Chemotropic Influence of Specific Target Epithelium on the Growth of Embryonic Sensory Neurites

1988 ◽  
pp. 323-340
Author(s):  
A. G. S. Lumsden ◽  
A. M. Davies
Keyword(s):  
Specific Target

Pre-Service Teachers’ Competences in Applying Knowledge of Mathematics and Language in Mathematical Fiction

2020 ◽  
pp. 247-261
Author(s):  
Vaiva Grabauskienė ◽  
Vaiva Schoroškienė
Keyword(s):  
University Students ◽  
Language Learning ◽  
Target Audience ◽  
Primary Students ◽  
Subject Knowledge ◽  
Specific Target ◽  
Mathematical Fiction ◽  
Subject Integration

The article explores possibilities of integrating mathematics and language learning. The language of mathematics differs remarkably from everyday speech, which may cause some difficulties not only for primary students, but also for pre-service teachers. One of the methods to resolve this issue is integrating mathematics and language learning. This method also develops university students’ skills to apply didactic and subject knowledge. The article examines skills of pre-service teachers that are revealed in their fictional stories on a chosen mathematical subject. The analysis of mathematical fiction demonstrates that subject integration emphasizes students’ abilities to distinguish essential aspects of the chosen mathematical phenomenon, as well as how students are able to apply and explain concepts, and to adjust to age-specific target audience.

scholarly journals STR technique for the detection of contamination by exogenous DNA in paraffin blocks and histological slides

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Denise Barcelos ◽  
Karina Funabashi ◽  
Susana Mazloum ◽  
Mariana Fernandes ◽  
Leonardo Cardili
Keyword(s):  
Target Therapy ◽  
Genetic Material ◽  
Gastric Gist ◽  
Sequence Analyses ◽  
Laboratory Procedure ◽  
Exogenous Dna ◽  
Stromal Tumors ◽  
Specific Target ◽  
Different Types ◽  
Short Tandem

Abstract Gastrointestinal Stromal Tumors (GIST) present different types of mutations that may or may not be sensitive to specific target therapy. The laboratory procedure required to prepare histological sections traditionally demands multiple steps, making the process prone to contamination by exogenous genetic material (DNA). An eventual contamination of the biological sample with exogenous DNA may jeopardize subsequent analysis of mutations. The Short Tandem Repeat (STR) technique is frequently used in forensic science fields and presents a potential application in surgical pathology, especially in situations of suspected sample exchange. In the present study, the objective is to verify the possible contamination by exogenous DNA in gastric GIST samples and to evaluate if the presence of contamination can interfere in the detection of the mutations of interest. We assessed eight gastric GISTs by the Sanger sequencing and STR sequence analyses. Seven samples presented more than one profile, a result interpreted as contamination. Our results indicate that exogenous DNA contamination occurred in most of the samples studied and that this was more frequent in samples obtained from the slides than those obtained from the block. The presence of contamination did not inhibit the detection of the mutations of interest for a specific target therapy. Furthermore, the histologic block revealed to be more advantageously when compared to the slide for molecular pathology diagnosis.

scholarly journals Crystal structure of chloroplastic thioredoxin z defines a type‐specific target recognition

2021 ◽  
Author(s):  
Théo Le Moigne ◽  
Libero Gurrieri ◽  
Pierre Crozet ◽  
Christophe H. Marchand ◽  
Mirko Zaffagnini ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Target Recognition ◽  
Specific Target

Electrophysiologic Correlates of Attention versus Distraction in Young and Elderly Listeners

2002 ◽  
Vol 13 (07) ◽  
pp. 383-391 ◽  
Author(s):  
Albert R. De Chicchis ◽  
Michael Carpenter ◽  
Jerry L. Cranford ◽  
Murvin R. Hymel
Keyword(s):  
Selective Attention ◽  
Evoked Potential ◽  
The Elderly ◽  
Auditory Evoked Potential ◽  
Competition Effect ◽  
Specific Target ◽  
Attention Effect ◽  
Competition Effects ◽  
Significant Attention ◽  
Versus Stimulus

This study examined the effects of selective attention versus stimulus competition on the late auditory evoked potential (LAEP) in 20 young and 20 elderly listeners. In a series of test runs, different oddball tonal sequences were presented to one or both ears, and listeners were instructed to attend to tones at a specific target ear. Peak amplitudes were recorded for the N1, P2, and the early and late N2 components of the LAEP. Significant attention effects were found for all four components. N1 amplitudes increased significantly when participants attended to the target stimuli, whereas the amplitudes of P2, N2e, and N2l decreased. For all LAEP components except N2l, the attention effect did not differ between young and elderly listeners. Significant competition effects also were found for all four components. Amplitudes were significantly larger in monaural than binaural conditions for all components except N2l. The magnitude of this competition effect also was significantly larger for the young listeners than the elderly for all components except N1. These results suggest that the ability to attend selectively to sounds may be more resistant to normal aging than are effects related to stimulus competition.

scholarly journals Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 233
Author(s):  
Tasuku Konno ◽  
Eduardo Pinho Melo ◽  
Joseph E. Chambers ◽  
Edward Avezov
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Endoplasmic Reticulum ◽  
Neurodegenerative Diseases ◽  
Antioxidative Enzymes ◽  
Redox Reactions ◽  
Ros Production ◽  
Oxygen Species ◽  
Specific Target

Reactive oxygen species (ROS) are produced continuously throughout the cell as products of various redox reactions. Yet these products function as important signal messengers, acting through oxidation of specific target factors. Whilst excess ROS production has the potential to induce oxidative stress, physiological roles of ROS are supported by a spatiotemporal equilibrium between ROS producers and scavengers such as antioxidative enzymes. In the endoplasmic reticulum (ER), hydrogen peroxide (H2O2), a non-radical ROS, is produced through the process of oxidative folding. Utilisation and dysregulation of H2O2, in particular that generated in the ER, affects not only cellular homeostasis but also the longevity of organisms. ROS dysregulation has been implicated in various pathologies including dementia and other neurodegenerative diseases, sanctioning a field of research that strives to better understand cell-intrinsic ROS production. Here we review the organelle-specific ROS-generating and consuming pathways, providing evidence that the ER is a major contributing source of potentially pathologic ROS.

Segmentation of physician-assisted suicide as a niche tourism market: An Initial Exploration

2021 ◽  
pp. 109634802110116
Author(s):  
Jun Wen ◽  
Edmund Goh ◽  
Chung-En Yu
Keyword(s):  
Content Analysis ◽  
Assisted Suicide ◽  
Emerging Market ◽  
Physician Assisted Suicide ◽  
Target Groups ◽  
Comprehensive Overview ◽  
Policy Makers ◽  
Thematic Content Analysis ◽  
Specific Target ◽  
Initial Exploration

Suicide travel, in which potential suicide candidates visit certain destinations to perform physician-assisted suicide (PAS), is an emerging topic in tourism. Despite noted discrepancies between suicide travel and traditional definitions of tourism, PAS practices in tourism have gained the attention of scholars and practitioners. This type of travel is inherently complex, and its segmentation remains ambiguous. This study examines a sample of PAS-related videos and viewer comments to identify relevant travel segments. Based on two rounds of thematic content analysis, the resultant segmentation offers a preliminary perspective on this emerging market. Theoretically, this study is among the first to provide a comprehensive overview of the roles of PAS practices in tourism in terms of specific target groups. Practically, the findings offer novel insight for industry practitioners and policy makers.

scholarly journals CLINICAL IMPACT OF A HYPOTHETICAL SEX-SPECIFIC TARGET DOSE IN WOMEN FOR THE TREATMENT OF HEART FAILURE WITH REDUCED EJECTION FRACTION

2020 ◽  
Vol 75 (11) ◽  
pp. 978
Author(s):  
Jesse Veenis ◽  
Gerard Linssen ◽  
Hans-Peter Brunner-La Rocca ◽  
Arno Hoes ◽  
Jasper J. Brugts
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Clinical Impact ◽  
Target Dose ◽  
Reduced Ejection Fraction ◽  
Specific Target

scholarly journals An Action Recognition network for specific target based on rMC and RPN

2019 ◽  
Vol 1325 ◽  
pp. 012073
Author(s):  
Mingjie Li ◽  
Youqian Feng ◽  
Zhonghai Yin ◽  
Cheng Zhou ◽  
Fanghao Dong ◽  
...  
Keyword(s):  
Action Recognition ◽  
Specific Target
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