Nitrite Biosensors: Analytical Tools for Determination of Toxicity Due to Presence of Nitrite Ions

2013 ◽  
pp. 217-226 ◽  
Author(s):  
V. Dhull ◽  
A. Gahlaut ◽  
A. Gothwal ◽  
J. S. Duhan ◽  
V. Hooda
Keyword(s):  
Analytical Tools

ANALYTICAL TOOLS AND MANAGEMENT METHOD OF CASH FLOWS AT THE ENTERPRISE

2017 ◽  
pp. 93-105
Author(s):  
Olha NIPIALIDI
Keyword(s):  
Financial Stability ◽  
Cash Flows ◽  
Sustainable Growth ◽  
Financial Health ◽  
Traditional Assessment ◽  
Financial Condition ◽  
Efficient Management ◽  
Expert Assessments ◽  
Analytical Tools

Introduction. The most important factors for “financial health” of the company are effectively structured cash flows, precondition for sustainable growth and achievement of high end results of economic activity as a whole. Knowledge and practical use of modern methods of organization and efficient management of cash flows enables transition of the company to a new quality of economic development. Purpose. The aim of the article is the research and development of theoretical, methodological and practical recommendations concerning the organization of the management process of cash flows at the enterprise. Results. Methodology of traditional assessment of financial stability of the enterprise, its elements and the factors influencing it can significantly complement and improve through the use of advanced mathematical models that allow to analyze the accuracy and objectivity of expert assessments for determination the level of the financial condition of the enterprise. Conclusion. The system of indicators used in the analysis of cash flows at the enterprises is investigated and systematized. It is advisable to choose those indicators from the total aggregate of indicators that are the most attracted to specific users of accounting information. Methods for analyzing cash flow is supplemented as regards the determination of the integral index of financial stability, which makes it possible to install ranked of the investigated enterprise. Proposals for amendments the methodological approaches to estimating of future cash flows will allow more effectively increase usefulness and reliability of accounting and analytical information for making management decisions.

scholarly journals A METHODOLOGICAL APPROACH TO THE CHARACTERIZATION OF BRAIN GLIOMAS, BY MEANS OF SEMI-AUTOMATIC MORPHOMETRIC ANALYSIS

2014 ◽  
Vol 33 (3) ◽  
pp. 201 ◽  
Author(s):  
Artur Dawid Surowka ◽  
Dariusz Adamek ◽  
Edyta Radwanska ◽  
Marek Lankosz ◽  
Magdalena Szczerbowska-Boruchowska
Keyword(s):  
Aspect Ratio ◽  
Digital Image Analysis ◽  
Methodological Approach ◽  
Morphometric Parameters ◽  
Mean Values ◽  
The Mean ◽  
Analytical Tools ◽  
Brain Gliomas

The aims of this paper were to present a reliable morphometric procedure for glioma analysis for preliminary prognosis and to develop a semi-automatic procedure that is easy to use. The data presented are important to the extent that they verify the reliability of the results by showing that they are consistent with the findings from more complicated automatic analytical tools. The objects for analysis were digital images of haematoxylin-eosin stained glioma samples. The overall analysis consisted of digital image analysis and the determination of morphometric parameters. Interestingly, an increase in the mean values of aspect ratio with increasing malignancy grade was found. Moreover, the morphometric parameters in relation to the histological origin of gliomas were examined and it was found that, the cellular nuclei of glioblastoma multiforme reveal the biggest mean values of aspect ratio compared with other gliomas.

scholarly journals ANALISIS PERILAKU KONSUMEN TERHADAP KOPI TELAPEN PADA ERA NEW NORMAL DI BATUKLIANG UTARA KABUPATEN LOMBOK TENGAH

2021 ◽  
Vol 22 (2) ◽  
pp. 119-133
Author(s):  
Nurul Aini ◽  
Syarif Husni ◽  
Muhamad Siddik
Keyword(s):  
Consumer Behavior ◽  
Decision Process ◽  
Descriptive Analysis ◽  
Sampling Technique ◽  
New Normal ◽  
Attribute Analysis ◽  
Quota Sampling ◽  
Buy Back ◽  
Analytical Tools

This study aims to identify general characteristics, analyze consumer behavior, analyze consumer attitudes, analyze the purchase decision process. telapen coffee in the new normal era in North Batukliang District, Central Lombok Regency. This research uses a descriptive method. Determination of the research location is determined by purposive sampling technique. Determination of the number of consumer samples is determined by the Quota sampling technique of 30 respondents. The analytical tools used in this study are fishbein multi-attribute analysis and subjective normative analysis to measure consumer behavior and attitudes. Descriptive analysis to measure the characteristics and purchasing decision process of telapen coffee consumers. The results of this study indicate that telapen coffee consumers have the possibility to buy back telapen coffee products and have a favorable attitude towards telapen coffee products and feel satisfied with telapen coffee products. Based on the results of these studies should KVWT Kaki Rinjani should be. lower prices to increase coffee demand. telapen. must be able to maintain the attributes that can attract new customers and retain old customers.

scholarly journals A Current Review on Analytical Tools for Determination of New Oral Antidiabetic Drugs, Empagliflozin, Linagliptin and Biguanides in Bulk Materials, Pharmaceuticals & Biological Samples

2020 ◽  
pp. 67-83
Author(s):  
S. Baokar ◽  
K. Mane ◽  
A. Bhujbal ◽  
S. Pharande ◽  
G. Patil ◽  
...  
Keyword(s):  
Dipeptidyl Peptidase 4 ◽  
Current Review ◽  
Anti Cancer ◽  
Cardio Vascular ◽  
Bioanalytical Assays ◽  
Analytical Tools ◽  
A Current ◽  
Metformin Hcl

Worldwide the R & D divisions of Pharma industry are actively involved in the development of new therapeutic agents. These agents may be either new entities or partial structural modification of the existing one. The recent FDA statistics represent that the average number of drug filings are increasing every year in the thrust areas like anti-cancer agents, anti-diabetic, antibiotics, cardio-vascular drugs, respiratory drugs etc. Sodium glucose co-transporter-2(SGLT-2) inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors and biguanides are effective oral anti-diabetic agents used in treatment of type 2 Diabetes Mellitus. Therefore, the necessity to explore and compare the existing analytical and bioanalytical assays used for determination of such drugs either single or in combination is crucial. Many methods were reported in the literature for the bio-analysis and analysis of four novel gliptins combinations, empagliflozin-linagliptin, empagliflozin-metformin HCl, linagliptin-metformin HCl, empagliflozin-linagliptin-metformin HCl combination with application on Glyxambi®, Synjardy®, Jentadueto®, Trijardy® XR tablets respectively. Furthermore, this review offered an overview of different methods used for determination of every drug alone as empagliflozin from SGLT-2 inhibitors, linagliptin from DPP-4 inhibitors and metformin from biguanides in a tabulated comparative way. Moreover, the current review emphasizes the most common stability indicating assays to be of interest to the analysts in the area of drug control. This review helps in understanding the further need for the development of analytical methods for the estimation of such drugs.

scholarly journals Therapeutic Drug Monitoring: Fundamentals, And Optimization

2021 ◽  
Author(s):  
Ahmed Ali ◽  
Mahran Abdel-Rahman
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Cost Effective ◽  
Drug Level ◽  
Therapeutic Drug ◽  
Relevant Research ◽  
Request Form ◽  
Narrow Therapeutic Range ◽  
Analytical Tools

Therapeutic drug monitoring (TDM) is a teamwork clinical pharmacokinetic services aimed to optimize pharmacotherapy of certain drugs such as those with a narrow therapeutic range, complicated pharmacokinetics. It involves the determination of drug level in blood samples taken at the appropriate time. Interpretation of results requires integration of pharmacokinetics, the pharmacodynamics of the drug and the patient’s clinical profile. To be cost-effective the service should be optimized. This review was written by experts from different developing countries to highlight the fundamentals of the service and provide suggestions for its optimization. These cover the rationale of requesting drug level, design of request form, optimal sampling, and analytical tools. guidelines for appropriate interpretation of drug levels; completeness of the roles of the qualified medical team; continuing education and skills development; involve the patients in improving the service, conducting relevant research; use PK software and integration of TDM with pharmacogenomics

scholarly journals Steroid Diagnostics of 21st Century in the Light of Their New Roles and Analytical Tools

2020 ◽  
pp. S193-S203 ◽  
Author(s):  
M. DUŠKOVÁ ◽  
L. KOLÁTOROVÁ ◽  
M. ŠIMKOVÁ ◽  
M. ŠRÁMKOVÁ ◽  
M. MALÍKOVÁ ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Steroid Hormones ◽  
21St Century ◽  
Reference Values ◽  
Current Technology ◽  
Amount Of Information ◽  
Analytical Phase ◽  
Analytical Tools ◽  
Fertile Women

The determination of steroid hormones and subsequent interpretation of results is accompanied by a range of difficulties. The amount of information that current technology can provide on the circulating concentrations of more than a hundred various steroid compounds can lead to problems with interpretation. The aim of this study is to help provide orientation in this maze of data on steroid hormones. First we focus on specific aspects arising from the pre-analytical phase of steroid determination that need to be considered when planning sampling, whether for diagnostics or research. Then, we provide a brief summary of the characteristics and diagnostic relevance of several steroid hormones and/or their metabolites: pregnenolone, 17α-hydroxy-pregnenolone, dehydroepiandrosterone, hydroxyderivatives of dehydroepiandrosterone, androstenedione, testosterone, estrone, estradiol, estriol, cortisol, cortisone, which in our institute are determined with validated LC-MS/MS methods. For these steroids, we also provide newly calculated reference values in fertile women according to the phase of their menstrual cycle.

Validated Chromatographic Methods for Simultaneous Estimation of Cinnarizine in Binary Mixture with Domperidone and Paracetamol in Tablets

2019 ◽  
Vol 15 (5) ◽  
pp. 429-438
Author(s):  
Marianne Alphonse Mahrouse ◽  
Asmaa Ahmed El-Zaher ◽  
Ahmed Mohammed Al-Ghani
Keyword(s):  
Quality Control ◽  
Hplc Method ◽  
Simultaneous Estimation ◽  
Chromatographic Methods ◽  
Treatment And Prevention ◽  
Rp Hplc ◽  
Linear Relationships ◽  
Ich Guidelines ◽  
Analytical Tools

Background:Cinnarizine, an antihistaminic drug, is commonly formulated in combination with domperidone and with paracetamol for treatment and prevention of motion sickness and migraine.Objective:The aim of this work was to develop new, simple, precise and selective chromatographic methods (RP-HPLC and TLC-densitometric methods) for the determination of these drugs. These methods can be used as analytical tools in the routine examination in quality control laboratories.Methods:The first method was RP-HPLC method, the separation was carried out on an Inertsil® ODS- 3V C18 column (250 mm × 4.6 mm, 5 µm) using a mobile phase composed of methanol: acetonitrile (45: 55, v/v) at a flow rate of 1 ml/min. The detection was carried out at 220 nm. The second method was a TLC-densitometric method where the studied components were separated using a developing system composed of toluene: ethyl acetate: methanol: triethylamine (5: 4.3: 0.7: 0.5, v/v/v/v) on TLC silica gel 60 F254 plates, followed by densitometric scanning at 270 nm.Results:In RP-HPLC method, the peaks were sharp and well separated, the retention times were 5.25, 3.48 and 2.78 min, for cinnarizine, domperidone and paracetamol, respectively. Linearity was obtained over the concentration ranges 1-22, 0.75-16.5 and 25-550 µg/ml, for cinnarizine, domperidone and paracetamol, respectively. In TLC-densitometric method, good separation of spots and linear relationships were achieved over the concentration ranges of 0.2-2, 0.15-1.5 and 5-50 µg/spot, for cinnarizine, domperidone and paracetamol, respectively. Method validation was conducted according to ICH guidelines in terms of linearity, accuracy, selectivity, precision and robustness.Conclusion:The developed methods were applied for the determination of the cited drugs in tablets containing binary drug mixtures. The methods are simple and precise and can be used for routine analysis of the labelled drugs in combined dosage forms in quality control laboratories.

Determination of NADH in Frozen Rat Brain Sections by Laser-Induced Fluorescence

2001 ◽  
Vol 382 (12) ◽  
pp. 1727-1732 ◽  
Author(s):  
André Rex ◽  
Lutz Pfeifer ◽  
Heidrun Fink
Keyword(s):  
Rat Brain ◽  
Metabolic Activity ◽  
Nicotinamide Adenine Dinucleotide ◽  
Brain Structures ◽  
Laser Induced Fluorescence ◽  
Fluorescence Detector ◽  
Nadh Fluorescence ◽  
Neurotoxic Lesions ◽  
Analytical Tools

Abstract Methods to assess metabolism are important analytical tools in neuroscience. The fluorophore nicotinamide adenine dinucleotide (NADH) is a parameter of cellular metabolism. NADH fluorescence was measured using a laserbased fluorescence detector with spectral and temporal filters. Distribution and intensity of NADH fluorescence were investigated in frozen brain sections. In sections containing hippocampus the intensity of NADH fluorescence was correlated to brain structures. In order to investigate the consequences of neurotoxic lesions, 5,7-dihydroxytryptamine was injected into the dorsal raphe nucleus 4 to 240 days prior to the measurement. NADH fluorescence decreased in the affected region by 50%, indicating that no recovery in metabolic activity had occurred.

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