dyslipidemic subjects. The study design was cross sectional survey involving 81 dyslipidemic subjects in Bogor. The study showed that there were significant correlations between BMI, waist-hip ratio, body fat mass, and diastolic blood pressure with blood CRP level (p<0.05). In conclusion, the higher percentage of over nutritional status, body fat mass, and diastolic blood pressure, the higher status of inflammation.<br />Keywords:

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