Radiation-Induced Cardiotoxicity: Experimental Data

The exciting force’s accurate measurement of is crucial to the structure-born sound radiation. Forced vibration and sound radiation of the ribbed cylinder is examined in the anechoic room. An approach called added mass and damping method is proposed to calculate the elastic vibration and acoustic field of the cylinder. Results obtained from simulation are show to be in good agreement with the experimental data. Sound radiation induced by different input loading form is examined via simulation and experiment. And the equipollence of force and pressure acting on the base is validated.

Download Full-text

Radiation-Induced Buoyancy-Driven Flow in Rectangular Enclosures: Experiment and Analysis

Journal of Heat Transfer ◽

10.1115/1.3248099 ◽

1987 ◽

Vol 109 (2) ◽

pp. 427-433 ◽

Cited By ~ 22

Author(s):

B. W. Webb ◽

R. Viskanta

Keyword(s):

Experimental Data ◽

Temperature Field ◽

Theoretical Model ◽

Radiation Flux ◽

Convective Motion ◽

Radiative Heating ◽

Working Fluid ◽

Injection Technique ◽

Flux Divergence ◽

Radiation Induced

Experiments have been performed to study the rate of internal radiative heating on the natural convective motion in a vertical rectangular enclosure irradiated from the side. A Mach–Zehnder interferometer has been used to determine the temperature field, and a fluorescing dye injection technique was employed to illustrate the flow structure with water as the working fluid. A theoretical model is developed for predicting the absorption of thermal radiation and the subsequent buoyancy-driven flow. Predictions based on spectral calculations for the radiation flux divergence agree well with the experimental data.

Download Full-text

Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA

Scientific Reports ◽

10.1038/s41598-020-75982-x ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Dousatsu Sakata ◽

Oleg Belov ◽

Marie-Claude Bordage ◽

Dimitris Emfietzoglou ◽

Susanna Guatelli ◽

...

Keyword(s):

Experimental Data ◽

Dna Damage ◽

Monte Carlo ◽

Biological Response ◽

Strand Break ◽

Track Structure ◽

Single Strand Break ◽

Fully Integrated ◽

Biological Responses ◽

Radiation Induced

AbstractIonising radiation induced DNA damage and subsequent biological responses to it depend on the radiation’s track-structure and its energy loss distribution pattern. To investigate the underlying biological mechanisms involved in such complex system, there is need of predicting biological response by integrated Monte Carlo (MC) simulations across physics, chemistry and biology. Hence, in this work, we have developed an application using the open source Geant4-DNA toolkit to propose a realistic “fully integrated” MC simulation to calculate both early DNA damage and subsequent biological responses with time. We had previously developed an application allowing simulations of radiation induced early DNA damage on a naked cell nucleus model. In the new version presented in this work, we have developed three additional important features: (1) modeling of a realistic cell geometry, (2) inclusion of a biological repair model, (3) refinement of DNA damage parameters for direct damage and indirect damage scoring. The simulation results are validated with experimental data in terms of Single Strand Break (SSB) yields for plasmid and Double Strand Break (DSB) yields for plasmid/human cell. In addition, the yields of indirect DSBs are compatible with the experimental scavengeable damage fraction. The simulation application also demonstrates agreement with experimental data of $$\gamma$$ γ -H2AX yields for gamma ray irradiation. Using this application, it is now possible to predict biological response along time through track-structure MC simulations.

Download Full-text

Radiation induced currents in mineral-insulated cables and in pick-up coils: model calculations and experimental verification in the BR1 reactor

EPJ Web of Conferences ◽

10.1051/epjconf/201817002008 ◽

2018 ◽

Vol 170 ◽

pp. 02008

Author(s):

Ludo Vermeeren ◽

Willem Leysen ◽

Benoit Brichard

Keyword(s):

Experimental Data ◽

Careful Analysis ◽

Mitigation Strategies ◽

Nuclear Radiation ◽

Model Calculations ◽

Irradiation Test ◽

Lower Amplitude ◽

Model Predictions ◽

Radiation Induced ◽

Induced Currents

Mineral-insulated (MI) cables and Low-Temperature Co-fired Ceramic (LTCC) magnetic pick-up coils are intended to be installed in various position in ITER. The severe ITER nuclear radiation field is expected to lead to induced currents that could perturb diagnostic measurements. In order to assess this problem and to find mitigation strategies models were developed for the calculation of neutron-and gamma-induced currents in MI cables and in LTCC coils. The models are based on calculations with the MCNPX code, combined with a dedicated model for the drift of electrons stopped in the insulator. The gamma induced currents can be easily calculated with a single coupled photon-electron MCNPX calculation. The prompt neutron induced currents requires only a single coupled neutron-photon-electron MCNPX run. The various delayed neutron contributions require a careful analysis of all possibly relevant neutron-induced reaction paths and a combination of different types of MCNPX calculations. The models were applied for a specific twin-core copper MI cable, for one quad-core copper cable and for silver conductor LTCC coils (one with silver ground plates in order to reduce the currents and one without such silver ground plates). Calculations were performed for irradiation conditions (neutron and gamma spectra and fluxes) in relevant positions in ITER and in the Y3 irradiation channel of the BR1 reactor at SCK•CEN, in which an irradiation test of these four test devices was carried out afterwards. We will present the basic elements of the models and show the results of all relevant partial currents (gamma and neutron induced, prompt and various delayed currents) in BR1-Y3 conditions. Experimental data will be shown and analysed in terms of the respective contributions. The tests were performed at reactor powers of 350 kW and 1 MW, leading to thermal neutron fluxes of 1E11 n/cm2s and 3E11 n/cm2s, respectively. The corresponding total radiation induced currents are ranging from 1 to 7 nA only, putting a challenge on the acquisition system and on the data analysis. The detailed experimental results will be compared with the corresponding values predicted by the model. The overall agreement between the experimental data and the model predictions is fairly good, with very consistent data for the main delayed current components, while the lower amplitude delayed currents and some of the prompt contributions show some minor discrepancies.

Download Full-text

Radiation-induced Heart Disease: Review of Experimental Data on Dose Reponse and Pathogenesis

International Journal of Radiation Biology ◽

10.1080/09553009214550761 ◽

1992 ◽

Vol 61 (2) ◽

pp. 149-160 ◽

Cited By ~ 71

Author(s):

S. Schultz-Hector

Keyword(s):

Experimental Data ◽

Heart Disease ◽

Radiation Induced

Download Full-text

Ion Beam Irradiation Effects on Polymers

MRS Proceedings ◽

10.1557/proc-792-r3.29 ◽

2003 ◽

Vol 792 ◽

Author(s):

Mircea Chipara

Keyword(s):

Experimental Data ◽

Free Radicals ◽

Energy Gap ◽

Ion Beam ◽

Beam Irradiation ◽

Irradiation Effects ◽

Ion Beam Irradiation ◽

Radiation Induced ◽

Main Effects

ABSTRACTThe main effects of the interaction of accelerated ions with polymeric targets are critically reviewed. The possibility of a relatively reduced heating of polymer during ion beam bombardment is analyzed. Experimental data pointing towards various radiation-induced modifications in polycarbonate (free radicals production, modifications of the energy gap) are discussed.

Download Full-text

First-Principles Simulations of Interstitial Atoms in Ionic Solids

MRS Proceedings ◽

10.1557/proc-408-509 ◽

1995 ◽

Vol 408 ◽

Cited By ~ 1

Author(s):

E. A. Kotomin ◽

A. Svane ◽

T. Brudevoll ◽

W. Schulz ◽

N. E. Christensen

Keyword(s):

Experimental Data ◽

First Principles ◽

Recent Experimental Data ◽

Full Potential ◽

Ionic Solids ◽

Interstitial Atoms ◽

Lmto Method ◽

Radiation Induced ◽

Anion Site ◽

Molecular Mode

The atomic and electronic structure of the radiation-induced interstitial atoms in MgO and KCl crystals representing two broad classes of ionic solids are calculated and compared. The first-principles full potential LMTO method is applied to a 16-atom supercell. For both crystals the energetically most favourable configuration is a dumbbell centered at a regular anion site. Its (110) and (111) orientations are very close in energy which permits the dumbbell to rotate easily on a lattice site. The mechanism and the relevant activation energy for thermally activated diffusion hops from the dumbbell equilibrium position to the cube face and cube center are discussed in the light of the available experimental data for MgO. In order to interpret recent experimental data on Raman spectroscopy, the local vibrational frequences are calculated for the dumbbell in KCl (the so-called H center). A strong coupling is found between its stretching molecular mode and the breathing mode of the nearest cations whose frequency is predicted.

Download Full-text

Mechanistic Model of Radiation-Induced Bystander Effects to Cells using Structured Population Approach

MATEMATIKA ◽

10.11113/matematika.v34.n3.1147 ◽

2018 ◽

Vol 34 (3) ◽

pp. 149-165

Author(s):

Fuaada Mohd Siam ◽

Muhamad Hanis Nasir

Keyword(s):

Experimental Data ◽

Model Simulation ◽

Mechanistic Model ◽

Signal Molecules ◽

Population Approach ◽

Strand Breaks ◽

Fitting Procedure ◽

Structured Population ◽

Radiation Induced ◽

Irradiation Process

In irradiation process, instead of traverse on the targeted cells, there is side effect happens to non-targeted cells. The targeted cells that had been irradiated with ionizing radiation emits damaging signal molecules to the surrounding and then, damage the bystander cells. The type of damage considered in this work is the number of double-strand breaks (DSBs) of deoxyribonucleic acid (DNA) in cell’s nucleus. By using mathematical approach, a mechanistic model that can describe this phenomenon is developed based on a structured population approach. Then, the accuracy of the model is validated by its ability to match the experimental data. The Particle Swarm (PS) optimization is employed for the data fitting procedure. PS optimization searches the parameter value that minimize the errors between the model simulation data and experimental data. It is obtained that the mathematical modelling proposed in this paper is strongly in line with the experimental data.

Download Full-text