Risk factors and predictors of lymph nodes metastasis and distant metastasis in newly diagnosed T1 colorectal cancer

Abstract Background: No.253 lymph nodes metastasis is related to poor prognosis of colorectal cancer, while the role of No.253 lymph nodes dissection in colorectal cancer is still controversial.Methods: A total of 157 patients who were received laparoscopic radical resection of colorectal cancer with preservation of the left colon artery + D3 lymph node dissection (low ligation + high dissection) in our hospital were enrolled. No.253 lymph nodes of each patients were dissected and sent for examination. Clinicaopathological factors correlated with No.253 lymph nodes metastasis, including gender, age, tumor location, tumor size, length of tumor from the anus, whether lymphovascular invasion, whether perineural invasion, tumor markers CEA, CA125 and CA199, tumor T stage, whether it is distant metastasis, the total number of lymph nodes harvested, tumor type, and histologic grade were respectively analyzed.Results: A total of 2286 lymph nodes were sent for examination, of which 557 No.253 lymph nodes were sent for examination. Among them, 5 patients had a total of 27 No.253 lymph node metastases. Preoperative CA125 level (X2=4.736, p=0.030), whether perineural invasion (X2=8.086, p<0.01), whether lymphovascular invasion (X2= 7.053, p<0.01), tumor type (X2=21.019, p<0.01), histologic grade (X2=15.315, p<0.01) were significantly correlated with positive No.253 lymph nodes metastasis. A multivariate logistic regression analysis showed that none of risk factor from above are independent risk factors for No.253 lymph node metastasis(P>0.05).Conclusion: Preoperative CA125 level, whether perineural invasion, whether lymphovascular invasion, tumor type, histologic grade were risk factors of the No.253 lymph nodes metastasis. Multivariate analysis showed that five risk factors from above were not the independent risk factor for No.253 lymph nodes metastasis. Colorectal cancer patients with the risk factors above were suggested to receive radical resection + D3 lymph node dissection.

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Examination of main lymph node (No.253) metastasis in left colorectal cancer: A retrospective analysis of a single-institution cohort

10.21203/rs.3.rs-1019251/v1 ◽

2021 ◽

Author(s):

Takefumi Yoshida ◽

Fumihiko Fujita ◽

Dai Shida ◽

Kenichi Koushi ◽

Kenji Fujiyoshi ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Lymph Node ◽

Lymph Nodes ◽

Poor Prognosis ◽

Advanced Colorectal Cancer ◽

D3 Lymphadenectomy ◽

Positive Group ◽

Factors Associated

Abstract Background. The extent of lymph node dissection in advanced colorectal cancer varies according to regional guidelines. D3 lymphadenectomy is routinely performed in Japan but is associated with several risk factors. Metastases of the main lymph nodes (No.253 lymph nodes), which are located at the root of the inferior mesenteric artery, are rare in left-sided colorectal cancer. Tumor depth (T4) is an identifier of No.253 lymph node metastasis (LNM) risk, but other risk factors associated with No.253 LNM are unclear. This study was undertaken to investigate the frequency of No.253 LNM and to identify other clinicopathological risk factors associated with No.253 LNM in left-sided colorectal cancer. In this study, we aimed to evaluate the clinical benefit of routine D3 lymphadenectomy in surgically treated advanced colorectal cancer. Methods. A retrospective database of patients with colorectal cancer who underwent D3 dissection and R0 resection at Kurume University Hospital from 1978 to 2017 was constructed and used to search for the frequency and risk factors of No.253 LNM to investigate long-term prognosis. Clinicopathological factors associated with No.253 LNM, including age, sex, tumor location, T stage, tumor diameter, carcinoembryonic antigen levels, and various dissected lymph nodes, were analyzed. Results. Among 1,614 consecutive patients, No.253 LNM was observed in 23 cases (1.4%). The presence of three or more regional LNMs was an independent risk factor for No.253 LNM (odds ratio: 26.8). The 5-year overall survival rate was 49.1% in the No.253 LNM-positive group and 78.4% in the No.253 LNM-negative group (p=0.002). Conclusion. In left-sided colorectal cancer, No.253 LNM was a poor prognosis factor, and three or more regional LNMs were a risk factor for No.253 LNM. The No.253 LNM-positive group had a poor prognosis, but there are cases of long-term survival, with a 5-year survival rate of 49%. D3 lymphadenectomy is suitable when three or more metastatic LNs are identified prior to surgery.

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Management of malignant colon and rectal polyps (T1) after endoscopic polypectomy: analysis of pathological risk factors for lymph nodes metastasis. A retrospective multicentric observational study. POST-1 (Polypectomy Or Surgery for T1)

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2018.10.205 ◽

2019 ◽

Vol 45 (2) ◽

pp. e52-e53

Author(s):

D. Parini ◽

L. Saadeh ◽

M. Zizzo ◽

J. Sancho-Muriel ◽

L. Lorenzon ◽

...

Keyword(s):

Risk Factors ◽

Observational Study ◽

Lymph Nodes ◽

Endoscopic Polypectomy ◽

Lymph Nodes Metastasis ◽

Rectal Polyps

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P-318 Risk Factors of Synchronous Inguinal Lymph Nodes Metastasis for Lower Rectal Cancer Involving the Anal Canal

Annals of Oncology ◽

10.1093/annonc/mdv233.314 ◽

2015 ◽

Vol 26 ◽

pp. iv93

Author(s):

R. Wang

Keyword(s):

Risk Factors ◽

Rectal Cancer ◽

Lymph Nodes ◽

Anal Canal ◽

Lower Rectal Cancer ◽

Inguinal Lymph Nodes ◽

Lymph Nodes Metastasis

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Risk Factors for Postoperative Recurrence in Patients with Pathologically T1 Colorectal Cancer

World Journal of Surgery ◽

10.1007/s00268-011-1378-y ◽

2011 ◽

Vol 36 (2) ◽

pp. 424-430 ◽

Cited By ~ 16

Author(s):

Shuji Iida ◽

Hirotoshi Hasegawa ◽

Koji Okabayashi ◽

Konosuke Moritani ◽

Makio Mukai ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Postoperative Recurrence ◽

T1 Colorectal Cancer

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Pattern and Risk Factors of Central Compartment Lymph Node Metastasis in Papillary Thyroid Cancer: A Prospective Study from an Endocrine Surgery Centre

Journal of Thyroid Research ◽

10.1155/2012/436243 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Sudhi Agarwal ◽

Gyan Chand ◽

Sushila Jaiswal ◽

Anjali Mishra ◽

Gaurav Agarwal ◽

...

Keyword(s):

Risk Factors ◽

Thyroid Cancer ◽

Lymph Nodes ◽

Tumour Size ◽

Central Compartment ◽

Papillary Thyroid ◽

Lymph Nodes Metastasis ◽

Lymph Nodes Dissection ◽

A Prospective Study

Lymphatic metastasis in papillary thyroid cancer (PTC) is eminent; however, the extent of central compartment lymph nodes dissection (CCD) is controversial and requires the knowledge of pattern and risk factors for central compartment lymph nodes metastasis (CCM). We did a prospective study of 47 cases with PTC who underwent total thyroidectomy (TT) with CCD with/without lateral lymph nodes dissection (LND). Clinicopathological profile including CCM as ipsilateral and contralateral was documented. On histopathology, the mean tumour size was3.57±2.42 cm 59.6% had CCM, which was bilateral in the majority (60.72%). The tumour-size was the most important predictor for lymph nodes metastasis-(P=0.018) whereas multicentricity-(P=0.002) and ipsilateral CCM-(P=0.001) were the predictors for contralateral CCM. The long-term morbidity of CCD done in primary setting is comparable with TT-alone. Bilateral CCD should be done with thyroidectomy in PTC, otherwise the risk of residual diseases and subsequent recurrence is high. The long-term morbidity is comparable in experienced hands.

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STUDY OF CLINICAL PROFILE OF PATIENTS WITH COLORECTAL CANCER

10.36106/ijsr/2015520 ◽

2020 ◽

pp. 1-2

Author(s):

MS Revathy ◽

Monali Nistane ◽

Manimaran M ◽

Sumati B

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Risk Factor ◽

Rectal Bleeding ◽

Clinical Profile ◽

Common Symptom ◽

Newly Diagnosed ◽

Common Risk Factor ◽

Female Ratio ◽

Fiber Diet

Background: Colorectal cancer (CRC) incidence and mortality rates vary markedly around the world with low reported cases in India. It is a lethal disease with high mortality. It has varied presentation from asymptomatic, anaemia, altered bowel habits to frank bleeding per rectum, intestinal obstruction. There are very few studies in India describing the clinical profile and risk factors of CRC. Objective: To study Clinical profile and risk factors in patients with colorectal cancer. Methods: A prospective single center study was conducted from August 2018 to August 2019. It included all patients who were newly diagnosed CRC. Their demographic profile, site of lesion, clinical presentations, risk factors, colonoscopic findings, histology of the lesion, biochemical analysis and imaging were performed. Results: 32 patients with newly diagnosed CRC were evaluated. Mean age was 52.4 years. Male to female ratio was 1.5:1. Overall fatigue was the most common symptom (87.5%) followed by per rectal bleeding (37.5%). Fatigue was the most common symptom with right sided CRC while per rectal bleeding was the most common symptom with rectal CRC. Low fiber diet was most common risk factor (71.9%). Histologically adenocarcinoma was the most common type (90.6%). Conclusion: Rectum was the most common site and adenocarcinoma was the most common histological type. Low fiber diet was the most common risk factor. Majority of the patients had localized or locally advanced disease observed in our study.

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Cohort profile: The National Colorectal Cancer Cohort (NCRCC) study in China

BMJ Open ◽

10.1136/bmjopen-2021-051397 ◽

2021 ◽

Vol 11 (12) ◽

pp. e051397

Author(s):

Yingshuang Zhu ◽

Yeting Hu ◽

Xiangxing Kong ◽

Qian Xiao ◽

Zhizhong Pan ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Research Evidence ◽

Clinical Information ◽

Newly Diagnosed ◽

Other Information ◽

Colorectal Cancer Patients ◽

Evidence Based Guidelines ◽

Future Plans

PurposeThe National Colorectal Cancer Cohort (NCRCC) study aims to specifically assess risk factors and biomarkers related to endpoints across the colorectal cancer continuum from the aetiology through survivorship.ParticipantsThe NCRCC study includes the Colorectal Cancer Screening Cohort (CRCSC), which recruited individuals who were at high risk of CRC between 2016 and 2020 and Colorectal Cancer Patients Cohort (CRCPC), which recruited newly diagnosed patients with CRC between 2015 and 2020. Data collection was based on questionnaires and abstraction from electronic medical record. Items included demographic and lifestyle factors, clinical information, survivorship endpoints and other information. Multiple biospecimens including blood, tissue and urine samples were collected. Participants in CRCSC were followed by a combination of periodic survey every 5 years and annual linkage with regional or national cancer and death registries for at least 10 years. In CRCPC, follow-up was conducted with both active and passive approaches at 6, 12, 18, 24, 36, 48 and 60 months after surgery.Findings to dateA total of 19 377 participants and 15 551 patients with CRC were recruited in CRCSC and in CRCPC, respectively. In CRCSC, 48.0% were men, and the average age of participants at enrolment was 58.7±8.3 years. In CRCPC, 61.4% were men, and the average age was 60.3±12.3 years with 18.9% of participants under 50 years of age.Future plansLongitudinal data and biospecimens will continue to be collected. Based on the cohorts, several studies to assess risk factors and biomarkers for CRC or its survivorship will be conducted, ultimately providing research evidence from Chinese population and optimising evidence-based guidelines across the CRC continuum.

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