PULMONARY FUNCTION IMPAIRMENT IN PNEUMOCONIOSES

1960 ◽  
Vol 172 (15) ◽  
pp. 1591 ◽  
Author(s):  
Hurley L. Motley
Keyword(s):  
Pulmonary Function ◽  
Function Impairment

scholarly journals Patterns of brain structural alteration in COPD with different levels of pulmonary function impairment and its association with cognitive deficits

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Minmin Yin ◽  
Haibao Wang ◽  
Xianwei Hu ◽  
Xiaoshu Li ◽  
Guanghe Fei ◽  
...  
Keyword(s):  
Lung Function ◽  
Pulmonary Function ◽  
Grey Matter ◽  
Inferior Frontal Gyrus ◽  
Structural Alteration ◽  
Functional Impairments ◽  
Copd Patients ◽  
Significant Difference ◽  
Function Impairment ◽  
Different Levels

Abstract Background To explore patterns of brain structural alteration in chronic obstructive pulmonary disease (COPD) patients with different levels of lung function impairment and the associations of those patterns with cognitive functional deficits using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analyses based on high-resolution structural MRI and diffusion tensor imaging (DTI). Methods A total of 115 right-handed participants (26 severe, 29 moderate, and 29 mild COPD patients and a comparison group of 31 individuals without COPD) completed tests of cognitive (Montreal Cognitive Assessment [MoCA]) and pulmonary function (forced expiratory volume in 1 s [FEV1]) and underwent MRI scanning. VBM and TBSS analyses were used to identify changes in grey matter density (GMD) and white matter (WM) integrity in COPD patients. In addition, correlation analyses between these imaging parameter changes and cognitive and pulmonary functional impairments were performed. Results There was no significant difference in brain structure between the comparison groups and the mild COPD patients. Patients with moderate COPD had atrophy of the left middle frontal gyrus and right opercular part/triangular part of the inferior frontal gyrus, and WM changes were present mainly in the superior and posterior corona radiata, corpus callosum and cingulum. Patients with severe COPD exhibited the most extensive changes in GMD and WM. Some grey matter (GM) and WM changes were correlated with MoCA scores and FEV1. Conclusions These findings suggest that patients with COPD exhibit progressive structural impairments in both the GM and the WM, along with impaired levels of lung function, highlighting the importance of early clinical interventions.

Pulmonary function impairment in patients with chronic heart failure: Lower limit of normal versus conventional cutoff values

Heart & Lung ◽  
2014 ◽  
Vol 43 (4) ◽  
pp. 311-316 ◽  
Author(s):  
Armine G. Minasian ◽  
Frank J.J. van den Elshout ◽  
P.N. Richard Dekhuijzen ◽  
Petra J.E. Vos ◽  
Frank F. Willems ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Pulmonary Function ◽  
Lower Limit ◽  
Cutoff Values ◽  
Function Impairment ◽  
Lower Limit Of Normal

scholarly journals Pulmonary Function Impairment May Be an Early Risk Factor for Late-Life Cognitive Impairment

2013 ◽  
Vol 61 (1) ◽  
pp. 79-83 ◽  
Author(s):  
Jean-Sébastien Vidal ◽  
Thor Aspelund ◽  
Maria K. Jonsdottir ◽  
Palmi V. Jonsson ◽  
Tamara B. Harris ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cognitive Impairment ◽  
Pulmonary Function ◽  
Late Life ◽  
Early Risk ◽  
Function Impairment ◽  
Early Risk Factor

scholarly journals Determinant Factor of Pulmonary Function Impairment on Rice Mill Workers

2020 ◽  
Vol 12 (4) ◽  
pp. 262
Author(s):  
Hernanda Arie Nurfitria ◽  
Shulkhiatus Syafa’ah ◽  
Retno Adriyani
Keyword(s):  
Pulmonary Function ◽  
Inverse Correlation ◽  
Test Results ◽  
Cross Sectional ◽  
Agricultural Industry ◽  
Function Impairment ◽  
Spearman Correlation Test ◽  
Independent Variable ◽  
Cross Sectional Design ◽  
Spearman Test

Introduction: Exposure to organic dust in the agricultural industry can cause pulmonary function problems for workers. This study aims to know the determinant of pulmonary function impairment on rice mill workers in Ujung Pangkah, Gresik, East Java. Method: This study was an analytical observational study using a cross-sectional design. This study’s population were all rice mill workers in Ketapang and Glatik Villages, Ujung Pangkah, Gresik, East Java there were 25 people. The sample of this study was 16 people. The independent variable in this study was the sex, working period, smoking, and using a mask, while the dependent variable was the pulmonary function status of workers. The data respondent obtained a questionnaire, observations, and measurement of workers’ pulmonary function using a spirometer. Data analysis was performed in analytic descriptive with the Spearman correlation test. Result and Discussion: The Spearman test results are known that the working period (r = -0.022) and smoking (r = -0.160) were very weak and an inverse correlation with pulmonary function status. In comparison, the use of masks (r = 0.462) was adequate and directly correlated with pulmonary function status. Smoking and working period will describe the length of exposure to rice dust, affecting the pulmonary function status. The obedience of using masks to workers will reduce the risk of pulmonary function impairment. Conclusion: Working period, smoking, and using mask are determinants of pulmonary function impairment on rice mill workers in Ujung Pangkah, Gresik, East Java.

scholarly journals Pulmonary Emphysema Regional Distribution and Extent Assessed by Chest Computed Tomography Is Associated With Pulmonary Function Impairment in Patients With COPD

2021 ◽  
Vol 8 ◽  
Author(s):  
Plácido Gomes ◽  
Hélder Novais e Bastos ◽  
André Carvalho ◽  
André Lobo ◽  
Alan Guimarães ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Lung Volume ◽  
Pulmonary Emphysema ◽  
Regional Distribution ◽  
Airway Disease ◽  
Forced Expiratory Volume ◽  
Chronic Obstructive ◽  
Total Lung Volume ◽  
Emphysema Severity ◽  
Function Impairment

Objective: This study aimed to evaluate how emphysema extent and its regional distribution quantified by chest CT are associated with clinical and functional severity in patients with chronic obstructive pulmonary disease (COPD).Methods/Design: Patients with a post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) < 0.70, without any other obstructive airway disease, who presented radiological evidence of emphysema on visual CT inspection were retrospectively enrolled. A Quantitative Lung Imaging (QUALI) system automatically quantified the volume of pulmonary emphysema and adjusted this volume to the measured (EmphCTLV) or predicted total lung volume (TLV) (EmphPLV) and assessed its regional distribution based on an artificial neural network (ANN) trained for this purpose. Additionally, the percentage of lung volume occupied by low-attenuation areas (LAA) was computed by dividing the total volume of regions with attenuation lower or equal to −950 Hounsfield units (HU) by the predicted [LAA (%PLV)] or measured CT lung volume [LAA (%CTLV)]. The LAA was then compared with the QUALI emphysema estimations. The association between emphysema extension and its regional distribution with pulmonary function impairment was then assessed.Results: In this study, 86 patients fulfilled the inclusion criteria. Both EmphCTLV and EmphPLV were significantly lower than the LAA indices independently of emphysema severity. CT-derived TLV significantly increased with emphysema severity (from 6,143 ± 1,295 up to 7,659 ± 1,264 ml from mild to very severe emphysema, p < 0.005) and thus, both EmphCTLV and LAA significantly underestimated emphysema extent when compared with those values adjusted to the predicted lung volume. All CT-derived emphysema indices presented moderate to strong correlations with residual volume (RV) (with correlations ranging from 0.61 to 0.66), total lung capacity (TLC) (from 0.51 to 0.59), and FEV1 (~0.6) and diffusing capacity for carbon monoxide DLCO (~0.6). The values of FEV1 and DLCO were significantly lower, and RV (p < 0.001) and TLC (p < 0.001) were significantly higher with the increasing emphysema extent and when emphysematous areas homogeneously affected the lungs.Conclusions: Emphysema volume must be referred to the predicted and not to the measured lung volume when assessing the CT-derived emphysema extension. Pulmonary function impairment was greater in patients with higher emphysema volumes and with a more homogeneous emphysema distribution. Further studies are still necessary to assess the significance of CTpLV in the clinical and research fields.

Sign in / Sign up

Export Citation Format

Share Document