Effect of nebulised BromAc® on rheology of artificial sputum: relevance to muco-obstructive respiratory diseases including COVID-19

Respiratory diseases such as cystic fibrosis, COPD, bronchiectasis asthma and COVID-19 are difficult to treat owing to viscous secretions in the airways that evade mucocilliary clearance. Since earlier studies have shown success with BromAc as mucolytic agent for treating a rare disease known as pseudomyxoma peritonei (PMP), we tested the formulation on two gelatinous airway representative sputa models, in order to determine whether similar efficacy exist. The sputum (1.5 ml) lodged in an endotracheal tube was treated to aerosolised N-acetylcysteine, bromelain, or their combination (BromAc) using a nebuliser with 6.0 ml of the agents in phosphate buffer saline, over 25 min. Controls received phosphate buffer saline. The dynamic viscosity was measured before and after treatment using a capillary tube method, whilst the sputum flow (ml/sec) was assessed using a 0.5 ml pipette. Finally, the sequestered agents (concentration) in the sputa after treatment were quantified using standard bromelain and N-acetylcysteine chromogenic assays. Results indicated that bromelain and N-acetylcysteine affected both the dynamic viscosities and pipette flow in the two sputa models, with changes in the former parameter having immense effect on the latter. BromAc showed a greater rheological effect on both the sputa models compared to individual agents. Further, correlation was found between the rheological effects and the concentration of agents in the sputa. Hence, this study indicates that BromAc may be used as a successful mucolytic for clearing airway congestion caused by thick mucinous immobile secretion, however further studies with patient sputum samples using aerosol BromAc is warranted.

Polydimethylsiloxane Elastomers Filled with Rod-Like α-MnO2 Nanoparticles: An Interplay of Structure and Electrorheological Performance

For the first time, electroactive nanocomposite elastomers based on polydimethylsiloxane and filled with rod-like α-MnO2 nanoparticles have been obtained. The curing of the filled elastomer in an electric field, resulting in the ordering of the α-MnO2 particles, had a significant effect on the degree of polymer crosslinking, as well as on the electrorheological characteristics of the nanocomposites obtained through this process, namely the values of the storage and loss moduli. The dielectric spectra of filled elastomers in the frequency range 25–106 Hz were analysed in terms of interfacial relaxation processes. It has been shown, for the first time, that the application of an electric field leads to a decrease in the value of the Payne effect in composite elastomers. Analysis of the rheological effect in the obtained materials has demonstrated the possibility of designing highly efficient electrorheological elastomers that change their elastic properties by 4.3 times in electric fields of up to 2 kV/mm.

Chemical and Rheological Evaluation of Aged Lignin-Modified Bitumen

As bitumen oxidizes, material stiffening and embrittlement occur, and bitumen eventually cracks. The use of anti-oxidants, such as lignin, could be used to delay oxidative aging and to extend the lifetime of asphalt pavements. In this study, the chemical and rheological effect of lignin on bitumen was evaluated by using a single dosage organsolv lignin (10 wt.% dosage). A pressure aging vessel (PAV) was used to simulate the long-term aging process after performing the standard short-term aging procedure, and the lignin-modified bituminous binders were characterized by an environmental scanning electron microscope (ESEM), Fourier-transform infrared (FTIR) spectroscopy, and a dynamic shear rheometer (DSR). From the ESEM results, the uniform microstructure was observed, indicating that the addition of lignin did not affect the worm structure of bitumen. Based on the FTIR test results, lignin-modified bitumen showed that a lower number of carbonyl and sulfoxide compounds were generated after aging than for neat bitumen. Based on the linear amplitude sweep (LAS) results, the addition of lignin slightly reduced the fatigue life of bitumen. From the frequency sweep results, it showed that lignin in bitumen acts as a modifier since the physical interaction between lignin and bitumen predominantly affects the material rheology. Overall, lignin could be a promising anti-oxidant due to its economic and environmental benefits.

Stability Analysis of Magneto-Rheological Damper for Suspension of Commercial Vehicles

This paper aims at improving the efficiency of magneto-rheological dampers, which utilizes a smart material in the form of magneto-rheological fluid, over the typical-build conventional dampers. The proposed design has been modeled for its implementation in commercial vehicles which extensively relies on conventional shock-absorbers for the safety and comfort of its occupants, considering the space available for mounting the system. Dimensional constraints based on commercial vehicles pertaining to the hatchback segment have been taken in COMSOL® and analyzed to generate a considerable amount of damping force for realizable inputs. As the analysis requires a profound consideration of highly coupled physics interface, COMSOL® Multi-physics is chosen as the relevant platform which makes it suitable to fulfill the criteria at hand. The damping forces achieved in the model are determined based on the linear Bingham model and the non-linear hysteretic Bouc-Wen model. A rigorousanalysis was conducted to realize the variation in damping force values on account of the hysteresis losses induced in the system. Optimization based on Taguchi’s mixed level design approach is used to attain the optimal design parameters of MR damper. MRF-140 CG fabricated by Lord Corporation is adopted to introduce the rheological effect of MR fluid on the proposed model.

Investigation on the Mechanical Properties of MRE Compounds

This paper describes an experimental investigation conducted on magneto-rheological elastomers (MREs) with the aim of adopting these materials to make mounts to be used as vibration isolators. These materials, consisting of an elastomeric matrix containing ferromagnetic particles, are considered to be smart materials, as it is possible to control their mechanical properties by means of an applied magnetic field. In the first part of the paper, the criteria adopted to define the characteristics of the material and the experimental procedures for making samples are described. The samples are subjected to a compressive static test and are then, adopting a testing machine specially configured, tested for shear periodic loads, each characterized by a different constant compressive preload. The testing machine is equipped with a coil, with which it is possible to vary the intensity of the magnetic field crossing the sample during testing to evaluate the magneto-rheological effect on the materials’ characteristics in terms of stiffness and damping.

Rheological effect of the concentration of nanoparticles in cassava starch

ABSTRACTBiodegradable material was prepared from cassava starch in combination with zinc oxide nanoparticles (ZnO NPs) to give the properties of microbial growth resistance, glycerin concentrations were varied to 5%, 10%, and 20% (w/v) for the study of the rheological properties. The nanoparticles were characterized by a spectrophotometer where an exciton peak at 370 nm was obtained. The different samples were subjected to a thermomechanical study through an AR-G2 hybrid rheometer, using a parallel plane geometry of 20 mm, a weak gel behavior is observed, it is a slimming material and it is thermostable, it is also established that the zinc oxide concentration nanoparticles do not affect the mechanical behavior of the material.