Concurrent environmental enrichment and chronic restraint stress: Effects on innate anxiety and depressive‐like behavior in male adolescent mice

2020 ◽  
Vol 80 (8) ◽  
pp. 730-736
Author(s):  
Yu Mao ◽  
Yanmei Chen ◽  
Xiaomi Yang ◽  
Jianhong Wang ◽  
Longjiao Ge ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Environmental Enrichment ◽  
Chronic Restraint Stress ◽  
Male Adolescent ◽  
Stress Effects ◽  
Innate Anxiety

scholarly journals Mustard Leaf Extract Suppresses Psychological Stress in Chronic Restraint Stress-Subjected Mice by Regulation of Stress Hormone, Neurotransmitters, and Apoptosis

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3640
Author(s):  
Kyung-A. Hwang ◽  
Hye-Jeong Hwang ◽  
Yu Jin Hwang ◽  
Young Jun Kim
Keyword(s):  
Restraint Stress ◽  
Leaf Extract ◽  
Caspase 3 ◽  
Chronic Restraint Stress ◽  
Stress Hormone ◽  
Induce Stress ◽  
Bdnf Expression ◽  
Stress Effects ◽  
Cytokine Levels ◽  
The Brain

Mustard leaf (Brassica juncea var. crispifolia L. H. Bailey) has been reported to have psychological properties such as anti-depressant activities. However, studies on chronic stress and depression caused by restraint have not been conducted. Therefore, this study aimed to evaluate the effects of a mustard leaf (ML) extract on chronic restraint stress (CRS) in mice. Male mice were subjected to a CRS protocol for a period of four weeks to induce stress. The results showed that the ML extract (100 and 500 mg/kg/perorally administered for four weeks) significantly decreased corticosterone levels and increased neurotransmitters levels in stressed mice. Apoptosis by CRS exposure was induced by Bcl-2 and Bax expression regulation and was suppressed by reducing caspase-3 and poly (ADP-ribose) polymerase expression after treatment with the ML extract. Our results confirmed that apoptosis was regulated by increased expression of brain-derived neurotrophic factor (BDNF). Additionally, cytokine levels were regulated by the ML extract. In conclusion, our results showed that the ML extract relieved stress effects by regulating hormones and neurotransmitters in CRS mice, BDNF expression, and apoptosis in the brain. Thus, it can be suggested that the studied ML extract is an agonist that can help relieve stress and depression.

Environmental enrichment and chronic restraint stress in ICR mice: Effects on prepulse inhibition of startle and Y-maze spatial recognition memory

2010 ◽  
Vol 212 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Yanmei Chen ◽  
Yu Mao ◽  
Dongming Zhou ◽  
Xintian Hu ◽  
Jianhong Wang ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Prepulse Inhibition ◽  
Restraint Stress ◽  
Environmental Enrichment ◽  
Chronic Restraint Stress ◽  
Icr Mice ◽  
Y Maze ◽  
Spatial Recognition

scholarly journals Chronic restraint stress impairs cognition via modulating HDAC2 expression

2021 ◽  
Vol 12 (1) ◽  
pp. 154-163
Author(s):  
Jie Wu ◽  
Cui Liu ◽  
Ling Zhang ◽  
Bing He ◽  
Wei-Ping Shi ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Hippocampal Neurons ◽  
Restraint Stress ◽  
Glucocorticoid Receptors ◽  
Chronic Restraint Stress ◽  
Akt Signaling Pathway ◽  
Object Recognition Test ◽  
Protein Levels ◽  
Synaptic Functions ◽  
Plus Maze

Abstract Background To investigate the effects of chronic restraint stress on cognition and the probable molecular mechanism in mice. Methods In the current work, a restraining tube was used as a way to induce chronic stress in mice. The protein levels were determined with ELISA and western blot. A series of behavior tests, including the Morris water maze, elevated plus maze, open field test, and novel object recognition test, were also performed to examine the anxiety and the ability of learning and memory. Moreover, murine neuroblastoma N2a cells were used to confirm the findings from mice under chronic stress. Results Decreased synaptic functions were impaired in chronic stress with the downregulation of PSD95, GluR-1, the neurotrophic factor BDNF, and immediate-onset genes Arc and Egr. Chronic restraint decreased the histone acetylation level in hippocampal neurons while HDAC2 was increased and was co-localized with glucocorticoid receptors. Moreover, chronic stress inhibited the PI3K/AKT signaling pathway and induced energy metabolism dysfunctions. Conclusion This work examining the elevated levels of HDAC2 in the hippocampus may provide new insights and targets for drug development for treating many neurodegenerative diseases.

Spleen tissue changes after restraint stress: effects of aerobic exercise training

Stress ◽  
2021 ◽  
pp. 1-12
Author(s):  
Daniele J. Feriani ◽  
Andressa S. Sousa ◽  
Maria Andreia Delbin ◽  
Olívia M. Ruberti ◽  
Carlos C. Crestani ◽  
...  
Keyword(s):  
Exercise Training ◽  
Aerobic Exercise ◽  
Restraint Stress ◽  
Aerobic Exercise Training ◽  
Spleen Tissue ◽  
Stress Effects ◽  
Tissue Changes

Ginsenoside Re protects against chronic restraint stress‐induced cognitive deficits through regulation of NLRP3 and Nrf2 pathways in mice

2021 ◽  
Author(s):  
Haixia Wang ◽  
Jingwei Lv ◽  
Ning Jiang ◽  
Hong Huang ◽  
Qiong Wang ◽  
...  
Keyword(s):  
Cognitive Deficits ◽  
Restraint Stress ◽  
Chronic Restraint Stress ◽  
Ginsenoside Re

Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress

2020 ◽  
Vol 18 (11) ◽  
pp. 872-880
Author(s):  
Ying-Li ZHU ◽  
Lin-Yuan WANG ◽  
Dan-Ping ZHAO ◽  
Cheng-Long WANG ◽  
Rui ZHANG ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Restraint Stress ◽  
Chronic Restraint Stress ◽  
No Signaling
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