My Sister Myself: A Controlled Study of the Relationship Between Women with a Lifetime Diagnosis of Anorexia Nervosa and Their Sisters

2016 ◽  
Vol 24 (6) ◽  
pp. 466-473 ◽  
Author(s):  
Ada H. Zohar ◽  
Lilac Lev Ari ◽  
Rachel Bachner-Melman
Keyword(s):  
Anorexia Nervosa ◽  
Controlled Study ◽  
Lifetime Diagnosis ◽  
The Relationship

A randomized, double-blind, placebo-controlled study of polyunsaturated fatty acids efficacy in adolescents with anorexia nervosa

2020 ◽  
Vol 36 (2) ◽  
pp. 95-106
Author(s):  
Agnieszka M. Piróg-Balcerzak ◽  
Anna K. Bażyńska ◽  
Katarzyna Biernacka ◽  
Joanna Brągoszewska ◽  
Lidia Popek ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Anorexia Nervosa ◽  
Polyunsaturated Fatty Acids ◽  
Small Sample Size ◽  
Small Sample ◽  
Female Adolescent ◽  
Eating Attitude ◽  
Controlled Study ◽  
Omega 3 ◽  
Eat 26

Objective. Omega–3 polyunsaturated fatty acids (PUFAs) were tested in adolescent depression and in several neurodevelopmental disorders with partial success. Anorexia nervosa (AN) is characterised by deficiencies in fatty food intake and frequent comorbidity, including depressive and cognitive symptoms. Thus supplementation with PUFAs may be beneficial in this group of patients. The aim of the study was to assess whether PUFAs as an add-on treatment is associated with better improvement of body mass index (BMI) and psychopathological symptoms than placebo in patients with AN. Method. 61 female adolescent inpatients with AN were randomly allocated to omega–3 PUFAs supplementation or placebo for 10 weeks. Patients also participated in the behavioural programme and eclectic psychotherapy (treatment as usual, TAU). At baseline and follow-up visits, patients’ BMI and psychopathology were assessed with Clinical Global Impression Scale (CGI), Patient Global Impression Scale (PGI), and Eating Attitude Test (EAT-26). Results. After 10 weeks, both groups showed improvement in all parameters. Improvement in CGI scores was observed greater in placebo vs. PUFA-s group (p = 0.015) while other differences were not statistically significant. Omega–3 PUFAs supplementation appears not to be effective as an add-on treatment in inpatient adolescent girls with anorexia nervosa. Conclusions. The results should be analysed with caution due to small sample size and heterogeneity in TAU. As the TAU turned out to be highly effective, additional therapeutic effect of PUFA might not be visible. Nevertheless, that does not explain the tendency for better improvement in the placebo group.

scholarly journals The relationship between craniofacial anatomy and obstructive sleep apnoea: a case-controlled study

2007 ◽  
Vol 16 (3) ◽  
pp. 319-326 ◽  
Author(s):  
AMA JOHAL ◽  
SHIVANI I. PATEL ◽  
JOANNA M. BATTAGEL
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Controlled Study ◽  
Obstructive Sleep ◽  
The Relationship

Are depression and denutrition good predictors of dexamethasone suppression test (DST) in anorexia nervosa?

1998 ◽  
Vol 13 (8) ◽  
pp. 411-418 ◽  
Author(s):  
C Massoubre ◽  
F Lang ◽  
L Millot ◽  
M Pichon ◽  
B Estour ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Stepwise Regression ◽  
Serum Cortisol ◽  
Dexamethasone Suppression Test ◽  
Stepwise Logistic Regression ◽  
Independent Variables ◽  
Suppression Test ◽  
Depression Scales ◽  
The Relationship ◽  
Dexamethasone Suppression

SummaryThis study was conducted to investigate the corticotropic axis in anorexia nervosa. In 93 female inpatients who met DSM-III-R criteria for anorexia nervosa, subsample (n = 64) with DSM-III criteria was also considered. Using stepwise regression analysis, this study examined the relationship between independent variables ie, age, body mass index, scores on depression scales and postdexamethasone serum cortisol, considered as a dependent variable. In patients who met DSM-III criteria, 16.7% of the variance of serum cortisol can be explained. The main predictors are depressive retardation, emaciation and age. Using stepwise logistic regression the main categorical predictors of the test suppression vs non suppression are of the same nature. The condition of realisation of DST are discussed.

scholarly journals Increased hypothalamic–pituitary–adrenal drive is associated with decreased appetite and hypoactivation of food-motivation neurocircuitry in anorexia nervosa

2013 ◽  
Vol 169 (5) ◽  
pp. 639-647 ◽  
Author(s):  
Elizabeth A Lawson ◽  
Laura M Holsen ◽  
Rebecca DeSanti ◽  
McKale Santin ◽  
Erinne Meenaghan ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Visual Processing ◽  
Serum Cortisol ◽  
Brain Regions ◽  
Cross Sectional Study ◽  
Food Motivation ◽  
Cross Sectional ◽  
Hypothalamic Pituitary Adrenal ◽  
Cortisol Levels ◽  
The Relationship

ObjectiveCorticotrophin-releasing hormone (CRH)-mediated hypercortisolemia has been demonstrated in anorexia nervosa (AN), a psychiatric disorder characterized by food restriction despite low body weight. While CRH is anorexigenic, downstream cortisol stimulates hunger. Using a food-related functional magnetic resonance imaging (fMRI) paradigm, we have demonstrated hypoactivation of brain regions involved in food motivation in women with AN, even after weight recovery. The relationship between hypothalamic–pituitary–adrenal (HPA) axis dysregulation and appetite and the association with food-motivation neurocircuitry hypoactivation are unknown in AN. We investigated the relationship between HPA activity, appetite, and food-motivation neurocircuitry hypoactivation in AN.DesignCross-sectional study of 36 women (13 AN, ten weight-recovered AN (ANWR), and 13 healthy controls (HC)).MethodsPeripheral cortisol and ACTH levels were measured in a fasting state and 30, 60, and 120 min after a standardized mixed meal. The visual analog scale was used to assess homeostatic and hedonic appetite. fMRI was performed during visual processing of food and non-food stimuli to measure the brain activation pre- and post-meal.ResultsIn each group, serum cortisol levels decreased following the meal. Mean fasting, 120 min post-meal, and nadir cortisol levels were high in AN vs HC. Mean postprandial ACTH levels were high in ANWR compared with HC and AN subjects. Cortisol levels were associated with lower fasting homeostatic and hedonic appetite, independent of BMI and depressive symptoms. Cortisol levels were also associated with between-group variance in activation in the food-motivation brain regions (e.g. hypothalamus, amygdala, hippocampus, orbitofrontal cortex, and insula).ConclusionsHPA activation may contribute to the maintenance of AN by the suppression of appetitive drive.

The relationship between premorbid body weight and weight at referral, at discharge and at 1-year follow-up in anorexia nervosa

2014 ◽  
Vol 24 (5) ◽  
pp. 537-544 ◽  
Author(s):  
Manuel Föcker ◽  
Katharina Bühren ◽  
Nina Timmesfeld ◽  
Astrid Dempfle ◽  
Susanne Knoll ◽  
...  
Keyword(s):  
Body Weight ◽  
Anorexia Nervosa ◽  
The Relationship

Redefining Beauty

Taking Flight ◽  
2020 ◽  
pp. 84-106
Author(s):  
Jennifer Donahue
Keyword(s):  
Breast Cancer ◽  
Body Image ◽  
Anorexia Nervosa ◽  
Side Effects ◽  
Temporary Migration ◽  
Elizabeth Nunez ◽  
Body Image Ideals ◽  
The Relationship

The fourth chapter turns to works by Pauline Melville and Elizabeth Nunez to explore how breast cancer and anorexia nervosa offer physical and emotional renewal for the protagonists. In The Migration of Ghosts, Boundaries, and Anna-In-Between, Melville and Nunez use their characters to question body-image ideals. The works attest to the life-altering impact of disease. The protagonists’ illnesses, rooted in their dis-ease with their bodies, their relationships, and their privilege, highlight the emotional side effects that can accompany physical maladies. In Melville and Nunez’s works, illness functions as the force of inertia that propels temporary migration and the protagonists’ intensely introspective experiences. Together, the texts afford a closer look at the relationship between disease, migration, and familial reconnection.

Pretreatment Predictors of Outcome in Anorexia Nervosa

1979 ◽  
Vol 134 (1) ◽  
pp. 71-78 ◽  
Author(s):  
Katherine A. Halmi ◽  
Solomon C. Goldberg ◽  
Regina C. Casper ◽  
Elke D. Eckert ◽  
John M. Davis
Keyword(s):  
Anorexia Nervosa ◽  
Weight Gain ◽  
Prognostic Indicators ◽  
Predictors Of Outcome ◽  
Outcome Predictor ◽  
Delivery Complications ◽  
The Poor ◽  
History Of ◽  
Relationship Of ◽  
The Relationship

SummaryThe relationship of selected pretreatment characteristics to weight gain during treatment was examined in 81 anorexia nervosa patients. Good prognostic indicators correlating positively with weight gain were: no previous hospitalizations for anorexia nervosa, a great amount of overactivity before treatment, less denial of illness, less psychosexual immaturity and the admission to feeling hunger. A perinatal history of delivery complications was associated with the poor outcome predictor of prior hospitalizations.

Males with anorexia nervosa: A controlled study of eating disorders in first-degree relatives

2001 ◽  
Vol 29 (3) ◽  
pp. 263-269 ◽  
Author(s):  
Michael Strober ◽  
Roberta Freeman ◽  
Carlyn Lampert ◽  
Jane Diamond ◽  
Walter Kaye
Keyword(s):  
Eating Disorders ◽  
Anorexia Nervosa ◽  
Controlled Study ◽  
First Degree Relatives
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