While innovation has become a popular topic when advocating for technology advancement and enhancing innovative processes in firms in both developed and developing economies, innovation in the context of micro-enterprises in emerging economies, such as Vietnam is not well understood nor has the topic been examined thoroughly. This chapter, in addition to looking at innovation within a micro-entrepreneurial context, includes a review of the academic literature on innovation, entrepreneurship, creativity, competitive advantages, and knowledge as some of the main drivers for social and economic development. Based on the field observations and interviews, it appears business owners of micro-enterprises in Vietnam might often use innovation by depending on their own individual adaptability and creativity to advance business opportunities by building upon existing knowledge as opposed to creating an entirely new business model or concept. Awareness of the nature of innovation within micro-enterprises could be helpful in designing governmental policies which are intended to create conditions which foster innovation and reduce throughout all levels of society and could have a role in reducing poverty.