Most growth regulators and crop protection chemicals are delivered to the plant as aqueous sprays. Spray droplet:plant surface interaction is central to establishing spray and, hence, dose retention by the plant. Further, the nature of chemical deposition from spray droplets plays an important role in determining the efficiency of the active ingredient (a.i.). Using scanning electron microscopy and dispersive x-ray analysis, we investigated chemical deposit formation of selected growth regulators (e.g. ethephon, 2,4, 5-TP, TIBA) on leaf surfaces differing in wettability and surface fine-structure. The a.i. frequently deposited in the form of an annulus on droplet drying, and the degree of spreading was related to surface tension of the spray solution, and wettability, fine-structure and morphology of the leaf surface. Marked differences were observed in spreading following impaction on veins vs. interveinal areas of leaves of Prunus and Pyrus sp. The epidermis over veins was more readily wetted leading to rapid lateral diffusion along veins. Surfactants (e.g. Tween 20, Regulaid) altered the deposition pattern, expanding the annulus and increasing spreading on the leaf surface.