Diallyl Trisulfide Prospectively Retrieves Arsenic Induced Lung Oxidative Stress, Inflammation Through the Activation of Nrf2/HO-1 Signaling

Sulfiredoxin (Srx) is a newly discovered antioxidant enzyme playing a role in the catalytic reduction of oxidative modifications. Srx is overexpressed in a variety of cancers. It may promote carcinogenesis as well as tumor progression. In this study, we report for the first time that Srx expression might be positively associated with the development of gastric cancer and tumor malignancy. Immunohistochemistry showed that, compared to normal tissues (42%, 20/47), Srx expression in gastric tumors (85%, 40/47) was much more common (chi-square test, p<0.01). In addition, the staining of Srx was stronger in poorly differentiated gastric cancer than in well-differentiated gastric cancer. Western blotting showed that, in the gastric tumor cell line BGC823, the Srx protein was upregulated in response to H2O2 treatment, although it was inadequate to counteract the increased oxidative stress, as indicated by the gradually increasing level of malondialdehyde (MDA). In addition, Srx expression, MDA levels, and ROS levels in BGC823 cells were markedly inhibited upon treatment with diallyl trisulfide (DATS), a major constituent of garlic oil with proven anticancer effects. These results suggest that Srx may be an oxidative stress marker. Antioxidation may account for the anticancer potential of garlic.

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Protective effects of diallyl trisulfide (DATS) against doxorubicin-induced inflammation and oxidative stress in the brain of rats

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2020.07.018 ◽

2020 ◽

Vol 160 ◽

pp. 141-148

Author(s):

Wai-Shing Leung ◽

Wei-Wen Kuo ◽

Da-Tong Ju ◽

Tian-De Wang ◽

William Shao-Tsu Chen ◽

...

Keyword(s):

Oxidative Stress ◽

Protective Effects ◽

Diallyl Trisulfide ◽

The Brain ◽

And Oxidative Stress

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Comparative study of diesel and biodiesel exhausts on lung oxidative stress and genotoxicity in rats

Environmental Pollution ◽

10.1016/j.envpol.2017.12.077 ◽

2018 ◽

Vol 235 ◽

pp. 514-524 ◽

Cited By ~ 29

Author(s):

Thierry Douki ◽

Cécile Corbière ◽

David Preterre ◽

Perrine J. Martin ◽

Valérie Lecureur ◽

...

Keyword(s):

Oxidative Stress ◽

Comparative Study ◽

Lung Oxidative Stress

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Epigallocatechin Gallate Potentially Abrogates Fluoride Induced Lung Oxidative Stress, Inflamation via Nrf2/Keap 1 Signaling Pathway in Rats

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2016.10.287 ◽

2016 ◽

Vol 100 ◽

pp. S111

Author(s):

Shanmugam Thangapandiyan

Keyword(s):

Oxidative Stress ◽

Signaling Pathway ◽

Epigallocatechin Gallate ◽

Lung Oxidative Stress

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Intermittent Hypoxia Increases the Severity of Bleomycin-Induced Lung Injury in Mice

Oxidative Medicine and Cellular Longevity ◽

10.1155/2018/1240192 ◽

2018 ◽

Vol 2018 ◽

pp. 1-13 ◽

Cited By ~ 10

Author(s):

Thomas Gille ◽

Morgane Didier ◽

Cécile Rotenberg ◽

Eva Delbrel ◽

Dominique Marchant ◽

...

Keyword(s):

Oxidative Stress ◽

Pulmonary Fibrosis ◽

Pulmonary Edema ◽

Cell Apoptosis ◽

Lung Fibrosis ◽

Intermittent Hypoxia ◽

Chronic Intermittent Hypoxia ◽

Obstructive Sleep ◽

The Impact ◽

Lung Oxidative Stress

Background. Severe obstructive sleep apnea (OSA) with chronic intermittent hypoxia (IH) is common in idiopathic pulmonary fibrosis (IPF). Here, we evaluated the impact of IH on bleomycin- (BLM-) induced pulmonary fibrosis in mice. Methods. C57BL/6J mice received intratracheal BLM or saline and were exposed to IH (40 cycles/hour; FiO2 nadir: 6%; 8 hours/day) or intermittent air (IA). In the four experimental groups, we evaluated (i) survival; (ii) alveolar inflammation, pulmonary edema, lung oxidative stress, and antioxidant enzymes; (iii) lung cell apoptosis; and (iv) pulmonary fibrosis. Results. Survival at day 21 was lower in the BLM-IH group (p<0.05). Pulmonary fibrosis was more severe at day 21 in BLM-IH mice, as assessed by lung collagen content (p=0.02) and histology. At day 4, BLM-IH mice developed a more severe neutrophilic alveolitis, (p<0.001). Lung oxidative stress was observed, and superoxide dismutase and glutathione peroxidase expression was decreased in BLM-IH mice (p<0.05 versus BLM-IA group). At day 8, pulmonary edema was observed and lung cell apoptosis was increased in the BLM-IH group. Conclusion. These results show that exposure to chronic IH increases mortality, lung inflammation, and lung fibrosis in BLM-treated mice. This study raises the question of the worsening impact of severe OSA in IPF patients.

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