This chapter sets up a comprehensive, multidimensional indicator framework for assessing performance of Smart, Sustainable, Resilient, and Inclusive Cities (S2RIC). A thorough review of contemporary, globally-initiated, indicator frameworks that address cities' smartness, sustainability, resilience, and inclusiveness is conducted – top-down approach; coupled with an attempt to integrate the different perspectives explored into a more enriched and coherent indicator framework. This aims at providing assistance to urban planners and policy makers in assessing, monitoring, managing cities, and making more informed sustainability decisions; while keeping in track with new concerns in the urban planning realm (e.g. resilience, disaster reduction) and recently endorsed global sustainability goals and frameworks. An indicators' selection process is also illustrated – bottom-up approach – for navigating in the proposed framework and identifying appropriate city- and citizen-specific indicators for carrying out relevant assessments and guiding sound policies.