Forage diversity, conservation and use.

This chapter outlines the scientific and development impacts of forage diversity conservation, characterization and distribution work under the international network of forage collections in CGIAR. The focus for the future will continue to be on the core operations that are essential to conserve and manage the diversity with increased emphasis on those that will ensure efficiency and value for money in gene bank operations. In addition to these essential activities, there are opportunities to be more forward and outward looking and to link with activities in the Livestock CRP and the Excellence in Breeding Platform, as well as to contribute to the global system of plant genetic resources, support the FAO Global Plan of Action and contribute to the Sustainable Development Goals.

Zoonoses.

This book chapter focuses on zoonoses that are not transmitted primarily through food. Establishing systematic data collection is the first step to manage zoonoses. Management is complicated by heterogeneity: zoonoses may have a significant and debilitating effect on some communities but not on others. Understanding the spatial distribution of the burden of zoonoses is important to better focus control efforts. A significant constraint is the lack of collaboration between medical and veterinary authorities: institutionally speaking, zoonoses typically find themselves homeless and ignored. There is a need for one-health thinking and research to overcome inter-sectoral barriers to effective control of zoonoses.

Control of pathogenesis in African animal trypanosomiasis: a search for answers at ILRAD, ILCA and ILRI, 1975-2018.

This book chapter describes the management of animal trypanosomiasis: (i) vector control/eradication; (ii) use of trypanocides; and (iii) use of trypanotolerant breeds of cattle. Vector control includes reducing the tsetse fly population with traps and insecticides, and in areas with a high population of trypanosome infected tsetse, animals are prophylactically administered antiparasitic drugs. To date, there is no AAT vaccine available, as discussed below. While disappointing with respect to AAT control, studies of AAT pathogenesis at ILRAD/ILRI did identify the definitive question for immunological research on AAT, namely, how do trypanosomes eliminate TD antibody responses in trypanosomiasis-susceptible mammals? In addition, the work at ILRI on the genetic basis of trypanotolerance contributed a high-density singlenucleotide polymorphism (SNP) map of the bovine genome that has intrinsic value for analysis of QTLs that control other traits, including susceptibility to other diseases.

Impact assessment of immunology and immunoparasitology research at ILRAD and ILRI.

This book chapter assesses the research on bovine immunology and immunoparasitology conducted over 42 years, from 1973 to 2015, first at ILRAD (1973-1994) and subsequently at ILRI, which was formed by merging ILRAD and the International Livestock Centre for Africa (ILCA) in 1995. This assessment covers the approaches taken, the performance of research teams, the scientific truths uncovered, the cost-effectiveness of the research undertaken and the practical outcomes achieved, notably, the development of monoclonal antibodies (mAbs) and other tools to better define the bovine immune system. The chapter makes extensive use of citation data along with the personal reflections of scientists who participated in the research and surveys of opinion leaders in the field. The specific scientific goals and achievements of ILRI and its predecessors were as follows: making a substantive contribution to bovine immunology was realistic and has been substantially achieved, measuring the diversity of strains of Theileria parva, Trypanosoma brucei, Trypanosoma vivax and Trypanosoma congolense was realistic and has been substantially achieved, identifying mechanisms of immunity that kill parasites or limit the growth of the above parasites was realistic and has been substantially achieved, and developing an effective subunit vaccine against any of the parasites was an ambitious goal and so far has not been achieved.

Veterinary epidemiology at ILRAD and ILRI, 1987-2018.

This chapter describes the activities of the International Livestock Research Institute (ILRI) and its predecessor, the International Laboratory for Research on Animal Diseases (ILRAD) from 1987 to 2018. Topics include scientific impacts; economic impact assessment; developmental impacts; capacity development; partnerships; impacts on human resources capacity in veterinary epidemiology; impacts on national animal health departments and services; impacts on animal health constraints in developing countries; impacts on ILRI's research and strategy; the introduction of veterinary epidemiology and economics at ILRAD; field studies in Kenya; tick-borne disease dynamics in eastern and southern Africa; heartwater studies in Zimbabwe; economic impact assessments of tick-borne diseases; tick and tick-borne disease distribution modelling; modelling the infection dynamics of vector-borne diseases; economic impact of trypanosomiasis; the epidemiology of resistance to trypanocides; the development of a modelling technique for evaluating control options; sustainable trypanosomiasis control in Uganda and in the Ghibe Valley of Ethiopia; spatial modelling of tsetse distributions; preventing and containing trypanocide resistance in the cotton zone of West Africa; rabies research; the economic impacts of rinderpest control; applying economic impact assessment tools to foot and mouth disease (FMD) control, the southern Africa FMD economic impact study; economic impacts of FMD in Peru, Colombia and India; economic impacts of FMD control in endemic settings in low- and middle-income countries; the global FMD research alliance (GFRA); Rift Valley fever; economic impact assessment of control options and calculation of disability-adjusted life years (DALYs); RVF risk maps for eastern Africa; land-use change and RVF infection and disease dynamics; epidemiology of gastrointestinal parasites; priorities in animal health research for poverty reduction; the Wellcome Trust Epidemiology Initiatives; the broader economic impact contributions; the responses to highly pathogenic avian influenza; the International Symposium on Veterinary Epidemiology and Economics (ISVEE) experience, the role of epidemiology in ILRAD and ILRI and the impacts of ILRAD and ILRI's epidemiology; capacity development in veterinary epidemiology and impact assessment; impacts on national animal health departments and services; impacts on animal health constraints in developing countries and impacts on ILRI's research and strategy.

African livestock systems research, 1975-2018.

Livestock systems research (LSR) at the International Livestock Research Institute (ILRI) sought to answer two questions: (1) What are the major livestock systems in the sub-Saharan Africa tropics and subtropics? (2) What technical and organizational changes can be introduced into these systems to make them productive? This chapter reports the answers of decades of research at ILRI, its predecessors and its principal partners to these questions. The chapter also examines the scientific and development impacts of LSR since the 1970s, and whether the development impacts of LSR be distinguished from long-term trends in African livestock systems.

The impact of ILRI research on gender.

This chapter discusses the evolution of gender research at the International Livestock Research Institute (ILRI) and its predecessors, and in the context of CGIAR. It then reviews the impact of ILRI's gender research in a number of areas including development, science, capacity and policy.

Transboundary animal diseases.

Transboundary animal diseases (TADs) are highly contagious epidemics with the potential for very rapid spread, causing serious economic and sometimes public health consequences while threatening farmers' livelihoods. TADs often cause high morbidity and mortality in susceptible animal populations. Some TADs are also emerging infectious diseases, food-borne diseases and/or zoonoses: these are covered in other chapters. This chapter covers those high-impact, highly contagious animal diseases, such as foot-andmouth disease (FMD), that do not infect humans but do affect food and nutrition security and trade that the International Livestock Research Institute (ILRI) has been working on since the 1990s. These are: African swine fever (ASF), mycoplasma disease (both contagious bovine pleuropneumonia (CBPP) and contagious caprine pleuropneumonia (CCPP)), peste des petits ruminants (PPR) and Newcastle disease (ND). Other TADs, which were to a lesser degree the focus of ILRI research, are briefly mentioned (including FMD, classical swine fever (CSF) and rinderpest).

Livestock genetics and breeding.

This chapter describes the contributions of the International Livestock Research Institute's (ILRI) to animal breeding. The specific topics include the genetic characterization and history of livestock, breeding technologies, genetic improvement of indigenous livestock, tools and methods for conducting breed surveys, classification of African livestock populations, molecular genetic characterization, the genetic history of cattle in Africa and linking livestock to human history, genetic history and geography of African sheep, genetic history and geography of African chickens, genetic history and geography of the African dromedary, establishment of a joint laboratory with CAAS in Beijing and expansion into Asia, ILRI's genetic characterization as a catalyst for international interest, genetics of trypanotolerance and genetics of resistance to gastrointestinal parasites.

Tsetse and trypanosomiasis control in West Africa, Uganda and Ethiopia: ILRI's role in the field.

This book chapter was to tackle the mission of International Laboratory for Research on Animal Disease (ILRAD): discuss AAT and East Coast fever. As a result, a large body of research on AAT was conducted over 30 years: genetics, breeding and immunology research. This chapter reviews the earlier field work of ILRAD followed by that of International Livestock Research Institute (ILRI) after 1994 in East and West Africa, including the engagement of those institutions with regional and global initiatives. Looking to the future, AAT is likely to remain a priority constraint for African livestock. We now have approaches that are highly effective at reducing the impact of AAT, either singly or in combination. We also understand better the challenges of adoption of even economically attractive strategies and how the changing dynamics of AAT may lead to future opportunities for optimized control.