Developmental Features of the Canid Proximocaudal Femur

2021 ◽  
Author(s):  
Dennis F. Lawler ◽  
Basil P. Tangredi ◽  
Jerry M. Owens ◽  
Christopher C. Widga ◽  
Terrance J. Martin ◽  
...  
Keyword(s):  
Developmental Features

scholarly journals Development of the mouse anterior amygdalar radial unit marked by Lhx9-expression

2021 ◽  
Vol 226 (2) ◽  
pp. 575-600 ◽  
Author(s):  
Elena Garcia-Calero ◽  
Luis Puelles
Keyword(s):  
Emotional Processing ◽  
Molecular Profile ◽  
Ring Model ◽  
Radial Model ◽  
Developmental Features ◽  
Anterior Posterior

AbstractThe amygdala in mammals plays a key role in emotional processing and learning, being subdivided in pallial and subpallial derivatives. Recently, the cortical ring model and the pallial amygdalar radial model (Puelles et al. 2019; Garcia-Calero et al. 2020) described the pallial amygdala as an histogenetic field external to the allocortical ring, and subdivided it in five major radial domains called lateral, basal, anterior, posterior and retroendopiriform units. The anterior radial unit, whose cells typically express the Lhx9 gene (see molecular profile in Garcia-Calero et al. 2020), is located next to the pallial/subpallial boundary. This radial domain shows massive radial translocation and accumulation of its derivatives into its intermediate and superficial strata, with only a glial palisade representing its final periventricular domain. To better understand the development of this singular radial domain, not described previously, we followed the expression of Lhx9 during mouse amygdalar development in the context of the postulated radial subdivisions of the pallial amygdala and other telencephalic developmental features.

scholarly journals Developmental features and predicting airway failure risk in critically ill children with mandibular hypoplasia using 3D computational tomographic analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Doo-Hwan Kim ◽  
Eunseo Gwon ◽  
Junheok Ock ◽  
Jong-Woo Choi ◽  
Jee Ho Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Difficult Airway ◽  
Hyoid Bone ◽  
Three Dimensional ◽  
Upper Airway ◽  
Critically Ill Children ◽  
Healthy Controls ◽  
Mandibular Hypoplasia ◽  
Tongue Position ◽  
Developmental Features

AbstractIn children with mandibular hypoplasia, airway management is challenging. However, detailed cephalometric assessment data for this population are sparse. The aim of this study was to find risk factors for predicting difficult airways in children with mandibular hypoplasia, and compare upper airway anatomical differences using three-dimensional computed tomography (3D CT) between children with mandibular hypoplasia and demographically matched healthy controls. There were significant discrepancies in relative tongue position (P < 0.01) and anterior distance of the hyoid bone (P < 0.01) between patients with mandibular hypoplasia and healthy controls. All mandibular measures were significantly different between the two groups, except for the height of the ramus of the mandible. After adjusting for age and sex, the anterior distance of hyoid bone and inferior pogonial angle were significantly associated with a difficult airway (P = 0.01 and P = 0.02). Quantitative analysis of upper airway structures revealed significant discrepancies, including relative tongue position, hyoid distance, and mandible measures between patients with mandibular hypoplasia and healthy controls. The anterior distance of the hyoid bone and inferior pogonial angle may be risk factors for a difficult airway in patients with mandibular hypoplasia.

scholarly journals Unusual phenotypes in patients with a pathogenic germline variant in DICER1

2021 ◽  
Author(s):  
Kateryna Venger ◽  
Miriam Elbracht ◽  
Julia Carlens ◽  
Peter Deutz ◽  
Felix Zeppernick ◽  
...  
Keyword(s):  
Wilms Tumor ◽  
Pleuropulmonary Blastoma ◽  
Global Developmental Delay ◽  
Facial Dysmorphism ◽  
Compound Heterozygous ◽  
Incomplete Penetrance ◽  
Developmental Abnormalities ◽  
Lung Cysts ◽  
Developmental Features ◽  
Skeletal Findings

AbstractPathogenic germline DICER1 variants are associated with pleuropulmonary blastoma, multinodular goiter, embryonal rhabdomyosarcoma and other tumour types, while mosaic missense DICER1 variants in the RNase IIIb domain are linked to cause GLOW (global developmental delay, lung cysts, overgrowth, and Wilms’ tumor) syndrome. Here, we report four families with germline DICER1 pathogenic variants in which one member in each family had a more complex phenotype, including skeletal findings, facial dysmorphism and developmental abnormalities. The developmental features occur with a variable expressivity and incomplete penetrance as also described for the neoplastic and dysplastic lesions associated with DICER1 variants. Whole exome sequencing (WES) was performed on all four cases and revealed no further pathogenic or likely pathogenic dominant, homozygous or compound heterozygous variants in three of them. Notably, a frameshift variant in ARID1B was detected in one patient explaining part of her phenotype. This series of patients shows that pathogenic DICER1 variants may be associated with a broader phenotypic spectrum than initially assumed, including predisposition to different tumours, skeletal findings, dysmorphism and developmental abnormalities, but genetic work up in syndromic patients should be comprehensive in order not to miss additional underlying /modifying causes.

The Later Developmental Features in the Skull of Sus barbatus barbatus

2009 ◽  
Vol 104 (3) ◽  
pp. 685-696 ◽  
Author(s):  
T. Wingate Todd ◽  
E. V. Cooke
Keyword(s):  
Developmental Features

Fetal Valproate Syndrome: Clinical and Neuro-developmental Features in Two Sibling Pairs

2008 ◽  
Vol 36 (4) ◽  
pp. 361-369 ◽  
Author(s):  
Arnold L. Christianson ◽  
Nicole Chester ◽  
Jennifer G. R. Kromberg
Keyword(s):  
Sibling Pairs ◽  
Fetal Valproate Syndrome ◽  
Developmental Features

Mucolipidosis Type IV: Clinical Spectrum and Natural History

PEDIATRICS ◽  
1987 ◽  
Vol 79 (6) ◽  
pp. 953-959
Author(s):  
Naomi Amir ◽  
Joel Zlotogora ◽  
Gideon Bach
Keyword(s):  
Age Of Onset ◽  
Clinical Manifestations ◽  
Psychomotor Retardation ◽  
Clinical Spectrum ◽  
Lysosomal Storage ◽  
Mucolipidosis Type Iv ◽  
Type Iv ◽  
First Year Of Life ◽  
Developmental Features ◽  
Mucolipidosis Type

The clinical spectrum and developmental features of mucolipidosis type IV, a recessive lysosomal storage disorder, are presented. The evaluation was based on information from the clinical charts and information obtained from the families of 20 patients between the ages of 2 to 17 years. The clinical manifestations of the disease, profound psychomotor retardation and visual impairment, appear during the first year of life. Definitive diagnosis is made by electron microscopy which reveals storage organelles typical of the mucolipidoses. This study details, for the first time, the heterogeneity of the ophthalmologic features, specifically as pertains to the age of onset, degree and clinical course of the corneal opacities, and the retinal involvement. Although the top developmental level was found to be 12 to 15 months in language and motor function, the course of the disease is protracted for some children, who show only a slight improvement, and others, little if any deterioration despite the early infantile onset of the disease. This presentation provides guidelines for the clinical diagnosis of mucolipidosis type IV.

THE HUMANIST IDEA OF INCLUSIVE EDUCATION AS A FORM OF EXPANDING THE EDUCATIONAL SPACE

2020 ◽  
Vol 64 (3) ◽  
pp. 118-122
Author(s):  
A. Kabdyrova ◽  
Keyword(s):  
Inclusive Education ◽  
Individual Characteristics ◽  
Education For All ◽  
Modern Education ◽  
The Individual ◽  
Developmental Features

The article examines the issues and problems of the implementation of inclusive education as a way to humanize modern "education for all", regardless of ethnicity, abilities, presence or absence of developmental features, where the individual characteristics of each person are respected and appreciated. The author considers the personality of a university teacher as one of the key figures in inclusive education.

Lexical richness development in Chinese second language writing: empirical research based on Cambodian Chinese learners

2021 ◽  
Vol 10 (2) ◽  
pp. 183-206
Author(s):  
Huan Zhang
Keyword(s):  
Second Language ◽  
Error Rate ◽  
Second Language Writing ◽  
Three Dimensions ◽  
Writing Quality ◽  
Lexical Variation ◽  
Lexical Richness ◽  
Language Writing ◽  
Lexical Errors ◽  
Developmental Features

Abstract This study investigates the developmental features of lexical richness in Chinese compositions by Cambodian native speakers (n = 40) and the relationship between lexical richness and writing quality in Chinese Second Language (CSL) writing from three dimensions of lexical variation, lexical sophistication and lexical error rate.The results show that with the improvement of Chinese level, there are notable increases in lexical variation (p = 0.000 < 0.05) and lexical sophistication (p = 0.000 < 0.05). As for lexical errors, the overall lexical error rate is decreasing. Among which, the form error rate is decreasing obviously (p = 0.000 < 0.05), while the usage error rate is increasing, but not significantly (p = 0.039 > 0.005). Multiple regression analysis shows that lexical sophistication and lexical error rate are more closely related to CSL writing quality, which can predict writing quality well, while lexical variation has less impact on writing quality.

A unifying statistical model for QTL mapping of genotype × sex interaction for developmental trajectories

2004 ◽  
Vol 19 (2) ◽  
pp. 218-227 ◽  
Author(s):  
Wei Zhao ◽  
Changxing Ma ◽  
James M. Cheverud ◽  
Rongling Wu
Keyword(s):  
Statistical Model ◽  
Growth Form ◽  
Structural Model ◽  
Developmental Trajectories ◽  
Growth Curves ◽  
Mouse Strains ◽  
Growth Trajectories ◽  
Mathematical Functions ◽  
Maximal Growth Rate ◽  
Developmental Features

Most organisms display remarkable differences in morphological, anatomical, and developmental features between the two sexes. It has been recognized that these sex-dependent differences are controlled by an array of specific genetic factors, mediated through various environmental stimuli. In this paper, we present a unifying statistical model for mapping quantitative trait loci (QTL) that are responsible for sexual differences in growth trajectories during ontogenetic development. This model is derived within the maximum likelihood context, incorporated by sex-stimulated differentiation in growth form that is described by mathematical functions. A typical structural model is implemented to approximate time-dependent covariance matrices for longitudinal traits. This model allows for a number of biologically meaningful hypothesis tests regarding the effects of QTL on overall growth trajectories or particular stages of development. It is particularly powerful to test whether and how the genetic effects of QTL are expressed differently in different sexual backgrounds. Our model has been employed to map QTL affecting body mass growth trajectories in both male and female mice of an F2 population derived from the large (LG/J) and small (SM/J) mouse strains. We detected four growth QTL on chromosomes 6, 7, 11, and 15, two of which trigger different effects on growth curves between the two sexes. All the four QTL display significant genotype-sex interaction effects on the timing of maximal growth rate in the ontogenetic growth of mice. The implications of our model for studying the genetic architecture of growth trajectories and its extensions to some more general situations are discussed.

scholarly journals Oviposition and development in the glass frog Hyalinobatrachium orientale (Anura: Centrolenidae)

2015 ◽  
Vol 14 (1) ◽  
pp. 3 ◽  
Author(s):  
Mohsen Nokhbatolfoghahai ◽  
Christopher J. Pollock ◽  
J. Roger Downie
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Small Area ◽  
Tail Length ◽  
Oral Disc ◽  
Progressive Development ◽  
Gland Cells ◽  
Developmental Features ◽  
Hatching Gland ◽  
Scanning Electron

Oviposition and development in the glass frog Hyalinobatrachium orientale (Anura: Centrolenidae). Oviposition and external embryonic developmental features are described in the Tobago glass frog, Hyalinobatrachium orientale. Egg clutches are nearly always laid on the undersides of leaves (one exception); usually leaves of Heliconia sp. are used, but Philodendron and palms may be used in the absence of Heliconia. Clutches contain 28.0 ± 5.3 eggs (mean ± SD) and eggs are 1.86 ± 0.11 mm in diameter. The behavior of one amplectant pair was followed for more than five hours; the pair rotated several times around a small area of the leaf depositing eggs in a tight spiral formation. External embryonic features were observed by scanning electron microscopy. Surface ciliation is extensive up to the time of hatching when it is lost; external gills are short and a cement gland is absent. Hatching gland cells were detectable on the anterodorsal surface of the head from Day 4 after deposition and persisted until at least Day 10, and hatching occurred between Days 9 and 16. During this period, progressive development in tail length, surface pigmentation, intestinal coiling, and oral disc features was observed. Post-hatching larvae reared for six weeks grew 37% in length and tripled in weight, but remained at Gosner Stage 25.

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