scholarly journals Investigating Protein–Protein Allosteric Network using Current‐Flow Scheme

2019 ◽  
Vol 41 (6) ◽  
pp. 552-560 ◽  
Author(s):  
Wesley M. Botello‐Smith ◽  
Yun Luo
Keyword(s):  
Current Flow ◽  
Flow Scheme

scholarly journals Using Current-Flow Scheme to Capture the Protein-Protein Binding Allostericity

2018 ◽  
Vol 114 (3) ◽  
pp. 420a
Author(s):  
Yun Luo ◽  
Wesley M. Botello-Smith
Keyword(s):  
Protein Binding ◽  
Current Flow ◽  
Flow Scheme

scholarly journals Investigating Protein-Protein Allosteric Network using Current-Flow Scheme

2018 ◽  
Author(s):  
Wesley M. Botello-Smith ◽  
Yun Luo
Keyword(s):  
Network Analysis ◽  
Current Flow ◽  
Signal Transmission ◽  
Dynamic Network ◽  
Contact Network ◽  
Smoothing Function ◽  
Inhibitory Protein ◽  
Atp Binding Site ◽  
Flow Scheme ◽  
Binding Interface

AbstractProtein dynamic network analysis provides a powerful tool for investigating protein allosteric regulation. We recently developed a current-flow betweenness scheme for protein network analysis and demonstrated that this method, i.e. using current-flow betweenness as edge weights, is more appropriate and more robust for investigating the signal transmission between two predefined protein residues or domains as compared with direct usage of correlation scores as edge weights. Here we seek to expand the current-flow scheme to study allosteric regulations involving protein-protein binding. Specifically, we investigated three gain-of-function mutations located at the binding interface of ALK2 (also known as ACVR1) kinase and its inhibitory protein FKBP12. We first searched for the optimal smoothing function for contact network construction and then calculated the subnetwork between FKBP12 protein and ALK2 ATP binding site using current-flow betweenness. By comparing the networks between the wild-type and three mutants, we have identified statistically significant changes in the protein-protein networks that are common among all three mutants that allosterically shift the kinase towards a catalytically competent configuration.

Proposal of a Flow scheme for the Chemical-form-based Quantitative analysis of Chlorine compounds in Pulp for Sanitary products and Safety assessment

2018 ◽  
Vol 72 (11) ◽  
pp. 1243-1250
Author(s):  
Shigeo Imai ◽  
Mitsuhiro Wada ◽  
Takeharu Wada ◽  
Kei Iwasaki ◽  
Ritsuko Katagiri ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Safety Assessment ◽  
Chemical Form ◽  
Flow Scheme ◽  
Sanitary Products

Fin Level Defect Isolation Inside a FinFET Using Electron Beam Alteration of Current Flow

2017 ◽  
Author(s):  
H.J. Ryu ◽  
A.B. Shah ◽  
Y. Wang ◽  
W.-H. Chuang ◽  
T. Tong
Keyword(s):  
Electron Microscopy ◽  
Electron Beam ◽  
Focused Ion Beam ◽  
Current Flow ◽  
Ion Beam ◽  
The Body ◽  
Complete Understanding ◽  
Root Cause ◽  
Transmission Electron ◽  
Defect Isolation

Abstract When failure analysis is performed on a circuit composed of FinFETs, the degree of defect isolation, in some cases, requires isolation to the fin level inside the problematic FinFET for complete understanding of root cause. This work shows successful application of electron beam alteration of current flow combined with nanoprobing for precise isolation of a defect down to fin level. To understand the mechanism of the leakage, transmission electron microscopy (TEM) slice was made along the leaky drain contact (perpendicular to fin direction) by focused ion beam thinning and lift-out. TEM image shows contact and fin. Stacking fault was found in the body of the silicon fin highlighted by the technique described in this paper.

Study of MFM Application in Semiconductor Failure Analysis

2004 ◽  
Author(s):  
Way-Jam Chen ◽  
Lily Shiau ◽  
Ming-Ching Huang ◽  
Chia-Hsing Chao
Keyword(s):  
Magnetic Field ◽  
Failure Analysis ◽  
Magnetic Force Microscopy ◽  
Magnetic Force ◽  
Current Flow ◽  
Force Microscopy ◽  
The Magnetic Field ◽  
A Current

Abstract In this study we have investigated the magnetic field associated with a current flowing in a circuit using Magnetic Force Microscopy (MFM). The technique is able to identify the magnetic field associated with a current flow and has potential for failure analysis.

All-Contactless Measurement of Series Resistance Distributions on Solar Cells with Photoluminescence Imaging

2011 ◽  
Author(s):  
M. Kasemann ◽  
L.M. Reindl ◽  
B. Michl ◽  
W. Warta ◽  
A. Schütt ◽  
...  
Keyword(s):  
Solar Cells ◽  
Solar Cell ◽  
Current Flow ◽  
Series Resistance ◽  
Electrical Contacts ◽  
New Method ◽  
Contactless Measurement ◽  
Sample Handling ◽  
Imaging Methods ◽  
Lateral Current

Abstract Conventional series resistance imaging methods require electrical contacts for current injection or extraction in order to generate lateral current flow in the solar cell. This paper presents a new method to generate lateral current flow in the solar cell without any electrical contacts. This reduces the sample handling complexity for inline application and allows for measurements on unfinished solar cell precursors.

THE EFFECT OF OXYGEN ADSORPTION ON THE CONDUCTIVITY OF PBTE FILMS.

2020 ◽  
Vol 6 (8(77)) ◽  
pp. 21-23
Author(s):  
S.N. Sarmasov ◽  
R.Sh. Rahimov ◽  
T.Sh. Abdullayev
Keyword(s):  
Spectral Region ◽  
Current Flow ◽  
Oxygen Adsorption ◽  
Tunneling Mechanism ◽  
Pn Junction ◽  
Flow Through ◽  
Pn Junctions ◽  
Effect Of Oxygen

The effect of oxygen adsorption on the conductivity of PbTe films is studied. Pn junctions based on PbTe films are photosensitive in the IR spectral region with a maximum photosensitivity of 𝜆𝑚𝑎𝑥 microns. The tunneling mechanism of current flow through the pn junction is shown.

Water Temperature Control Using PID Control System Based on LabVIEW

2016 ◽  
Vol 4 (2) ◽  
pp. 35-46
Author(s):  
Ari Ramadhani
Keyword(s):  
Water Temperature ◽  
Pid Control ◽  
Temperature Sensor ◽  
Pid Controller ◽  
Current Flow ◽  
Electrical Energy ◽  
Heating Process ◽  
Water Heater ◽  
Digital Thermometer ◽  
Flow Through

Abstract - Automatic system have grown widespread across all sector so do water heater. Traditionally, heating water is done by utilizing fire as heat source. As the growing of technology, the heating process could be done by manipulating electrical energy by convert it to heat. Electrical energy is flown to a metal rod that contact directly with the water which increase the water temperature. On some case, appropiate water temperature is needed. Altough, a thermometer is needed to read the actual temperature as a feedback value for the system and a system that can control the electricity current flow through the heater that the heat produced is linear to the current flow. With implementing microcontroller as a process node for generating PWM signal, this problem can be solved. Also, Labview is needed as an interface for monitoring and bursting an output which have been processed by Proportional, Integral, and Devivative (PID) controller to producing accurate and stable heat. Based on the results of testing, the system is able to provide a rapid response to any changes that occur, both changes in set-point and changes in water temperature (actual value). Another test is done by comparing the temperature value detected by the temperature sensor in this device with an external digital thermometer placed in the same place, and from some of the tests the temperature value detected by the temperature sensor in this device has a difference of ± 0.19 ℃ with a digital thermometer. Keyword : Water Heater, Thermometer, Microcontroller, LabView, PID.

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