The Founding, Fantastic Growth, and Fast Decline of Norsk Data AS

The present investigation was undertaken to assess the effects of different doses (100, 300, and 500 mJ) of low power He–Ne laser (632.8 nm) irradiation on seed germination and thermodynamics attributes and activities of potential germinating enzymes in relation with changes in seed metabolites. He–Ne laser seed irradiation increased the amylase (Amy), protease (Pro) and glucosidase (Gluco) activities, with a significant improvement in seed thermodynamics and seed germination attributes. A fast increase was found in free fatty acids (FFA), free amino acids (FAA), chlorophyll (Chl), carotenoids (Car), total soluble sugars (TSS) and reducing sugars (RS) in laser treated seeds in parallel with fast decline in seed oil contents and total soluble proteins (TSP). Significant positive correlations were recorded in laser-induced enhanced seed energy levels, germination, activities of germination enzymes with levels of FAA, FFA, Chl, TSS and RS, but a negative correlation with the levels of TSP and oil. In conclusion, the seed treatment with 100 and 300 mJ He–Ne laser was more effective to improve the seed germination potential associated with an improvement in seed energy levels due to increased activities of germination enzymes due to the speedy breakdown of seed reserves to simple metabolites as building blocks.

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Concentration of FeSO4 spent solutions by membrane distillation

Polish Journal of Chemical Technology ◽

10.2478/v10026-007-0016-9 ◽

2007 ◽

Vol 9 (2) ◽

pp. 15-18 ◽

Cited By ~ 2

Author(s):

Marek Gryta

Keyword(s):

Potential Application ◽

Ph Value ◽

Membrane Surface ◽

Membrane Distillation ◽

Permeate Flux ◽

Salt Solutions ◽

Iron Compounds ◽

Fast Decline ◽

Waste Salt

Concentration of FeSO4 spent solutions by membrane distillation The possibility of potential application of membrane distillation for the concentration of waste salt solutions has been presented in this work. It was found that the oxidation of iron compounds takes place during the process that was associated with the formation of a layer of oxides on the membrane surface. A fast decline of the permeate flux was observed due to the scaling phenomena. The problem of scaling was eliminated by the acidification with H2SO4 of the feed to the pH value of 2.

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Nocturnal blood pressure increments indicate fast decline in renal function.

American Journal of Hypertension ◽

10.1016/0895-7061(95)97968-w ◽

1995 ◽

Vol 8 (4) ◽

pp. 162A

Author(s):

J MEHLSEN

Keyword(s):

Blood Pressure ◽

Renal Function ◽

Nocturnal Blood Pressure ◽

Fast Decline

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A lake-level chronology based on feldspar luminescence dating of beach ridges at Tangra Yum Co (Southern Tibet)

Quaternary Research ◽

10.1016/j.yqres.2015.03.002 ◽

2015 ◽

Vol 83 (3) ◽

pp. 469-478 ◽

Cited By ~ 23

Author(s):

Eike F. Rades ◽

Sumiko Tsukamoto ◽

Manfred Frechen ◽

Qiang Xu ◽

Lin Ding

Keyword(s):

Tibetan Plateau ◽

Lake Level ◽

Environmental Changes ◽

Luminescence Dating ◽

Rapid Decline ◽

The Tibetan Plateau ◽

Southern Tibet ◽

Beach Ridges ◽

Slow Decline ◽

Fast Decline

Many lakes on the Tibetan Plateau exhibit strandplains with a series of beach ridges extending high above the current lake levels. These beach ridges mark former lake highstands and therefore dating their formation allows the reconstruction of lake-level histories and environmental changes. In this study, we establish a lake-level chronology of Tangra Yum Co (fifth largest lake on the Tibetan Plateau) based on luminescence dating of feldspar from 17 beach-ridge samples. The samples were collected from two strandplains southeast and north of the lake and range in elevation from the current shore to 140 m above the present lake. Using a modified post-infrared IRSL protocol at 170°C we successfully minimised the anomalous fading in the feldspar IRSL signal, and obtained reliable dating results. The luminescence ages indicate three different stages of lake-level decline during the Holocene: (1) a phase of rapid decline (~ 50 m) from ~ 6.4 to ~ 4.5 ka, (2) a period of slow decline between ~ 4.5 and ~ 2.0 ka (~ 20 m), and (3) a fast decline by 70 m between ~ 2 ka and today. Our findings suggest a link between a decrease in monsoonal activity and lake-level decline since the early Holocene.

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Serum metabolomics study of women with different annual decline rates of anti-Müllerian hormone: an untargeted gas chromatography–mass spectrometry-based study

Human Reproduction ◽

10.1093/humrep/deaa279 ◽

2020 ◽

Author(s):

Nazanin Moslehi ◽

Parvin Mirmiran ◽

Rezvan Marzbani ◽

Hassan Rezadoost ◽

Mehdi Mirzaie ◽

...

Keyword(s):

Mass Spectrometry ◽

Gas Chromatography ◽

Pyroglutamic Acid ◽

Gas Chromatography Mass Spectrometry ◽

Ovarian Aging ◽

Decline Rate ◽

Fast Decline ◽

Metabolomics Study ◽

Annual Decline

Abstract STUDY QUESTION Which metabolites are associated with varying rates of ovarian aging, measured as annual decline rates of anti-Müllerian hormone (AMH) concentrations? SUMMARY ANSWER Higher serum concentrations of metabolites of phosphate, N-acetyl-d-glucosamine, branched chained amino acids (BCAAs), proline, urea and pyroglutamic acid were associated with higher odds of fast annual decline rate of AMH. WHAT IS KNOWN ALREADY Age-related rate of ovarian follicular loss varies among women, and the factors underlying such inter-individual variations are mainly unknown. The rate of ovarian aging is clinically important due to its effects on both reproduction and health of women. Metabolomics, a global investigation of metabolites in biological samples, provides an opportunity to study metabolites or metabolic pathways in relation to a physiological/pathophysiological condition. To date, no metabolomics study has been conducted regarding the differences in the rates of ovarian follicular loss. STUDY DESIGN, SIZE, DURATION This prospective study was conducted on 186 reproductive-aged women with regular menstrual cycles and history of natural fertility, randomly selected using random case selection option in SPSS from the Tehran Lipid and Glucose Study. PARTICIPANTS/MATERIALS, SETTING, METHODS AMH concentrations were measured at baseline (1999–2001) and the fifth follow-up examination (2014–2017), after a median follow-up of 16 years, by immunoassay using Gen II kit. The annual decline rate of AMH was calculated by dividing the AMH decline rate by the follow-up duration (percent/year). The women were categorized based on the tertiles of the annual decline rates. Untargeted metabolomics analysis of the fasting-serum samples collected during the second follow-up examination cycle (2005–2008) was performed using gas chromatography–mass spectrometry. A combination of univariate and multivariate approaches was used to investigate the associations between metabolites and the annual decline rates of AMH. MAIN RESULTS AND THE ROLE OF CHANCE After adjusting the baseline values of age, AMH and BMI, 29 metabolites were positively correlated with the annual AMH decline rates. The comparisons among the tertiles of the annual decline rate of AMH revealed an increase in the relative abundance of 15 metabolites in the women with a fast decline (tertile 3), compared to those with a slow decline (tertile 1). There was no distinct separation between women with slow and fast decline rates while considering 41 metabolites simultaneously using the principal component analysis and the partial least-squares discriminant analysis models. The odds of fast AMH decline was increased with higher serum metabolites of phosphate, N-acetyl-d-glucosamine, BCAAs, proline, urea and pyroglutamic acid. Amino sugar and nucleotide sugar metabolism, BCAAs metabolism and aminoacyl tRNA biosynthesis were among the most significant pathways associated with the fast decline rate of AMH. LIMITATIONS, REASONS FOR CAUTION Estimating the annual decline rates of AMH using the only two measures of AMH is the main limitation of the study which assumes a linear fixed reduction in AMH during the study. Since using the two-time points did not account for the variability in the decline rate of AMH, the annual decline rates estimated in this study may not accurately show the trend of the reduction in AMH. In addition, despite the longitudinal nature of the study and statistical adjustment of the participants’ ages, it is difficult to distinguish the AMH-related metabolites observed in this study can accelerate ovarian aging or they are reflections of different rates of the aging process. WIDER IMPLICATIONS OF THE FINDINGS Some metabolite features related to the decline rates of AMH have been suggested in this study; further prospective studies with multiple measurements of AMH are needed to confirm the findings of this study and to better understand the molecular process underlying variations in ovarian aging. STUDY FUNDING/COMPETING INTEREST(S) This study, as a part of PhD thesis of Ms Nazanin Moslehi, was supported by Shahid Beheshti University of Medical Sciences (10522-4). There were no competing interests. TRIAL REGISTRATION NUMBER N/A

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Ca2+-dependent desensitization of insulin secretion by strong potassium depolarization

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.00010.2012 ◽

2012 ◽

Vol 303 (2) ◽

pp. E223-E233 ◽

Cited By ~ 10

Author(s):

M. Willenborg ◽

M. Belz ◽

K. Schumacher ◽

A. Paufler ◽

K. Hatlapatka ◽

...

Keyword(s):

Insulin Secretion ◽

Glucose Concentration ◽

Choline Chloride ◽

Inhibitory Effect ◽

High K ◽

Nacl Concentration ◽

Voltage Dependent ◽

Fast Decline ◽

Insulinotropic Effect ◽

Initial Peak

Depolarization by a high K+ concentration is a widely used experimental tool to stimulate insulin secretion. The effects occurring after the initial rise in secretion were investigated here. After the initial peak a fast decline occurred, which was followed by a slowly progressive decrease in secretion when a strong K+ depolarization was used. At 40 mM KCl, but not at lower concentrations, the decrease continued when the glucose concentration was raised from 5 to 10 mM, suggesting an inhibitory effect of the K+ depolarization. When tolbutamide was added instead of the glucose concentration being raised, a complete inhibition down to prestimulatory values was observed. Equimolar reduction of the NaCl concentration to preserve isoosmolarity enabled an increase in secretion in response to glucose. Unexpectedly, the same was true when the Na+-reduced media were made hyperosmolar by choline chloride or mannitol. The insulinotropic effect of tolbutamide was not rescued by the compensatory reduction of NaCl, suggesting a requirement for activated energy metabolism. These inhibitory effects could not be explained by a lack of depolarizing strength or by a diminished free cytosolic Ca2+ concentration ([Ca2+]i). Rather, the complexation of extracellular Ca2+ concomitant with the K+ depolarization markedly diminished [Ca2+]i and attenuated the inhibitory action of 40 mM KCl. This suggests that a strong but not a moderate depolarization by K+ induces a [Ca2+]i-dependent, slowly progressive desensitization of the secretory machinery. In contrast, the decline immediately following the initial peak of secretion may result from the inactivation of voltage-dependent Ca2+ channels.

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Fast decline of the sea cucumber Isostichopus badionotus as a consequence of high exploitation in Yucatan, Mexico

Regional Studies in Marine Science ◽

10.1016/j.rsma.2019.100547 ◽

2019 ◽

Vol 27 ◽

pp. 100547 ◽

Cited By ~ 2

Author(s):

Jorge A. López-Rocha ◽

Iván Velázquez-Abunader

Keyword(s):

Sea Cucumber ◽

Fast Decline

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Physical performance trajectories and mortality among nursing home residents: results of the SENIOR cohort

Age and Ageing ◽

10.1093/ageing/afaa034 ◽

2020 ◽

Vol 49 (5) ◽

pp. 800-806 ◽

Cited By ~ 1

Author(s):

Alexia Charles ◽

Johann Detilleux ◽

Fanny Buckinx ◽

Jean-Yves Reginster ◽

Bastien Gruslin ◽

...

Keyword(s):

Nursing Home ◽

Older People ◽

Physical Performance ◽

Nursing Home Residents ◽

Value Added ◽

Growth Curve Analysis ◽

Risk Of Mortality ◽

Slow Decline ◽

Increased Risk ◽

Fast Decline

Abstract Background Previous studies have shown that older people can experience a considerable change in their physical performance (PP) over time. Objectives To identify PP trajectories and their association with mortality among nursing home residents who were followed up for 3 years. Design Three-year longitudinal observational study. Setting Subjects of the SENIOR cohort. Subjects Six hundred and four nursing home residents with a mean age of 82.9 ± 9.1 years. Methods Baseline characteristics and the date of death were collected from the medical records. PP was assessed annually by the short physical performance battery (SPPB) test. Multiple imputations were performed to manage the missing data. PP trajectory groups were estimated using latent growth curve analysis. Cox proportional hazard regression models were applied to examine the risk of mortality according to the PP trajectory groups. Results Three PP trajectory groups were identified: slow decline (N = 96), moderate decline (N = 234) and fast decline (N = 274). After adjustments for potential confounding variables and the baseline SPPB scores, the residents in the fast decline and moderate decline trajectory groups had an increased risk of mortality compared to those in the slow decline trajectory group, with hazard ratio values of 1.78 (95% confidence interval [CI] = 1.34–2.26) and 1.37 (95% CI = 1.10–1.66), respectively. Conclusions PP trajectories provide value-added information to baseline geriatric assessments and could be used for predicting 3-year mortality among nursing home residents. It may be important to regularly monitor the SPPB score and signal an alert when a fast decline in PP is detected in older people.

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Novel Cathode Materials Based on Organic Couples for Lithium Batteries

MRS Proceedings ◽

10.1557/proc-496-263 ◽

1997 ◽

Vol 496 ◽

Cited By ~ 8

Author(s):

N. Ravet ◽

C. Michot ◽

M. Armand

Keyword(s):

Solid State ◽

Carbon Black ◽

Electrochemical Reduction ◽

Lithium Batteries ◽

Cathode Materials ◽

Irreversible Process ◽

Lithium Salts ◽

Potential Range ◽

Residual Water ◽

Fast Decline

ABSTRACTThe electrochemical reduction of the oxocarbons: squarate, croconate and especially rhodizonate lithium salts have been studied in all solid state lithium batteries. Lithium rhodizonate cells were tested on cycling in the 1.5 – 3.5 V potential range The reduction of lithium rhodizonate occurs in two waves of two electrons. The number of electrons transferred in reduction on the first cycle was around 3.5 based on a capacity of 515 mA.h.g−1 and a discharge depth of 87 %. This process is quite reversible but we observed a fast decline of the capacity on cycling. This loss of capacity may be attributed to residual water in the salt. The reduction of the lithium croconate occurs at a potential of 1.8 V in a quasi-irreversible process. We could not observe the reduction of lithium squarate which occurs in the potential range where the lithium is inserted in carbon black. We also report an investigation on rhodizonate salts of transition metals. The best results, in term of capacity, on the 1.5 – 3.5 V potential range, were obtained with copper rhodizonate which exhibits a capacity of 579 mA.h.g−1 on the first discharge.

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