scholarly journals Outcome Analysis

2021 ◽  
pp. 43-52
Author(s):  
Anne Emmett
Keyword(s):  
Positive Impact ◽  
Outcome Data ◽  
Haematopoietic Stem Cell ◽  
Outcome Analysis ◽  
Related Risk ◽  
Car T ◽  
Recent Developments ◽  
Practice Variations ◽  
High Treatment ◽  
Transplant Procedure

AbstractTo understand and hence improve the positive impact of any healthcare activity, procedure or intervention, it is essential that there is an objective analysis of the activity, procedure or intervention based on predetermined standards.In the field of haematopoietic stem cell transplantation, outcome analysis is the process by which the results of a transplant procedure are formally assessed. It includes a series of reviews for evaluating the effectiveness of the health care provided and for identifying the most promising therapies and transplant approaches, given the available medical evidence and healthcare resources.Outcome analysis allows the transplant team to understand the effects of their practice and improve quality. Its relevance is due to transplant involving high treatment-related risk, significant practice variations, and continual practice developments – for example, recent developments in CAR-T and IEC therapies.The main aim of this chapter is to discuss how to find outcome data and how and when to present it. This will need to be adapted to the local programme.

scholarly journals Impact of a Virtual Culinary Medicine Curriculum on Biometric Outcomes, Dietary Habits, and Related Psychosocial Factors among Patients with Diabetes Participating in a Food Prescription Program

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4492
Author(s):  
Shreela V. Sharma ◽  
John W. McWhorter ◽  
Joanne Chow ◽  
Melisa P. Danho ◽  
Shannon R. Weston ◽  
...  
Keyword(s):  
Low Income ◽  
Fruits And Vegetables ◽  
Dietary Habits ◽  
Positive Impact ◽  
Glycosylated Hemoglobin ◽  
Outcome Data ◽  
Outcome Analysis ◽  
Program Impact ◽  
Culinary Medicine ◽  
Patients With Diabetes

Culinary medicine is an evidence-based approach that blends the art of cooking with the science of medicine to inculcate a healthy dietary pattern. Food prescription programs are gaining popularity in the Unites States, as a means to improve access to healthy foods among patient populations. The purpose of this paper is to describe the implementation and preliminary impact of A Prescription for Healthy Living (APHL) culinary medicine curriculum on biometric and diet-related behavioral and psychosocial outcomes among patients with diabetes participating in a clinic-led food prescription (food Rx) program. We used a quasi-experimental design to assess APHL program impact on patient biometric outcome data obtained from electronic health records, including glycosylated hemoglobin (HbA1c), body mass index (BMI), and blood pressure (n = 33 patients in the APHL group, n = 75 patients in the food Rx-only group). Pre-post surveys were administered among those in the APHL group to monitor program impact on psychosocial and behavioral outcomes. Results of the outcome analysis showed significant pre-to-post reduction in HbA1c levels among participants within the APHL group (estimated mean difference = −0.96% (−1.82, −0.10), p = 0.028). Between-group changes showed a greater decrease in HbA1c among those participating in APHL as compared to food Rx-only, albeit these differences were not statistically significant. Participation in APHL demonstrated significant increases in the consumption of fruits and vegetables, fewer participants reported that cooking healthy food is difficult, increased frequency of cooking from scratch, and increased self-efficacy in meal planning and cooking (p < 0.01). In conclusion, the results of our pilot study suggest the potential positive impact of a virtually-implemented culinary medicine approach in improving health outcomes among low-income patients with type 2 diabetes, albeit studies with a larger sample size and a rigorous study design are needed.

scholarly journals A Reference Framework to Combine Model-Based Design and AR to Improve Social Sustainability

2021 ◽  
Vol 13 (4) ◽  
pp. 2031
Author(s):  
Fabio Grandi ◽  
Riccardo Karim Khamaisi ◽  
Margherita Peruzzini ◽  
Roberto Raffaeli ◽  
Marcello Pellicciari
Keyword(s):  
Positive Impact ◽  
Cost Effective ◽  
Digital Models ◽  
Model Based ◽  
Digital Contents ◽  
Recent Developments ◽  
Virtual Simulations ◽  
Product And Process ◽  
The Impact ◽  
Time Information

Product and process digitalization is pervading numerous areas in the industry to improve quality and reduce costs. In particular, digital models enable virtual simulations to predict product and process performances, as well as to generate digital contents to improve the general workflow. Digital models can also contain additional contents (e.g., model-based design (MBD)) to provide online and on-time information about process operations and management, as well as to support operator activities. The recent developments in augmented reality (AR) offer new specific interfaces to promote the great diffusion of digital contents into industrial processes, thanks to flexible and robust applications, as well as cost-effective devices. However, the impact of AR applications on sustainability is still poorly explored in research. In this direction, this paper proposed an innovative approach to exploit MBD and introduce AR interfaces in the industry to support human intensive processes. Indeed, in those processes, the human contribution is still crucial to guaranteeing the expected product quality (e.g., quality inspection). The paper also analyzed how this new concept can benefit sustainability and define a set of metrics to assess the positive impact on sustainability, focusing on social aspects.

scholarly journals The soft side of environmentally-sustainable organizations

2018 ◽  
Vol 53 (4) ◽  
pp. 622-627 ◽  
Author(s):  
Charbel Jose Chiapetta Jabbour ◽  
Douglas William Scott Renwick
Keyword(s):  
Research Agenda ◽  
Positive Impact ◽  
Content Type ◽  
Environmentally Sustainable ◽  
Recent Developments ◽  
Ecological Objectives ◽  
Human Side ◽  
Green Human Resource Management ◽  
New Research ◽  
Sustainable Organizations

Purpose The purpose of the paper is to present a discussion on the “soft and human” side of building environmentally sustainable organizations, a flourishing management subfield called “green human resource management” (GHRM), which concerns alignment of people and environmental management objectives of organizations. Design/methodology/approach The authors reviewed some of the most relevant research results in GHRM. Findings In this paper, the authors define GHRM, its workplace-based practices and some recent developments’ evidence on the positive impact of it on firms’ ecological objectives. The authors conclude by detailing a new research agenda in GHRM. Originality/value The authors conclude by detailing a new and contemporary research agenda in GHRM.

scholarly journals The Positive Impact of Registered Nurse Sedation Teams

2019 ◽  
pp. 21-24
Author(s):  
Marlea A Judd ◽  
Mary Ellen Warner
Keyword(s):  
Patient Safety ◽  
Registered Nurse ◽  
Positive Impact ◽  
Retrospective Chart Review ◽  
Outcome Data ◽  
Moderate Sedation ◽  
The Impact ◽  
Team Model ◽  
General Care ◽  
Care Nursing

Background: Sedation care documentation and patient safety on general care nursing units need improvement. Purpose: To assess the impact of implementation of a registered nurse sedation team model on patient safety and thoroughness of documentation in patients receiving moderate sedation on general care units. Methods: In 2010 a 3-month retrospective chart review determined adverse patient outcomes and incompleteness of documentation for patients receiving sedation on general care units. After implementation of the registered nurse sedation team model for 3 months, patient’s sedation documentation and outcomes were assessed. The registered nurse sedation team model was implemented into practice and further outcome data from implementation through 2017 also were assessed. Results: There was clear improvement in both required documentation during moderate sedation and patient safety (P<0.001). Conclusion: The registered nurse sedation team model in this study improved both completeness of required sedation documentation and patient safety.

scholarly journals Minireview: Translocator Protein (TSPO) and Steroidogenesis: A Reappraisal

2015 ◽  
Vol 29 (4) ◽  
pp. 490-501 ◽  
Author(s):  
Vimal Selvaraj ◽  
Douglas M. Stocco ◽  
Lan N. Tu
Keyword(s):  
Positive Impact ◽  
Transmembrane Protein ◽  
Steroid Hormone ◽  
Benzodiazepine Receptor ◽  
Translocator Protein ◽  
Research Progress ◽  
Peripheral Benzodiazepine Receptor ◽  
Hormone Production ◽  
Recent Developments ◽  
Mitochondrial Cholesterol

Abstract The 18-kDa translocator protein (TSPO), also known as the peripheral benzodiazepine receptor, is a transmembrane protein in the outer mitochondrial membrane. TSPO has long been described as being indispensable for mitochondrial cholesterol import that is essential for steroid hormone production. In contrast to this initial proposition, recent experiments reexamining TSPO function have demonstrated that it is not involved in steroidogenesis. This fundamental change has forced a reexamination of the functional interpretations made for TSPO that broadly impacts both basic and clinical research across multiple fields. In this minireview, we recapitulate the key studies from 25 years of TSPO research and concurrently examine their limitations that perhaps led towards the incorrect association of TSPO and steroid hormone production. Although this shift in understanding raises new questions regarding the molecular function of TSPO, these recent developments are poised to have a significant positive impact for research progress in steroid endocrinology.

Implementation of Sepsis Bundles in Intensive Care Units of Bangladesh: A Prospective Observational Study

2013 ◽  
Vol 1 (1) ◽  
pp. 8-17
Author(s):  
Mohammad Omar Faruq ◽  
ASM Areef Ahsan ◽  
Mirza Nazim Uddin ◽  
UH Shahera Khatun ◽  
Md Abdul Mannan ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Positive Impact ◽  
Delayed Diagnosis ◽  
Outcome Data ◽  
Surviving Sepsis Campaign ◽  
Sepsis Bundles ◽  
Impact On Survival ◽  
The Impact

Objective: To assess compliance of Intensive Care Units (ICUs) of Bangladesh to the components of resuscitation & management bundles of Surviving Sepsis Campaign (SSC). Secondary objective was to assess the impact of compliance on mortality and to determine how its compliance & mortality compared with other Asian and Western countries. Design: Prospective Cohort study. Setting: 14 ICUs of Bangladesh. Participants: 65 adult patients with severe sepsis admitted into these ICUs in July 2009. The organizational characteristics of the participating centers, the patients’ baseline characteristics, the achievement of target within the resuscitation & management bundle & outcome data were recorded. Outcome: Compliance with the Surviving Sepsis Campaign’s resuscitation (6 hrs) & management (24 hrs) bundles. Results: Hospital mortality in ICU patients of Bangladesh suffering from severe sepsis was 49·2%. It was significantly higher than countries reported. Compliance to entire components of both resuscitation & management bundles were reported to be zero in ICUs of Bangladesh. Compliance of individual components of the bundles did not predict improved survival. Conclusion: In ICUs of Bangladesh, high mortality of severe sepsis and failure of compliance of SSC bundle guidelines to have positive impact on survival were presumably attributed to delayed diagnosis, poor adherence to & delayed application of SSC guidelines on sepsis bundles. DOI: http://dx.doi.org/10.3329/bccj.v1i1.14359 Bangladesh Crit Care J March 2013; 1: 8-17

Retrospective single-center outcome analysis of neoadjuvant and palliative treatment with dual trastuzumab and pertuzumab in HER2-positive breast cancer.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e12114-e12114
Author(s):  
Maximilian Marhold ◽  
Lea Roxana Ionce ◽  
Alexandra Christ ◽  
Marie-Bernadette Aretin ◽  
Verena Sagaster ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Progression Free Survival ◽  
Dual Therapy ◽  
Outcome Data ◽  
Outcome Analysis ◽  
Published Data ◽  
Breast Cancer Patients ◽  
Single Center ◽  
Her2 Positive ◽  
Outcomes Measures

e12114 Background: Her2-positive (Her2pos) breast cancer (BCa) is the second most lethal subtype of BCa. The treatment of Her2-positive BCa was revolutionized due to the dual use of trastuzumab and pertuzumab (T+P) in recent years both in the neoadjuvant and the palliative setting. Although several years have passed after initial approval of these drugs, single-center outcome data as reported by clinicians is sparse. In this retrospective study, we set to assess outcomes measures at our institution, Austria’s largest academic hospital, for the use of T+P in early and metastasized BCa. Methods: We acquired records on combined pertuzumab and trastuzumab orders from our intramural drug order software (CATO, Cato Research, Durham, NC, USA) for the time period of May 2013 to March 2018. Further, using electronic patient histories, we described both the neoadjuvant and palliative patient groups by assessment of body weight/size, tumor stage, histology including immunohistochemistry (IHC), lines of oncological therapies received, ejection fraction (EF) drops>10%, deaths and most importantly the outcomes measures pathological complete response (pCR, neoadjuvant cohort) rate and progression-free survival (PFS, palliative cohort). Results: 120 breast cancer patients were given dual therapy with T+P. The neoadjuvant cohort contained 63 patients, while the palliative cohort included 57 patients. All patients included were female. Full histology including IHC data was available for 47 of 63 patients in the neoadjuvant cohort and 30 of 57 patients in the palliative cohort. BMI was 25.6 and 23.3, respectively, on average. The mean age was 54 years in the neoadjuvant and 56 years in the palliative cohort. 73.6% (39/53) and 65.9% (29/44) of tumors were ER positive as determined by IHC. While neoadjuvant patients obtained an average of 6.5 cycles, patients within the palliative cohort received a mean of 17.3 cycles of T+P. 0 and 17 deaths were observed in the respective cohorts. Data on pCR and PFS was available for 95.2% and 91.2% of patients, respectively. The pCR rate within the neoadjuvant cohort was 46.7% (28/60), and mean PFS across all treatment lines of the palliative cohort was 10.2 months. Conclusions: We report retrospective single-center outcome data for the combined use of trastuzumab and pertuzumab in both early and metastatic Her2pos BCa in line with previously published data.

Severe combined immunodeficiency: recent developments and guidance on clinical management

2015 ◽  
Vol 100 (7) ◽  
pp. 667-672 ◽  
Author(s):  
Lizzy Rivers ◽  
H Bobby Gaspar
Keyword(s):  
Early Diagnosis ◽  
Cell Function ◽  
Immune Cell ◽  
Severe Combined Immunodeficiency ◽  
Recurrent Infection ◽  
Haematopoietic Stem Cell ◽  
Combined Immunodeficiency ◽  
General Paediatrician ◽  
Recent Developments ◽  
First Year Of Life

Severe combined immunodeficiency (SCID) is a rare but important condition. Affected infants are born with profound abnormalities of immune cell function that lead to severe and recurrent infection that are almost always fatal in the first year of life without treatment. Infants with SCID are often initially seen by general paediatricians in the hospital care setting, and the recognition of the cardinal features of the disease and alertness to specific laboratory parameters are important in making an early diagnosis. There is also increasing interest in newborn screening for SCID, which has the potential to significantly improve outcome through early diagnosis and implementation of prophylactic medications. Definitive treatments such as haematopoietic stem cell transplantation and gene therapy have also made major advances over the last decade and again promise to improve the overall outcome for SCID with reduced long-term toxicities. In this review, we highlight some of the major advances in diagnosis and management of the disease, but we also want to emphasise the important role of the general paediatrician in making an early diagnosis and in ongoing management.

scholarly journals China-Pakistan Economic Corridor (CPEC): Fostering the Trade, Investment and Economic Globalization

2019 ◽  
Vol IV (II) ◽  
pp. 283-290
Author(s):  
Noor Fatima ◽  
Asia Baig ◽  
Burhan Ali Shah
Keyword(s):  
21St Century ◽  
Positive Impact ◽  
Economic Globalization ◽  
New Wave ◽  
Central Asian Republic ◽  
Central Asian ◽  
Recent Developments ◽  
Belt And Road ◽  
Recent Initiative ◽  
The Belt And Road

Though the 21st century was considered hallmark economic globalization and trade partnership but recent developments of Brexit and President Trumps protective and anti-multilateral trading have challenged the established liberal consensus on economic globalization. This paper would argue that on the contrary the case of CPEC is the recent initiative from China and Pakistan which is giving boost to the new wave of economic Globalization as the economic corridor China projected the Belt and Road as a road to prosperity whereas isolation brings backwardness, will be more true with regard to CPEC. For Pakistan it is a gamechanger as it is a framework of regional connectivity. CPEC will not only benefit China and Pakistan but will have positive impact on Iran, Afghanistan, India, Central Asian Republic, and the region. The enhancement of geographical linkages will further the economic globalization as against the anti-globalization moves.

scholarly journals Creating and sustaining collaborative multi-institutional industry site visit programs: a toolkit

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 1317
Author(s):  
Tammy R.L. Collins ◽  
Kiri Hoff ◽  
Molly Starback ◽  
Patrick D. Brandt ◽  
Christopher E. Holmquist ◽  
...  
Keyword(s):  
Program Implementation ◽  
Positive Impact ◽  
Small Sample Size ◽  
Outcome Data ◽  
Small Sample ◽  
Early Career ◽  
Site Visit ◽  
Contract Research Organization ◽  
For Profit ◽  
Graduate Trainees

Background: As more early career scientists enter into diverse career pathways, visiting local companies or organizations can support their exploration of these paths. As an efficient way to facilitate this, we developed a collaborative regional site visit program: the Enhancing Local Industry Transitions through Exploration (ELITE) Consortium.  Consortium members arrange half-day visits to local industry sites, thus providing companies and trainees the opportunity to meet and identify potential professional and career opportunities. Three different training institutions worked cooperatively in the development and maintenance of the program. The ELITE Consortium was developed with eight phased steps; guidelines and operating procedures were created for each of these steps and are provided along with sample materials for institutions interested in building similar programs. Methods: Prior to fully developing the program, trainee interests were evaluated via questionnaire. During program implementation and thereafter, program directors tracked attendance and collected career outcome data from publicly available sources to identify first job positions after training. Regression analyses and chi-squared analyses were used to examine site visit matches and career outcome data. Results: Analyses suggest a positive impact of site visits on postdoctoral and graduate trainees’ career outcomes at companies or institutions that match a similar sector (e.g., for-profit) and type (e.g., biotech, pharmaceutical, contract research organization). Despite a small sample size, evidence suggests an especially positive impact on trainees who organize site visits to companies compared with those who simply participate. Conclusions: The ELITE Consortium was successful in helping trainees explore and identify a multitude of career paths. Trainees attained employment either directly or in related companies and institutions visited by ELITE participants. The joint, three-institution, flexible nature of the ELITE Consortium positively impacts the program’s sustainability and reach. The toolkit provided here will help other institutions to replicate and adapt the program with minimal effort.

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