Design of polyurea networks containing anticancer and anti‐inflammatory drugs for dual drug delivery purposes

In recent years, different processing technologies have been engineered to fabricate capsules or particles with peculiar properties (e.g., swelling, pH-sensitive response) at the micro and sub-micrometric size scale, to be used as carriers for controlled drug and molecular release. Herein, the development of cellulose acetate (CA) micro-carriers with mono- (MC) or bi-phasic (BC) composition is proposed, fabricated via electrohydrodynamic atomization (EHDA)—an electro-dropping technology able to micro-size polymer solution by the application of high voltage electrostatic forces. Image analysis allows identification of the process parameters to optimize morphology, in terms of size distribution and shape. Meanwhile, an accurate rheological study has enabled investigating the interface between CA solutions with different viscosities to optimize BC systems. Release tests have confirmed that BC carriers can retain the drug more efficiently in acidic conditions, also providing a more gradual and sustained release until six days, with respect to MC carriers. Hence, all these results have proven that biphasic architecture significantly improves the capability of CA microcarriers to release ketoprofen lysinate, thus suggesting a new route to design core/shell systems for the retarded oral administration of anti-inflammatory drugs.

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The role of anti-inflammatory drugs and nanoparticle-based drug delivery models in the management of ischemia-induced heart failure

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2021.112014 ◽

2021 ◽

Vol 142 ◽

pp. 112014

Author(s):

Kathryn E. Haley ◽

Talal Almas ◽

Saeed Shoar ◽

Shan Shaikh ◽

Maimoona Azhar ◽

...

Keyword(s):

Heart Failure ◽

Drug Delivery ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Delivery Models

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Sustained acoustic medicine; sonophoresis for nonsteroidal anti-inflammatory drug delivery in arthritis

Therapeutic Delivery ◽

10.4155/tde-2020-0009 ◽

2020 ◽

Vol 11 (6) ◽

pp. 363-372

Author(s):

Jack Masterson ◽

Brett Kluge ◽

Aaron Burdette ◽

George Lewis Sr

Keyword(s):

Drug Delivery ◽

Transdermal Drug Delivery ◽

Standard Of Care ◽

Delivery Device ◽

Skin Model ◽

Penetration Enhancement ◽

Drug Delivery Device ◽

Ultrasound Device ◽

Inflammatory Drugs ◽

Anti Inflammatory

Background: Arthritis pain is primarily managed by nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac. Topical diclofenac gel is limited in efficacy due to its limited penetration through the skin. This study investigates the use of a multihour, wearable, localized, sonophoresis transdermal drug delivery device for the penetration enhancement of diclofenac through the skin. Materials & methods: A commercially available, sustained acoustic medicine (sam®) ultrasound device providing 4 h, 1.3 W, 132 mW/cm2, 3 MHz ultrasound treatment was evaluated for increasing the drug delivery of diclofenac gel through a human skin model and was compared with standard of care topical control diclofenac gel. Results: Sonophoresis of the diclofenac gel for 4 h increases diclofenac delivery by 3.8× (p < 0.01), and penetration by 32% (p < 0.01). Conclusion: Sustained acoustic medicine can be used as a transdermal drug-delivery device for nonsteroidal anti-inflammatory drugs.

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Imidazolium-Based Ionic Liquid-Assisted Preparation of Nano-Spheres Loaded with Bio-Active Peptides to Decrease Inflammation in an Osteoarthritis Model: Ex Vivo Evaluations

Journal of Biomedical Nanotechnology ◽

10.1166/jbn.2021.3069 ◽

2021 ◽

Vol 17 (5) ◽

pp. 859-872

Author(s):

Yingzhuo Song ◽

Tao Zhang ◽

Huiguang Cheng ◽

Wei Jiang ◽

Pu Li ◽

...

Keyword(s):

Electron Microscopy ◽

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Ex Vivo ◽

Cartilage Explants ◽

Therapeutic Drug ◽

Therapeutic Peptides ◽

Inflammatory Drugs ◽

Anti Inflammatory

Osteoarthritis is one of the most prevalent chronic diseases. Cartilage inflammation in osteoarthritis results from pain in articular joints. Anti-inflammatory drugs provide relief by hindering the production of pro-inflammatory cytokines and interleukin-6. Targeted delivery of anti-inflammatory drugs is very effective in the treatment of osteoarthritis. This approach reduces the usage of therapeutic drug dosages and unwanted side effects. Here, we fabricated a non-invasive and efficient targeted drug delivery system to reduce persistent inflammation in an osteoarthritis model. Temperature-sensitive hollow dextran/poly(N-isopropyl acrylamide) nanoparticles were synthesized by the destruction of N,N’-bis(acryloyl)cystamine crosslinked cores in imidazolium-based ionic liquids. The copolymerized 2-acrylamido-2-methylpropane sulfonic acid created sulfur functionalities that increase the loading of therapeutic KAFAK peptides. The chemical structure of the polymer nanoparticles was analyzed with UV-Visible, Fourier transform infrared, and X-ray photoelectron spectroscopy. The thermal responsive characteristics of the nanoparticles were determined with dynamic light scattering, scanning electron microscopy, and transmission electron microscopy analyses. Moreover, the synthesized nanoparticles were used as drug carriers to reduce inflammation in an Ex Vivo osteoarthritis model. The KAFAK-loaded hollow dextran/PNIPAM nanoparticles effectively delivered therapeutic peptides in cartilage explants to suppress inflammation. These thermoresponsive nanoparticles could be an effective drug delivery system to deliver anti-inflammatory therapeutic peptides in a highly osteoarthritic environment.

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Localized and targeted delivery of NSAIDs for treatment of inflammation: A review

Experimental Biology and Medicine ◽

10.1177/1535370218787770 ◽

2018 ◽

Vol 244 (6) ◽

pp. 433-444 ◽

Cited By ~ 16

Author(s):

Rebecca M Haley ◽

Horst A von Recum

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Targeted Delivery ◽

Local Drug Delivery ◽

Future Research ◽

Systemic Delivery ◽

Number Of Patients ◽

Long Term Treatment ◽

Inflammatory Drugs ◽

Anti Inflammatory

Inflammatory processes are increasingly being identified at the core of many different disease states (e.g. heart disease, cancer, diabetes). As such, anti-inflammatory strategies available through drug delivery have undergone renewed interest. Due to the systemic side effects of steroidal drugs, non-steroidal anti-inflammatory drugs are often preferred for long-term treatment of inflammation in a variety of applications. While non-steroidal anti-inflammatory drugs are generally safe, there are some serious side effects that can be associated with their usage, particularly when given systemically or orally. Due to the high number of patients taking non-steroidal anti-inflammatory drugs, the reduction or elimination of these side effects, such as is possible through local drug delivery, could have a very powerful effect on patient quality of life. This review comments on a sampling of existing methods for localized or targeted delivery of non-steroidal anti-inflammatory drugs, with the goal of helping future research groups to focus on bettering methods shown to be effective and filling the gaps of knowledge in this field. Additionally, commentary is made on the field as a whole, and the standardization issues that arise from its expansiveness and diversity. Impact statement This work provides an overview of research currently being done exploring potential drug delivery device strategies for NSAIDs as an alternative to systemic delivery. Commentary on this field is made in an attempt to aid future experimental design, enabling researchers to determine the drugs and delivery vehicles which are most advantageous for them to pursue, as well as suggestions to standardize the reporting of such future research.

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