Utilizing Biologically Based Models to Estimate Carcinogenic Risk

1990 ◽  
pp. 252-266 ◽  
Author(s):  
Christopher J. Portier
Keyword(s):  
Carcinogenic Risk

Papillomavirus infection and reproduction

2020 ◽  
Vol 75 (3) ◽  
pp. 189-195
Author(s):  
Vladislav I. Krasnopolsky ◽  
Nina V. Zarochentseva ◽  
Ksenia V. Krasnopolskaya ◽  
Yulia N. Bashankaeva ◽  
Varvara S. Kuzmicheva
Keyword(s):  
Human Papillomavirus ◽  
Hpv Vaccination ◽  
Carcinogenic Risk ◽  
Human Papillomaviruses ◽  
World Health ◽  
Sexually Transmitted ◽  
Associated Diseases ◽  
Trophoblastic Cells ◽  
Papillomavirus Infection ◽  
Health Organization

The purpose of the review a synthesis of research data on the role of human papillomavirus infection in the reproductive health of women and men. Key Points. Human papillomavirus (HPV) is one of the most common sexually transmitted viruses worldwide. According to the World Health Organization, HPV is the main cause of the development of HPV-associated diseases among both women and men. Viruses are subdivided into HPV with low carcinogenic risk, which cause benign warts, and HPV with high carcinogenic risk, which cause cancer. Different types of human papillomaviruses depending on their characteristic tropism, are divided into skin and mucous types. Viral infection in men leads to a decrease in the quality of sperm (for example, asthenozoospermia) due to apoptosis in sperm cells and due to the development of antisperm immunity. A negative viral effect on the fertility of women is manifested in an increase in the frequency of spontaneous miscarriages and a premature rupture of the amniotic membranes during pregnancy. There is evidence that HPV decreases the number of trophoblastic cells and abnormal trophoblastic-endometrial adhesion is also observed. In trophoblastic cells transfected with high-risk HPV, the level of apoptosis increases. HPV vaccination is safe, and the results show not only protection against HPV-associated diseases in women and men, but also a reduction of gestational complications, reduced preterm birth rates and the protection of newborns from infection.

Carcinogenic Risk of UV Treatment

2013 ◽  
Vol 75 (3) ◽  
pp. 197-199
Author(s):  
Yuichi KURIHARA ◽  
MASUTAKA Furue
Keyword(s):  
Carcinogenic Risk ◽  
Uv Treatment

Evaluation of the carcinogenic risk of chemicals landfill of municipal solid waste

2020 ◽  
pp. 683-683
Author(s):  
O. A. Loktionov ◽  
O. E. Kondrateva ◽  
V. V. Yushin
Keyword(s):  
Municipal Solid Waste ◽  
Solid Waste ◽  
Residential Development ◽  
Carcinogenic Risk ◽  
Municipal Waste ◽  
Development Zone ◽  
Protection Zone ◽  
Waste Landfill ◽  
Solid Municipal Waste

The paper assesses the carcinogenic risks from emissions of solid municipal waste landfill for the case when the residential development zone potentially falls within the boundaries of the sanitary protection zone, as well as for the normal situation when the employee of the landfill is on its territory for 8-hour shift.

Carcinogenic risk assessment in population living in the ecologically problematic areas of Irkutsk region

2019 ◽  
pp. 117-121
Author(s):  
N. V. Yefi mova ◽  
I. V. Myl’nikova ◽  
M. V. Kuz’mina ◽  
L. G. Lisetskaya ◽  
Ye. Ye. Loznevaya
Keyword(s):  
Rural Area ◽  
Industrial Development ◽  
Ambient Air ◽  
Carcinogenic Risk ◽  
Environmental Objects ◽  
Irkutsk Region ◽  
Regional Population ◽  
Drinkable Water ◽  
Route Of Exposure ◽  
Risk Parameters

Irkutsk region is among territories of intense industrial development. Considerable part of the regional population is long exposed to chemical pollutants of environmental objects. Th e authors evaluated carcinogenic risk for the population of industrial centers and rural area. Findings are that maximal carcinogenic risk is carried by the urban population. Aggregated carcinogenic risk parameters evaluation proved inhalation to be a priority route of exposure. Irkutsk region appeared to have territories with high carcinogenic risk for public health. Among a list of chemicals in the ambient air are priority carcinogens: six-valent chromium and lead. The evidences necessitate measures on the risks minimization. Due to absent data on carcinogens content of drinkable water in some rural area, the necessity is to evaluate risk for the rural population by studies of drinkable water quality that does not match hygienic regulations, because oral one is a main route of carcinogens intake.

scholarly journals Spatial distribution and risk assessment of toxic metals in agricultural soils from endemic nasopharyngeal carcinoma region in South China

2020 ◽  
Vol 12 (1) ◽  
pp. 568-579
Author(s):  
Liping Mo ◽  
Yongzhang Zhou ◽  
Gnanachandrasamy Gopalakrishnana ◽  
Xingyuan Li
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
South China ◽  
Toxic Metals ◽  
Agricultural Soils ◽  
Hazard Index ◽  
Toxic Metal ◽  
Carcinogenic Risk ◽  
Pollution Indices ◽  
High Incidence ◽  
Low Incidence

AbstractSihui city (South China) is much affected by nasopharyngeal carcinoma (NPC). To investigate the relationships between the toxic metals in soil and NPC incidence in Sihui, 119 surface soil samples were collected from agricultural fields and analyzed. The soil As–Cr contents in Longjiang (high-incidence area) are significantly lower than those in Weizheng and Jianglin (low-incidence areas), whereas the soil Pb content in Longjiang is significantly higher than that in Weizheng. The Nemerow pollution indices (PIN) of soils decrease in the order of Jianglin > Weizheng > Longjiang. The enrichment factor (EF) of Cd indicates that the Cd enrichment is contributed by human activities. Potential toxic metal-related ecological risk values decrease in the order of Jianglin > Weizheng > Longjiang. The mean hazard index (HI) value of Longjiang was lower than those of Weizheng and Jianglin. There are no adverse noncarcinogenic health effects of soil toxic metals to adults in the study areas. Carcinogenic risks of As and Cr via ingestion and dermal contact and total carcinogenic risk are within the warning range, from 10−6 to 10−4. Hence, we suggest that toxic metals in the soil may not be major geochemical carcinogenic factors of high NPC incidence in Sihui.

scholarly journals Asbestos Exposure Level and the Carcinogenic Risk Due to Corrugated Asbestos-Cement Slate Roofs in Korea

2021 ◽  
Vol 18 (13) ◽  
pp. 6925
Author(s):  
Eun-Soo Lee ◽  
Young-Ki Kim
Keyword(s):  
Asbestos Exposure ◽  
Health Impact ◽  
Pooled Analysis ◽  
Carcinogenic Risk ◽  
University Hospital ◽  
Exposure Level ◽  
Lifetime Cancer Risk ◽  
Indoor Exposure ◽  
Asbestos Cement ◽  
Environmental Causes

Asbestos-cement slate roofs are one of the most common environmental causes of asbestos exposure. However, few studies have examined residential asbestos-cement slate-related exposure and its effects on human health. This study was performed to evaluate cumulative asbestos exposure levels and to calculate the Excess Lifetime Cancer Risk (ELCR) of residents of asbestos-cement slate-roofed houses. We reviewed previous Korean literature to estimate the concentration of airborne asbestos from asbestos-cement slate roofed buildings. Finally, eight studies were selected, and a pooled analysis was performed. The results derived from the pooled analysis were combined with the data from a health impact survey conducted from 2009 to 2016 at the Environmental Health Center for Asbestos (EHCA) of the Yangsan Pusan National University Hospital, and a carcinogenic risk assessment was performed. As a result, the representative value of the indoor exposure concentration related to asbestos-cement slate was found to be 0.0032 f/cc on average, and the representative value of the exposure related to occupational asbestos-cement slate dismantling and demolition was found to be 0.0034 f/cc. In addition, the ELCR of asbestos-cement slate related indoor exposure and occupational dismantling and demolition was found to be of medium risk, and the ELCR of residential dismantling and demolition of asbestos-cement slate was less than 10−6, indicating that the risk was low. Since there is no threshold for carcinogenicity related to asbestos, this should not be ignored even if the risk appears low, and it would be reasonable to calculate the carcinogenic risk based on total lifetime exposure. More studies on asbestos exposure scenarios and the scope of similar exposure groups through additional data collection and further analysis of risk are needed.

scholarly journals Risk assessment of Ni, Cr, and Si release from alkaline minerals during enhanced weathering

2020 ◽  
Vol 5 (1) ◽  
pp. 166-175
Author(s):  
Fatima Haque ◽  
Yi Wai Chiang ◽  
Rafael M. Santos
Keyword(s):  
Risk Assessment ◽  
Environmental Protection Agency ◽  
Hazard Index ◽  
Carcinogenic Risk ◽  
Contamination Level ◽  
Potential Threat ◽  
Silicate Minerals ◽  
Guideline Value ◽  
Quality Guideline ◽  
Index Value

AbstractCalcium- and magnesium-rich alkaline silicate minerals, when applied to soil, can aid in carbon dioxide sequestration via enhanced weathering. The weathering of these silicate minerals is also associated with the release of heavy metals such as Ni and Cr, depending on the composition of the parent rock, and also labile Si. This paper critically analyses the risk associated with the release of Ni, Cr, and Si from alkaline silicate minerals as a result of enhanced weathering to evaluate its potential to be applied as a soil amendment. Based on the available data in the literature, this study evaluates the soil contamination level and quantifies the risk these elements pose to human health as well as the environment. To assess these potential threat levels, the geoaccumulation index was applied, along with the method recommended by the US Environmental Protection Agency for health risk assessment. The main findings of this study indicate the potential release of Ni, Cr, and Si to exceed the soil quality guideline value. The geochemical index suggests that the analyzed samples are in the class 0–3 and represents sites that lie between uncontaminated zones to highly contaminated zones. The hazard index value for Ni and Cr is greater than unity, which suggests that Ni and Cr release poses a non-carcinogenic risk. The probability of labile Si concentration in the soil to exceed the critical value is found to be 75%.

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