scholarly journals Chitosan nanofiber biocomposites for potential wound healing applications: Antioxidant activity with synergic antibacterial effect

Author(s):  
Mitra Bagheri ◽  
Majid Validi ◽  
Abolfazl Gholipour ◽  
Pooyan Makvandi ◽  
Esmaeel Sharifi

AGE ◽  
2014 ◽  
Vol 36 (2) ◽  
pp. 733-748 ◽  
Author(s):  
Andrea N. Moor ◽  
Evan Tummel ◽  
Jamie L. Prather ◽  
Michelle Jung ◽  
Jonathan J. Lopez ◽  
...  


2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Shokhan H. Azeez ◽  
Shanaz M. Gaphor

Objective. This study investigates the antibacterial effect of essential oil extracted from the gum ofPistacia atlantica KurdicaagainstPorphyromonas gingivalisand histological evaluation of an experimental gel of the extract in wound healing in the back subcutaneous tissue of Wistar rats.Methods. Clinical strains of bacteria obtained from subgingival plaque samples of individuals having periodontitis, isolation, and confirmation were done by conventional microbiological tests and molecular technique. Essential oil was extracted by using hydrodistillation method; antibacterial activity has been determined by two fold serial dilution method. Histological evaluation conducted on fifteen Wistar rats. Incisions were made on the dorsal surface of each animal for implanting of 3 polysilicone tubes (empty, tetracycline gel, and the experimental gel). After 1, 4, and 8 weeks, the animals were euthanized and the specimens were prepared histologically.Result. The extract demonstrated antimicrobial effect and significant wound healing in the different study durations particularly our product showed progression in epidermal wound healing and decrease in cellularity and scoring of inflammatory cells.Conclusion. The extract was able to pose inhibitory and bactericidal activity againstP. gingivalisand the experimental gel was able to have a good wound healing that enable it to be considered as a compatible material.



2020 ◽  
Vol 392 ◽  
pp. 123775 ◽  
Author(s):  
Shaohan Zhang ◽  
Jingyi Hou ◽  
Qijuan Yuan ◽  
Peikun Xin ◽  
Huitong Cheng ◽  
...  


RSC Advances ◽  
2019 ◽  
Vol 9 (67) ◽  
pp. 39434-39434
Author(s):  
Chunyi Tong ◽  
Wei Zou ◽  
Weimin Ning ◽  
Jialong Fan ◽  
Li Li ◽  
...  

Correction for ‘Synthesis of DNA-guided silver nanoparticles on a graphene oxide surface: enhancing the antibacterial effect and the wound healing activity’ by Chunyi Tong et al., RSC Adv., 2018, 8, 28238–28248.



2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
K. C. Lamounier ◽  
L. C. S. Cunha ◽  
S. A. L. de Morais ◽  
F. J. T. de Aquino ◽  
R. Chang ◽  
...  

Maclura tinctoria(L.) D. Don ex Steud. has one of the highest qualities among the coefficients for Brazilian woods (up to 9.6) and resistance rates equivalent to Indian teak (Tectona grandis). In this study, the macromolecular constituents and total phenols compounds as well as the antioxidant and antibacterial activities of this wood were evaluated. Total phenols and proanthocyanidin levels were higher in wood when compared with bark levels. The antioxidant activity of wood extracts (IC50= 18.7 μg/mL) was more effective than that of bark extracts (IC50= 20.9 μg/mL). Wood and bark extracts revealed a high potential for inhibition of aerobic and anaerobic bacteria. The bark extracts were the most active (MIC from 20 to 60 μg/mL). Both antioxidant activity and high potential for bacteria inhibition turn these extracts promising for drug formulations, especially as antibacterial agent.





2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Regina Celis Lopes Affonso ◽  
Ana Paula Lorenzen Voytena ◽  
Simone Fanan ◽  
Heloísa Pitz ◽  
Daniela Sousa Coelho ◽  
...  

The world coffee consumption has been growing for its appreciated taste and its beneficial effects on health. The residual biomass of coffee, originated in the food industry after oil extraction from coffee beans, called coffee beans residual press cake, has attracted interest as a source of compounds with antioxidant activity. This study investigated the chemical composition of aqueous extracts of coffee beans residual press cake (AE), their antioxidant activity, and the effect of topical application on the skin wound healing, in animal model, of hydrogels containing the AE, chlorogenic acid (CGA), allantoin (positive control), and carbopol (negative control). The treatments’ performance was compared by measuring the reduction of the wound area, with superior result (p<0.05) for the green coffee AE (78.20%) with respect to roasted coffee AE (53.71%), allantoin (70.83%), and carbopol (23.56%). CGA hydrogels reduced significantly the wound area size on the inflammatory phase, which may be associated with the well known antioxidant and anti-inflammatory actions of that compound. The topic use of the coffee AE studied improved the skin wound healing and points to an interesting biotechnological application of the coffee bean residual press cake.



2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Heloisa da S. Pitz ◽  
Aline Pereira ◽  
Mayara B. Blasius ◽  
Ana Paula L. Voytena ◽  
Regina C. L. Affonso ◽  
...  

Jaboticaba is a fruit from a native tree to Brazil,Plinia peruviana. Jaboticaba peels are an important source of antioxidant molecules such as phenolic compounds. This study aimed to evaluatein vitrothe activity of a hydroalcoholic extract of jaboticaba fruit peels (HEJFP) in wound healing processes and antioxidant activity in murine fibroblasts (L929 cell line). HEJFP concentrations (0.5, 1, 5, 10, 25, 50, 100, and 200 µg/mL) were tested in MTT assay and cell proliferation was verified at 100 µg/mL after 24 h and at 25, 50, and 100 µg/mL after 48 h of extract exposure. Evaluation of antioxidant activity was performed at 0.5, 5, 25, 50, and 100 µg/mL HEJFP concentrations. Cell treatment with HEJFP at 25, 50, and 100 µg/mL for 24 h followed by H2O2exposure for 3 h showed a strong cytoprotective effect.In vitroscratch wound healing assay indicated that none of tested HEJFP concentrations (0.5, 5, 25, 50, and 100 µg/mL) were capable of increasing migration rate after 12 h of incubation. These results demonstrate a positive effect of HEJFP on the wound healing process on L929 fibroblasts cell line, probably due to the antioxidant activity exhibited by phytochemicals in the extract.



2009 ◽  
Vol 44 (3) ◽  
pp. 981-989 ◽  
Author(s):  
Halehatty R. Prakash Naik ◽  
Halehatty S. Bhojya Naik ◽  
Thangali R. Ravikumar Naik ◽  
H. Raja Naika ◽  
K. Gouthamchandra ◽  
...  


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