Synthesis of Some Novel Pharmacologically Active Schiff Bases Using Microwave Method and Their Derivatives Formazans by Conventional Method.

ChemInform ◽  
2006 ◽  
Vol 37 (5) ◽  
Author(s):  
Krunal G. Desai ◽  
K. R. Desai
Keyword(s):  
Schiff Bases ◽  
Conventional Method ◽  
Microwave Method ◽  
Pharmacologically Active

Synthesis and Characterization of (1, 4)-4-benzylidene-1-(1- phenylethylidene) thiosemicarbazide and their Antifungal Activities

10.26524/sa2 ◽  
2018 ◽  
Vol 7 (3) ◽  
pp. 08-19
Author(s):  
L Ilavarasan ◽  
A Ravi ◽  
M Ganapathi ◽  
R Sapthagiri ◽  
K Mohanraj ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Schiff Bases ◽  
1H Nmr ◽  
Conventional Method ◽  
Research Work ◽  
Synthesis And Characterization ◽  
Antifungal Activities ◽  
Aryl Aldehydes ◽  
Anti Fungal

The Present research work is aimed to synthesize a serious of various substituted Schiff bases compounds of 1-(1-phenylethylidene)thiosemicarbazide form (1,4)-4-benzylidene-1-(1-phenylethylidene)Thiosemicarbazide condenses with Four different substituted aryl aldehydes under Microwave irradiation and conventional method. The structure for compounds has been determined by UV, FTIR, 1H-NMR and Mass s spectroscopy. All the compounds are evaluated for its anti-fungal activity.

scholarly journals Comparison between Conventional Decalcification and a Microwave-Assisted Method in Bone Tissue Affected with Mycetoma

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Magdi Mansour Salih
Keyword(s):  
Nitric Acid ◽  
Hydrochloric Acid ◽  
Bone Tissue ◽  
Conventional Method ◽  
Bone Structure ◽  
Complete Removal ◽  
Microwave Method ◽  
Silver Stain ◽  
Tissue Samples ◽  
Different Characteristics

Mycetoma is a lifelong granulomatous disease of subcutaneous tissues and bones. Histopathology is a substantiated indicative method based on the assumption of a definitive diagnosis of mycetoma. It requires efficient processing of tissues including bone decalcification. The decalcification process must ensure complete removal of calcium and also a proper preservation of tissue and microorganisms’ staining ability. Objectives. To compare the conventional method used in decalcification with the microwave method using different decalcification solutions. Different characteristics were tested, including the speed of decalcification and morphological and fungal preservation in bone tissue affected with mycetoma. Materials and Methods. Three decalcification solutions were employed to remove calcium from 50 bone tissue samples affected with mycetoma, including 10% neutral buffered EDTA (pH 7.4), 5% nitric acid, and 5% hydrochloric acid. Conventional and microwave methods were used. Haematoxylin-eosin (HE) stain, Gridley’s stain, and Grocott hexamine-silver stain were employed to evaluate the bone and fungi morphologies. Results. The decalcification time of the conventional method compared with the microwave method with 10% EDTA (pH 7.4) took 120 hours and 29 hours, while 5% hydrochloric acid and 5% nitric acid took 8 hours and 3 hours, separately. Also, 10% EDTA is the best decalcifying agent for HE staining and fungal stains. 5% hydrochloric acid and 5% nitric acid can be used for fungal staining. Conclusion. The current study investigated the effects of different decalcifying agents as well as two decalcification procedures on the preservation of the bone structure and fungal staining, which will help to develop suitable protocols for the analyses of the bone tissue affected with mycetoma infection.

Influence of Process Methods on the Hepatoprotective Effect of Curcumin Analogs Synthesized from Culilawan Oil in Mice (Mus musculus L.) with CCl4 Induced Liver Damage

2019 ◽  
Vol 119 (2) ◽  
pp. 28
Author(s):  
Imanuel B. D. Kapelle ◽  
Wasmen Manalu ◽  
Meillisa C. Mainassy
Keyword(s):  
Conventional Method ◽  
Liver Damage ◽  
Mus Musculus ◽  
Aldol Condensation ◽  
Synthesis Process ◽  
Microwave Method ◽  
Pharmacological Effects ◽  
Curcumin Analogues ◽  
Curcumin Analogs

One of the downstream products which can be synthesized from culilawan oil is an analog curcumin compound (AKS) with a dioxolane ring. AKS products can be synthesized using conventional and microwave methods. The method of synthesis can influence physical properties, compound geometry, and pharmacological effects. The purpose of this study was to determine the effect of the processing method on the hepatoprotective ability of AKS, and to determine a protective dose. AKS was synthesized using insulated safrole compounds from Lawang oil and involved isomerization, oxidation, and aldol condensation of curcumin analogues. At the final stage of the analog curcumin synthesis process, 2 different methods were employed: the conventional method heated the chemical in a water bath at 30 °C for 3 hours, the microwave method heated the chemical using 140 watts of power for 2 minutes. Analogs were tested in vivo in mice (Mus musculus L.) with CCl4 induced liver damage. Hepatoprotective efficacy of AKS products processed by the conventional method and the microwave method were compared using histology and liver enzyme (AST and ALT) assessment. Animals treated with conventionally produced AKS products had lower AST and lower ALT levels—and fewer histological signs of liver damage at a lower dose of AKS—than seen in either untreated animals or those treated with microwave produced AKS. Thus, products that are processed by conventional methods are more hepatoprotective.

scholarly journals Transformation of Synthetic Allicin: The Influence of Ultrasound, Microwaves, Different Solvents and Temperatures, and the Products Isolation

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Dušica Ilić ◽  
Vesna Nikolić ◽  
Mihajlo Stanković ◽  
Ljubiša Nikolić ◽  
Ljiljana Stanojević ◽  
...  
Keyword(s):  
Activation Energy ◽  
Kinetic Parameters ◽  
Conventional Method ◽  
Room Temperature ◽  
Transformation Products ◽  
Diallyl Disulfide ◽  
Optimal Method ◽  
Degradation Kinetic ◽  
Pharmacologically Active ◽  
Pharmacologically Active Compounds

The transformation of the synthesized allicin, using conventional method, the influence of ultrasound and microwaves, in different organic solvents (acetonitrile, acetone, methanol, and chloroform), at various temperatures (room temperature,45∘C, and55∘C) was investigated. Allicin degradation kinetic was monitored by HPLC. Allicin transformation under the effect of microwaves is faster than transformations performed under the influence of ultrasound or by conventional method. Increase of the temperature accelerates allicin transformation. Pharmacologically active compounds of (E)-ajoene, (Z)-ajoene, 3-vinyl-4H-1,2-dithiin, 2-vinyl-4H-1,3-dithiin, and diallyl disulfide were isolated from the mixture of transformation products of allicin under the influence of microwaves in methanol at55∘C, which is according to kinetic parameters (highest values of the order of reaction and the lowest activation energy) the optimal method.

scholarly journals Microwave-Assisted Synthesis of Some New Mixed Ligand Ni(II) Complexes Its Characterization and Its Antimicrobial Study

2021 ◽  
pp. 143-152
Author(s):  
Jitendra M. Pawara ◽  
Sunil S. Patil
Keyword(s):  
Thermal Analysis ◽  
Conventional Method ◽  
Mixed Ligand ◽  
High Yield ◽  
Microwave Assisted Synthesis ◽  
Microwave Method ◽  
Preparation Time ◽  
Microwave Assisted ◽  
Microwave Assisted Method ◽  
Very High

Nickel(II) complexes of the type [Ni(P)(L).2H2O] has been synthesized by using 2-amino-6-methyl pyrimidine-4-ol (HP) and amino acids (HL). Complexes synthesized by conventional as well as microwave methods. Results indicate that complexes synthesized by the microwave method are more efficient than the conventional method. In the microwave method preparation time is short (4-7 min.) compared to the conventional method (45 min.). Moreover, the microwave Assisted method gives a very high yield (90%) of the complexes. The microwave method used for the synthesis of the complexes has been found easier, convenient and eco-friendly. Complexes have been characterized by FTIR, Elemental analysis, Gouy experiment, Thermogravimetric Analysis (TGA) and Differential Thermal Analysis (DTA). Complexes have shown significant antimicrobial activity.

scholarly journals Microwave-Assisted Synthesis of Some Quinoxaline-Incorporated Schiff Bases and Their Biological Evaluation

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
L. Achutha ◽  
R. Parameshwar ◽  
B. Madhava Reddy ◽  
V. Harinadha Babu
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Schiff Bases ◽  
Biological Evaluation ◽  
Conventional Heating ◽  
Microwave Assisted Synthesis ◽  
Microwave Method ◽  
Heating Method ◽  
Chemical Structures ◽  
Microwave Assisted

Quinoxaline-incorporated Schiff bases(4a–j)were synthesized by the condensation of 2-[(3-methylquinoxalin-2-yl)oxy]acetohydrazide(3)with indole-3-carbaldehyde, furfuraldehyde, 5-(4-nitrophenyl)-2-furfuraldehyde, and substituted benzaldehydes under conventional and microwave irradiation methods. The microwave method was found to be remarkably successful with higher yields, less reaction time, and environmentally friendly compared to conventional heating method. The chemical structures of the synthesized compounds have been confirmed by analytical and spectral data. All the compounds have been evaluated for antitubercular and anti-inflammatory activities.

scholarly journals Comparison Between Conventional and Microwave Methods For Extraction Pectin and Degree of Esterification from Orange (Citrus sinesis) and Grapefruit (Citrus paradisi) Peels

2016 ◽  
Vol 13 (1) ◽  
pp. 26-30
Author(s):  
Baghdad Science Journal
Keyword(s):  
Nitric Acid ◽  
Conventional Method ◽  
Microwave Method ◽  
Citrus Paradisi ◽  
Degree Of Esterification ◽  
Orange Peels ◽  
Grape Fruit ◽  
Conventional Methods

In this study Microwave and conventional methods have been used to extract and estimate pectin and its degree of esterification from dried grapefruit and orange peels. Acidified solution water with nitric acid in pH (1.5) was used. In conventional method, different temperature degrees for extraction pectin from grape fruit and orange(85 ,90 , 95 and 100?C) for 1 h were used The results showed grapefruit peels contained 12.82, 17.05, 18.47, 15.89% respectively, while the corresponding values were 5.96, 6.74, 7.41 and 8.00 %, respectively in orange peels. In microwave method, times were 90, 100, 110 and 120 seconds. Grapefruit peels contain 13.86, 16.57, 18.69, and 17.87%, respectively, while the corresponding values were of 6.53, 6.68, 7.28 and 9.05 %, respectively in orange peels. The degree of esterification increased gradually in both methods. The maximum values were of 69.7% in orange and of 67% in grapefruit at 95 °C in conventional method, while microwave method the values gave 68.8% and 66.6% for orange and grape fruit pectin at 110 sec, respectively .

scholarly journals A review on synthesis methods of tricyclic 1,2,3,4-tetrahydrocarbazoles

2022 ◽  
Vol 13 (1) ◽  
pp. 160-171
Author(s):  
Nitin Kumar ◽  
Vinod Kumar ◽  
Yogita Chowdhary
Keyword(s):  
Conventional Method ◽  
Review Article ◽  
Biologically Active ◽  
Synthetic Methods ◽  
Synthesis Methods ◽  
Microwave Method ◽  
Selective Method ◽  
Percentage Yield ◽  
Good Percentage

In this review article, we discussed old to new synthetic methods used for the preparation of 1,2,3,4-Tetrahydrocarbazole (THCz) based on reported literature. Around the worldwide, various researchers energetically reported new synthetic methods for tetrahydrocarbazoles preparation using conventional method or microwave method or use of catalyst. This review will be helpful to synthetic and medicinal chemist to find selective method for the preparation of 1,2,3,4-Tetrahydrocarbazoles with good percentage yield and less time. This review will also useful to medicinal chemist to design new biologically active tetrahydrocarbazoles based on reported synthetic methods.

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