Tick-Borne Encephalitis: From Microfocus to Human Disease

2011 ◽  
pp. 323-331 ◽  
Author(s):  
G. Dobler ◽  
F. Hufert ◽  
M. Pfeffer ◽  
S. Essbauer
Keyword(s):  
Human Disease ◽  
Tick Borne Encephalitis

scholarly journals Heartland virus: a novel and emerging tick-borne encephalitis

2016 ◽  
pp. 5099-5101
Author(s):  
Salim Mattar V. ◽  
Marco González T.
Keyword(s):  
United States ◽  
Causative Agent ◽  
Human Disease ◽  
Fatal Case ◽  
The United States ◽  
Tick Borne Encephalitis

Heartland virus (HRTV) is a Bunyaviridae, phlebovirus that it has recently emerged as the causative agent of human disease characterized by thrombocytopenia and leukopenia in the United States and China. It seems to be the HRTV has been also reported in China, Japan and Korea. Recently the first fatal case of HRTV disease in an 80-year-old Tennessee resident was reported (1)

scholarly journals Basis of long-term perspective of prophylaxis and treatmentof tick-borne encephalitis

2008 ◽  
Vol 7 (1) ◽  
pp. 124-129
Author(s):  
N. P. Tolokonskaya ◽  
E. A. Spiridonov ◽  
Yu. V. Kazakova ◽  
V. V. Provorov ◽  
Ye. V. Druzhinina
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Disease Resistance ◽  
Natural Population ◽  
Human Disease ◽  
Mutual Adaptation ◽  
Tick Borne Encephalitis ◽  
Population Interactions ◽  
Tick Borne Encephalitis Virus

A reflection of natural population interactions between tick-borne encephalitis virus and a human being on condition of mutual adaptation appears to be a frequent persistence of an agent and a high human disease resistance. Mixed somatic pathology of degenerative nature, which was revealed in the study of the majority of patients with tick-borne encephalitis, more often including the initial central nervous system affliction under conditions of negative changes of organism reactivity, is regarded as one of the main reasons of infection conversion into disease. The virus becomes an aggression factor at such joint biological causes, changing endobiocenosis, which is of great importance for substantiation of curing therapy.

Climate, ticks and tick-borne encephalitis in Central Europe.

2021 ◽  
pp. 331-340
Author(s):  
Vlasta Danielová ◽  
Milan Daniel
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Europe ◽  
Human Disease ◽  
European Area ◽  
Tick Borne Encephalitis ◽  
The Family ◽  
The Central Nervous System ◽  
Tick Borne Encephalitis Virus ◽  
European Subtype

Abstract Tick-borne encephalitis (TBE) is a serious human disease of the central nervous system (CNS) caused by the European subtype of tick-borne encephalitis virus (TBEV) - genus Flavivirus of the family Flaviviridae - in the European area of its distribution. Its major vector is the tick, Ixodes ricinus. This expert opinion discusses the ecology of I. ricinus and the epidemiology of TBE in relation to changing climate in Central Europe.

scholarly journals Detection of novel tick-borne pathogen, Alongshan virus, in Ixodes ricinus ticks, south-eastern Finland, 2019

2019 ◽  
Vol 24 (27) ◽  
Author(s):  
Suvi Kuivanen ◽  
Lev Levanov ◽  
Lauri Kareinen ◽  
Tarja Sironen ◽  
Anne J. Jääskeläinen ◽  
...  
Keyword(s):  
Ixodes Ricinus ◽  
Human Disease ◽  
Human Pathogen ◽  
South Eastern ◽  
Virus Group ◽  
Virus Rna ◽  
Tick Borne Encephalitis ◽  
Ixodes Ricinus Ticks ◽  
Eastern Finland

The newly identified tick-borne Alongshan virus (ALSV), a segmented Jingmen virus group flavivirus, was recently associated with human disease in China. We report the detection of ALSV RNA in Ixodes ricinus ticks in south-eastern Finland. Screening of sera from patients suspected for tick-borne encephalitis for Jingmen tick virus-like virus RNA and antibodies revealed no human cases. The presence of ALSV in common European ticks warrants further investigations on its role as a human pathogen.

Use of Protein a Conjugated to Peroxidase to Localize Immunoglobulin G in SSPE Ferret Brain

1982 ◽  
Vol 40 ◽  
pp. 350-351
Author(s):  
Hannah R. Brown ◽  
Anthony F. Nostro ◽  
Halldor Thormar
Keyword(s):  
Immunoglobulin G ◽  
Human Disease ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Protein A ◽  
Inflammatory Lesions ◽  
Sspe Virus ◽  
Specific Immunoglobulin ◽  
Antibody Titers ◽  
The Brain

Subacute sclerosing panencephalitis (SSPE) is a slowly progressing disease of the CNS in children which is caused by measles virus. Ferrets immunized with measles virus prior to inoculation with the cell associated, syncytiogenic D.R. strain of SSPE virus exhibit characteristics very similar to the human disease. Measles virus nucleocapsids are present, high measles antibody titers are found in the sera and inflammatory lesions are prominent in the brains. Measles virus specific immunoglobulin G (IgG) is present in the brain,and IgG/ albumin ratios indicate that the antibodies are synthesized within the CNS.

Spectroscopic imaging of human disease

1996 ◽  
Vol 54 ◽  
pp. 884-885
Author(s):  
D.J. Meyerhoff
Keyword(s):  
Magnetic Field ◽  
Magnetic Resonance ◽  
Field Gradient ◽  
Human Disease ◽  
Morphological Changes ◽  
Magnetic Field Gradient ◽  
Spectroscopic Imaging ◽  
Resonance Spectroscopy ◽  
Tissue Water

Magnetic Resonance Imaging (MRI) observes tissue water in the presence of a magnetic field gradient to study morphological changes such as tissue volume loss and signal hyperintensities in human disease. These changes are mostly non-specific and do not appear to be correlated with the range of severity of a certain disease. In contrast, Magnetic Resonance Spectroscopy (MRS), which measures many different chemicals and tissue metabolites in the millimolar concentration range in the absence of a magnetic field gradient, has been shown to reveal characteristic metabolite patterns which are often correlated with the severity of a disease. In-vivo MRS studies are performed on widely available MRI scanners without any “sample preparation” or invasive procedures and are therefore widely used in clinical research. Hydrogen (H) MRS and MR Spectroscopic Imaging (MRSI, conceptionally a combination of MRI and MRS) measure N-acetylaspartate (a putative marker of neurons), creatine-containing metabolites (involved in energy processes in the cell), choline-containing metabolites (involved in membrane metabolism and, possibly, inflammatory processes),

Dual Specificity, Tyrosine phosphorylation Regulated Kinases (DYRKs) in human disease: the therapeutic potential of pharmacological inhibitors

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
O Lozach ◽  
Y Ferandin ◽  
B Baratte ◽  
F Le Sourd ◽  
L Meijer
Keyword(s):  
Tyrosine Phosphorylation ◽  
Human Disease ◽  
Therapeutic Potential ◽  
Dual Specificity

Model Characterization of Pulmonary Arterial Hypertension: Analysis of Lung Pathology with Respect to Human Disease

2020 ◽  
Author(s):  
◽  
Eptisam lambu
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Human Disease ◽  
Vascular Remodeling ◽  
Vascular Wall ◽  
Lung Pathology ◽  
Pulmonary Arterial ◽  
Lung Pathogenesis ◽  
Arterial Endothelial Cells

Pulmonary arterial hypertension (PAH) is a rare multifactorial disease characterized by abnormal high blood pressure in the pulmonary artery, or increased pulmonary vascular resistance (PVR), caused by obstruction in the small arteries of the lung. Increased PVR is also thought to be caused by abnormal vascular remodeling, due to thickening of the pulmonary vascular wall resulting from significant hypertrophy of pulmonary arterial smooth-muscle cells (PASMCs) and increased proliferation/impaired apoptosis of pulmonary arterial endothelial cells (PAECs). Herein, we investigated the mechanisms and explored molecular pathways mediating the lung pathogenesis in two PAH rat models: Monocrotaline (MCT) and Sugen5416/Hypoxia (SuHx). We analyzed these disease models to determine where the vasculature shows the most severe PAH pathology and which model best recapitulates the human disease. We investigated the role vascular remodeling, hypoxia, cell proliferation, apoptosis, DNA damage and inflammation play in the pathogenesis of PAH. Neither model recapitulated all features of the human disease, however each model presented with some of the pathology seen in PAH patients.

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