The inhibition of enterovirus 71 induced apoptosis by Durvillaea antarctica through P53 and STAT1 signaling pathway

2020 ◽  
Author(s):  
Tiantian Xu ◽  
Yinghua Li ◽  
Hua‐lian Wu ◽  
Haiyang Chen ◽  
Houbo Wu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Enterovirus 71 ◽  
Durvillaea Antarctica ◽  
Stat1 Signaling ◽  
Induced Apoptosis

scholarly journals Gambogic acid protects LPS-induced apoptosis and inflammation in a cell model of neonatal pneumonia through the regulation of TrkA/Akt signaling pathway

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Xu Gao ◽  
Jingya Dai ◽  
Guifang Li ◽  
Xinya Dai
Keyword(s):  
Western Blot ◽  
Signaling Pathway ◽  
Cell Model ◽  
Akt Signaling ◽  
Gambogic Acid ◽  
Akt Signaling Pathway ◽  
Western Blot Assay ◽  
A Cell ◽  
Induced Apoptosis ◽  
Apoptosis And Inflammation

Abstract Objective In this work, we investigated the effects of gambogic acid (GA) on lipopolysaccharide (LPS)-induced apoptosis and inflammation in a cell model of neonatal pneumonia. Method Human WI-38 cells were maintained in vitro and incubated with various concentrations of GA to examine WI-38 survival. GA-preincubated WI-38 cells were then treated with LPS to investigate the protective effects of GA on LPS-induced death, apoptosis and inflammation. Western blot assay was utilized to analyze the effect of GA on tropomyosin receptor kinase A (TrkA) signaling pathway in LPS-treated WI-38 cells. In addition, human AKT serine/threonine kinase 1 (Akt) gene was knocked down in WI-38 cells to further investigate the associated genetic mechanisms of GA in protecting LPS-induced inflammation and apoptosis. Results Pre-incubating WI-38 cells with low and medium concentrations GA protected LPS-induced cell death, apoptosis and inflammatory protein productions of IL-6 and MCP-1. Using western blot assay, it was demonstrated that GA promoted TrkA phosphorylation and Akt activation in LPS-treated WI-38 cells. Knocking down Akt gene in WI-38 cells showed that GA-associated protections against LPS-induced apoptosis and inflammation were significantly reduced. Conclusions GA protected LPS-induced apoptosis and inflammation, possibly through the activations of TrkA and Akt signaling pathway. This work may broaden our understanding on the molecular mechanisms of human neonatal pneumonia.

scholarly journals Role of NF-κB signaling pathway in increased tumor necrosis factor-α-induced apoptosis of lymphocytes in aged humans

2005 ◽  
Vol 12 (2) ◽  
pp. 177-183 ◽  
Author(s):  
S Gupta ◽  
R Bi ◽  
C Kim ◽  
S Chiplunkar ◽  
L Yel ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Signaling Pathway ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Induced Apoptosis ◽  
Factor Α ◽  
Necrosis Factor

Signaling pathway for radiation-induced apoptosis in the lymphoblasts from neuronopathic (type A) and non-neuronopathic (type B) forms of Niemann–Pick disease

2002 ◽  
Vol 199 (1-2) ◽  
pp. 39-43 ◽  
Author(s):  
Tamaki Mikami ◽  
Tsutomu Takahashi ◽  
Akira Ishida ◽  
Yoshihiro Minamiya ◽  
Hiroyuki Ida ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Type A ◽  
Type B ◽  
Niemann Pick Disease ◽  
Radiation Induced ◽  
Niemann Pick ◽  
Induced Apoptosis ◽  
Pick Disease

Ghrelin protects human umbilical vein endothelial cells against high glucose-induced apoptosis via mTOR/P70S6K signaling pathway

Peptides ◽  
2014 ◽  
Vol 52 ◽  
pp. 23-28 ◽  
Author(s):  
Jianhua Zhu ◽  
Chenghong Zheng ◽  
Jie Chen ◽  
Jing Luo ◽  
Bintao Su ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Signaling Pathway ◽  
High Glucose ◽  
Umbilical Vein ◽  
Human Umbilical Vein ◽  
Induced Apoptosis ◽  
Umbilical Vein Endothelial Cells

scholarly journals Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Yan-Fang Xian ◽  
Zhi-Xiu Lin ◽  
Qing-Qiu Mao ◽  
Jian-Nan Chen ◽  
Zi-Ren Su ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Pc12 Cells ◽  
Molecular Mechanisms ◽  
Glycogen Synthase ◽  
Neuroprotective Effect ◽  
Protective Action ◽  
Protective Effects ◽  
Phosphorylated Akt ◽  
Induced Apoptosis

The neurotoxicity of amyloid-β(Aβ) has been implicated as a critical cause of Alzheimer’s disease. Isorhynchophylline (IRN), an oxindole alkaloid isolated fromUncaria rhynchophylla,exerts neuroprotective effect againstAβ25–35-induced neurotoxicityin vitro. However, the exact mechanism for its neuroprotective effect is not well understood. The present study aimed to investigate the molecular mechanisms underlying the protective action of IRN againstAβ25–35-induced neurotoxicity in cultured rat pheochromocytoma (PC12) cells. Pretreatment with IRN significantly increased the cell viability, inhibited the release of lactate dehydrogenase and the extent of DNA fragmentation inAβ25–35-treated cells. IRN treatment was able to enhance the protein levels of phosphorylated Akt (p-Akt) and glycogen synthase kinase-3β(p-GSK-3β). Lithium chloride blockedAβ25–35-induced cellular apoptosis in a similar manner as IRN, suggesting that GSK-3βinhibition was involved in neuroprotective action of IRN. Pretreatment with LY294002 completely abolished the protective effects of IRN. Furthermore, IRN reversedAβ25–35-induced attenuation in the level of phosphorylated cyclic AMP response element binding protein (p-CREB) and the effect of IRN could be blocked by the PI3K inhibitor. These experimental findings unambiguously suggested that the protective effect of IRN againstAβ25–35-induced apoptosis in PC12 cells was associated with the enhancement of p-CREB expression via PI3K/Akt/GSK-3βsignaling pathway.

scholarly journals Activation of the c-Jun N-terminal Kinase (JNK) Signaling Pathway Is Essential during PBOX-6-induced Apoptosis in Chronic Myelogenous Leukemia (CML) Cells

2002 ◽  
Vol 277 (21) ◽  
pp. 18383-18389 ◽  
Author(s):  
Margaret M. Mc Gee ◽  
Giuseppe Campiani ◽  
Anna Ramunno ◽  
Vito Nacci ◽  
Mark Lawler ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Chronic Myelogenous Leukemia ◽  
Myelogenous Leukemia ◽  
Jnk Signaling ◽  
Jnk Signaling Pathway ◽  
Induced Apoptosis

scholarly journals Blue light-induced apoptosis of human promyelocytic leukemia cells via the mitochondrial-mediated signaling pathway

2018 ◽  
Author(s):  
Jianjian Zhuang ◽  
Yange Liu ◽  
Qingxia Yuan ◽  
Junsong Liu ◽  
Yan Liu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Blue Light ◽  
Promyelocytic Leukemia ◽  
Leukemia Cells ◽  
Induced Apoptosis

Betulinic acid protects the neuronal damage in new born rats from isoflurane-induced apoptosis in the developing brain by blocking FASL-FAS signaling pathway

2017 ◽  
Vol 95 ◽  
pp. 1631-1635 ◽  
Author(s):  
Dongwei Wang ◽  
Ping Chen ◽  
Lei Chen ◽  
Fanrong Zeng ◽  
Rongjia Zang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Betulinic Acid ◽  
Neuronal Damage ◽  
Developing Brain ◽  
New Born ◽  
Fas Signaling ◽  
Induced Apoptosis
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