Reliability and Agreement of Ultrasonographic Measures of the Ovarian Stroma

2021 ◽  
Author(s):  
Heidi Vanden Brink ◽  
Avigdor Nosrati ◽  
Andrés E. Ortiz‐Flores ◽  
Ashley Tam ◽  
Brittany Y. Jarrett ◽  
...  
Keyword(s):  
Ovarian Stroma

scholarly journals CENTROSOME AND SPHERE IN CELLS OF THE OVARIAN STROMA OF MAMMALS

1897 ◽  
Vol 1 (2) ◽  
pp. 87-94
Author(s):  
C. M. CHILD
Keyword(s):  
Ovarian Stroma ◽  
In Cells

Mixed Epithelial and Stromal Tumors of the Kidney: An Overview

2009 ◽  
Vol 133 (9) ◽  
pp. 1483-1486 ◽  
Author(s):  
Sambit K. Mohanty ◽  
Anil V. Parwani
Keyword(s):  
Progesterone Receptor ◽  
Growth Pattern ◽  
Current Knowledge ◽  
Cystic Mass ◽  
Stromal Tumor ◽  
Renal Neoplasms ◽  
Imaging Studies ◽  
Stromal Tumors ◽  
Ovarian Stroma ◽  
Estrogen And Progesterone Receptor

Abstract Mixed epithelial and stromal tumor of the kidney is a recently recognized distinct neoplasm that should be distinguished from other renal neoplasms. These tumors are relatively rare with a female preponderance. Imaging studies are not diagnostic but reveal a solid or solid and cystic mass in most cases. Histopathologically, these tumors reveal biphasic growth pattern comprising mesenchymal and epithelial elements with characteristic estrogen and progesterone receptor immunoreactive mesenchyme reminiscent of ovarian stroma. Malignant transformation, recurrence, and metastasis are rare; however, recently a few cases of malignant mixed epithelial and stromal tumors have been reported in the literature. Recently a case with translocation t(1;19) has been described. This article provides a brief overview of the current knowledge of mixed epithelial and stromal tumor of the kidney.

Expression of CD56 and WT1 in Ovarian Stroma and Ovarian Stromal Tumors

2008 ◽  
Vol 32 (6) ◽  
pp. 884-890 ◽  
Author(s):  
Huiying He ◽  
Daniel J. Luthringer ◽  
Pei Hui ◽  
Sean K. Lau ◽  
Lawrence M. Weiss ◽  
...  
Keyword(s):  
Stromal Tumors ◽  
Ovarian Stroma

Biliary cystadenoma and cystadenocarcinoma: clinical-imaging-pathologic correlations with emphasis on the importance of ovarian stroma.

Radiology ◽  
1995 ◽  
Vol 196 (3) ◽  
pp. 805-810 ◽  
Author(s):  
P C Buetow ◽  
J L Buck ◽  
L Pantongrag-Brown ◽  
P R Ros ◽  
K Devaney ◽  
...  
Keyword(s):  
Biliary Cystadenoma ◽  
Clinical Imaging ◽  
Ovarian Stroma

scholarly journals Loss of PTEN in Fallopian Tube Epithelium Results in Multicellular Tumor Spheroid Formation and Metastasis to the Ovary

Cancers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 884 ◽  
Author(s):  
Matthew Dean ◽  
Vivian Jin ◽  
Tova M. Bergsten ◽  
Julia R. Austin ◽  
Daniel D. Lantvit ◽  
...  
Keyword(s):  
Fallopian Tube ◽  
Single Gene ◽  
Similar Rate ◽  
Genetic Alterations ◽  
Wild Type ◽  
Spheroid Formation ◽  
Multicellular Tumor Spheroid ◽  
Ovarian Stroma

High-grade serous ovarian cancer (HGSOC) can originate in the fallopian tube and then spread to the ovary. Our objective was to evaluate the role of multicellular tumor spheroids (MTS) in ovarian metastasis. By testing a panel of murine oviductal epithelial (MOE) cells with genetic alterations mimicking those seen in HGSOC, we found that loss of PTEN allowed MTS formation under ultra-low adhesion conditions. Confirming these results in vivo, MTS-like structures were observed in the oviducts of PAX8Cre/+ PTENflox/flox mice. MOE PTENshRNA cells could incorporate up to 25% wild type cells into MTS, while higher percentages of wild type cells resulted in a loss of MTS formation. MTS formation allowed MOE PTENshRNA cells to survive better under ultra-low adhesion conditions than control cells. MTS also attached to the ovarian stroma, as would be exposed during ovulation. Interestingly, MTS more robustly cleared monolayers of murine ovarian surface epithelia than murine ovarian fibroblasts. When xenografted into the ovarian bursa, OVCAR8 MTS were able to form tumors in the ovary at a similar rate as an equal number of OVCAR8 cells grown on traditional cell culture plastic. In conclusion, loss of a single gene (PTEN) allows the fallopian tube epithelia to form MTS, which survive better under ultra-low adhesion conditions, attach to the extracellular matrix exposed during ovulation, and colonize the ovary. These results suggest that MTS may contribute to seeding of the ovary in HGSOC patients.

Stromal Hyperplasia in Women with Mammary Cancer

1966 ◽  
Vol 52 (3) ◽  
pp. 187-199
Author(s):  
Vinicio Carmelo Catania ◽  
Francesco Di Re ◽  
Annamaria Giarrusso
Keyword(s):  
Comparative Evaluation ◽  
Mammary Cancer ◽  
Quantitative Relation ◽  
Control Group ◽  
Functional Aspect ◽  
Control Groups ◽  
Cancer Disease ◽  
Testosterone Treatment ◽  
Ovarian Stroma ◽  
Menopausal Women

The frequency and extent of stromal hyperplasia were studied in 103 menopausal women with mammary cancer submitted to oophorectomy. Results were compared to those obtained in a control group of 57 menopausal women who had undergone oophorectomy for non-cancer disease. Hyperplasia of the ovarian cortical stroma was classified as scanty, moderate, and significant. The comparative evaluation of the two groups did not show appreciable differences. Testosterone treatment at the conventional therapeutical doses was not found to induce significant variations at the level of the ovarian stroma. In order to evidence a possible relation between hyperplasia of the ovarian cortical stroma and estrogenic function of the ovary, the dosage of urinary phenolsteroids and the colpo-cytologic findings in mammary cancer women were considered. No quantitative relation was observed between hyperplasia and estrogenic function of the ovary. Hyperplasia of the ovarian cortical stroma is not considered to be a particular functional aspect of the ovary and, on the basis of the results obtained, does not seem to be more frequent in mammary cancer women as compared to control groups.

Morphology of the barren-ground caribou ovary

1978 ◽  
Vol 56 (8) ◽  
pp. 1684-1696 ◽  
Author(s):  
T. Charles Dauphiné Jr.
Keyword(s):  
Connective Tissue ◽  
Rangifer Tarandus ◽  
Corpora Lutea ◽  
Seasonal Incidence ◽  
Histological Techniques ◽  
Northern Canada ◽  
Ovary Weight ◽  
Barren Ground ◽  
Ovarian Stroma ◽  
Rangifer Tarandus Groenlandicus

Reproductive tracts were collected from 532 female caribou (Rangifer tarandus groenlandicus) in northern Canada over a [Formula: see text]-year period. Ovaries were weighed and scrutinized by gross and histological techniques. Ovaries of nulliparous and nongravid, parous cows responded to follicular fluctuations by increasing in weight in summer and declining in winter. Weights of ovaries from calves, yearlings, and 2 year olds overlapped extensively. Formation of corpora lutea of pregnancy more than doubled ovary weight. During gestation ovary weight declined and then partially recovered; it increased with age in pregnant cows. The number and size of follicles [Formula: see text] diameter increased with age until puberty, reaching greatest development just before the autumn rut. After puberty the seasonal incidence of such follicles remained stable except during gestation, when it declined. Corpora lutea of pregnancy regressed to form apparently permanent scars composed of vascular and connective tissue remnants. Secondary corpora lutea developed in 35% of the cows at or before conception and upon regression produced scars which were not permanent. Regressing corpora lutea of estrus also disappeared into the ovarian stroma, apparently within 1 year. In individual cows one ovary, selected at random, dominated in the production of ova and corpora lutea.

Histoarchitecture and Δ5-3β hydroxysteroid dehydrogenase profile in ovaries of the non-pregnant, pregnant and lactating insectivorous rat-tailed bat, Rhinopoma microphyllum kinneari

2007 ◽  
Vol 57 (1) ◽  
pp. 97-114 ◽  
Author(s):  
Seema Trivedi ◽  
Suresh Bihari Lall
Keyword(s):  
Enzyme Activity ◽  
Annual Cycle ◽  
Steroid Hormone ◽  
Post Partum ◽  
Hydroxysteroid Dehydrogenase ◽  
Follicular Atresia ◽  
Ovarian Stroma ◽  
Thecal Cells ◽  
Hormone Biosynthesis ◽  
Seasonally Breeding

AbstractThe histoarchitecture and profile of Δ5-3β hydroxysteroid dehydrogenase were studied in an insectivorous seasonally-breeding microchiropteran, Rhinopoma microphyllum kinneari (rattailed bat) ovaries during non-pregnant, pregnant and lactation phases. Mid-sections of follicles and ova showed variation in their diameter (0.013-0.182 mm and 0.010-0.075 mm, respectively). Though dextral and sinistral ovaries are functionally equivalent, ovulation occurs only once (alternately from one ovary) in each annual cycle. An extroverted corpus luteum (0.792 mm) was observed in either the dextral or sinistral ovary of a pregnant R. m. kinneari. This exhibited two types of cells. Follicular atresia was pronounced in ovaries during these reproductive stages. No post-partum 'heat' was discerned. Δ5-3β HSDH is a crucial catalyst in steroid hormone biosynthesis and the reaction product indicates status of steroidogenesis in different follicle types. Differential Δ5-3β HSDH activity evident from reaction product staining in three reproductive states and in different ovarian components was seen. Consistent sites of enzyme activity were thecal cells and ovarian stroma. However, intensity varied in different reproductive states.

scholarly journals A Preliminary Study on the Characteristics of microRNAs in Ovarian Stroma and Follicles of Chuanzhong Black Goat during Estrus

Genes ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 970
Author(s):  
Tingting Lu ◽  
Xian Zou ◽  
Guangbin Liu ◽  
Ming Deng ◽  
Baoli Sun ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Mirna Expression ◽  
Expression Profiles ◽  
Expression Patterns ◽  
Hormone Secretion ◽  
Mapk Signaling ◽  
Functional Enrichment ◽  
Small Rna Sequencing ◽  
Follicular Maturation ◽  
Ovarian Stroma

microRNAs (miRNAs) play a significant role in ovarian follicular maturity, but miRNA expression patterns in ovarian stroma (OS), large follicles (LF), and small follicles (SF) have been rarely explored. We herein aimed to identify miRNAs, their target genes and signaling pathways, as well as their interaction networks in OS, LF, and SF of Chuanzhong black goats at the estrus phase using small RNA-sequencing. We found that the miRNA expression profiles of LF and SF were more similar than those of OS—32, 16, and 29 differentially expressed miRNAs were identified in OS vs. LF, OS vs. SF, and LF vs. SF, respectively. Analyses of functional enrichment and the miRNA-targeted gene interaction network suggested that miR-182 (SMC3), miR-122 (SGO1), and miR-206 (AURKA) were involved in ovarian organogenesis and hormone secretion by oocyte meiosis. Furthermore, miR-202-5p (EREG) and miR-485-3p (FLT3) were involved in follicular maturation through the MAPK signaling pathway, and miR-2404 (BMP7 and CDKN1C) played a key role in follicular development through the TGF-β signaling pathway and cell cycle; nevertheless, further research is warranted. To our knowledge, this is the first study to investigate miRNA expression patterns in OS, LF, and SF of Chuanzhong black goats during estrus. Our findings provide a theoretical basis to elucidate the role of miRNAs in follicular maturation. These key miRNAs might provide candidate biomarkers for the diagnosis of follicular maturation and will assist in developing new therapeutic targets for female goat infertility.

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