Interaction of maternal asthma history and plasma folate levels on child asthma risk in the Boston Birth Cohort

2021 ◽  
Author(s):  
You Wang ◽  
Xiumei Hong ◽  
Tsung‐Chieh Yao ◽  
Hui‐Ju Tsai ◽  
Xiaobin Wang
Keyword(s):  
Birth Cohort ◽  
Plasma Folate ◽  
Asthma Risk ◽  
Child Asthma

scholarly journals Maternal intake of vitamins A, E and K in pregnancy and child allergic disease: a longitudinal study from the Danish National Birth Cohort

2013 ◽  
Vol 111 (6) ◽  
pp. 1096-1108 ◽  
Author(s):  
Ekaterina Maslova ◽  
Susanne Hansen ◽  
Marin Strøm ◽  
Thorhallur I. Halldorsson ◽  
Sjurdur F. Olsen
Keyword(s):  
Allergic Rhinitis ◽  
Vitamin A ◽  
Birth Cohort ◽  
Allergic Disease ◽  
Vitamin K ◽  
Current Asthma ◽  
Maternal Vitamin ◽  
Danish National Birth Cohort ◽  
Child Asthma ◽  
Fat Soluble Vitamins

Fat-soluble vitamins A, E and K have been shown to play roles in immunity and inflammation, but studies on child allergic disease have been few and inconsistent. The aim of the present study was to examine the relationship between maternal intake of vitamins A, E and K in mid-pregnancy and child asthma and allergic rhinitis. We used data on 44 594 mother–child pairs from the Danish National Birth Cohort. Maternal intake of fat-soluble vitamins was calculated based on the information from a validated FFQ completed in mid-pregnancy. At 18 months, interviews with the mothers were conducted to evaluate doctor-diagnosed child asthma. At age 7 years, we assessed child asthma and allergic rhinitis using questions from the International Study of Asthma and Allergies in Childhood questionnaire and by national registries on hospital contacts and medication use. Current asthma was defined as asthma diagnosis and wheeze in the past 12 months by maternal report. We calculated multivariable risk ratios and 95 % CI by comparing the highestv. lowest quintile (Q) of maternal vitamin A, E and K intake in relation to child allergic disease outcomes. Maternal total vitamin K intake was directly associated with ever admitted asthma (Q5v. Q1: 1·23, 95 % CI 1·01, 1·50) and current asthma at 7 years (Q5v. Q1: 1·30, 95 % CI 0·99, 1·70). Weak inverse associations were present for maternal vitamin A and E intake during pregnancy with child allergic rhinitis. Maternal vitamin K intake during pregnancy may increase the risk of child asthma, and should be explored further on a mechanistic level. Conversely, maternal vitamin A and E intake may protect against child allergic rhinitis.

Early environmental determinants of asthma risk in a high-risk birth cohort

2008 ◽  
Vol 19 (6) ◽  
pp. 482-489 ◽  
Author(s):  
Moira Chan-Yeung ◽  
Richard G. Hegele ◽  
Helen Dimich-Ward ◽  
Alexander Ferguson ◽  
Michael Schulzer ◽  
...  
Keyword(s):  
High Risk ◽  
Birth Cohort ◽  
Environmental Determinants ◽  
Asthma Risk

scholarly journals Maternal postpartum plasma folate status and preterm birth in a high-risk US population

2018 ◽  
pp. 1-11 ◽  
Author(s):  
Bolanle Olapeju ◽  
Ahmed Saifuddin ◽  
Guoying Wang ◽  
Yuelong Ji ◽  
Xiumei Hong ◽  
...  
Keyword(s):  
Folic Acid ◽  
Preterm Birth ◽  
High Risk ◽  
Birth Cohort ◽  
Folic Acid Fortification ◽  
Folate Status ◽  
Plasma Folate ◽  
Multivitamin Supplement ◽  
The Relationship ◽  
Supplement Intake

AbstractObjectiveWhile maternal folate deficiency has been linked to poor pregnancy outcomes such as neural tube defects, anaemia and low birth weight, the relationship between folate and preterm birth (PTB) in the context of the US post-folic acid fortification era is inconclusive. We sought to explore the relationship between maternal folate status and PTB and its subtypes, i.e. spontaneous and medically indicated PTB.DesignObservational study.SettingBoston Birth Cohort, a predominantly urban, low-income, race/ethnic minority population at a high risk for PTB.ParticipantsMother–infant dyads (n 7675) enrolled in the Boston Birth Cohort. A sub-sample (n 2313) of these dyads had maternal plasma folate samples collected 24–72 h after delivery.ResultsUnadjusted and adjusted logistic regressions revealed an inverse relationship between the frequency of multivitamin supplement intake and PTB. Compared with less frequent use, multivitamin supplement intake 3–5 times/week (adjusted OR (aOR) = 0·78; 95 % CI 0·64, 0·96) or >5 times/week (aOR = 0·77; 95 % CI 0·64, 0·93) throughout pregnancy was associated with reduced risk of PTB. Consistently, higher plasma folate levels (highest v. lowest quartile) were associated with lower risk of PTB (aOR = 0·74; 95 % CI 0·56, 0·97). The above associations were similar among spontaneous and medically indicated PTB.ConclusionsIf confirmed by future studies, our findings raise the possibility that optimizing maternal folate levels across pregnancy may help to reduce the risk of PTB among the most vulnerable US population in the post-folic acid fortification era.

scholarly journals Maternal Metabolome in Pregnancy and Childhood Asthma or Recurrent Wheeze in the Vitamin D Antenatal Asthma Reduction Trial

Metabolites ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 65
Author(s):  
Mengna Huang ◽  
Rachel S. Kelly ◽  
Su H. Chu ◽  
Priyadarshini Kachroo ◽  
Gözde Gürdeniz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Respiratory Health ◽  
P Value ◽  
Third Trimester ◽  
Logistic Regression Models ◽  
Asthma Risk ◽  
Child Asthma ◽  
In Utero Environment ◽  
Recurrent Wheeze ◽  
In Pregnancy

The in utero environment during pregnancy has important implications for the developing health of the child. We aim to examine the potential impact of maternal metabolome at two different timepoints in pregnancy on offspring respiratory health in early life. In 685 mother-child pairs from the Vitamin D Antenatal Asthma Reduction Trial, we assessed the prospective associations between maternal metabolites at both baseline (10–18 weeks gestation) and third trimester (32–38 weeks gestation) and the risk of child asthma or recurrent wheeze by age three using logistic regression models accounting for confounding factors. Subgroup analyses were performed by child sex. Among 632 metabolites, 19 (3.0%) and 62 (9.8%) from baseline and third trimester, respectively, were associated with the outcome (p-value < 0.05). Coffee-related metabolites in the maternal metabolome appeared to be of particular importance. Caffeine, theophylline, trigonelline, quinate, and 3-hydroxypyridine sulfate were inversely associated with asthma risk at a minimum of one timepoint. Additional observations also highlight the roles of steroid and sphingolipid metabolites. Overall, there was a stronger relationship between the metabolome in later pregnancy and offspring asthma risk. Our results suggest that alterations in prenatal metabolites may act as drivers of the development of offspring asthma.

scholarly journals Fish intake during pregnancy and the risk of child asthma and allergic rhinitis – longitudinal evidence from the Danish National Birth Cohort

2013 ◽  
Vol 110 (7) ◽  
pp. 1313-1325 ◽  
Author(s):  
Ekaterina Maslova ◽  
Marin Strøm ◽  
Emily Oken ◽  
Hannia Campos ◽  
Christoph Lange ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Birth Cohort ◽  
Fish Intake ◽  
Self Report ◽  
Multivariate Logistic Regression ◽  
Medication Prescription ◽  
Danish National Birth Cohort ◽  
Child Asthma ◽  
Recurrent Wheeze ◽  
High Fish

Maternal fish intake during pregnancy may influence the risk of child asthma and allergic rhinitis, yet evidence is conflicting on its association with these outcomes. We examined the associations of maternal fish intake during pregnancy with child asthma and allergic rhinitis. Mothers in the Danish National Birth Cohort (n 28 936) reported their fish intake at 12 and 30 weeks of gestation. Using multivariate logistic regression, we examined the associations of fish intake with child wheeze, asthma and rhinitis assessed at several time points: ever wheeze, recurrent wheeze (>3 episodes), ever asthma and allergic rhinitis, and current asthma, assessed at 18 months (n approximately 22 000) and 7 years (n approximately 17 000) using self-report and registry data on hospitalisations and prescribed medications. Compared with consistently high fish intake during pregnancy (fish as a sandwich or hot meal ≥ 2–3 times/week), never eating fish was associated with a higher risk of child asthma diagnosis at 18 months (OR 1·30, 95 % CI 1·05, 1·63, P= 0·02), and ever asthma by hospitalisation (OR 1·46, 95 % CI 0·99, 2·13, P= 0·05) and medication prescription (OR 1·37, 95 % CI 1·10, 1·71, P= 0·01). A dose–response was present for asthma at 18 months only (P for trend = 0·001). We found no associations with wheeze or recurrent wheeze at 18 months or with allergic rhinitis. The results suggest that high (v. no) maternal fish intake during pregnancy is protective against both early and ever asthma in 7-year-old children.

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