Attributing of global evapotranspiration trends based on the Budyko framework

Actual evapotranspiration (ET) is an essential variable in the hydrological process, linking the carbon, water, and energy cycles. Global ET has significantly changed in the warming climate. Although increasing vapour pressure deficit (VPD) due to global warming enhances atmospheric water demand, it remains unclear how the dynamics of ET are affected. In this study, using multiple datasets, we disentangled the relative contributions of precipitation, net radiation, air temperature (T1), VPD, and wind speed on affecting annual ET linear trend using an advanced separation method that considers the Budyko framework. It is found that the precipitation variability dominantly controls global ET in the dry climates, the net radiation has substantial control over ET in the tropical regions, and VPD is impacting ET trends in boreal mid-latitude climate. The critical role of VPD in controlling ET trends is particularly emphasized due to its influence in controlling the land-atmosphere interactions.

Survey of Remote Sensing Technique in Plant Disease Management

Agriculture can be contemplated as the “vertebral column” of the human life and has substantial control on country’s economy. In the aim of enhancing agricultural sustainability, effectiveness and plant health, cultivators are continuously innovating high technical and scientific estimation. Remote sensing is a quick, broad-spectrum, and sophisticated approach for analysing the spectral properties of earth surfaces from a variety of distances, ranging from satellites to ground-based platforms. In this process, the information can be obtained without coming into direct contact with the object. One of the main focus of remote sensing in agriculture production of crop including crop protection from various diseases and pests. Remote sensing technique is very helpful for incredibly spatial diagnostic results and its execution in agriculture, more sustain and safe by evading expensive and excessive use of different pesticides, fungicides etc. in production of crops.

Quantification of circadian interactions and protein abundance defines a mechanism for operational stability of the circadian clock

The mammalian circadian clock exerts substantial control of daily gene expression through cycles of DNA binding. Understanding of mechanisms driving the circadian clock is hampered by lack of quantitative data, without which predictive mathematical models cannot be developed. Here we develop a quantitative understanding of how a finite pool of BMAL1 protein can regulate thousands of target sites over daily time scales. We have used fluorescent correlation spectroscopy (FCS) to track dynamic changes in CRISPR-modified fluorophore-tagged proteins in time and space in single cells across SCN and peripheral tissues. We determine the contribution of multiple rhythmic processes in coordinating BMAL1 DNA binding, including the roles of cycling molecular abundance, binding affinities and two repressive modes of action. We find that nuclear BMAL1 protein numbers determine corresponding nuclear CLOCK concentrations through heterodimerization and define a DNA residence time of 2.6 seconds for this complex. Repression of CLOCK:BMAL1 is in part achieved through rhythmic changes to BMAL1:CRY1 affinity as well as a high affinity interaction between PER2:CRY1 which mediates CLOCK:BMAL1 displacement from DNA. Finally, stochastic modelling of these data reveals a dual role for PER:CRY complexes in which increasing concentrations of PER2:CRY1 promotes removal of BMAL1:CLOCK from genes consequently enhancing ability to move to new target sites.

Controlling the pandemic during the SARS-CoV-2 vaccination rollout

There is a consensus that mass vaccination against SARS-CoV-2 will ultimately end the COVID-19 pandemic. However, it is not clear when and which control measures can be relaxed during the rollout of vaccination programmes. We investigate relaxation scenarios using an age-structured transmission model that has been fitted to age-specific seroprevalence data, hospital admissions, and projected vaccination coverage for Portugal. Our analyses suggest that the pressing need to restart socioeconomic activities could lead to new pandemic waves, and that substantial control efforts prove necessary throughout 2021. Using knowledge on control measures introduced in 2020, we anticipate that relaxing measures completely or to the extent as in autumn 2020 could launch a wave starting in April 2021. Additional waves could be prevented altogether if measures are relaxed as in summer 2020 or in a step-wise manner throughout 2021. We discuss at which point the control of COVID-19 would be achieved for each scenario.

Expiratory aerosol particle escape from surgical masks due to imperfect sealing

Wearing surgical masks or other similar face coverings can reduce the emission of expiratory particles produced via breathing, talking, coughing, or sneezing. Although it is well established that some fraction of the expiratory airflow leaks around the edges of the mask, it is unclear how these leakage airflows affect the overall efficiency with which masks block emission of expiratory aerosol particles. Here, we show experimentally that the aerosol particle concentrations in the leakage airflows around a surgical mask are reduced compared to no mask wearing, with the magnitude of reduction dependent on the direction of escape (out the top, the sides, or the bottom). Because the actual leakage flowrate in each direction is difficult to measure, we use a Monte Carlo approach to estimate flow-corrected particle emission rates for particles having diameters in the range 0.5–20 μm. in all orientations. From these, we derive a flow-weighted overall number-based particle removal efficiency for the mask. The overall mask efficiency, accounting both for air that passes through the mask and for leakage flows, is reduced compared to the through-mask filtration efficiency, from 93 to 70% for talking, but from only 94–90% for coughing. These results demonstrate that leakage flows due to imperfect sealing do decrease mask efficiencies for reducing emission of expiratory particles, but even with such leakage surgical masks provide substantial control.

Vaccine and vaccination as a part of human life: in view of Covid-19

Vaccination created a breakthrough towards the improvement to the global health. The development of vaccine and their practice made a substantial control in infectious diseases. The emergence of new vaccines has facilitated targeting populations to alleviate and eliminate contagious pathogens from their innate reservoir. However, along with the infections like malaria and human immunodeficiency virus (HIV), effective immunisation remains obscure and imparts a great challenge unto the realm of science. The vaccines developed after utilizing plant based system supported technology comprises the incorporation of the preferred genes to express the specific protein (antigen) for a particular disease condition into the genome of plant tissues using several techniques. Though plant-supported vaccines propose several benefits to the vaccine industry, still there remain challenges that limit the rate of effective production of vaccines of this third-generation. A novel Corona virus SARS-CoV-2 reason for causing Corona virus diseases 2019 (COVID-19) crashed the human population and rapidly spread round the world within the half of 2020 created a worldwide epidemic. The need for establishing a protected and compelling COVID-19 immunization is a global requirement to end this pandemic. Even though there exist lot of limitations, continuous efforts has put forward so as to develop highly competent and effective vaccine for many human and animal linked diseases due to its unlimited prospective. This review article focus on the historical outlook and the development of the vaccine as it is a crucial area of research where the life of the human is saved from various potential dise

Controlling the pandemic during the SARS-CoV-2 vaccination rollout: a modeling study

There is a consensus that mass vaccination against SARS-CoV-2 will ultimately end the COVID-19 pandemic. However, it is not clear when and which control measures can be relaxed during the rollout of vaccination programmes. We investigate relaxation scenarios using an age-structured transmission model that has been fitted to age-specific seroprevalence data, hospital admissions, and projected vaccination coverage for Portugal. Our analyses suggest that the pressing need to restart socioeconomic activities could lead to new pandemic waves, and that substantial control efforts prove necessary throughout 2021. Using knowledge on control measures introduced in 2020, we anticipate that relaxing measures completely or to the extent as in autumn 2020 could launch a wave starting in April 2021. Additional waves could be prevented altogether if measures are relaxed as in summer 2020 or in a step-wise manner throughout 2021. We discuss at which point control of COVID-19 would be achieved for each scenario.

Controlling the pandemic during the SARS-CoV-2 vaccination rollout: a modeling study

There is a consensus that mass vaccination against SARS-CoV-2 will ultimately end the COVID-19 pandemic. However, it is not clear when and which control measures can be relaxed during the rollout of vaccination programmes. We investigate relaxation scenarios using an age-structured transmission model that has been fitted to age-specific seroprevalence data, hospital admissions, and projected vaccination coverage for Portugal. Our analyses suggest that the pressing need to restart socioeconomic activities could lead to new pandemic waves, and that substantial control efforts prove necessary throughout 2021. Using knowledge on control measures introduced in 2020, we anticipate that relaxing measures completely or to the extent as in autumn 2020 could launch a wave starting in April 2021. Additional waves could be prevented altogether if measures are relaxed as in summer 2020 or in a step-wise manner throughout 2021. We discuss at which point control of COVID-19 would be achieved for each scenario.

Long-term efficacy of triple semicircular canal plugging in the treatment of patients with ipsilateral delayed endolymphatic hydrops

This study aims to explore the long-term efficacy of triple semicircular canal plugging (TSCP) in the treatment of intractable ipsilateral delayed endolymphatic hydrops (DEH), so as to provide an alternative therapy for this disease. Forty-eight patients diagnosed with ipsilateral DEH referred to vertigo clinic of our hospital between Dec. 2010 and Dec. 2017, were included in this study for retrospective analysis. All patients were followed up for 2 years. Vertigo control and auditory functions were measured and analyzed. Pure tone audiometry, caloric test, and vestibular evoked myogenic potential (VEMP) were performed in two-year follow-up. Forty-five patients who accepted intratympanic gentamicin (26.7 mg/mL) twice given one week apart were selected as a control group. The total control rate of vertigo in TSCP group was 97.9% (47/48) in the two-year follow-up, with complete control rate of 83.3% (40/48) and substantial control rate of 14.6% (7/48). The rate of hearing loss was 22.9% (11/48). The total control rate of vertigo in intratympanic gentamicin group was 80.0% (36/45), with complete control rate of 57.8% (26/45) and substantial control rate of 22.2% (10/45), and the rate of hearing loss was 20.0% (9/45). The vertigo control rate of TSCP was significantly higher than that of intratympanic gentamicin (χ2 = 6.01, p < 0.05). There was no significant difference of hearing loss rate between two groups. (χ2 = 0.12, p > 0.05). TSCP, which can reduce vertiginous symptoms in patients with intractable ipsilateral DEH, represents an effective therapy for this disorder.

Expiratory aerosol particle escape from surgical masks due to imperfect sealing

Wearing surgical masks or other similar face coverings can reduce the emission of expiratory particles produced via breathing, talking, coughing, or sneezing. Although it is well established that some fraction of the expiratory airflow leaks around the edges of the mask, it is unclear how these leakage airflows affect the overall mask efficiency at blocking emission of expiratory aerosol particles. Here, we show experimentally that the aerosol particle concentrations in the leakage airflows around a surgical mask are reduced compared to no mask wearing, with the magnitude of reduction dependent on the direction of escape (out the top, the sides, or the bottom). Because the actual leakage flowrate in each direction is difficult to measure, we use a Monte Carlo approach to estimate flow-corrected particle emission rates in all orientations, from which a flow-weighted overall efficiency is derived. The overall mask efficiency, accounting both for air that passes through the mask and for leakage flows, is reduced compared to the through-mask efficiency, from 93% to 70% for talking, but from only 94% to 90% for coughing. These results demonstrate that leakage flows due to imperfect sealing do decrease mask efficiencies for reducing emission of expiratory particles, but even with such leakage surgical masks provide substantial control.