Computed tomography images are widely used in the diagnosis of ischemic stroke because of its faster acquisition and compatibility with most life support devices. This chapter presents a new approach to automated detection of ischemic stroke using k-means clustering technique which separates the lesion region from healthy tissues and classification of ischemic stroke using texture features. The proposed method has five stages, pre-processing, tracing midline of the brain, extraction of texture features and feature selection, classification and segmentation. In the first stage noise is suppressed using a median filtering and skull bone components of the images are removed. In the second stage, midline shift of the brain is calculated. In the third stage, fourteen texture features are extracted and optimal features are selected using genetic algorithm. In the fourth stage, support vector machine, artificial neural network and decision tree classifiers have been used. Finally, the ischemic stroke region is extracted by using k-means clustering technique.