Involvement of Syndecan-1 and Heparanase in Cancer and Inflammation

2020 ◽  
pp. 97-135 ◽  
Author(s):  
Felipe C. O. B. Teixeira ◽  
Martin Götte
Keyword(s):  
Cancer And Inflammation

PET Imaging of Adenosine Receptors in Diseases

2019 ◽  
Vol 19 (16) ◽  
pp. 1445-1463 ◽  
Author(s):  
Jindian Li ◽  
Xingfang Hong ◽  
Guoquan Li ◽  
Peter S. Conti ◽  
Xianzhong Zhang ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Adenosine Receptors ◽  
Neurological Diseases ◽  
G Protein Coupled Receptors ◽  
Extracellular Adenosine ◽  
Positron Emission ◽  
Imaging Probes ◽  
Pet Probes ◽  
Cancer And Inflammation ◽  
G Protein Coupled

Adenosine receptors (ARs) are a class of purinergic G-protein-coupled receptors (GPCRs). Extracellular adenosine is a pivotal regulation molecule that adjusts physiological function through the interaction with four ARs: A1R, A2AR, A2BR, and A3R. Alterations of ARs function and expression have been studied in neurological diseases (epilepsy, Alzheimer’s disease, and Parkinson’s disease), cardiovascular diseases, cancer, and inflammation and autoimmune diseases. A series of Positron Emission Tomography (PET) probes for imaging ARs have been developed. The PET imaging probes have provided valuable information for diagnosis and therapy of diseases related to alterations of ARs expression. This review presents a concise overview of various ARs-targeted radioligands for PET imaging in diseases. The most recent advances in PET imaging studies by using ARs-targeted probes are briefly summarized.

scholarly journals Interplay between Hypoxia and Extracellular Vesicles in Cancer and Inflammation

Biology ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 606
Author(s):  
Marta Venturella ◽  
Mattia Criscuoli ◽  
Fabio Carraro ◽  
Antonella Naldini ◽  
Davide Zocco
Keyword(s):  
Extracellular Vesicles ◽  
Stress Condition ◽  
Biological Functions ◽  
Severe Stress ◽  
Cancer And Inflammation

Hypoxia is a severe stress condition often observed in cancer and chronically inflamed cells and tissues. Extracellular vesicles play pivotal roles in these pathological processes and carry biomolecules that can be detected in many biofluids and may be exploited for diagnostic purposes. Several studies report the effects of hypoxia on extracellular vesicles’ release, molecular content, and biological functions in disease. This review summarizes the most recent findings in this field, highlighting the areas that warrant further investigation.

scholarly journals Advances in the Development Ubiquitin-Specific Peptidase (USP) Inhibitors

2021 ◽  
Vol 22 (9) ◽  
pp. 4546
Author(s):  
Shiyao Chen ◽  
Yunqi Liu ◽  
Huchen Zhou
Keyword(s):  
Signaling Pathways ◽  
Transforming Growth Factor ◽  
Regulatory System ◽  
Transforming Growth Factor Β ◽  
Molecular Signaling ◽  
Post Translational Modification ◽  
The Past ◽  
Damage Repair ◽  
Wide Range ◽  
Cancer And Inflammation

Ubiquitylation and deubiquitylation are reversible protein post-translational modification (PTM) processes involving the regulation of protein degradation under physiological conditions. Loss of balance in this regulatory system can lead to a wide range of diseases, such as cancer and inflammation. As the main members of the deubiquitinases (DUBs) family, ubiquitin-specific peptidases (USPs) are closely related to biological processes through a variety of molecular signaling pathways, including DNA damage repair, p53 and transforming growth factor-β (TGF-β) pathways. Over the past decade, increasing attention has been drawn to USPs as potential targets for the development of therapeutics across diverse therapeutic areas. In this review, we summarize the crucial roles of USPs in different signaling pathways and focus on advances in the development of USP inhibitors, as well as the methods of screening and identifying USP inhibitors.

scholarly journals Mediterranean Diet to Prevent the Development of Colon Diseases: A Meta-Analysis of Gut Microbiota Studies

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2234
Author(s):  
Oscar Illescas ◽  
Miriam Rodríguez-Sosa ◽  
Manuela Gariboldi
Keyword(s):  
Gut Microbiota ◽  
Mediterranean Diet ◽  
Meta Analysis ◽  
Intestinal Barrier ◽  
Preventive Measure ◽  
Bowel Diseases ◽  
Preventive Method ◽  
Inflammatory Bowel ◽  
Colon Diseases ◽  
Cancer And Inflammation

Gut microbiota dysbiosis is a common feature in colorectal cancer (CRC) and inflammatory bowel diseases (IBD). Adoption of the Mediterranean diet (MD) has been proposed as a therapeutic approach for the prevention of multiple diseases, and one of its mechanisms of action is the modulation of the microbiota. We aimed to determine whether MD can be used as a preventive measure against cancer and inflammation-related diseases of the gut, based on its capacity to modulate the local microbiota. A joint meta-analysis of publicly available 16S data derived from subjects following MD or other diets and from patients with CRC, IBD, or other gut-related diseases was conducted. We observed that the microbiota associated with MD was enriched in bacteria that promote an anti-inflammatory environment but low in taxa with pro-inflammatory properties capable of altering intestinal barrier functions. We found an opposite trend in patients with intestinal diseases, including cancer. Some of these differences were maintained even when MD was compared to healthy controls without a defined diet. Our findings highlight the unique effects of MD on the gut microbiota and suggest that integrating MD principles into a person’s lifestyle may serve as a preventive method against cancer and other gut-related diseases.

scholarly journals RNA regulons in cancer and inflammation

2018 ◽  
Vol 48 ◽  
pp. 97-103 ◽  
Author(s):  
Laura Simone Bisogno ◽  
Jack Donald Keene
Keyword(s):  
Cancer And Inflammation

Immunopharmacological Activity of Betulin in Inflammation-associated Carcinogenesis

2018 ◽  
Vol 18 (5) ◽  
pp. 645-651 ◽  
Author(s):  
Anja Schwiebs ◽  
Heinfried H. Radeke
Keyword(s):  
Immune Cell ◽  
Inflammatory Diseases ◽  
Innate Immune ◽  
Interleukin 12 ◽  
Dual Function ◽  
Special Focus ◽  
Birch Bark ◽  
Pentacyclic Triterpene ◽  
Cancer And Inflammation ◽  
Potential Use

This review highlights the multiple properties of the birch bark-derived pentacyclic triterpene betulin with special focus on its pharmacological activity in cancer and inflammation. While less well characterized compared to its hydrophilic derivative, betulinic acid, it exhibits potent anticancer activity described in many publications. Indeed, underinvestigated are its immunomodulatory functions in inflammatory diseases that appeared to enhance innate immune cell activities in an adjuvant-like fashion towards an interleukin-12 driven antitumor immunity. Herein, we like to emphasize the simultaneous and dual function of betulin on the basis of recent investigations of the tumor microenvironment and enlighten the potential use of betulin in the control of inflammation-associated carcinogenesis.

Sign in / Sign up

Export Citation Format

Share Document