Diabetic Foot

Diabetic foot syndrome is a complex complex of anatomical and functional changes that occur in 40-60% of patients with diabetes mellitus. It is believed that a high blood glucose content reduces its fluidity, impairs arterial and capillary blood circulation (angiopathy), leads to damage to the vessels and nerves of the lower extremities, and to a disorder of muscle innervation processes (neuropathy). At first, gangrene develops on one leg, which can be seen from the swelling and color difference of the skin of the legs, the appearance of a feeling of "foot in a trap", when its squeezing is felt, the temperature of the tissues rises

Acceptance of Hybrid Sperm Indian Male Less Sunlight Pharmacy Institutions in Indian University India Keep Woman Happy in Bed Privately

Hybrid sperm has accepted. Tongue has the strongest muscle body it has definitely one of the most unique: The tongue can be a harbinger for the health of your entire body. According to researcher tongue and mouth tissues are more transparent than skin in the game so medical providers can more easily see signs of a medical condition beneath the surface.

The Role of the Pharmacist in Patient Care (Book Review)

Most people on the outside of the health care profession are not familiar with this new role of the pharmacist. The general public has created a stereotypical pharmacist's picture as being a person who stands behind a counter, dispenses medicine with some instructions to the respective consumer. Pharmacy practice has changed substantially in recent years. Today’s pharmacists have unique training and expertise in the appropriate use of medications and provide a wide array of patient care services in many different practice settings. As doctors are busy with the diagnosis and treatment of patients, the pharmacist can assist them by selecting the most appropriate drug for a patient. Interventions by the pharmacists have always been considered as a valuable input by the health care community in the patient care process by reducing the medication errors, rationalizing the therapy and reducing the cost of therapy. The development and approval of the Pharmacists’ Patient Care Process by the Joint Commission of Pharmacy Practitioners and incorporation of the Process into the 2016 Accreditation Council for Pharmacy Education Standards has the potential to lead to important changes in the practice of pharmacy, and to the enhanced acknowledgment, acceptance, and reimbursement for pharmacy and pharmacist services. As an author, it is my heartiest believe that the book will adjoin significant apprehension to future pharmacists in patient care as most of the portion created from recently published articles focusing pharmacists in patient care settings.

Opioid Prescribing Risk Management Opportunities for the Advance Nurse Practitioners

All clinicians are ethically obliged to prescribe responsibly and cautiously to diminish the potential for opioid diversion and to help minimize the growth of the current opioid abuse epidemic. Advance nurse practitioners should establish procedures to better control and limit opioid prescription and develop analgesic regimens to treat pain. The main purpose and goal for this review is to present data congruent with clinical, medical, and legal reports for allowing an appreciation of the possibility of the risk assumed when ordering and prescribing opioids within our podiatry profession. First, the concept and process of risk management as illustrated using a root cause analysis approach will be introduced as well as applying these principles specifically to opioid prescribing will be presented. Then, several examples found in both medical and legal literature documenting the reasons for opioid prescription risk will be presented. Finally, mitigating strategies for safe opioid prescribing will be presented so that mitigation of opioid harm can be possible and realized by the advance nurse practitioner

Mixing of Sputnik V and AstraZeneca COVID-19 vaccines

Background and Aim: The coronavirus disease 2019 (COVID-19) vaccine helps to develop immunity to SARS-CoV-2, the virus that causes COVID-19, in most cases preventing the disease. Although various brands of vaccines work in different modes, all COVID-19 vaccines prompt an immune reaction to make the body remembers how to protect from the virus in the future. The present study aims to evaluate the safety and the immune response for mixing of Sputnik V and AstraZeneca COVID-19 vaccines on mice. Materials and Methods: Our experimental study was performed on mice weighing on average of 20 g, selected by random allocation. The mice were divided into four groups of 12. Group one received a single dose of 0.5 ml Sputnik V COVID-19 vaccine, group two received two doses of 0.5 ml AstraZeneca COVID-19 vaccine, group three received two doses of 0.5 ml Sputnik V together with 0.5 ml AstraZeneca COVID-19 vaccine and group four received two doses of 0.5 ml of 0.9 % NaCl. Results: Our study shows that mixing of Sputnik V and AstraZeneca COVID-19 vaccines is safe and induces good immunity for mice. Conclusion: Mixing of Sputnik V and AstraZeneca COVID-19 vaccines creates no problems and provides good immunity to mice and may be an interesting technique to help to overcome shortcomings of one or the other vaccine. Further toxicity studies are required to assess potential hazards for humans to evaluate the histopathological characteristics.

A New Reality of Race Course Lady Begs Principal of Low Level Private Pharmacy Institution in Pune University

Single mother cannot produce benefit properly which has required to children, playing, and other food source into energy. Researcher has been looking for simple and effective ways to deliver benefit into the children who have a single mother to child by their choices as well as single mother has to her choice. The most common one has taking orally that has financial support from organization which has privately manage and ruled out by under the surveillances of Pharmacy council of India and abused principal of the college. However research shows that has easily broken down by the system. This problem has solved by using intervention by secretarial level department of health research (DHR) government of India. These can be done by binding pharmacy council of India by department of health research with government of India. The encouragement has protected with monthly salary that has single mother by choice which has service privately manage under the influence of abuse principal pharmaceutical Institutions which has linkage of slums and rural area in India. Once financial support reaches the children’s, another pathway takes over to help financial pass into the children needs. Binding of regulatory of pharmacy council of India to single mother by choice residing in private pharmacy institution in slum makes the financial hitch a ride on this protected supply chain, where it has released to do its work. Financial help also causes stimulation of brain which leads to increased release of sertraline moieties. Finding simpler ways to deliver cause into the slums pharmacy institution has one important avenue for tackling the myth of single mother by choice that has sweeping the developing world and GDP in slum occupied pharmacy Institutions. Single mother by choice has specific mechanisms for protecting and absorbing valuable things that would usually be correlate by financial conditions and better delivery method to their children.

Impact of COSARS-Cov-2 on Cardio-Pulmonary-Immune Signatures: A Review of Recent Developments with a Look toward the Future

In December 2019, the first case of patient with severe acute respiratory syndrome (SARS) caused by the novel coronavirus, SARS-CoV-2, was reported in Wuhan, Hubei Province, Central China. SARS-CoV-2 causes CoronaVirus Disease-2019 (COVID-19 or nCoV-19) disease, which rapidly spread all over the world. In response to this serious situation, on 30 January 2020, the World Health Organization (WHO) declared a global public health emergency of international concern, putting all health organizations on high alert. In mid-March 2020, WHO declared nCoV-19 a pandemic. By the end of September 2020, there were ~33.67 million confirmed cases and ~10.08 lakh deaths worldwide and the trend rising on each passing day. SARS-CoV-2 mainly infects the pulmonary system, but cause damage to other organs such as heart, kidney and intestine. Understanding the cardio-pulmonary issues underpinning of nCOV-19 pathogenesis is key to managing outcomes and mortality. SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease inhibitor TMPRSS2 for S protein priming. Alveolar cells and cardiomyocytes express ACE2 and TMPRSS2. In this Review, we summarize the current understanding of nCOV-19 pandemic from basic mechanisms to clinical perspectives, focusing on the interaction between SARS-CoV-2 and the cardio-pulmonary-immune signatures. The study provides crucial insights into the first step of SARS-CoV-2 infection, and potential targets for antiviral intervention.

Opioid Oligopoly and the Seven Deadly Sins (007)

An oligopoly is defined as a market structure with a small number of firms that dominate an industry, of which none can keep the other from significantly influencing the market. This market structure is distinctly different from other market forms. In today’s market, the oligopoly structure is the most common market structure. It can be argued that the few pharmaceutical companies who market, manufacture, and distribute opioids all over the world constitute “opioid oligopoly.” Bachtell has reported that dozens of opioid manufacturers, distributors, pharmacies, and doctors turn a blind eye to the opioid crisis swamping the United States.

The Disordered Human Specie

In pre-historic times the human specie was balanced in: body, mind, spirit, however; today the majority of us have lost this natural internal harmony. As a result, numerous mental, emotional, physical issues will continue to rise, forcing the human specie to devolve, evolve, or become a new semi-robotic specie.

A Rare Presentation in a Patient With Silicosis: Soft Tissue Tuberculosis

Silicosis, the most common of the pneumoconioses, is associated with inhaled crystalline silica. Silica particles exposed people have increased risk for tuberculosis and other mycobacterium-associated diseases.