This chapter discusses the interaction between (the law of) self-defence and the rules of engagement (ROE), and how they play out against the military, and subsequently the political objectives of governments. It analyses the various forms of self-defence, from a national to individual perspective, including unit self-defence and force protection, and examines the legal basis and framework for each type of self-defence. The chapter goes on to analyse how these frameworks interact with, and influence, the ROE for military operations, discussing the concepts and applications of Hostile Act and Hostile Intent as followed by the North America Treaty Organization and the European Union in specific detail.