Docosahexaenoic acid-enriched phospholipids exhibit superior effects on obesity-related metabolic disorders to egg yolk phospholipids and soybean phospholipids in mice

2016 ◽  
Vol 118 (11) ◽  
pp. 1712-1721 ◽  
Author(s):  
Xiaofang Liu ◽  
Jie Cui ◽  
Kailiang Leng ◽  
Changhu Xue ◽  
Zhaojie Li ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
Metabolic Disorders ◽  
Egg Yolk ◽  
Soybean Phospholipids

DHA-enriched phospholipids from large yellow croaker roe regulate lipid metabolic disorders and gut microbiota imbalance on SD rats with a high-fat diet

2021 ◽  
Author(s):  
Xiaodan Lu ◽  
Rongbin Zhong ◽  
Ling Hu ◽  
Luyao Huang ◽  
Lijiao Chen ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Docosahexaenoic Acid ◽  
Gut Microbiota ◽  
Polyunsaturated Fatty Acids ◽  
High Fat Diet ◽  
Nutritional Value ◽  
Metabolic Disorders ◽  
Large Yellow Croaker ◽  
High Fat ◽  
Sd Rats

Abstract Large yellow croaker roe phospholipids (LYCRPLs) has great nutritional value because of containing rich docosahexaenoic acid (DHA), which is a kind of n-3 polyunsaturated fatty acids (n-3 PUFAs). In...

scholarly journals 137 Dietary Supplementations of Ethanolamine and Serine Enhance Docosahexaenoic Acid Deposition in Eggs of Laying Hens

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 107-108
Author(s):  
Andrew D Magnuson ◽  
Xingen Lei
Keyword(s):  
Gene Expression ◽  
Docosahexaenoic Acid ◽  
Laying Hens ◽  
Total Phospholipid ◽  
Choline Chloride ◽  
Basal Diet ◽  
Egg Yolk ◽  
Analysis Data ◽  
Mrna Levels ◽  
Dha Enrichment

Abstract Enrichment of docosahexaenoic-acid (DHA) into eggs of laying-hens may be limited by the availability phospholipids as a deposition sink. The present study was to determine if dietary supplementations of phospholipid-component molecules or synthesis-enhancers: choline, serine, and ethanolamine could elevate phospholipid and DHA enrichment in the eggs and tissues of hens. A total of 50-White-Leghorn-Shavers (42-wk old) were individually caged and divided into 5 groups (n = 10/group). The 5 groups of hens were fed the following diets for 3 wk: Diet-1 = a corn soybean-meal basal-diet, Diet-2 = Diet-1 + 4%-microalgae (Aurantiochytrium, Heliae, Gibert, AZ, 1.81 g-DHA/kg) + choline-chloride (26.3 g/kg diet, 60% purity, DSM-Co., Basel, Switzerland), Diet-3 = Diet-2 + 1.41% of L-serine (100% purity, Ajinomoto-Co., Inc., Kawasaki, Japan), Diet-4 = Diet-2 + 100 mg of ethanolamine/kg (99% purity, Sigma-Aldirch-Co., St Loius, MO), and Diet-5 = Diet-3 + 100 mg of ethanolamine/kg. At the end of study, eggs, liver, ovary, and adipose samples were collected from 6 hens/group for biochemical analysis. Data were analyzed by one-way ANOVA. Compared with Diet-1, Diet-2 enhanced (P < 0.05) DHA concentrations in egg yolk and liver by 213 mg/egg and 2.98 mg/g tissue, respectively, but decreased (P < 0.05) total phospholipid-concentrations of yolk and liver by 50%, and hepatic-mRNA levels of elongases-2/5 and desaturases-4/6 by 25–50%. Compared with Diet-2, Diet-5 enhanced (P < 0.05) DHA (by 20%) and phospholipid (by 40%) concentrations in the egg yolk, and upregulated (P < 0.05) lipid-metabolism genes involved in the citicoline (CDP, up-to-3-fold) and CDP-ethanolamine (up-to-2.5-fold) pathways in the liver and ovary-tissue. In comparison, Diets-3 and 4 resulted in only 3–11% higher (P < 0.05) DHA-concentrations in the liver over Diet-2. In conclusion, feeding hens a high DHA and choline diet enriched DHA in the egg yolk and down-regulated lipogenesis-gene-expression in the tissues. Supplementing the diet with extra-serine and ethanolamine further-enhanced the DHA enrichment in the egg yolk and restored the high DHA-mediated changes in the gene-expression. (Supported in part by DOE-MAGIC-grant DE-EE0007091, USDA-grant 2019-69012-29905, and Cornell-University-Hatch-grants NYC-127419/127302).

scholarly journals Ikan teri Engraulis encrasicolus berpotensi sebagai pangan fungsional

2021 ◽  
Vol 6 (1) ◽  
pp. 75
Author(s):  
Wa Ode Salma ◽  
Ruwiah Ruwiah ◽  
Febriana Muchtar ◽  
Nabilah Hanum Mudjahidah ◽  
Karwika Dwi Saputri Nurdin ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
Functional Food ◽  
Metabolic Disorders ◽  
Extraction Process ◽  
Good Prospect ◽  
Engraulis Encrasicolus ◽  
The Future ◽  
Soxhlet Method ◽  
Oil Extract ◽  
The City

Anchovy Engraulis encrasicolus is a good prospect to be developed in the future, maybe it can be used for hyperlipidemia diet.  This study, therefore, aims to measure and assess the content of EPA (eikosapentaenoat acid)  and DHA (docosahexaenoic acid).from Anchovy Engraulis encrasicolus  oil extract. The samples were obtained from the city of Kendari in Southeast Sulawesi, Indonesia. It was processed and manufactured at the Halu Oleo University in Pharmacy Laboratory. Furthermore, the extraction process utilized the Soxhlet method, while measuring and analyzing the content of EPA and DHA using UV/Vis Spectropometric. It was found that 25 mg of Anchovy Engraulis encrasicolus oil produced DHA levels of 145,5 mg/g (14,5%) and EPA levels of 97,15 mg/g (7,71%). Anchovy Engraulis encrasicolus is a potential for functional food used to provide protection against diseases associated with metabolic disorders and diet hyperlipidemia.

scholarly journals Effect of Dietary Incorporation of Linseed Alone or Together with Tomato-Red Pepper Mix on Laying Hens’ Egg Yolk Fatty Acids Profile and Health Lipid Indexes

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 813 ◽  
Author(s):  
Besma Omri ◽  
Raja Chalghoumi ◽  
Luana Izzo ◽  
Alberto Ritieni ◽  
Massimo Lucarini ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Docosahexaenoic Acid ◽  
Laying Hens ◽  
Dietary Treatment ◽  
Egg Yolk ◽  
Red Pepper ◽  
Standard Diet ◽  
Fatty Acids Profile ◽  
Tomato Paste ◽  
Diet Control

This study evaluated the effect of linseed incorporation in laying hens’ feed (alone or along with a tomato-red pepper mix) on laying hens’ egg yolk fatty acids profile, as well as on their atherogenic (IA) and thrombogenic (IT) health lipid indexes, and the ratio between the hypocholesterolemic and hypercholesterolemic fatty acids (HH). Sixty 27 weeks-old Novogen White laying hens were divided into three groups and given 100 g/hen/day of a standard diet (Control, C) containing 4.5% of ground linseed (Linseed diet, L), containing 1% of dried tomato paste and 1% sweet red pepper (Lineseeds-Tomato-Pepper, LTP). The linseed dietary inclusion significantly reduced the egg yolk content of palmitic acid from 25.41% (C) to 23.43% (L) and that of stearic acid from 14.75% (C) to 12.52% (L). Feeding 4.5% ground linseed did not affect the egg yolk content of α-Linolenic acid but significantly increased the egg yolk concentration of eicosapentaenoic acid (EPA) from 0.011% (C) to 0.047% (L) and that of docosahexaenoic acid (DHA) from 1.94% (C) to 2.73% (L). The IA and the HH were not affected (p > 0.05) by the dietary addition of linseed, whereas the IT decreased (p < 0.05) from 1.16 (C) to 0.86 (L). Adding tomato-sweet red pepper mix to the linseed-supplemented feed did not affect the measured parameters as compared to the linseed dietary treatment.

scholarly journals Time course of nutritional and functional property changes in egg yolk from laying hens fed docosahexaenoic acid-rich microalgae

2020 ◽  
Vol 99 (9) ◽  
pp. 4616-4625 ◽  
Author(s):  
Bing Liu ◽  
Qin Zhou ◽  
Jiaming Zhu ◽  
Gang Lin ◽  
Dongyou Yu ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
Functional Property ◽  
Time Course ◽  
Laying Hens ◽  
Egg Yolk ◽  
Property Changes

Effects of dietary algal docosahexaenoic acid oil supplementation on fatty acid deposition and gene expression in laying Leghorn hens

2004 ◽  
Vol 142 (6) ◽  
pp. 683-690 ◽  
Author(s):  
C. H. CHENG ◽  
T. F. SHEN ◽  
W. L. CHEN ◽  
S. T. DING
Keyword(s):  
Transcription Factors ◽  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Acid Deposition ◽  
Egg Production ◽  
Laying Hens ◽  
Regulatory Element ◽  
Egg Yolk ◽  
Total Fatty Acids ◽  
Egg Yolks

The purpose of the current study was to determine the effects of dietary docosahexaenoic acid (DHA) on fatty acid deposition in egg yolk and various tissues of laying Leghorn hens, and on the expression of hepatic lipogenesis-related transcription factors. There were three treatments with 10 Leghorn hens per treatment. Diets were based on maize-soybean meal (ME: 12 MJ/kg; CP: 171 g/kg; Ca: 34 g/kg) supplemented with 0 (plus 20 g butter/kg), 5 g (plus 15 g butter/kg) or 20 g algal DHA oil/kg. The egg production of the birds was not affected by dietary DHA oil (P>0·05). The DHA content in egg yolks of the laying hens increased significantly (P<0·01) with the dietary supplementation of DHA. The DHA content of the total fatty acids in the egg yolk of laying hens was 4±16, 11±43 and 20±90 g/kg for 0, 5 and 20 g/kg DHA treatments, respectively for the first week, and 6±16, 18±49 and 31±86 g/kg for the second week. Therefore, algal DHA oil can be utilized by laying Leghorn hens to enhance egg yolk DHA content and produce high DHA eggs. The concentrations of triacylglycerol (TG) and cholesterol in plasma of laying Leghorn hens were not affected by dietary DHA treatments (P>0·005). The DHA content in plasma and livers of laying hens was increased with the addition of DHA in the diet (P<0·05). The DHA content in the skeletal muscle of Leghorn hens was also increased with the increase in dietary DHA. The data indicate that dietary DHA oil can be incorporated into plasma, egg yolks and various tissues. The mRNA concentrations of the lipogenesis-related transcription factors, sterol regulatory element binding protein 1 (SREBP1) and SREBP2, in the livers of laying Leghorn hens were not affected by the supplement of algal DHA oil for 2 weeks, suggesting that the expressions of these transcription factors are tightly controlled and not sensitive to DHA treatments in laying hens.

scholarly journals Dietary choline and phospholipid supplementation enhanced docosahexaenoic acid enrichment in egg yolk of laying hens fed a 2% Schizochytrium powder-added diet

2017 ◽  
Vol 96 (8) ◽  
pp. 2786-2794 ◽  
Author(s):  
H. Wang ◽  
H.J. Zhang ◽  
X.C. Wang ◽  
S.G. Wu ◽  
J. Wang ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
Laying Hens ◽  
Egg Yolk ◽  
Dietary Choline

scholarly journals Schizochytrium limacinum SR-21 as a source of docosahexaenoic acid: optimal growth and use as a dietary supplement for laying hens

2006 ◽  
Vol 57 (1) ◽  
pp. 13 ◽  
Author(s):  
H. J. Chin ◽  
T. F. Shen ◽  
H. P. Su ◽  
S. T. Ding
Keyword(s):  
Docosahexaenoic Acid ◽  
Dietary Supplement ◽  
Egg Production ◽  
Laying Hens ◽  
Optimal Growth ◽  
Egg Yolk ◽  
Culture Conditions ◽  
Marine Fungus ◽  
Lipogenic Genes ◽  
Schizochytrium Limacinum

Culture conditions for the marine fungus Schizochytrium limacinum SR-21 (SR-21) to produce microbial docosahexaenoic acid (DHA) were evaluated, and the practicality of using this fungus product as a dietary supplement for laying Leghorn hens was investigated. The data showed that the cultured fungus produced high biomass and DHA. It generated 584 mg DHA/L of culture at the end of a 6-day culture. The fungus grew better at 25ºC than at 20ºC or 30ºC. With an increase in glucose concentration from 1% to 5% in the culture medium, biomass and DHA production were enhanced. A 6% glucose treatment reduced the biomass production compared with 5% glucose. A bioreactor was used to mass-produce SR-21. The biomass was increased from 1.12 g/L at Day 0 to 12 g/L at Day 4. We established optimal culture conditions of 5% glucose, 2% sea salt, and 1% yeast extract for SR-21. Three concentrations of dried fungal meal (0, 1, or 3% in the diet) were fed to birds over a 3-week period. There were no negative effects of 1 and 3% dietary SR-21 on egg production, egg weight, and egg yolk weight. The DHA content of yolk was increased by the dietary supplementation with the fungal meal both in the 1 and 3% treatments. Dietary fungal meal treatments increased the DHA concentrations of liver and plasma. However, dietary DHA enrichment had no effect on the expression of hepatic lipogenic genes in laying hens.

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